Unfolding or aggregation, that is the question
- Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V5T 1Z4, Canada
- ↵1 To whom correspondence should be addressed: Dept. of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver, British Columbia V5T 1Z4, Canada. E-mail: mayor{at}mail.ubc.ca.
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Edited by George N. DeMartino
Abstract
Cellular processes accompanying protein aggregation are diverse and entangled, making it difficult to investigate the underlying molecular processes in a time-resolved way. Gottlieb, Thompson, and colleagues address this shortcoming using a chemical biology approach to monitor ubiquitination within the first 10 min after the initiation of protein aggregation. Intriguingly, unfolding rather than aggregation seems to trigger the observed events. This work might provide a method to answer open questions regarding the regulation of the proteostasis network upon protein misfolding.
Footnotes
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This work was supported by Canadian Institute of Health Research (CIHR) Grants PJT-148489 and PJT-159804. The authors declare that they have no conflicts of interest with the contents of this article.
- © 2019 Bolten et al.
Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.
