Cloning of a Putative Ligand for the T1/ST2 Receptor (*)
- Margit A. Gayle(§),
- Jennifer L. Slack,
- Timothy P. Bonnert,
- Blair R. Renshaw,
- Gonosuke Sonoda(1),
- Takahiro Taguchi(1),
- Joseph R. Testa(1),
- Steven K. Dower(¶) and
- John E. Sims(**)
- From the From Immunex Corporation, Seattle, Washington 98101 and the
- Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
- **To whom correspondence should be addressed: Immunex Corp., 51 University St., Seattle, WA 98101.
Abstract
T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.
Footnotes
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↵* The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore by hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBank(™)/EMBL Data Bank with accession number(s) U41804, U41805.
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↵1 The abbreviations used are:
- IL-1
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interleukin 1
- IL-1RI
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type I interleukin 1 receptor.
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↵2T. P. Bonnert and J. E. Sims, manuscript in preparation.
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- Received October 24, 1995.
- Revision received December 12, 1995.
- © 1996 by The American Society for Biochemistry and Molecular Biology, Inc.
