Papers in Press

JBC Papers in Press are papers in manuscript form which have been accepted but which have not been copyedited and not yet appeared in a regular issue of the journal. Copyediting may lead to small differences between the Papers in Press version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article’s unique Digital Object Identifier (DOI).
 

Accelerated Communication

    Accelerated Communication - Enzymology - Membrane Biology:
    • James J. Asciolla,
    • Matthew M. Miele,
    • Ronald C. Hendrickson,
    • and Marilyn D. Resh
    An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine J. Biol. Chem. jbc.C117.800136. doi:10.1074/jbc.C117.800136
    Accelerated Communication - Signal Transduction - Computational Biology:
    • Yanfei Jiang,
    • Zohreh AkhavanAghdam,
    • Lev S. Tsimring,
    • and Nan Hao
    Coupled feedback loops control the stimulus-dependent dynamics of the yeast transcription factor Msn2 J. Biol. Chem. jbc.C117.800896. doi:10.1074/jbc.C117.800896
    Accelerated Communication - Metabolism:
    • Xiaoxin X. Wang,
    • Yuhuan Luo,
    • Dong Wang,
    • Luciano Adorini,
    • Mark Pruzanski,
    • Evgenia Dobrinskikh,
    • and Moshe Levi
    A Dual Agonist of Farnesoid X Receptor (FXR) and the G protein-coupled Receptor TGR5, INT-767, Slows Down Age-Related Kidney Disease in Mice J. Biol. Chem. jbc.C117.794982. doi:10.1074/jbc.C117.794982

Enzymology

    Accelerated Communication - Enzymology - Membrane Biology:
    • James J. Asciolla,
    • Matthew M. Miele,
    • Ronald C. Hendrickson,
    • and Marilyn D. Resh
    An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine J. Biol. Chem. jbc.C117.800136. doi:10.1074/jbc.C117.800136
    Bioenergetics - Enzymology:
    • C. A. Starbird,
    • Elena Maklashina,
    • Pankaj Sharma,
    • Susan Qualls-Histed,
    • Gary Cecchini,
    • and T. M. Iverson
    Structural and biochemical analyses reveal insights into covalent flavinylation of the Escherichia coli Complex II homolog quinol:fumarate reductase J. Biol. Chem. jbc.M117.795120. doi:10.1074/jbc.M117.795120
    Bioenergetics - Enzymology:
    • John P. Hoben,
    • Carolyn E. Lubner,
    • Michael W. Ratzloff,
    • Gerrit J. Schut,
    • Diep M. N. Nguyen,
    • Karl W. Hempel,
    • Michael W. W. Adams,
    • Paul W. King,
    • and Anne-Frances Miller
    Equilibrium and ultrafast kinetic studies manipulating electron transfer: a short-lived flavin semiquinone is not sufficient for electron bifurcation J. Biol. Chem. jbc.M117.794214. doi:10.1074/jbc.M117.794214
    Cell Biology - Enzymology:
    • Andrew S Murray,
    • Fausto A Varela,
    • Thomas E Hyland,
    • Andrew J Schoenbeck,
    • Jordan M White,
    • Lauren M Tanabe,
    • Sokol V Todi,
    • and Karin List
    Phosphorylation of the type II transmembrane serine protease, TMPRSS13 in Hepatocyte Growth Factor Activator Inhibitor-1 and 2-mediated cell surface localization J. Biol. Chem. jbc.M117.775999. doi:10.1074/jbc.M117.775999
    DNA and Chromosomes - Enzymology:
    • Christina A. Gerodimos,
    • Howard H. Y. Chang,
    • Go Watanabe,
    • and Michael R. Lieber
    Effects of DNA end configuration on XRCC4:DNA ligase IV and its stimulation of Artemis activity J. Biol. Chem. jbc.M117.798850. doi:10.1074/jbc.M117.798850
    Enzymology - Protein Synthesis and Degradation:
    • Sungjin Park,
    • Peter K Foote,
    • David T Krist,
    • Sarah E Rice,
    • and Alexander V Statsyuk
    UbMES and UbFluor: Novel Probes For RBR E3 Ubiquitin Ligase PARKIN J. Biol. Chem. jbc.M116.773200. doi:10.1074/jbc.M116.773200
    Enzymology - Metabolism:
    • Diep M. N. Nguyen,
    • Gerrit J. Schut,
    • Oleg A. Zadvornyy,
    • Monika Tokmina-Lukaszewska,
    • Saroj Poudel,
    • Gina L. Lipscomb,
    • Leslie A. Adams,
    • Jessica T. Dinsmore,
    • William J. Nixon,
    • Eric S. Boyd,
    • Brian Bothner,
    • John W. Peters,
    • and Michael W. W. Adams
    Two functionally distinct NADP+-dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus J. Biol. Chem. jbc.M117.794172. doi:10.1074/jbc.M117.794172
    Enzymology - Plant Biology:
    • Hajo Kries,
    • Franziska Kellner,
    • Mohamed Omar Kamileen,
    • and Sarah E. O'Connor
    Inverted stereocontrol of iridoid synthase in snapdragon J. Biol. Chem. jbc.M117.800979. doi:10.1074/jbc.M117.800979
    Enzymology - Metabolism:
    • Kevin M. Johnson,
    • Thanh T. N. Phan,
    • Matthew E. Albertolle,
    • and F. Peter Guengerich
    Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol J. Biol. Chem. jbc.M116.773937. doi:10.1074/jbc.M116.773937
    Enzymology - Protein Structure and Folding:
    • David L. Nelson,
    • Gregory A. Applegate,
    • Matthew L. Beio,
    • Danielle L. Graham,
    • and David B. Berkowitz
    Human Serine Racemase Structure/Activity Relationship Studies Provide Mechanistic Insight and Point to Position-84 as a Hotspot for β-Elimination Function J. Biol. Chem. jbc.M117.777904. doi:10.1074/jbc.M117.777904
    Enzymology:
    • Nicole Motl,
    • Meredith A Skiba,
    • Omer Kabil,
    • Janet L Smith,
    • and Ruma Banerjee
    Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation J. Biol. Chem. jbc.M117.790170. doi:10.1074/jbc.M117.790170
    Enzymology - Protein Structure and Folding:
    • Giulia Pontarollo,
    • Laura Acquasaliente,
    • Daniele Peterle,
    • Ilaria Artusi,
    • and Vincenzo De Filippis
    Noncanonical Proteolytic Activation of Human Prothrombin by Subtilisin from Bacillus subtilis may Shift the Procoagulant-Anticoagulant Equilibrium Toward Thrombosis J. Biol. Chem. jbc.M117.795245. doi:10.1074/jbc.M117.795245
    Enzymology - Signal Transduction:
    • Markus Dagnell,
    • Paul E. Pace,
    • Qing Cheng,
    • Jeroen Frijhoff,
    • Arne Östman,
    • Elias S.J. Arnér,
    • Mark B. Hampton,
    • and Christine C Winterbourn
    Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure J. Biol. Chem. jbc.M117.793745. doi:10.1074/jbc.M117.793745
    Enzymology - Molecular Bases of Disease:
    • Eric Gonzalez and
    • F. Peter Guengerich
    Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1 J. Biol. Chem. jbc.M117.794917. doi:10.1074/jbc.M117.794917
    Enzymology:
    • Sweta Maheshwari,
    • Michelle S Miller,
    • Robert O'Meally,
    • Robert N Cole,
    • L. Mario Amzel,
    • and Sandra B Gabelli
    Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition J. Biol. Chem. jbc.M116.772426. doi:10.1074/jbc.M116.772426
    Enzymology - Molecular Bases of Disease:
    • Kednerlin Dornevil,
    • Ian Davis,
    • Andrew J. Fielding,
    • James R. Terrell,
    • Li Ma,
    • and Aimin Liu
    Crosslinking of Dicyclotyrosine by the Cytochrome P450 Enzyme CYP121 from Mycobacterium tuberculosis Proceeds through a Catalytic Shunt Pathway J. Biol. Chem. jbc.M117.794099. doi:10.1074/jbc.M117.794099
    Enzymology - Lipids:
    • Natalia Mast,
    • Kyle W. Anderson,
    • Kevin M. Johnson,
    • Thanh T.N. Phan,
    • F. Peter Guengerich,
    • and Irina A. Pikuleva
    In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds J. Biol. Chem. jbc.M117.794909. doi:10.1074/jbc.M117.794909
    Enzymology - Glycobiology and Extracellular Matrices:
    • José Munoz-Munoz,
    • Alan Cartmell,
    • Nicolas Terrapon,
    • Arnaud Baslé,
    • Bernard Henrissat,
    • and Harry J. Gilbert
    An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins J. Biol. Chem. jbc.M117.794578. doi:10.1074/jbc.M117.794578
    Enzymology - Metabolism:
    • Bulat Khaliullin,
    • Richard Ayikpoe,
    • Mason Tuttle,
    • and John A. Latham
    Mechanistic elucidation of the mycofactocin-biosynthetic radical-S-adenosylmethionine protein, MftC. J. Biol. Chem. jbc.M117.795682. doi:10.1074/jbc.M117.795682
    Enzymology - Protein Structure and Folding:
    • Christian W Johnson,
    • Derion Reid,
    • Jillian A Parker,
    • Shores Salter,
    • Ryan Knihtila,
    • Petr Kuzmic,
    • and Carla Mattos
    The small GTPases K-Ras, N-Ras and H-Ras have distinct biochemical properties determined by allosteric effects J. Biol. Chem. jbc.M117.778886. doi:10.1074/jbc.M117.778886
    Enzymology - Molecular Biophysics:
    • Wan-Chen Huang,
    • Chun-Ying Lee,
    • and Tao-shih Hsieh
    Single-molecule FRET analysis discloses the dynamics of the DNA-topoisomerase II (TOP2) interaction in the presence of TOP2-targeting agents J. Biol. Chem. jbc.M117.792861. doi:10.1074/jbc.M117.792861
    Enzymology - Cell Biology:
    • Hanna Wallin,
    • Jenny Apelqvist,
    • Freddi Andersson,
    • Ulf Ekstr&oumlm,
    • and Magnus Abrahamson
    Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells J. Biol. Chem. jbc.M117.776138. doi:10.1074/jbc.M117.776138
    Enzymology - Computational Biology:
    • Anil R Mhashal,
    • Alexandra Vardi-Kilshtain,
    • Amnon Kohen,
    • and Dan Thomas Major
    The Role of the M20 Loop in the Hydride Transfer in E. Coli Dihydrofolate Reductase J. Biol. Chem. jbc.M117.777136. doi:10.1074/jbc.M117.777136
    Enzymology - Microbiology:
    • Leonardo Astolfi Rosado,
    • Khadija Wahni,
    • Giulia Degiacomi,
    • Brandan Pedre,
    • David Young,
    • Alfonso G. de la Rubia,
    • Francesca Boldrin,
    • Edo Martens,
    • Laura Marcos-Pascual,
    • Enea Sancho-Vaello,
    • David Albesa-Jové,
    • Roberta Provvedi,
    • Charlotte Martin,
    • Vadim Makarov,
    • Wim Versées,
    • Guido Verniest,
    • Marcelo E. Guerin,
    • Luis M. Mateos,
    • Riccardo Manganelli,
    • and Joris Messens
    The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis J. Biol. Chem. jbc.M117.797837. doi:10.1074/jbc.M117.797837
    Enzymology - Protein Structure and Folding:
    • Darryl R. Jones,
    • Muhammed Salah Uddin,
    • Robert J. Gruninger,
    • Thi Thanh My Pham,
    • Dallas Thomas,
    • Alisdair B. Boraston,
    • Jonathan Briggs,
    • Benjamin Pluvinage,
    • Tim A. McAllister,
    • Robert J. Forster,
    • Adrian Tsang,
    • L. Brent Selinger,
    • and D. Wade Abbott
    Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl-substrates J. Biol. Chem. jbc.M117.789008. doi:10.1074/jbc.M117.789008
    Enzymology - Protein Structure and Folding:
    • Yaozong Chen,
    • Tin Lok Li,
    • Xingbang Lin,
    • Xin Li,
    • Xiang David Li,
    • and Zhihong Guo
    Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate binding mode J. Biol. Chem. jbc.M117.790410. doi:10.1074/jbc.M117.790410
    Enzymology - Protein Structure and Folding:
    • Mayo Sato,
    • Dorothee Liebschner,
    • Yusuke Yamada,
    • Naohiro Matsugaki,
    • Takatoshi Arakawa,
    • Siobhan S. Wills,
    • Mitchell Hattie,
    • Keith A. Stubbs,
    • Tasuku Ito,
    • Toshiya Senda,
    • Hisashi Ashida,
    • and Shinya Fushinobu
    The First Crystal Structure of a Family 129 Glycoside Hydrolase from a Probiotic Bacterium Reveals Critical Residues and Metal Co-factors J. Biol. Chem. jbc.M117.777391. doi:10.1074/jbc.M117.777391
    Metabolism - Enzymology:
    • Umakant Sahu,
    • Hunsur R Vinod Kumar,
    • Shankar S Kapnoor,
    • Raghu Bhagavat,
    • Nagasuma Chandra,
    • and Pundi N. Rangarajan
    Methionine synthase is localized to the nucleus in Pichia pastoris and Candida albicans and to the cytoplasm in Saccharomyces cerevisiae J. Biol. Chem. jbc.M117.783019. doi:10.1074/jbc.M117.783019
    Microbiology - Enzymology:
    • Ahmet H. Badur,
    • Matthew J. Plutz,
    • Geethika Yalamanchili,
    • Sujit Sadashiv Jagtap,
    • Thomas Schweder,
    • Frank Unfried,
    • Stephanie Markert,
    • Martin F. Polz,
    • Jan-Hendrik Hehemann,
    • and Christopher V. Rao
    Exploiting Fine-scale Genetic and Physiological Variation of Closely Related Microbes to Reveal Unknown Enzyme Functions J. Biol. Chem. jbc.M117.787192. doi:10.1074/jbc.M117.787192
    Minireview - Cell Biology - Enzymology:
    • Joseph J. Braymer and
    • Roland Lill
    Iron-Sulfur Cluster Biogenesis and Trafficking in Mitochondria J. Biol. Chem. jbc.R117.787101. doi:10.1074/jbc.R117.787101
    Minireview - Enzymology - Metabolism:
    • F. Peter Guengerich
    MINIREVIEW PROLOGUE Introduction: Metals in Biology 2017: Iron transport, storage, and the ramifications J. Biol. Chem. jbc.R117.801332. doi:10.1074/jbc.R117.801332
    Molecular Biophysics - Enzymology:
    • Kayla M Bell,
    • Hyo Keun Cha,
    • Charles V. Sindelar,
    • and Jared C Cochran
    The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner J. Biol. Chem. jbc.M117.797662. doi:10.1074/jbc.M117.797662
    Protein Structure and Folding - Enzymology:
    • Matthew Bratkowski,
    • Xin Yang,
    • and Xin Liu
    Polycomb repressive complex 2 in an autoinhibited state J. Biol. Chem. jbc.M117.787572. doi:10.1074/jbc.M117.787572
    Protein Structure and Folding - Enzymology:
    • Zongyang Lv,
    • Lingmin Yuan,
    • James H. Atkison,
    • Grace Aldana-Masangkay,
    • Yuan Chen,
    • and Shaun K. Olsen
    Domain alternation and active site remodeling are conserved structural features of ubiquitin E1 J. Biol. Chem. jbc.M117.787622. doi:10.1074/jbc.M117.787622

