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Papers In Press, published online ahead of print April 14, 2003
J. Biol. Chem, 10.1074/jbc.M212966200
Submitted on December 19, 2002
Revised on April 7, 2003
Accepted on April 14, 2003

YB-1 as a cell cycle regulated transcription factor facilitating cyclin A and cyclin B1 gene expression

Karsten Jürchott, Stephan Bergmann, Ulrike Stein, Wolfgang Walther, Martin Janz, Isabella Manni, Giulia Piaggio, Ellen Fietze, Manfred Dietel, and Hans-Dieter Royer

Department of Molecular Tumorpathology, Charité, Berlin, Berlin D-10117

Corresponding Author: karsten.juerchott{at}charite.de

Expression of the Y-box protein YB-1 is increased in proliferating normal and cancer cells, but its role in cell proliferation and cell cycle progression is unclear. We have identified a cell cycle dependent relocalization of YB-1 from the cytoplasm to the nucleus at the G1/S phase transition and demonstrate that both the charged zipper and the cold shock domain are involved in regulating this process. Using cell lines which constitutively overexpress YB-1, we show that nuclear accumulation of YB-1 is associated with increased cyclin A and cyclin B1 mRNA and protein expression. We provide evidence that deregulated YB-1 expression is linked to adhesion-independent cell proliferation through the induction of cyclin A. Thus, we have identified YB-1 as a cell cycle stage specific transcription factor important for cell proliferation.


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