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Papers In Press, published online ahead of print April 15, 2004
Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612
Corresponding Author: setoe{at}moffitt.usf.edu
YY1 is a ubiquitous zinc finger transcription factor that binds to and regulates promoters and enhancers of many cellular and viral genes. Here we report the isolation of a human cDNA encoding a DNA sequence-specific binding protein with significant homology to the transcription factor YY1. Sequence analysis of this novel protein, YY2, revealed an overall 65% identity in DNA sequence and 56% identity in protein sequence compared with human YY1. The most pronounced similarity between YY1 and YY2 exists within the zinc finger regions of the two proteins, and consistent with this observation, YY2 can bind to and regulate some promoters known to be controlled by YY1. Similar to YY1, YY2 contains both transcriptional activation and repression functions. The finding of a protein with structure and function similar to YY1 provides new opportunity to explore additional mechanisms by which YY1-responsive genes can be regulated and suggests that gene regulation by YY1 is far more complicated than previously assumed.
J. Biol. Chem, 10.1074/jbc.M402525200
Submitted on March 5, 2004
Revised on April 6, 2004
Accepted on April 15, 2004
Molecular cloning and functional characterization of the transcription factor YY2
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