Membrane Biology

    Accelerated Communication - Enzymology - Membrane Biology:
    • James J. Asciolla,
    • Matthew M. Miele,
    • Ronald C. Hendrickson,
    • and Marilyn D. Resh
    An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine J. Biol. Chem. jbc.C117.800136. doi:10.1074/jbc.C117.800136
    Cell Biology - Membrane Biology:
    • Jennifer Virginia Roche,
    • Sabeen Survery,
    • Stefan Kreida,
    • Veronika Nesverova,
    • Henry Ampah-Korsah,
    • Maria Gourdon,
    • Peter M.T. Deen,
    • and Susanna Toernroth-Horsefield
    Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5 J. Biol. Chem. jbc.M117.788364. doi:10.1074/jbc.M117.788364
    Lipids - Membrane Biology:
    • Jennifer Prashek,
    • Samuel Bouyain,
    • Mingui Fu,
    • Yong Li,
    • Dusan Berkes,
    • and Xiaolan Yao
    Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain J. Biol. Chem. jbc.M117.780007. doi:10.1074/jbc.M117.780007
    Lipids - Membrane Biology:
    • Hideo Shindou,
    • Hideto Koso,
    • Junko Sasaki,
    • Hiroki Nakanishi,
    • Hiroshi Sagara,
    • Koh M. Nakagawa,
    • Yoshikazu Takahashi,
    • Daisuke Hishikawa,
    • Yoshiko Iizuka-Hishikawa,
    • Fuyuki Tokumasu,
    • Hiroshi Noguchi,
    • Sumiko Watanabe,
    • Takehiko Sasaki,
    • and Takao Shimizu
    Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells J. Biol. Chem. jbc.M117.790568. doi:10.1074/jbc.M117.790568
    Membrane Biology:
    • Hiba Qasem Abdullah,
    • Michal Perach,
    • Nurit Livnat-Levanon,
    • and Oded Lewinson
    ATP binding and hydrolysis disrupts the high-affinity interaction between the heme ABC transporter HmuUV and its cognate substrate binding protein J. Biol. Chem. jbc.M117.779975. doi:10.1074/jbc.M117.779975
    Membrane Biology - Molecular Bases of Disease:
    • Benedict Reilly-O'Donnell,
    • Gavin B Robertson,
    • Angela Karumbi,
    • Connor McIntyre,
    • Wojciech Bal,
    • Miyuki Nishi,
    • Hiroshi Takeshima,
    • Alan J Stewart,
    • and Samantha J Pitt
    Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage J. Biol. Chem. jbc.M117.781708. doi:10.1074/jbc.M117.781708
    Membrane Biology - Molecular Biophysics:
    • Eva Fortea,
    • Vincent Lemieux,
    • Léna Potvin,
    • Vimbai Chikwana,
    • Samantha Griffin,
    • Thimothy Hey,
    • David McCaskill,
    • Kenneth Narva,
    • Sek Yee Tan,
    • Xiaoping Xu,
    • Vincent Vachon,
    • and Jean-Louis Schwartz
    Cry6Aa1, a Bacillus thuringiensis Nematocidal and Insecticidal Toxin, Forms Pores in Planar Lipid Bilayers at Extremely Low Concentrations and Without the Need of Proteolytic Processing J. Biol. Chem. jbc.M116.765941. doi:10.1074/jbc.M116.765941
    Membrane Biology - Protein Synthesis and Degradation:
    • Kana Marunaka,
    • Chisa Furukawa,
    • Naoko Fujii,
    • Toru Kimura,
    • Takumi Furuta,
    • Toshiyuki Matsunaga,
    • Satoshi Endo,
    • Hajime Hasegawa,
    • Naohiko Anzai,
    • Yasuhiro Yamazaki,
    • Masahiko Yamaguchi,
    • and Akira Ikari
    The RING Finger- and PDZ Domain-Containing Protein PDZRN3 Controls Localization of the Mg2+ Regulator Claudin-16 in Renal Tube Epithelial Cells J. Biol. Chem. jbc.M117.779405. doi:10.1074/jbc.M117.779405
    Membrane Biology - Molecular Biophysics:
    • Bharat Ramasubramanian Iyer,
    • Punit Zadafiya,
    • Pallavi Vijay Vetal,
    • and Radhakrishnan Mahalakshmi
    Energetics of side chain partitioning of β-signal residues in unassisted folding of a transmembrane β-barrel protein J. Biol. Chem. jbc.M117.789446. doi:10.1074/jbc.M117.789446
    Membrane Biology - Lipids:
    • Yoshiko Iizuka-Hishikawa,
    • Daisuke Hishikawa,
    • Junko Sasaki,
    • Keiyo Takubo,
    • Motohito Goto,
    • Katsuyuki Nagata,
    • Hiroki Nakanishi,
    • Hideo Shindou,
    • Tadashi Okamura,
    • Chizuru Ito,
    • Kiyotaka Toshimori,
    • Takehiko Sasaki,
    • and Takao Shimizu
    Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem. jbc.M117.791277. doi:10.1074/jbc.M117.791277
    Membrane Biology - Protein Structure and Folding:
    • Moshe Giladi,
    • Liat van Dijk,
    • Bosmat Refaeli,
    • Lior Almagor,
    • Reuben Hiller,
    • Petr Man,
    • Eric Forest,
    • and Daniel Khananshvili
    Dynamic distinctions in the sodium-calcium exchanger adopting the inward- and outward-facing conformational states J. Biol. Chem. jbc.M117.787168. doi:10.1074/jbc.M117.787168
    Molecular Bases of Disease - Membrane Biology:
    • Zhihui Li,
    • Daochuan Li,
    • Eun Yong Choi,
    • Rena Lapidus,
    • Lei Zhang,
    • Shiew-Mei Huang,
    • Paul Shapiro,
    • and Hongbing Wang
    Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells J. Biol. Chem. jbc.M117.783860. doi:10.1074/jbc.M117.783860
    Signal Transduction - Membrane Biology:
    • Yang Gao,
    • Gerwin Westfield,
    • Jon W. Erickson,
    • Richard A. Cerione,
    • Georgios Skiniotis,
    • and Sekar Ramachandran
    Isolation and Structure-function Characterization of a Signaling-active Rhodopsin-G protein Complex J. Biol. Chem. jbc.M117.797100. doi:10.1074/jbc.M117.797100
    Signal Transduction - Membrane Biology:
    • Zack Zurawski,
    • Brian Page,
    • Michael C. Chicka,
    • Rebecca L Brindley,
    • Christopher A Wells,
    • Anita M Preininger,
    • Karren Hyde,
    • James A Gilbert,
    • Osvaldo Cruz-Rodriguez,
    • Kevin P. M. Currie,
    • Edwin R Chapman,
    • Simon Alford,
    • and Heidi E Hamm
    Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes. J. Biol. Chem. jbc.M116.773523. doi:10.1074/jbc.M116.773523

