JBC Anatrace, Inc.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on December 20, 2002
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
277/52/50776    most recent
M209900200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guo, L.
Right arrow Articles by Michalak, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guo, L.
Right arrow Articles by Michalak, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print October 10, 2002
J. Biol. Chem, 10.1074/jbc.M209900200
Submitted on September 26, 2002
Revised on October 9, 2002
Accepted on October 10, 2002

Cardiac specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse

Lei Guo, Kimitoshi Nakamura, Jeffrey Lynch, Michal Opas, Eric N. Olson, Louis B. Agellona, and Marek Michalak

Department of Biochemistry, University of Alberta, Edmonton, Alberta T6J 2H7

Corresponding Author: Marek.Michalak{at}ualberta.ca

Calreticulin is an endoplasmic reticulum resident Ca2+ binding chaperone. The importance of the protein is illustrated by embryonic lethality due to impaired cardiac development in calreticulin deficient mice. The molecular details underlying this phenotype are not understood. In this study we show that over-expression of activated calcineurin reverses the defect in cardiac development observed in calreticulin-deficient mice and rescues them from embryonic lethality. The surviving mice show no defect in cardiac development but exhibited growth retardation, hypoglycemia, increased levels of serum triacylglycerols and cholesterol. Reversal of embryonic lethality due to calreticulin-deficiency by activated calcineurin underscores the impact of the calreticulin-calcineurin functions on the Ca2+-dependent signaling cascade during early cardiac development. These findings show that calreticulin and calcineurin play fundamental roles in Ca2+-dependent pathways essential for normal cardiac development and explain the molecular basis for the rescue of calreticulin deficient phenotype.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M. E. Grespin, G. M. C. Bonamy, V. R. Roggero, N. G. Cameron, L. E. Adam, A. P. Atchison, V. M. Fratto, and L. A. Allison
Thyroid Hormone Receptor {alpha}1 Follows a Cooperative CRM1/Calreticulin-mediated Nuclear Export Pathway
J. Biol. Chem., September 12, 2008; 283(37): 25576 - 25588.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
E. Szabo, Y. Qiu, S. Baksh, M. Michalak, and M. Opas
Calreticulin inhibits commitment to adipocyte differentiation
J. Cell Biol., July 14, 2008; 182(1): 103 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
X.-Y. Jia, C.-Y. Xu, R.-L. Jing, R.-Z. Li, X.-G. Mao, J.-P. Wang, and X.-P. Chang
Molecular cloning and characterization of wheat calreticulin (CRT) gene involved in drought-stressed responses
J. Exp. Bot., March 1, 2008; 59(4): 739 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. Wanderling, B. B. Simen, O. Ostrovsky, N. T. Ahmed, S. M. Vogen, T. Gidalevitz, and Y. Argon
GRP94 Is Essential for Mesoderm Induction and Muscle Development Because It Regulates Insulin-like Growth Factor Secretion
Mol. Biol. Cell, October 1, 2007; 18(10): 3764 - 3775.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Isaji, Y. Sato, Y. Zhao, E. Miyoshi, Y. Wada, N. Taniguchi, and J. Gu
N-Glycosylation of the beta-Propeller Domain of the Integrin {alpha}5 Subunit Is Essential for {alpha}5beta1 Heterodimerization, Expression on the Cell Surface, and Its Biological Function
J. Biol. Chem., November 3, 2006; 281(44): 33258 - 33267.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. L. Gooch, R. L. Guler, J. L. Barnes, and J. J. Toro
Loss of calcineurin A{alpha} results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus
J. Cell Sci., June 15, 2006; 119(12): 2468 - 2476.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. Porcellini, E. Traggiai, U. Schenk, D. Ferrera, M. Matteoli, A. Lanzavecchia, M. Michalak, and F. Grassi
Regulation of peripheral T cell activation by calreticulin.
J. Exp. Med., February 20, 2006; 203(2): 461 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
D. B. Williams
Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum
J. Cell Sci., February 15, 2006; 119(4): 615 - 623.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. Lynch, L. Guo, P. Gelebart, K. Chilibeck, J. Xu, J. D. Molkentin, L. B. Agellon, and M. Michalak
Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca2+-dependent signaling cascade
J. Cell Biol., July 4, 2005; 170(1): 37 - 47.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sipione, C. Ewen, I. Shostak, M. Michalak, and R. C. Bleackley
Impaired Cytolytic Activity in Calreticulin-Deficient CTLs
J. Immunol., March 15, 2005; 174(6): 3212 - 3219.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.