JBC INTERFERin siRNA transfection reagent

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on October 24, 2003
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
278/43/42660    most recent
M304984200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Onuma, M.
Right arrow Articles by Iwamoto, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onuma, M.
Right arrow Articles by Iwamoto, Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print August 5, 2003
J. Biol. Chem, 10.1074/jbc.M304984200
Submitted on May 13, 2003
Revised on July 22, 2003
Accepted on August 5, 2003

Prostate cancer cell-adipocyte interaction: Leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase

Michiko Onuma, Jeffrey D. Bub, Thomas L. Rummel, and Yoshiki Iwamoto

Human and Molecular Genetics Center/Urology, Medical College of Wisconsin, Milwaukee, WI 53226-0509

Corresponding Author: yiwamoto{at}mcw.edu

Prostate cancer is one of the leading causes of death among men in the United States, and acquisition of hormone resistance (androgen independence) by cancer cells is a fatal event during the natural history of prostate cancer. Obesity is another serious health problem and has been shown associated with prostate cancer. However, little is known about the molecular basis of this association. Here we show that factor(s) secreted from adipocytes stimulate prostate cancer cell proliferation. Leptin is one of the major adipose cytokines, and controls body weight homeostasis through food intake and energy expenditure. We identify leptin as a novel growth factor in androgen-independent prostate cancer cell growth. Strikingly, leptin stimulates cell proliferation specifically in androgen-independent DU145 and PC-3 prostate cancer cells but not in androgen-dependent LNCaP-FGC cells, although both cell types express functional leptin receptor isoforms. c-Jun NH2-terminal kinase (JNK) has recently been shown to play a crucial role in obesity and insulin resistance. Intriguingly, leptin induces JNK activation in androgen-independent prostate cancer cells, and the pharmacological inhibition of JNK blocked the leptin stimulation of androgen-independent prostate cancer cell proliferation. This suggests that JNK activation is required for leptin-mediated, androgen-independent prostate cancer cell proliferation. Furthermore, other cytokines produced by adipocytes and critical for body weight homeostasis cooperate with leptin in androgen-independent prostate cancer cell proliferation: interleukin-6 and insulin-like growth factor I demonstrate additive and synergistic effects on the leptin stimulation of androgen-independent prostate cancer cell proliferation, respectively. Therefore, adipose cytokines, as well as JNK, are key mediators between obesity and hormone-resistant prostate cancer, and could be therapeutic targets.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
A. M. Butturini, F. J. Dorey, B. J. Lange, D. W. Henry, P. S. Gaynon, C. Fu, J. Franklin, S. E. Siegel, N. L. Seibel, P. C. Rogers, et al.
Obesity and Outcome in Pediatric Acute Lymphoblastic Leukemia
J. Clin. Oncol., May 20, 2007; 25(15): 2063 - 2069.
[Abstract] [Full Text] [PDF]

Home page
 Epidemiol RevHome page
S. J. Freedland and E. A. Platz
Obesity and Prostate Cancer: Making Sense out of Apparently Conflicting Data
Epidemiol. Rev., May 3, 2007; (2007) mxm006v1.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. M. Huffman, M. S. Johnson, A. Watts, A. Elgavish, I. A. Eltoum, and T. R. Nagy
Cancer Progression in the Transgenic Adenocarcinoma of Mouse Prostate Mouse Is Related to Energy Balance, Body Mass, and Body Composition, but not Food Intake
Cancer Res., January 1, 2007; 67(1): 417 - 424.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
S-N Wang, Y-T Yeh, S-F Yang, C-Y Chai, and K-T Lee
Potential role of leptin expression in hepatocellular carcinoma
J. Clin. Pathol., September 1, 2006; 59(9): 930 - 934.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. Baillargeon, E. A. Platz, D. P. Rose, B. H. Pollock, D. P. Ankerst, S. Haffner, B. Higgins, A. Lokshin, D. Troyer, J. Hernandez, et al.
Obesity, adipokines, and prostate cancer in a prospective population-based study.
Cancer Epidemiol. Biomarkers Prev., July 1, 2006; 15(7): 1331 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. J. Freedland
Obesity and Prostate Cancer: A Growing Problem
Clin. Cancer Res., October 1, 2005; 11(19): 6763 - 6766.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Ishikawa, J. Kitayama, and H. Nagawa
Enhanced Expression of Leptin and Leptin Receptor (OB-R) in Human Breast Cancer
Clin. Cancer Res., July 1, 2004; 10(13): 4325 - 4331.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.