Signal Transduction

    Accelerated Communication - Signal Transduction - Computational Biology:
    • Yanfei Jiang,
    • Zohreh AkhavanAghdam,
    • Lev S. Tsimring,
    • and Nan Hao
    Coupled feedback loops control the stimulus-dependent dynamics of the yeast transcription factor Msn2 J. Biol. Chem. jbc.C117.800896. doi:10.1074/jbc.C117.800896
    Cell Biology - Signal Transduction:
    • Rui Tang,
    • Gui Zhang,
    • Yung-Chun Wang,
    • Xiaohan Mei,
    • and Shi-You Chen
    The long non-coding RNA GAS5 regulates TGF-β-induced smooth muscle cell differentiation via RNA-Smad binding element J. Biol. Chem. jbc.M117.790030. doi:10.1074/jbc.M117.790030
    Cell Biology - Signal Transduction:
    • Vinita Yadav,
    • Xing-Huang Gao,
    • Belinda Willard,
    • Maria Hatzoglou,
    • Ruma Banerjee,
    • and Omer Kabil
    Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress response pathway J. Biol. Chem. jbc.M117.778654. doi:10.1074/jbc.M117.778654
    Cell Biology - Signal Transduction:
    • Wee K Lin,
    • Emma L Bolton,
    • Wilian A Cortopassi,
    • Yanwen Wang,
    • Fiona O'Brien,
    • Matylda Maciejewska,
    • Matthew P Jacobson,
    • Clive Garnham,
    • Margarida Ruas,
    • John Parrington,
    • Ming Lei,
    • Rebecca Sitsapesan,
    • Antony Galione,
    • and Derek A Terrar
    Synthesis of the Ca2+-mobilizing messengers, NAADP and cADPR, by intracellular CD38 enzyme in mouse heart: role in β-adrenoceptor signaling J. Biol. Chem. jbc.M117.789347. doi:10.1074/jbc.M117.789347
    DNA and Chromosomes - Signal Transduction:
    • Michael G Kemp
    DNA damage-induced ATR kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor II-H (TFIIH) J. Biol. Chem. jbc.M117.788406. doi:10.1074/jbc.M117.788406
    Enzymology - Signal Transduction:
    • Markus Dagnell,
    • Paul E. Pace,
    • Qing Cheng,
    • Jeroen Frijhoff,
    • Arne Östman,
    • Elias S.J. Arnér,
    • Mark B. Hampton,
    • and Christine C Winterbourn
    Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure J. Biol. Chem. jbc.M117.793745. doi:10.1074/jbc.M117.793745
    Gene Regulation - Signal Transduction:
    • Clàudia Salat-Canela,
    • Esther Paulo,
    • Laura Sánchez-Mir,
    • Mercè Carmona,
    • José Ayté,
    • Baldo Oliva,
    • and Elena Hidalgo
    Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation J. Biol. Chem. jbc.M117.794339. doi:10.1074/jbc.M117.794339
    Gene Regulation - Signal Transduction:
    • Shuman Gao,
    • Zhiqiang Wang,
    • Wencai Wang,
    • Xueli Hu,
    • Peilin Chen,
    • Jiwen Li,
    • Xin Hua Feng,
    • Jiemin Wong,
    • and James X Du
    The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling J. Biol. Chem. jbc.M117.776278. doi:10.1074/jbc.M117.776278
    Glycobiology and Extracellular Matrices - Signal Transduction:
    • Patricia Y Akinfenwa,
    • Wesley S Bond,
    • Cristhian J Ildefonso,
    • Mary Y Hurwitz,
    • and Richard L Hurwitz
    Versican G1 Domain Enhances Adenoviral-Mediated Transgene Expression and Can Be Modulated by Inhibitors of the Janus Kinase (JAK)/STAT and Src Family Kinase Pathways J. Biol. Chem. jbc.M116.773549. doi:10.1074/jbc.M116.773549
    Immunology - Signal Transduction:
    • Raquel Domingo-Fernández,
    • Rebecca C. Coll,
    • Jay Kearney,
    • Samuel Breit,
    • and Luke AJ. O'Neill
    The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome J. Biol. Chem. jbc.M117.797126. doi:10.1074/jbc.M117.797126
    Lipids - Signal Transduction:
    • Mariangela Vessichelli,
    • Stefania Mariggi&ograve,
    • Alessia Varone,
    • Pasquale Zizza,
    • Angelomaria Di Santo,
    • Concetta Amore,
    • Giuseppe Dell'Elba,
    • Adele Cutignano,
    • Angelo Fontana,
    • Carmela Cacciapuoti,
    • Gaetano Di Costanzo,
    • Mariastella Zannini,
    • Tiziana de Cristofaro,
    • Virgilio Evangelista,
    • and Daniela Corda
    The Natural Phosphoinositide-Derivative Glycerophosphoinositol Inhibits the Lipopolysaccharide-Induced Inflammatory and Thrombotic Responses J. Biol. Chem. jbc.M116.773861. doi:10.1074/jbc.M116.773861
    Metabolism - Signal Transduction:
    • Qi Sun,
    • Yue Zhao,
    • Yunxia Yang,
    • Xiao Yang,
    • Minghui Li,
    • Xi Xu,
    • Dan Weng,
    • Junsong Wang,
    • and Jianfa Zhang
    Loss of the clock protein PER2 shortens the erythrocyte life span in mice J. Biol. Chem. jbc.M117.783985. doi:10.1074/jbc.M117.783985
    Minireview - Cell Biology - Signal Transduction:
    • Mohammed Adnan Mohammed Hanif Qureshi,
    • Cole M. Haynes,
    • and Mark W. Pellegrino
    The mitochondrial unfolded protein response: signaling from the powerhouse J. Biol. Chem. jbc.R117.791061. doi:10.1074/jbc.R117.791061
    Molecular Bases of Disease - Signal Transduction:
    • Nikhlesh K. Singh,
    • Jagadeesh Janjanam,
    • and Gadiparthi N. Rao
    p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1-induced vascular smooth muscle cell migration and proliferation J. Biol. Chem. jbc.M117.777896. doi:10.1074/jbc.M117.777896
    Plant Biology - Signal Transduction:
    • Jan Petersen,
    • Shin-ichiro Inoue,
    • Sharon M Kelly,
    • Stuart Sullivan,
    • Toshinori Kinoshita,
    • and John Mackie Christie
    Functional Characterization of a Constitutively Active Kinase Variant of Arabidopsis Phototropin 1 J. Biol. Chem. jbc.M117.799643. doi:10.1074/jbc.M117.799643
    Plant Biology - Signal Transduction:
    • Christian Orth,
    • Nils Niemann,
    • Lars Hennig,
    • Lars-Oliver Essen,
    • and Alfred Batschauer
    Hyperactivity of the Arabidopsis cryptochrome (cry1) L407F mutant is caused by a structural alteration close to the cry1 ATP-binding sit J. Biol. Chem. jbc.M117.788869. doi:10.1074/jbc.M117.788869
    Protein Structure and Folding - Signal Transduction:
    • Dene R Littler,
    • Sheng Y Ang,
    • Danilo G Moriel,
    • Martina Kocan,
    • Oded Kleifeld,
    • Mathew D Johnson,
    • Mai T Tran,
    • Adrienne W Paton,
    • James C Paton,
    • Roger Summers,
    • Mark Schrembri,
    • Jamie Rossjohn,
    • and Travis T Beddoe
    Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins J. Biol. Chem. jbc.M117.796094. doi:10.1074/jbc.M117.796094
    Protein Structure and Folding - Signal Transduction:
    • Hikaru Shimizu,
    • Sachiko Toma-Fukai,
    • Shinya Saijo,
    • Nobutaka Shimizu,
    • Kenji Kontani,
    • Toshiaki Katada,
    • and Toshiyuki Shimizu
    Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding J. Biol. Chem. jbc.M117.792556. doi:10.1074/jbc.M117.792556
    Protein Synthesis and Degradation - Signal Transduction:
    • Jeffrey A. Willy,
    • Sara K. Young,
    • Amber L. Mosley,
    • Samer Gawrieh,
    • James L. Stevens,
    • Howard C. Masuoka,
    • and Ronald C. Wek
    Function of Inhibitor of Brutons Tyrosine Kinase Isoform α (IBTKα) in Nonalcoholic Steatohepatitis links Autophagy and the Unfolded Protein Response J. Biol. Chem. jbc.M117.799304. doi:10.1074/jbc.M117.799304
    Protein Synthesis and Degradation - Signal Transduction:
    • Shinwon Ha,
    • Seol-Hwa Jeong,
    • Kyungrim Yi,
    • Kyung Min Chung,
    • Caroline Jeeyeon Hong,
    • Seong Who Kim,
    • Eun-Kyoung Kim,
    • and Seong-Woon Yu
    Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells J. Biol. Chem. jbc.M117.780874. doi:10.1074/jbc.M117.780874
    Signal Transduction - Cell Biology:
    • Rachit Badolia,
    • Vaishali Inamdar,
    • Bhanu Kanth Manne,
    • Carol Dangelmaier,
    • and Satya P. Kunapuli
    Gq pathway regulates proximal C-type lectin-like receptor 2 (CLEC-2) signaling in platelets J. Biol. Chem. jbc.M117.791012. doi:10.1074/jbc.M117.791012
    Signal Transduction - Molecular Bases of Disease:
    • Dong An,
    • Feng Hao,
    • Fuqiang Zhang,
    • Wei Kong,
    • Jerold Chun,
    • Xuemin Xu,
    • and Mei-Zhen Cui
    CD14 Is a Key Mediator of Both Lysophosphatidic Acid and Lipopolysaccharide Induction of Foam Cell Formation J. Biol. Chem. jbc.M117.781807. doi:10.1074/jbc.M117.781807
