Metabolomics, Pathway Regulation, and Pathway Discovery*
- From the Departments of ‡Nutrition and
- §Chemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
- ↵1 To whom correspondence should be addressed. E-mail: hxb8{at}case.edu.
Abstract
Metabolomics is a data-based research strategy, the aims of which are to identify biomarker pictures of metabolic systems and metabolic perturbations and to formulate hypotheses to be tested. It involves the assay by mass spectrometry or NMR of many metabolites present in the biological system investigated. In this minireview, we outline studies in which metabolomics led to useful biomarkers of metabolic processes. We also illustrate how the discovery potential of metabolomics is enhanced by associating it with stable isotopic techniques.
- Isotopic Tracers
- Mass Spectrometry (MS)
- Metabolic Tracers
- Metabolic Regulation
- Metabolomics
- NMR
- Biomarker
- Mass Isotopomer
Footnotes
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↵* This work was supported, in whole or in part, by National Institutes of Health Roadmap Grant R33DK070291 and Grant R01ES013925. This is the second article in the Thematic Minireview Series on Computational Systems Biology. This minireview will be reprinted in the 2011 Minireview Compendium, which will be available in January, 2012
- © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.
