| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print July 7, 2003
EMI 0116, INSERM, Marseille 13276
Corresponding Author: dusetti{at}inserm-nacre.inserm-adr2.univ-mrs.fr
The TP53INP1 gene encodes two protein isoforms named TP53INP1 and TP53INP1 located into the nucleus. Their synthesis is increased during cellular stress by p53-mediated activation of transcription. Overexpression of these isoforms induces apoptosis, suggesting an involvement of TP53INP1s in p53-mediated cell death. It was recently shown that p53-dependent apoptosis is promoted by HIPK2 which is known to bind p53 and induce its phosphorylation in PML-NBs. In this work we show that TP53INP1s localize with p53, PML-IV and HIPK2 into the PML-NBs. In addition, we show that TP53INP1s interact physically with HIPK2 and p53. In agreement with these results we demonstrate that TP53INP1s, in association with HIPK2, regulate p53 transcriptional activity on p21, mdm2, PIG3, and Bax promoters. Furthermore, TP53INP1s overexpression induces G1 arrest and increases p53-mediated apoptosis. While a TP53INP1s and HIPK2 additive effect was observed on apoptosis, G1 arrest was weaker when HIPK2 was transfected together with TP53INP1. These results indicate that TP53INP1s and HIPK2 could be partners in regulating p53 activity.
J. Biol. Chem, 10.1074/jbc.M301979200
Submitted on February 25, 2003
Revised on July 7, 2003
Accepted on July 7, 2003
TP53INP1s and HIPK2 are partners in regulating p53 activity
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. G. Fuhrken, P. A. Apostolidis, S. Lindsey, W. M. Miller, and E. T. Papoutsakis Tumor Suppressor Protein p53 Regulates Megakaryocytic Polyploidization and Apoptosis J. Biol. Chem., June 6, 2008; 283(23): 15589 - 15600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Choi, Y.-M. Seo, E.-A Kim, K. S. Sung, J. W. Ahn, S.-J. Park, S.-R. Lee, and C. Y. Choi Ubiquitination and Degradation of Homeodomain-interacting Protein Kinase 2 by WD40 Repeat/SOCS Box Protein WSB-1 J. Biol. Chem., February 22, 2008; 283(8): 4682 - 4689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gironella, M. Seux, M.-J. Xie, C. Cano, R. Tomasini, J. Gommeaux, S. Garcia, J. Nowak, M. L. Yeung, K.-T. Jeang, et al. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development PNAS, October 9, 2007; 104(41): 16170 - 16175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Filippov, M. Filippova, and P. J. Duerksen-Hughes The Early Response to DNA Damage Can Lead to Activation of Alternative Splicing Activity Resulting in CD44 Splice Pattern Changes Cancer Res., August 15, 2007; 67(16): 7621 - 7630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gommeaux, C. Cano, S. Garcia, M. Gironella, S. Pietri, M. Culcasi, M.-J. Pebusque, B. Malissen, N. Dusetti, J. Iovanna, et al. Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deficient for Tumor Protein 53-Induced Nuclear Protein 1 Mol. Cell. Biol., March 15, 2007; 27(6): 2215 - 2228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Anensen, A. M. Oyan, J.-C. Bourdon, K. H. Kalland, O. Bruserud, and B. T. Gjertsen A Distinct p53 Protein Isoform Signature Reflects the Onset of Induction Chemotherapy for Acute Myeloid Leukemia. Clin. Cancer Res., July 1, 2006; 12(13): 3985 - 3992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Saifudeen, V. Diavolitsis, J. Stefkova, S. Dipp, H. Fan, and S. S. El-Dahr Spatiotemporal Switch from {Delta}Np73 to TAp73 Isoforms during Nephrogenesis: IMPACT ON DIFFERENTIATION GENE EXPRESSION J. Biol. Chem., June 17, 2005; 280(24): 23094 - 23102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Martinez, M. Sanchez-Beato, A. Carnero, V. Moneo, J. C. Tercero, I. Fernandez, M. Navarrete, J. Jimeno, and M. A. Piris Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naive patients Mol. Cancer Ther., May 1, 2005; 4(5): 814 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Giraud, C. Diaz-Latoud, S. Hacot, J. Textoris, R. P. Bourette, and J.-J. Diaz US11 of Herpes Simplex Virus Type 1 Interacts with HIPK2 and Antagonizes HIPK2-Induced Cell Growth Arrest J. Virol., March 15, 2004; 78(6): 2984 - 2993. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