    Signal Transduction - Cell Biology:
    • Liangshuai Yuan,
    • Yun Mao,
    • Wei Luo,
    • Weiwei Wu,
    • Hao Xu,
    • Xing Li Wang,
    • and Ying H Shen
    Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling J. Biol. Chem. jbc.M117.804005. doi:10.1074/jbc.M117.804005
    Signal Transduction - Molecular Bases of Disease:
    • Xiaohong Guo,
    • Tingting Li,
    • Yun Xu,
    • Xiayan Xu,
    • Zhengyi Zhu,
    • Yun Zhang,
    • Jiaqi Xu,
    • Kaihong Xu,
    • Hongqiang Cheng,
    • Xue Zhang,
    • and Yuehai Ke
    Increased levels of Gab1 and Gab2 adaptor proteins skew IL-4 signaling toward M2 macrophage-driven pulmonary fibrosis in mice J. Biol. Chem. jbc.M117.802066. doi:10.1074/jbc.M117.802066
    Signal Transduction - Cell Biology:
    • Shuvomoy Banerjee,
    • Pushpak Bhattacharjee,
    • Juni Chakraborty,
    • Abir K. Panda,
    • Arnab Bandyopadhyay,
    • Suman K. Banik,
    • and Gaurisankar Sa
    Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis J. Biol. Chem. jbc.M117.784868. doi:10.1074/jbc.M117.784868
    Signal Transduction - Cell Biology:
    • Conggang Zhang,
    • Zeyu Liu,
    • Eric Bunker,
    • Adrian Ramirez,
    • Schuyler Lee,
    • Yinghua Peng,
    • Aik Choon Tan,
    • S Gail Eckhardt,
    • Douglas A Chapnick,
    • and Xuedong Liu
    Sorafenib Targets the Mitochondrial Electron Transport Chain Complexes and ATP Synthase to Activate the PINK1-Parkin Pathway and Modulate Cellular Drug Response J. Biol. Chem. jbc.M117.783175. doi:10.1074/jbc.M117.783175
    Signal Transduction:
    • Justine M Pinskey,
    • Nicole E Franks,
    • Alexandra N McMellen,
    • Roman J Giger,
    • and Benjamin L Allen
    Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif J. Biol. Chem. jbc.M117.783845. doi:10.1074/jbc.M117.783845
    Signal Transduction - Membrane Biology:
    • Yang Gao,
    • Gerwin Westfield,
    • Jon W. Erickson,
    • Richard A. Cerione,
    • Georgios Skiniotis,
    • and Sekar Ramachandran
    Isolation and Structure-function Characterization of a Signaling-active Rhodopsin-G protein Complex J. Biol. Chem. jbc.M117.797100. doi:10.1074/jbc.M117.797100
    Signal Transduction - Cell Biology:
    • Taner Dogan,
    • Florian Gnad,
    • Jocelyn Chan,
    • Lilian Phu,
    • Amy Young,
    • Mark J Chen,
    • Sophia Doll,
    • Matthew P Stokes,
    • Marcia Belvin,
    • Lori S Friedman,
    • Donald S Kirkpatrick,
    • Klaus P Hoeflich,
    • and Georgia Hatzivassiliou
    Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling to the cell cycle J. Biol. Chem. jbc.M117.792754. doi:10.1074/jbc.M117.792754
    Signal Transduction - Cell Biology:
    • Kátia M Lima,
    • Juliana P Vago,
    • Thaís R Caux,
    • Graziele Letícia Negreiros-Lima,
    • Michelle A Sugimoto,
    • Luciana P Tavares,
    • Raquel G Arribada,
    • Aline Alves F Carmo,
    • Izabela Galvão,
    • Bruno Rocha C Costa,
    • Frederico M Soriani,
    • Vanessa Pinho,
    • Egle Solito,
    • Mauro Perretti,
    • Mauro M Teixeira,
    • and Lirlândia P Sousa
    The resolution of acute Inflammation induced by cyclic AMP is dependent on annexin A1 J. Biol. Chem. jbc.M117.800391. doi:10.1074/jbc.M117.800391
    Signal Transduction - Cell Biology:
    • Thomas H Smith,
    • Julia G Li,
    • Michael R Dores,
    • and JoAnn Trejo
    Protease-activated receptor-4 and P2Y12 Dimerize, Co-Internalize and Activate Akt Signaling via Endosomal Recruitment of β-arrestin J. Biol. Chem. jbc.M117.782359. doi:10.1074/jbc.M117.782359
    Signal Transduction - Molecular Bases of Disease:
    • Angela M Gocher,
    • Gissou Azabdaftari,
    • Lindsey M Euscher,
    • Shuhang Dai,
    • Loukia G Karacosta,
    • Thomas F Franke,
    • and Arthur M Edelman
    Akt Activation by Ca2+/calmodulin-dependent protein Kinase Kinase 2 (CaMKK2) in Ovarian Cancer Cells J. Biol. Chem. jbc.M117.778464. doi:10.1074/jbc.M117.778464
    Signal Transduction - Molecular Biophysics:
    • Hisao Tsukamoto,
    • I-Shan Chen,
    • Yoshihiro Kubo,
    • and Yuji Furutani
    A ciliary opsin in the brain of a marine annelid zooplankton is UV-sensitive and the sensitivity is tuned by a single amino acid residue J. Biol. Chem. jbc.M117.793539. doi:10.1074/jbc.M117.793539
    Signal Transduction - Cell Biology:
    • Subhashree Pradhan,
    • Tanvir Khatlani,
    • Angus C. Nairn,
    • and K Vinod Vijayan
    The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein coupled receptor signaling in platelets J. Biol. Chem. jbc.M117.796656. doi:10.1074/jbc.M117.796656
    Signal Transduction - Cell Biology:
    • Magda Nohemí Hernández-Vásquez,
    • Sendi Rafael Adame-García,
    • Noumeira Hamoud,
    • Rony Chidiac,
    • Guadalupe Reyes-Cruz,
    • Jean Philippe Gratton,
    • Jean-François Côté,
    • and José Vázquez-Prado
    Cell adhesion controlled by adhesion G-protein coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising Intersectins and Elmo/Dock J. Biol. Chem. jbc.M117.780304. doi:10.1074/jbc.M117.780304
    Signal Transduction - Gene Regulation:
    • Wenliang Qian,
    • Xiaoxu Gang,
    • Tianlei Zhang,
    • Ling Wei,
    • Xinxin Yang,
    • Zheng Li,
    • Yan Yang,
    • Liang Song,
    • Peng Wang,
    • Jian Peng,
    • Daojun Cheng,
    • and Qingyou Xia
    Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity J. Biol. Chem. jbc.M117.775130. doi:10.1074/jbc.M117.775130
    Signal Transduction - Molecular Biophysics:
    • Rory Sleno,
    • Dominic Devost,
    • Darlaine Pétrin,
    • Alice Zhang,
    • Kyla Bourque,
    • Yuji Shinjo,
    • Junken Aoki,
    • Asuka Inoue,
    • and Terence E. Hébert
    Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors J. Biol. Chem. jbc.M117.793877. doi:10.1074/jbc.M117.793877
    Signal Transduction - Neurobiology:
    • Andrew C Emery,
    • Wenqin Xu,
    • Maribeth V Eiden,
    • and Lee E Eiden
    Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells J. Biol. Chem. jbc.M117.790329. doi:10.1074/jbc.M117.790329
    Signal Transduction:
    • Michelle Duong,
    • Xuejiao Yu,
    • Beina Teng,
    • Patricia Schroder,
    • Hermann Haller,
    • Susanne Eschenburg,
    • and Mario Schiffer
    Protein Kinase C ε Stabilizes β-Catenin and Regulates Its Subcellular Localization in Podocytes J. Biol. Chem. jbc.M117.775700. doi:10.1074/jbc.M117.775700
    Signal Transduction - Protein Structure and Folding:
    • Sergey A. Vishnivetskiy,
    • Regina J. Lee,
    • X. Edward Zhou,
    • Andreas Franz,
    • Qiuyi Xu,
    • H. Eric Xu,
    • and Vsevolod V. Gurevich
    Functional role of the three conserved cysteines in the N-domain of visual arrestin-1 J. Biol. Chem. jbc.M117.790386. doi:10.1074/jbc.M117.790386
    Signal Transduction - Cell Biology:
    • Abhishek Roy,
    • Shabbir A. Ansari,
    • Kaushik Das,
    • Ramesh Prasad,
    • Anindita Bhattacharya,
    • Suman Mallik,
    • Asis Mukherjee,
    • and Prosenjit Sen
    Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to β-catenin accumulation via the AKT/GSK3β pathway and contributes to breast cancer progression J. Biol. Chem. jbc.M116.764670. doi:10.1074/jbc.M116.764670
    Signal Transduction - Membrane Biology:
    • Zack Zurawski,
    • Brian Page,
    • Michael C. Chicka,
    • Rebecca L Brindley,
    • Christopher A Wells,
    • Anita M Preininger,
    • Karren Hyde,
    • James A Gilbert,
    • Osvaldo Cruz-Rodriguez,
    • Kevin P. M. Currie,
    • Edwin R Chapman,
    • Simon Alford,
    • and Heidi E Hamm
    Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes. J. Biol. Chem. jbc.M116.773523. doi:10.1074/jbc.M116.773523
    Signal Transduction - Molecular Biophysics:
    • Braden D Siempelkamp,
    • Manoj K Rathinaswamy,
    • Meredith L Jenkins,
    • and John E Burke
    Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas J. Biol. Chem. jbc.M117.789263. doi:10.1074/jbc.M117.789263

