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M605948200v1
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Papers In Press, published online ahead of print November 2, 2006
J. Biol. Chem, 10.1074/jbc.M605948200
Submitted on June 21, 2006
Revised on October 13, 2006
Accepted on November 2, 2006

YB-1 is important for an early stage embryonic development: Neural tube formation and cell proliferation

Takeshi Uchiumi, Abbas Fotovati, Takakazu Sasaguri, Kohtaro Shibahara, Tatsuo Shimada, Takao Fukuda, Takanori Nakamura, Hiroto Izumi, Teruhisa Tsuzuki, Michihiko Kuwano, and Kimitoshi Kohno

Molecular Biology, UOEH university, Kitakyushu 807-8555

Corresponding Author: uchiumi{at}med.uoeh-u.ac.jp

The eukaryotic Y-box binding protein-1 (YB-1) is involved in the transcriptional and translational control of many biological processes including cell proliferation. In clinical studies, the cellular level of YB-1 closely correlates with tumor growth and prognosis. To understand the role of YB-1 in vivo, especially in the developmental process, we generated YB-1 knockout mice, which are embryonic lethal and exhibit exencephaly associated with abnormal patterns of cell proliferation within the neuroepithelium. ß-actin expression and F-actin formation were reduced in the YB-1 null embryo and YB-1-/- mouse embryonic fibroblasts (MEF), suggesting that the neural tube defect is caused by abnormal cell morphology and actin assembly within the neuroepithelium. Fibroblasts derived from YB-1-/-embryos demonstrated reduced growth and cell density. A colony formation assay showed that YB-1-/-MEFs failed to undergo morphological transformation and remained contact inhibited in culture. These results demonstrate that YB-1 is involved in early mouse development including neural tube closure and cell proliferation.


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