An Adenosine 3',5'-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle
Abstract
A protein kinase that catalyzes an adenosine 3',5'-monophosphate (cyclic AMP)-dependent phosphorylation of casein and protamine has been purified from rabbit skeletal muscle. The Km values of cyclic AMP for these reactions are 1 x 10-7 and 6 x 10-8 m, respectively. The protein kinase markedly increases the rate of the cyclic AMP-dependent activation and phosphorylation of phosphorylase kinase by ATP.
Footnotes
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- Received April 2, 1968.
- © 1968, by the American Society of Biological Chemists, Inc.