Computational Biology

    Accelerated Communication - Signal Transduction - Computational Biology:
    • Yanfei Jiang,
    • Zohreh AkhavanAghdam,
    • Lev S. Tsimring,
    • and Nan Hao
    Coupled feedback loops control the stimulus-dependent dynamics of the yeast transcription factor Msn2 J. Biol. Chem. jbc.C117.800896. doi:10.1074/jbc.C117.800896
    Computational Biology - Molecular Biophysics:
    • Hyunbum Jang,
    • Avik Banerjee,
    • Tanmay Chavan,
    • Vadim Gaponenko,
    • and Ruth Nussinov
    Flexible-Body Motions of Calmodulin and the Farnesylated Hypervariable Region Yield a High-Affinity Interaction Enabling K-Ras4B Membrane Extraction J. Biol. Chem. jbc.M117.785063. doi:10.1074/jbc.M117.785063
    Computational Biology - Molecular Biophysics:
    • Asghar M Razavi,
    • Lucie Delemotte,
    • Joshua R Berlin,
    • Vincenzo Carnevale,
    • and Vincent A Voelz
    Molecular simulations and free-energy calculations suggest conformation-dependent anion binding to a cytoplasmic site as a mechanism for Na+/K+-ATPase ion selectivity J. Biol. Chem. jbc.M117.779090. doi:10.1074/jbc.M117.779090
    Computational Biology - Molecular Biophysics:
    • Mary Hongying Cheng,
    • Jennie Garcia-Olivares,
    • Steven Wasserman,
    • Jennifer DiPietro,
    • and Ivet Bahar
    Allosteric Modulation of Human Dopamine Transporter Activity under Conditions Promoting its Dimerization J. Biol. Chem. jbc.M116.763565. doi:10.1074/jbc.M116.763565
    Computational Biology - Molecular Biophysics:
    • David D. Mowrey,
    • Le Xu,
    • Yingwu Mei,
    • Daniel A. Pasek,
    • Gerhard Meissner,
    • and Nikolay V. Dokholyan
    Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor J. Biol. Chem. jbc.M116.760199. doi:10.1074/jbc.M116.760199
    Enzymology - Computational Biology:
    • Anil R Mhashal,
    • Alexandra Vardi-Kilshtain,
    • Amnon Kohen,
    • and Dan Thomas Major
    The Role of the M20 Loop in the Hydride Transfer in E. Coli Dihydrofolate Reductase J. Biol. Chem. jbc.M117.777136. doi:10.1074/jbc.M117.777136
    Protein Structure and Folding - Computational Biology:
    • Robert M. Vernon,
    • P. Andrew Chong,
    • Hong Lin,
    • Zhengrong Yang,
    • Qingxian Zhou,
    • Andrei A Aleksandrov,
    • Jennifer E Dawson,
    • John R. Riordan,
    • Christie G. Brouillette,
    • Patrick H. Thibodeau,
    • and Julie D. Forman-Kay
    Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations J. Biol. Chem. jbc.M116.772335. doi:10.1074/jbc.M116.772335

