The Three-Dimensional Structure at 6 A Resolution of a Human γG1 Immunoglobulin Molecule
- From the Laboratory of Molecular Biology, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014, and the Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
Abstract
A three-dimensional electron density map has been calculated at 6 A resolution for a human γG1 immunoglobulin molecule. X-ray diffraction data have been collected for the native protein crystals and for three heavy atom derivatives prepared by soaking crystals in p-chloromercuribenzenesulfonate, Hg(CN)2, and PtCl6=. The electron density map is interpreted in terms of four possible models, of which a T-shaped model is favored. The dimensions of this model are compared with those reported by other physical and chemical techniques for immunoglobulin molecules.
Footnotes
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- Received December 17, 1970.
- © 1971, by the American Society of Biological Chemists, Inc.
