Cytochalasin A and B
INHIBITION OF SUGAR UPTAKE IN CULTURED CELLS
Abstract
A mold metabolite, cytochalasin B, inhibits uptake of 2-deoxy-d-glucose in chick fibroblasts and cultured liver cells. This inhibition is rapid, reversible, and is achieved at very low concentrations of the metabolite. Cytochalasin A also inhibits sugar uptake, but the magnitude and reversibility of inhibition differs from that produced by cytochalasin B.
Footnotes
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- Received January 26, 1972.
- © 1972, by the American Society of Biological Chemists, Inc.