Metabolism

    Accelerated Communication - Metabolism:
    • Xiaoxin X. Wang,
    • Yuhuan Luo,
    • Dong Wang,
    • Luciano Adorini,
    • Mark Pruzanski,
    • Evgenia Dobrinskikh,
    • and Moshe Levi
    A Dual Agonist of Farnesoid X Receptor (FXR) and the G protein-coupled Receptor TGR5, INT-767, Slows Down Age-Related Kidney Disease in Mice J. Biol. Chem. jbc.C117.794982. doi:10.1074/jbc.C117.794982
    Bioenergetics - Metabolism:
    • Julianna Dias Zeidler,
    • Lorena O. Fernandes-Siqueira,
    • Ana S. Carvalho,
    • Eduardo Cararo-Lopes,
    • Matheus H.S. Dias,
    • Luisa A. Ketzer,
    • Antonio Galina,
    • and Andrea T. Da Poian
    Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria J. Biol. Chem. jbc.M117.786582. doi:10.1074/jbc.M117.786582
    Cell Biology - Metabolism:
    • Izumi Yanatori,
    • Des R. Richardson,
    • Shinya Toyokuni,
    • and Fumio Kishi
    The Iron Chaperone Poly (rC)-binding Protein 2 Forms a Metabolon with the Heme Oxygenase 1/Cytochrome P450 Reductase Complex for Heme Catabolism and Iron Transfer J. Biol. Chem. jbc.M117.776021. doi:10.1074/jbc.M117.776021
    Cell Biology - Metabolism:
    • Filip Liebsch,
    • Mark R. P. Aurousseau,
    • Tobias Bethge,
    • Hugo McGuire,
    • Silvia Scolari,
    • Andreas Herrmann,
    • Rikard Blunck,
    • Derek Bowie,
    • and Gerd Multhaup
    Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization J. Biol. Chem. jbc.M117.779165. doi:10.1074/jbc.M117.779165
    Enzymology - Metabolism:
    • Diep M. N. Nguyen,
    • Gerrit J. Schut,
    • Oleg A. Zadvornyy,
    • Monika Tokmina-Lukaszewska,
    • Saroj Poudel,
    • Gina L. Lipscomb,
    • Leslie A. Adams,
    • Jessica T. Dinsmore,
    • William J. Nixon,
    • Eric S. Boyd,
    • Brian Bothner,
    • John W. Peters,
    • and Michael W. W. Adams
    Two functionally distinct NADP+-dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus J. Biol. Chem. jbc.M117.794172. doi:10.1074/jbc.M117.794172
    Enzymology - Metabolism:
    • Kevin M. Johnson,
    • Thanh T. N. Phan,
    • Matthew E. Albertolle,
    • and F. Peter Guengerich
    Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol J. Biol. Chem. jbc.M116.773937. doi:10.1074/jbc.M116.773937
    Enzymology - Metabolism:
    • Bulat Khaliullin,
    • Richard Ayikpoe,
    • Mason Tuttle,
    • and John A. Latham
    Mechanistic elucidation of the mycofactocin-biosynthetic radical-S-adenosylmethionine protein, MftC. J. Biol. Chem. jbc.M117.795682. doi:10.1074/jbc.M117.795682
    Immunology - Metabolism:
    • Javier Traba,
    • Sarah S Geiger,
    • Miriam Kwarteng Siaw,
    • Kim Han,
    • One Hyuk Ra,
    • Richard M Siegel,
    • David Gius,
    • and Michael N Sack
    Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3 mediated activation of Superoxide Dismutase 2 J. Biol. Chem. jbc.M117.791715. doi:10.1074/jbc.M117.791715
    Lipids - Metabolism:
    • Maidina Tuohetahuntila,
    • Martijn R. Molenaar,
    • Bart Spee,
    • Jos F. Brouwers,
    • Richard Wubbolts,
    • Martin Houweling,
    • Cong Yan,
    • Hong Du,
    • Brian C VanderVen,
    • Arie B. Vaandrager,
    • and J. Bernd Helms
    Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation J. Biol. Chem. jbc.M117.778472. doi:10.1074/jbc.M117.778472
    Metabolism - Enzymology:
    • Umakant Sahu,
    • Hunsur R Vinod Kumar,
    • Shankar S Kapnoor,
    • Raghu Bhagavat,
    • Nagasuma Chandra,
    • and Pundi N. Rangarajan
    Methionine synthase is localized to the nucleus in Pichia pastoris and Candida albicans and to the cytoplasm in Saccharomyces cerevisiae J. Biol. Chem. jbc.M117.783019. doi:10.1074/jbc.M117.783019
    Metabolism - Gene Regulation:
    • Mark E. Corkins,
    • Stevin Wilson,
    • Jean-Christophe Cocuron,
    • Ana P. Alonso,
    • and Amanda J. Bird
    The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast J. Biol. Chem. jbc.M117.798488. doi:10.1074/jbc.M117.798488
    Metabolism - Gene Regulation:
    • Yong Xue,
    • Stefan Schmollinger,
    • Narsis Attar,
    • Oscar Campos,
    • Maria Vogelauer,
    • Michael F Carey,
    • Sabeeha S. Merchant,
    • and Siavash K Kurdistani
    Endoplasmic reticulum-mitochondria junction is required for iron homeostasis J. Biol. Chem. jbc.M117.784249. doi:10.1074/jbc.M117.784249
    Metabolism - Microbiology:
    • Irina A Rodionova,
    • Zhongge Zhang,
    • Jitender Mehla,
    • Norman Goodacre,
    • Mohan Babu,
    • Andrew Emili,
    • Peter Uetz,
    • and Milton H Saier, Jr.
    The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli J. Biol. Chem. jbc.M117.795294. doi:10.1074/jbc.M117.795294
    Metabolism - Molecular Bases of Disease:
    • Pranavi Koppula,
    • Yilei Zhang,
    • Jiejun Shi,
    • Wei Li,
    • and Boyi Gan
    The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate J. Biol. Chem. jbc.M117.798405. doi:10.1074/jbc.M117.798405
    Metabolism - Neurobiology:
    • Jennifer R. Chao,
    • Kaitlen Knight,
    • Abbi L. Engel,
    • Connor Jankowski,
    • Yekai Wang,
    • Megan A. Manson,
    • Haiwei Gu,
    • Danijel Djukovic,
    • Daniel Raftery,
    • James B. Hurley,
    • and Jianhai Du
    Human Retinal Pigment Epithelium Cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side J. Biol. Chem. jbc.M117.788422. doi:10.1074/jbc.M117.788422
    Metabolism - Signal Transduction:
    • Qi Sun,
    • Yue Zhao,
    • Yunxia Yang,
    • Xiao Yang,
    • Minghui Li,
    • Xi Xu,
    • Dan Weng,
    • Junsong Wang,
    • and Jianfa Zhang
    Loss of the clock protein PER2 shortens the erythrocyte life span in mice J. Biol. Chem. jbc.M117.783985. doi:10.1074/jbc.M117.783985
    Metabolism - Molecular Bases of Disease:
    • Xiao Jian Sun,
    • Soohyun Park Kim,
    • Dongming Zhang,
    • Helen Sun,
    • Qi Cao,
    • Xin Lu,
    • Zhekang Ying,
    • Liwu Li,
    • Robert R. Henry,
    • Theodore P. Ciaraldi,
    • Simeon I. Taylor,
    • and Michael J. Quon
    Deletion of interleukin 1 receptor associated kinase 1 (IRAK1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle J. Biol. Chem. jbc.M117.779108. doi:10.1074/jbc.M117.779108
    Microbiology - Metabolism:
    • John G. Mina,
    • Julie K. Thye,
    • Amjed Q.I. Alqaisi,
    • Louise E. Bird,
    • Robert H. Dods,
    • Morten K. Groftehauge,
    • Jackie A. Mosely,
    • Steven Pratt,
    • Hosam Shams-Eldin,
    • Ralph T. Schwarz,
    • Ehmke Pohl,
    • and Paul W. Denny
    Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites J. Biol. Chem. jbc.M117.792374. doi:10.1074/jbc.M117.792374
    Microbiology - Metabolism:
    • Laura Hobley,
    • Bin Li,
    • Jennifer L Wood,
    • Sok-Ho Kim,
    • Jacinth Naidoo,
    • Ana Sofia Ferreira,
    • Maxim Khomutov,
    • Alexey Khomutov,
    • Nicola R. Stanley-Wall,
    • and Anthony J. Michael
    Spermidine promotes Bacillus subtilis biofilm formation by activating expression of the matrix regulator slrR J. Biol. Chem. jbc.M117.789644. doi:10.1074/jbc.M117.789644
    Minireview - Cell Biology - Metabolism:
    • Caroline C. Philpott,
    • Moon-Suhn Ryu,
    • Avery G. Frey,
    • and Sarju Patel
    Cytosolic iron chaperones: proteins delivering iron cofactors in the cytosol of mammalian cells. J. Biol. Chem. jbc.R117.791962. doi:10.1074/jbc.R117.791962
    Minireview - Protein Structure and Folding - Metabolism:
    • Tracey A Rouault and
    • Nunziata Maio
    Biogenesis and Functions of Mammalian Iron-Sulfur Proteins in the Regulation of Iron Homeostasis and Pivotal Metabolic Pathways J. Biol. Chem. jbc.R117.789537. doi:10.1074/jbc.R117.789537
    Minireview - Metabolism - Cell Biology:
    • Mitchell D. Knutson
    Iron Transport Proteins: Gateways of Cellular and Systemic Iron Homeostasis J. Biol. Chem. jbc.R117.786632. doi:10.1074/jbc.R117.786632
    Minireview - Enzymology - Metabolism:
    • F. Peter Guengerich
    MINIREVIEW PROLOGUE Introduction: Metals in Biology 2017: Iron transport, storage, and the ramifications J. Biol. Chem. jbc.R117.801332. doi:10.1074/jbc.R117.801332
    Minireview - Metabolism - Cell Biology:
    • Richard Coffey and
    • Tomas Ganz
    Iron Homeostasis--an Anthropocentric Perspective J. Biol. Chem. jbc.R117.781823. doi:10.1074/jbc.R117.781823
    Molecular Bases of Disease - Metabolism:
    • Hervé Lerat,
    • Mohamed Rabah Imache,
    • Jacqueline Polyte,
    • Aurore Gaudin,
    • Marion Mercey,
    • Flora Donati,
    • Camille Baudesson,
    • Martin R. Higgs,
    • Alexandre Picard,
    • Christophe Magnan,
    • Fabienne Foufelle,
    • and Jean-Michel Pawlotsky
    Hepatitis C virus induces a pre-diabetic state by directly impairing hepatic glucose metabolism in mice J. Biol. Chem. jbc.M117.785030. doi:10.1074/jbc.M117.785030

