JBC Origene Your Gene Company

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on February 14, 2003
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
278/8/5728    most recent
M210656200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Palka, H. L.
Right arrow Articles by Tonks, N. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Palka, H. L.
Right arrow Articles by Tonks, N. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print December 9, 2002
J. Biol. Chem, 10.1074/jbc.M210656200
Submitted on October 17, 2002
Revised on December 3, 2002
Accepted on December 9, 2002

"Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1"

Helena L. Palka, Morag Park, and Nicholas K. Tonks

Cold Spring Harbor Laboratory, Cold Spring harbor, NY 11724

Corresponding Author: tonks{at}cshl.org

The receptor protein-tyrosine phosphatase DEP-1 (CD148/PTP-eta ) has been implicated in the regulation of cell growth, differentiation and transformation and most recently has been identified as a potential tumor suppressor gene mutated in colon, lung and breast cancers. We have generated constructs comprising the cytoplasmic segment of DEP-1 fused to the maltose binding protein to identify potential substrates and thereby suggest a physiological function for DEP-1. We have shown that the substrate-trapping mutant form of DEP-1 interacted with a small subset of tyrosine-phosphorylated proteins from lysates of the human breast tumor cell lines MDA-MB-231, T-47D and T-47D/Met and have identified the hepatocyte growth factor/scatter factor (HGF/SF) receptor Met, the adapter protein Gab1 and the junctional component p120 catenin as potential substrates. Following ligand stimulation, phosphorylation of specific tyrosyl residues in Met induces mitogenic, motogenic and morphogenic responses. When co-expressed in 293 cells, the full-length substrate trapping mutant form of DEP-1 formed a stable complex with the chimeric receptor CSF.MET and wild type DEP-1 dephosphorylated CSF.MET. Furthermore, we observed that DEP-1 preferentially dephosphorylated a Gab1 binding site (Tyr1349) and a C-terminal tyrosine implicated in morphogenesis (Tyr1365), whereas tyrosine residues in the activation loop of Met (Tyr1230, Tyr1234, Tyr1235) were not preferred targets of the PTP. The ability of DEP-1 preferentially to dephosphorylate particular tyrosine residues that are required for Met-induced signaling suggests that DEP-1 may function in controlling the specificity of signals induced by this PTK, rather than as a simple “off-switch” to counteract PTK activity.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
V. Sangwan, G. N. Paliouras, J. V. Abella, N. Dube, A. Monast, M. L. Tremblay, and M. Park
Regulation of the Met Receptor-tyrosine Kinase by the Protein-tyrosine Phosphatase 1B and T-cell Phosphatase
J. Biol. Chem., December 5, 2008; 283(49): 34374 - 34383.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
L. Karagyozov, R. Godfrey, S.-A. Bohmer, A. Petermann, S. Holters, A. Ostman, and F.-D. Bohmer
The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation
Nucleic Acids Res., August 1, 2008; 36(13): 4443 - 4453.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
T. Shintani and M. Noda
Protein Tyrosine Phosphatase Receptor Type Z Dephosphorylates TrkA Receptors and Attenuates NGF-dependent Neurite Outgrowth of PC12 Cells
J. Biochem., August 1, 2008; 144(2): 259 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Arena, A. Pattarozzi, A. Massa, J.-P. Esteve, R. Iuliano, A. Fusco, C. Susini, and T. Florio
An Intracellular Multi-Effector Complex Mediates Somatostatin Receptor 1 Activation of Phospho-Tyrosine Phosphatase {eta}
Mol. Endocrinol., January 1, 2007; 21(1): 229 - 246.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Takahashi, K. Takahashi, R. L. Mernaugh, N. Tsuboi, H. Liu, and T. O. Daniel
A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis
Blood, August 15, 2006; 108(4): 1234 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. G. Lampugnani, F. Orsenigo, M. C. Gagliani, C. Tacchetti, and E. Dejana
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
J. Cell Biol., August 14, 2006; 174(4): 593 - 604.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Iervolino, R. Iuliano, F. Trapasso, G. Viglietto, R. M. Melillo, F. Carlomagno, M. Santoro, and A. Fusco
The Receptor-Type Protein Tyrosine Phosphatase J Antagonizes the Biochemical and Biological Effects of RET-Derived Oncoproteins.
