| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print January 10, 2006
Biochemistry & Molecular Biology, University of Calgary, Calgary, AB T2N 4N1
Corresponding Author: jlytton{at}ucalgary.ca
Plasma membrane Na+/Ca2+-exchangers play a predominant role in Ca2+ extrusion in brain. Neurons express several different Na+/Ca2+-exchangers belonging to both the K+-independent NCX family and the K+-dependent NCKX family. The unique contributions of each of these proteins to neuronal Ca2+ homeostasis and/or physiology remains largely unexplored. To address this question, we generated mice in which the gene encoding the abundant neuronal K+-dependent Na+/Ca2+-exchanger protein, NCKX2, was knocked out. Analysis of these animals revealed a significant reduction in Ca2+ flux in cortical neurons, a profound loss of long-term potentiation and an increase in long-term depression at hippocampal Schaffer/CA1 synapses, and clear deficits in specific tests of motor learning and spatial working memory. Surprisingly, there was no obvious loss of photoreceptor function in cones, where expression of the NCKX2 protein had been reported previously. These data emphasize the critical and non-redundant role of NCKX2 in the local control of neuronal [Ca2+] that is essential for the development of synaptic plasticity associated with learning and memory.
J. Biol. Chem, 10.1074/jbc.M512137200
Submitted on November 11, 2005
Revised on January 5, 2006
Accepted on January 10, 2006
Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  O. Cuomo, R. Gala, G. Pignataro, F. Boscia, A. Secondo, A. Scorziello, A. Pannaccione, D. Viggiano, A. Adornetto, P. Molinaro, et al. A Critical Role for the Potassium-Dependent Sodium-Calcium Exchanger NCKX2 in Protection against Focal Ischemic Brain Damage J. Neurosci., February 27, 2008; 28(9): 2053 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Visser and J. Lytton K+-Dependent Na+/Ca2+ Exchangers: Key Contributors to Ca2+ Signaling Physiology, June 1, 2007; 22(3): 185 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Empson, M. L. Garside, and T. Knopfel Plasma Membrane Ca2+ ATPase 2 Contributes to Short-Term Synapse Plasticity at the Parallel Fiber to Purkinje Neuron Synapse J. Neurosci., April 4, 2007; 27(14): 3753 - 3758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Visser, V. Valsecchi, L. Annunziato, and J. Lytton Analysis of Ion Interactions with the K+ -dependent Na+/Ca+ Exchangers NCKX2, NCKX3, and NCKX4: IDENTIFICATION OF THR-551 AS A KEY RESIDUE IN DEFINING THE APPARENT K+ AFFINITY OF NCKX2 J. Biol. Chem., February 16, 2007; 282(7): 4453 - 4462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Altimimi and P. P. M. Schnetkamp Na+-dependent Inactivation of the Retinal Cone/Brain Na+/Ca2+-K+ Exchanger NCKX2 J. Biol. Chem., February 9, 2007; 282(6): 3720 - 3729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Paillart, R. J. Winkfein, P. P.M. Schnetkamp, and J. I. Korenbrot Functional Characterization and Molecular Cloning of the K+-dependent Na+/Ca2+ Exchanger in Intact Retinal Cone Photoreceptors J. Gen. Physiol., January 1, 2007; 129(1): 1 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Lee, F. Visser, J. S. Lee, K.-H. Lee, J.-W. Soh, W.-K. Ho, J. Lytton, and S.-H. Lee Protein Kinase C-dependent Enhancement of Activity of Rat Brain NCKX2 Heterologously Expressed in HEK293 Cells J. Biol. Chem., December 22, 2006; 281(51): 39205 - 39216. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