Bioenergetics

    Bioenergetics - Methods and Resources:
    • Edward T. Chouchani,
    • Andrew M. James,
    • Carmen Methner,
    • Victoria R. Pell,
    • Tracy A. Prime,
    • Brian K. Erikson,
    • Marleen Forkink,
    • Gigi Y. Lau,
    • Thomas P. Bright,
    • Katja E. Menger,
    • Ian M. Fearnley,
    • Thomas Krieg,
    • and Michael P. Murphy
    Identification and Quantification of Protein S-nitrosation by Nitrite in the Mouse Heart during Ischemia J. Biol. Chem. jbc.M117.798744. doi:10.1074/jbc.M117.798744
    Bioenergetics - Metabolism:
    • Julianna Dias Zeidler,
    • Lorena O. Fernandes-Siqueira,
    • Ana S. Carvalho,
    • Eduardo Cararo-Lopes,
    • Matheus H.S. Dias,
    • Luisa A. Ketzer,
    • Antonio Galina,
    • and Andrea T. Da Poian
    Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria J. Biol. Chem. jbc.M117.786582. doi:10.1074/jbc.M117.786582
    Bioenergetics - Microbiology:
    • Andreia F. Verisssimo,
    • Bahia Khalfaoui-Hassani,
    • Josephine Hwang,
    • Stefan Steimle,
    • Nur Selamoglu,
    • Carsten Sanders,
    • Camilo Khatchikian,
    • and Fevzi Daldal
    The thioreduction component CcmG confers efficiency and the heme ligation component CcmH ensures stereo-specificity during cytochrome c maturation J. Biol. Chem. jbc.M117.794586. doi:10.1074/jbc.M117.794586
    Bioenergetics - Enzymology:
    • C. A. Starbird,
    • Elena Maklashina,
    • Pankaj Sharma,
    • Susan Qualls-Histed,
    • Gary Cecchini,
    • and T. M. Iverson
    Structural and biochemical analyses reveal insights into covalent flavinylation of the Escherichia coli Complex II homolog quinol:fumarate reductase J. Biol. Chem. jbc.M117.795120. doi:10.1074/jbc.M117.795120
    Bioenergetics - Enzymology:
    • John P. Hoben,
    • Carolyn E. Lubner,
    • Michael W. Ratzloff,
    • Gerrit J. Schut,
    • Diep M. N. Nguyen,
    • Karl W. Hempel,
    • Michael W. W. Adams,
    • Paul W. King,
    • and Anne-Frances Miller
    Equilibrium and ultrafast kinetic studies manipulating electron transfer: a short-lived flavin semiquinone is not sufficient for electron bifurcation J. Biol. Chem. jbc.M117.794214. doi:10.1074/jbc.M117.794214

Methods and Resources

    Bioenergetics - Methods and Resources:
    • Edward T. Chouchani,
    • Andrew M. James,
    • Carmen Methner,
    • Victoria R. Pell,
    • Tracy A. Prime,
    • Brian K. Erikson,
    • Marleen Forkink,
    • Gigi Y. Lau,
    • Thomas P. Bright,
    • Katja E. Menger,
    • Ian M. Fearnley,
    • Thomas Krieg,
    • and Michael P. Murphy
    Identification and Quantification of Protein S-nitrosation by Nitrite in the Mouse Heart during Ischemia J. Biol. Chem. jbc.M117.798744. doi:10.1074/jbc.M117.798744

Microbiology

    Bioenergetics - Microbiology:
    • Andreia F. Verisssimo,
    • Bahia Khalfaoui-Hassani,
    • Josephine Hwang,
    • Stefan Steimle,
    • Nur Selamoglu,
    • Carsten Sanders,
    • Camilo Khatchikian,
    • and Fevzi Daldal
    The thioreduction component CcmG confers efficiency and the heme ligation component CcmH ensures stereo-specificity during cytochrome c maturation J. Biol. Chem. jbc.M117.794586. doi:10.1074/jbc.M117.794586
    Cell Biology - Microbiology:
    • Smriti Parashar and
    • Amitabha Mukhopadhyay
    GTPase Sar1 regulates the trafficking and secretion of the virulence factor gp63 in Leishmania J. Biol. Chem. jbc.M117.784033. doi:10.1074/jbc.M117.784033
    Enzymology - Microbiology:
    • Leonardo Astolfi Rosado,
    • Khadija Wahni,
    • Giulia Degiacomi,
    • Brandan Pedre,
    • David Young,
    • Alfonso G. de la Rubia,
    • Francesca Boldrin,
    • Edo Martens,
    • Laura Marcos-Pascual,
    • Enea Sancho-Vaello,
    • David Albesa-Jové,
    • Roberta Provvedi,
    • Charlotte Martin,
    • Vadim Makarov,
    • Wim Versées,
    • Guido Verniest,
    • Marcelo E. Guerin,
    • Luis M. Mateos,
    • Riccardo Manganelli,
    • and Joris Messens
    The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis J. Biol. Chem. jbc.M117.797837. doi:10.1074/jbc.M117.797837
    Metabolism - Microbiology:
    • Irina A Rodionova,
    • Zhongge Zhang,
    • Jitender Mehla,
    • Norman Goodacre,
    • Mohan Babu,
    • Andrew Emili,
    • Peter Uetz,
    • and Milton H Saier, Jr.
    The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli J. Biol. Chem. jbc.M117.795294. doi:10.1074/jbc.M117.795294
    Microbiology - Molecular Bases of Disease:
    • Heather K. Kroh,
    • Ramyavardhanee Chandrasekaran,
    • Kim Rosenthal,
    • Rob Woods,
    • Xiaofang Jin,
    • Melanie D. Ohi,
    • Andrew C. Nyborg,
    • G. Jonah Rainey,
    • Paul Warrener,
    • Benjamin W. Spiller,
    • and D. Borden Lacy
    Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface J. Biol. Chem. jbc.M117.781112. doi:10.1074/jbc.M117.781112
    Microbiology - Gene Regulation:
    • Xiaoduo Zhi,
    • Samantha Dages,
    • Kelley Dages,
    • Yingting Liu,
    • Zi-Chun Hua,
    • John Makemson,
    • and Fenfei Leng
    Transient and dynamic DNA supercoiling potently stimulates the leu-500 promoter in Escherichia coli J. Biol. Chem. jbc.M117.794628. doi:10.1074/jbc.M117.794628
    Microbiology - DNA and Chromosomes:
    • Russell W. Goetze,
    • Dong-Hyun Kim,
    • Raymond F. Schinazi,
    • and Baek Kim
    A CRISPR/Cas9 approach reveals that the polymerase activity of DNA Polymerase β is dispensable for HIV-1 infection in dividing and nondividing cells J. Biol. Chem. jbc.M117.793661. doi:10.1074/jbc.M117.793661
    Microbiology - Immunology:
    • Xianzhu Wu,
    • Kiran K Dayanand,
    • Ramesh P Thylur,
    • Christopher C Norbury,
    • and D. Channe Gowda
    Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes J. Biol. Chem. jbc.M116.770313. doi:10.1074/jbc.M116.770313
    Microbiology:
    • Sandra Muschiol,
    • Simon Erlendsson,
    • Marie-Stephanie Aschtgen,
    • Vitor Oliveira,
    • Peter Schmieder,
    • Casper de Lichtenberg,
    • Kaare Teilum,
    • Thomas Boesen,
    • Umit Akbey,
    • and Birgitta Henriques-Normark
    Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae J. Biol. Chem. jbc.M117.787671. doi:10.1074/jbc.M117.787671
    Microbiology:
    • Laetitia Houot,
    • Romain Navarro,
    • Matthieu Nouailler,
    • Denis Duché,
    • Françoise Guerlesquin,
    • and Roland Lloubes
    Electrostatic interactions between the CTX phage minor coat protein and the bacterial host receptor TolA drives the pathogenic conversion of Vibrio cholerae. J. Biol. Chem. jbc.M117.786061. doi:10.1074/jbc.M117.786061
    Microbiology - Enzymology:
    • Ahmet H. Badur,
    • Matthew J. Plutz,
    • Geethika Yalamanchili,
    • Sujit Sadashiv Jagtap,
    • Thomas Schweder,
    • Frank Unfried,
    • Stephanie Markert,
    • Martin F. Polz,
    • Jan-Hendrik Hehemann,
    • and Christopher V. Rao
    Exploiting Fine-scale Genetic and Physiological Variation of Closely Related Microbes to Reveal Unknown Enzyme Functions J. Biol. Chem. jbc.M117.787192. doi:10.1074/jbc.M117.787192
    Microbiology - Gene Regulation:
    • Kristin M. Keck,
    • Stephanie A. Moquin,
    • Amanda He,
    • Samantha G. Fernandez,
    • Jessica J. Somberg,
    • Stephanie M. Liu,
    • Delsy M. Martinez,
    • and JJ L. Miranda
    BET inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps J. Biol. Chem. jbc.M116.751644. doi:10.1074/jbc.M116.751644
    Microbiology - Metabolism:
    • John G. Mina,
    • Julie K. Thye,
    • Amjed Q.I. Alqaisi,
    • Louise E. Bird,
    • Robert H. Dods,
    • Morten K. Groftehauge,
    • Jackie A. Mosely,
    • Steven Pratt,
    • Hosam Shams-Eldin,
    • Ralph T. Schwarz,
    • Ehmke Pohl,
    • and Paul W. Denny
    Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites J. Biol. Chem. jbc.M117.792374. doi:10.1074/jbc.M117.792374
    Microbiology - Neurobiology:
    • Rahul Basu,
    • Abhishek Bose,
    • Deepthi Thomas,
    • and Jayasri Das Sarma
    Microtubule assisted altered trafficking of Astrocytic Gap Junction Protein Connexin 43 is associated with depletion of Connexin 47 during Mouse Hepatitis Virus infection J. Biol. Chem. jbc.M117.786491. doi:10.1074/jbc.M117.786491
    Microbiology - Molecular Bases of Disease:
    • Bidyottam Mittra,
    • Maria Fernanda Laranjeira-Silva,
    • Danilo Ciccone Miguel,
    • Juliana Perrone Bezerra de Menezes,
    • and Norma W Andrews
    The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence J. Biol. Chem. jbc.M116.772624. doi:10.1074/jbc.M116.772624
    Microbiology - Metabolism:
    • Laura Hobley,
    • Bin Li,
    • Jennifer L Wood,
    • Sok-Ho Kim,
    • Jacinth Naidoo,
    • Ana Sofia Ferreira,
    • Maxim Khomutov,
    • Alexey Khomutov,
    • Nicola R. Stanley-Wall,
    • and Anthony J. Michael
    Spermidine promotes Bacillus subtilis biofilm formation by activating expression of the matrix regulator slrR J. Biol. Chem. jbc.M117.789644. doi:10.1074/jbc.M117.789644
    Protein Structure and Folding - Microbiology:
    • Koree W. Ahn and
    • Michael J. Root
    Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors J. Biol. Chem. jbc.M117.791731. doi:10.1074/jbc.M117.791731

