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Papers In Press, published online ahead of print February 11, 2004
J. Biol. Chem, 10.1074/jbc.R300038200
Submitted on December 10, 2003
Revised on February 2, 2004
Accepted on February 11, 2004

Integrins in mechanotransduction

Akira Katsumi, A. Wayne Orr, Eleni Tzima, and Martin Alexander Schwartz

University of Virginia, Charlottesville, VA 22908

Corresponding Author: maschwartz{at}virginia.edu

Mechanical forces are crucial to regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and integrins are implicated in sensing mechanical forces. We review the relationship between integrins and mechanical forces, the role of integrins in cellular responses to stretch and fluid flow, and propose that some of these events are mechanistically related.


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