Current prospects of type II interferon gamma signaling and autoimmunity

Abstract

Interferon gamma (IFNg) is a pleotropic protein secreted by immune cells. IFNg signals through the IFNg receptor, a protein complex that mediates a number of down-stream signaling events. Studies into IFNg signaling have provided insight into general concepts of receptor signaling, receptor internalization, the regulation of distinct signaling pathways and transcriptional regulation. While IFNg is central mediator of the adaptive immune response to pathogens, it has been shown to be involved in a number of non-infectious physiological processes. This review will provide an introduction into IFNg signaling biology and the functional roles of IFNg in the autoimmune response.