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Papers In Press, published online ahead of print February 8, 2006
J. Biol. Chem, 10.1074/jbc.R500029200
Submitted on December 19, 2005
Revised on February 3, 2006
Accepted on February 8, 2006

The chromosome replication machinery of the Archaeon Sulfolobus solfataricus

Iain G. Duggin and Stephen D. Bell

MRC Cancer Cell Unit, Cambridge CB2 2XZ

Corresponding Author: sdb{at}mole.bio.cam.ac.uk

In the three domains of life, the archaea, bacteria and eukarya, there are two general lineages of DNA replication proteins: the bacterial and the eukaryal/archaeal lineages. The hyperthermophilic archaeon Sulfolobus solfataricus provides an attractive model for biochemical study of DNA replication. Its relative simplicity in both genomic and biochemical contexts, together with high protein thermostability, has already provided insight into the function of the more complex yet homologous molecules of the eukaryotic domain. Here, we provide an overview of recent insights into the functioning of the chromosome replication machinery of S. solfataricus, focusing on some of the relatively well-characterized core components that act at the DNA replication fork.


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