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A more recent version of this article appeared on April 22, 2005
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M411382200v1
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Papers In Press, published online ahead of print February 16, 2005
J. Biol. Chem, 10.1074/jbc.M411382200
Submitted on October 5, 2004
Revised on February 16, 2005
Accepted on February 16, 2005

Phosphorylated Rb complexes with pp32 and inhibits pp32-mediated apoptosis

Onikepe Adegbola and Gary R. Pasternack

Department of Pathology, Johns Hopkins University, Baltimore, MD 21231

Corresponding Author: gpastern{at}jhmi.edu

The retinoblastoma gene product (Rb) is tumor suppressor that affects apoptosis paradoxically. Most sporadic cancers inactivate Rb by preferentially targeting the pathway that regulates Rb phosphorylation resulting in resistance to apoptosis - in contrast to Rb inactivation by mutation, which is associated with high rates of apoptosis. How phosphorylated Rb protects cells from apoptosis is not well understood, but there is evidence that Rb may sequester a pro-apoptotic nuclear factor. pp32 (ANP32A) is a pro-apoptotic nuclear phosphoprotein whose expression is commonly increased in cancer. We report that hyperphosphorylated Rb interacts with pp32 but not with the closely related proteins pp32r1 and pp32r2. We further demonstrate that the pp32-Rb interaction inhibits the apoptotic activity of pp32 and stimulates proliferation. These results suggest a mechanism whereby cancer cells gain both a proliferative and survival advantage when Rb is inactivated by hyperphosphorylation.


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