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Papers In Press, published online ahead of print November 3, 2003
Cardiology Dept., Beth Israel Deaconess Medical Center, Boston, MA 02215
Corresponding Author: jmcmulle{at}bidmc.harvard.edu
Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of heart failure. However, some animal studies and clinical trials have questioned whether elevating IGF1 chronically is beneficial. Secondary effects of increased serum IGF1 levels on other tissues may explain these unfavorable results. The aim of the current study was to examine the role of IGF1 in cardiac myocytes in the absence of secondary effects, and to elucidate downstream signaling pathways and transcriptional regulatory effects of the IGF1 receptor (IGF1R). Transgenic mice over-expressing IGF1R in the heart displayed cardiac hypertrophy which was due to an increase in myocyte size, and there was no evidence of histopathology. IGF1R transgenics also displayed enhanced systolic function at 3 months of age and this was maintained at 12-16 months of age. The phosphoinositide 3-kinase (PI3K)-Akt-p70S6K1 pathway was significantly activated in hearts from IGF1R transgenics. Cardiac hypertrophy induced by over-expression of IGF1R was completely blocked by a dominant negative PI3K(p110
J. Biol. Chem, 10.1074/jbc.M310405200
Submitted on September 22, 2003
Revised on October 27, 2003
Accepted on November 3, 2003
The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110
) pathway
) mutant, suggesting IGF1R promotes compensated cardiac hypertrophy in a PI3K(p110) dependent manner. This study suggests that targeting the cardiac IGF1R-PI3K(p110) pathway could be a potential therapeutic strategy for the treatment of heart failure.
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