| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print January 5, 2006
J. Biol. Chem, 10.1074/jbc.M511629200
Submitted on October 27, 2005
Revised on January 4, 2006
Accepted on January 4, 2006
Human Genetics, University of Utah, Salt Lake City, UT 84112-5330
Corresponding Author: john.atkins{at}genetics.utah.edu
A bioinformatics approach to finding new cases of -1 frameshifting in the expression of human genes revealed a classical retroviral-like heptanucleotide shift site followed by a potential structural stimulator in the paraneo-plastic antigen Ma3 gene. Analysis of the sequence 3’ of the shift site demonstrated that an RNA pseudoknot in Ma3 is important for promoting efficient -1 frameshifting. Ma3 is a member of a family of six genes in humans that contain homology to retroviral Gag proteins. The -1 frameshift site and pseudoknot structure are conserved in other mammals, but there are some sequence differences. Although the functions of the Ma genes are unknown, the serious neurological effects of ectopic expression in tumor cells indicate their importance in the brain.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. B. Clark, M. Janicke, U. Gottesbuhren, T. Kleffmann, M. Legge, E. S. Poole, and W. P. Tate Mammalian Gene PEG10 Expresses Two Reading Frames by High Efficiency 1 Frameshifting in Embryonic-associated Tissues J. Biol. Chem., December 28, 2007; 282(52): 37359 - 37369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. P. Ivanov and J. F. Atkins Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation Nucleic Acids Res., March 19, 2007; 35(6): 1842 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Jacobs, A. T. Belew, R. Rakauskaite, and J. D. Dinman Identification of functional, endogenous programmed -1 ribosomal frameshift signals in the genome of Saccharomyces cerevisiae Nucleic Acids Res., January 12, 2007; 35(1): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Cobucci-Ponzano, F. Conte, D. Benelli, P. Londei, A. Flagiello, M. Monti, P. Pucci, M. Rossi, and M. Moracci The gene of an archaeal {alpha}-L-fucosidase is expressed by translational frameshifting Nucleic Acids Res., September 10, 2006; 34(15): 4258 - 4268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Wills and J. F. Atkins The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseases RNA, July 1, 2006; 12(7): 1149 - 1153. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
