| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print December 19, 2003
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, Faculty of Life Sciences, Dundee DD1 5EK
Corresponding Author: j.zomerdijk{at}dundee.ac.uk
Regulation of ribosomal RNA gene transcription by RNA Polymerase I (Pol I) is fundamental to ribosome biogenesis and therefore protein translation capacity and cell growth, yet little is known of the key signaling cascades involved. We show here that Insulin-like Growth Factor-1-induced Pol I transcription in HEK293 cells is entirely dependent on Phosphatidylinositol-3 Kinase activity and, additionally, is modulated by the mammalian Target Of Rapamycin, which coordinates Pol I transcription with the availability of amino acids. The Mitogen Activated Protein Kinase pathway is weakly stimulated by IGF-1 in these cells and partly contributes to Pol I transcription regulation. Activation of Pol I transcription by IGF-1 results from enhancement of the activity of the Pol I transcription machinery and increased occupancy by SL1 of the endogenous tandemly repeated ribosomal promoters in vivo. The inputs from PI3K, mTOR (and MAPK) pathways converge to direct appropriate rRNA gene expression by Pol I in the nucleolus of mammalian cells in response to environmental cues, such as growth factors and nutrients.
J. Biol. Chem, 10.1074/jbc.M307735200
Submitted on July 17, 2003
Revised on December 17, 2003
Accepted on December 19, 2003
Phosphatidylinositol-3 kinase and mTOR signaling pathways regulate RNA Polymerase I transcription in response to IGF-1 and nutrients
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Wall, G. Poortinga, K. M. Hannan, R. B. Pearson, R. D. Hannan, and G. A. McArthur Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation Blood, September 15, 2008; 112(6): 2305 - 2317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Grewal, J. R. Evans, and B. A. Edgar Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway J. Cell Biol., December 17, 2007; 179(6): 1105 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. B. Panova, K. I. Panov, J. Russell, and J. C. B. M. Zomerdijk Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription. Mol. Cell. Biol., August 1, 2006; 26(16): 5957 - 5968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. I. Panov, T. B. Panova, O. Gadal, K. Nishiyama, T. Saito, J. Russell, and J. C. B. M. Zomerdijk RNA Polymerase I-Specific Subunit CAST/hPAF49 Has a Role in the Activation of Transcription by Upstream Binding Factor. Mol. Cell. Biol., July 1, 2006; 26(14): 5436 - 5448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Anand and P. A. Gruppuso Rapamycin Inhibits Liver Growth during Refeeding in Rats via Control of Ribosomal Protein Translation but Not Cap-Dependent Translation Initiation J. Nutr., January 1, 2006; 136(1): 27 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Sheng, Y. Liang, C.-Y. Lin, L. Comai, and W. J. Chirico Direct Regulation of rRNA Transcription by Fibroblast Growth Factor 2 Mol. Cell. Biol., November 1, 2005; 25(21): 9419 - 9426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Li, C. X Fang, N. S Aberle II, B. H Ren, A. F Ceylan-Isik, and J. Ren Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function J. Endocrinol., September 1, 2005; 186(3): 491 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Friedrich, K. I. Panov, P. Cabart, J. Russell, and J. C. B. M. Zomerdijk TBP-TAF Complex SL1 Directs RNA Polymerase I Pre-initiation Complex Formation and Stabilizes Upstream Binding Factor at the rDNA Promoter J. Biol. Chem., August 19, 2005; 280(33): 29551 - 29558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, A. Wu, H. Sun, R. Drakas, C. Garofalo, S. Cascio, E. Surmacz, and R. Baserga Functional Significance of Type 1 Insulin-like Growth Factor-mediated Nuclear Translocation of the Insulin Receptor Substrate-1 and {beta}-Catenin J. Biol. Chem., August 19, 2005; 280(33): 29912 - 29920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhang, L. Comai, and D. L. Johnson PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex Mol. Cell. Biol., August 15, 2005; 25(16): 6899 - 6911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Taguchi, T. Kondo, M. Watanabe, M. Miyaji, H. Umehara, Y. Kozutsumi, and T. Okazaki Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase Blood, November 15, 2004; 104(10): 3285 - 3293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Kim and J. Chen Regulation of Peroxisome Proliferator-Activated Receptor-{gamma} Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis Diabetes, November 1, 2004; 53(11): 2748 - 2756. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