Cancer Res., June 15, 2006; 66(12): 6280 - 6287.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Wu, A. Katrekar, L. A. Honigberg, A. M. Smith, M. T. Conn, J. Tang, D. Jeffery, K. Mortara, J. Sampang, S. R. Williams, et al.
Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22
J. Biol. Chem., April 21, 2006; 281(16): 11002 - 11010.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Machide, A. Hashigasako, K. Matsumoto, and T. Nakamura
Contact Inhibition of Hepatocyte Growth Regulated by Functional Association of the c-Met/Hepatocyte Growth Factor Receptor and LAR Protein-tyrosine Phosphatase
J. Biol. Chem., March 31, 2006; 281(13): 8765 - 8772.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. J. Phillips-Mason, T. J. Gates, D. L. Major, D. B. Sacks, and S. M. Brady-Kalnay
The Receptor Protein-tyrosine Phosphatase PTP{micro} Interacts with IQGAP1
J. Biol. Chem., February 24, 2006; 281(8): 4903 - 4910.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Xu, L.-J. Tan, V. Grachtchouk, J. J. Voorhees, and G. J. Fisher
Receptor-type Protein-tyrosine Phosphatase-{kappa} Regulates Epidermal Growth Factor Receptor Function
J. Biol. Chem., December 30, 2005; 280(52): 42694 - 42700.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
T. A. Berset, E. F. Hoier, and A. Hajnal
The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions
Genes & Dev., June 1, 2005; 19(11): 1328 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Basar, Y. Shen, and K. Ireton
Redundant Roles for Met Docking Site Tyrosines and the Gab1 Pleckstrin Homology Domain in InlB-Mediated Entry of Listeria monocytogenes
Infect. Immun., April 1, 2005; 73(4): 2061 - 2074.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. Kappert, K. G. Peters, F. D. Bohmer, and A. Ostman
Tyrosine phosphatases in vessel wall signaling
Cardiovasc Res, February 15, 2005; 65(3): 587 - 598.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Motiwala, H. Kutay, K. Ghoshal, S. Bai, H. Seimiya, T. Tsuruo, S. Suster, C. Morrison, and S. T. Jacob
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer
PNAS, September 21, 2004; 101(38): 13844 - 13849.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Massa, F. Barbieri, C. Aiello, S. Arena, A. Pattarozzi, P. Pirani, A. Corsaro, R. Iuliano, A. Fusco, G. Zona, et al.
The Expression of the Phosphotyrosine Phosphatase DEP-1/PTP{eta} Dictates the Responsivity of Glioma Cells to Somatostatin Inhibition of Cell Proliferation
J. Biol. Chem., July 9, 2004; 279(28): 29004 - 29012.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-H. Ahn, J.-S. Kim, H.-K. Yu, H.-J. Lee, and Y. Yoon
A Truncated Kringle Domain of Human Apolipoprotein(a) Inhibits the Activation of Extracellular Signal-regulated Kinase 1 and 2 through a Tyrosine Phosphatase-dependent Pathway
J. Biol. Chem., May 21, 2004; 279(21): 21808 - 21814.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Gensler, M. Buschbeck, and A. Ullrich
Negative Regulation of HER2 Signaling by the PEST-type Protein-tyrosine Phosphatase BDP1
J. Biol. Chem., March 26, 2004; 279(13): 12110 - 12116.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Frank, C. Burkhardt, D. Imhof, J. Ringel, O. Zschornig, K. Wieligmann, M. Zacharias, and F.-D. Bohmer
Effective Dephosphorylation of Src Substrates by SHP-1
J. Biol. Chem., March 19, 2004; 279(12): 11375 - 11383.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
D. J. Mariner, M. A. Davis, and A. B. Reynolds
EGFR signaling to p120-catenin through phosphorylation at Y228
J. Cell Sci., March 15, 2004; 117(8): 1339 - 1350.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Persson, C. Savenhed, A. Bourdeau, M. L. Tremblay, B. Markova, F. D. Bohmer, F. G. Haj, B. G. Neel, A. Elson, C.-H. Heldin, et al.
Site-Selective Regulation of Platelet-Derived Growth Factor {beta} Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase
Mol. Cell. Biol., March 1, 2004; 24(5): 2190 - 2201.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. N. ANDERSEN, P. G. JANSEN, S. M. ECHWALD, O. H. MORTENSEN, T. FUKADA, R. DEL VECCHIO, N. K. TONKS, and N. P. H. MOLLER
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage
FASEB J, January 1, 2004; 18(1): 8 - 30.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. G. Lampugnani, A. Zanetti, M. Corada, T. Takahashi, G. Balconi, F. Breviario, F. Orsenigo, A. Cattelino, R. Kemler, T. O. Daniel, et al.
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, {beta}-catenin, and the phosphatase DEP-1/CD148
J. Cell Biol., May 26, 2003; 161(4): 793 - 804.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.