Cell Biology

    Cell Biology - Enzymology:
    • Andrew S Murray,
    • Fausto A Varela,
    • Thomas E Hyland,
    • Andrew J Schoenbeck,
    • Jordan M White,
    • Lauren M Tanabe,
    • Sokol V Todi,
    • and Karin List
    Phosphorylation of the type II transmembrane serine protease, TMPRSS13 in Hepatocyte Growth Factor Activator Inhibitor-1 and 2-mediated cell surface localization J. Biol. Chem. jbc.M117.775999. doi:10.1074/jbc.M117.775999
    Cell Biology - Membrane Biology:
    • Jennifer Virginia Roche,
    • Sabeen Survery,
    • Stefan Kreida,
    • Veronika Nesverova,
    • Henry Ampah-Korsah,
    • Maria Gourdon,
    • Peter M.T. Deen,
    • and Susanna Toernroth-Horsefield
    Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5 J. Biol. Chem. jbc.M117.788364. doi:10.1074/jbc.M117.788364
    Cell Biology:
    • Daniel A Cunha,
    • Monia Cito,
    • Fabio A Grieco,
    • Cristina Cosentino,
    • Tatiana Danilova,
    • Laurence Ladriere,
    • Maria Lindahl,
    • Andrii Domanskyi,
    • Marco Bugliani,
    • Piero Marchetti,
    • Decio L Eizirik,
    • and Miriam Cnop
    Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF) J. Biol. Chem. jbc.M116.769877. doi:10.1074/jbc.M116.769877
    Cell Biology - Protein Synthesis and Degradation:
    • Narmadha Reddy Gangula and
    • Subbareddy Maddika
    Interplay between the phosphatase PHLPP1 and an E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1 J. Biol. Chem. jbc.M117.782896. doi:10.1074/jbc.M117.782896
    Cell Biology - Molecular Bases of Disease:
    • Robert W. Button,
    • Sheridan L. Roberts,
    • Thea L. Willis,
    • C. Oliver Hanemann,
    • and Shouqing Luo
    Accumulation of autophagosomes confers cytotoxicity J. Biol. Chem. jbc.M117.782276. doi:10.1074/jbc.M117.782276
    Cell Biology:
    • Can Huang,
    • Maryam Alapa,
    • Ping Shu,
    • Narayan Nagarajan,
    • Changgong Wu,
    • Junichi Sadoshima,
    • Vladyslav Kholodovych,
    • Hong Li,
    • and Annie Beuve
    Guanylyl Cyclase Sensitivity to Nitric Oxide is Protected by a Thiol Oxidation-Driven Interaction with Thioredoxin1 J. Biol. Chem. jbc.M117.787390. doi:10.1074/jbc.M117.787390
    Cell Biology - Signal Transduction:
    • Rui Tang,
    • Gui Zhang,
    • Yung-Chun Wang,
    • Xiaohan Mei,
    • and Shi-You Chen
    The long non-coding RNA GAS5 regulates TGF-β-induced smooth muscle cell differentiation via RNA-Smad binding element J. Biol. Chem. jbc.M117.790030. doi:10.1074/jbc.M117.790030
    Cell Biology:
    • Brian C. Goh,
    • Vandana Singhal,
    • Angelica J. Herrera,
    • Ryan E. Tomlinson,
    • Soohyun Kim,
    • Marie-Claude Faugere,
    • Emily L. Germain-Lee,
    • Thomas L. Clemens,
    • Se-Jin Lee,
    • and Douglas J. DiGirolamo
    Activin Receptor Type IIA (ACVR2A) Functions Directly in Osteoblasts as a Negative Regulator of Bone Mass J. Biol. Chem. jbc.M117.782128. doi:10.1074/jbc.M117.782128
    Cell Biology - Metabolism:
    • Izumi Yanatori,
    • Des R. Richardson,
    • Shinya Toyokuni,
    • and Fumio Kishi
    The Iron Chaperone Poly (rC)-binding Protein 2 Forms a Metabolon with the Heme Oxygenase 1/Cytochrome P450 Reductase Complex for Heme Catabolism and Iron Transfer J. Biol. Chem. jbc.M117.776021. doi:10.1074/jbc.M117.776021
    Cell Biology - Gene Regulation:
    • Javier Gaytan-Cervantes,
    • Carolina Gonzalez-Torres,
    • Vilma Maldonado,
    • Cecilia Zampedri,
    • Gisela Ceballos-Cancino,
    • and Jorge Melendez-Zajgla
    Sam68 Regulates the Alternative Splicing of Survivin DEx3 J. Biol. Chem. jbc.M117.800318. doi:10.1074/jbc.M117.800318
    Cell Biology - Gene Regulation:
    • Lu Jiang,
    • Jiannan Xiong,
    • Junsi Zhan,
    • Fengjie Yuan,
    • Ming Tang,
    • Chaohua Zhang,
    • Ziyang Cao,
    • Yongcan Chen,
    • Xiaopeng Lu,
    • Yinglu Li,
    • Hui Wang,
    • Lina Wang,
    • Jiadong Wang,
    • Wei-Guo Zhu,
    • and Haiying Wang
    Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis J. Biol. Chem. jbc.M117.780130. doi:10.1074/jbc.M117.780130
    Cell Biology - Molecular Bases of Disease:
    • Sanming Li,
    • Jing Zhou,
    • Jinghua Bu,
    • Ke Ning,
    • Liying Zhang,
    • Juan Li,
    • Yuli Guo,
    • Xin He,
    • Hui He,
    • Xiaoxin Cai,
    • Yongxiong Chen,
    • Peter Sol Reinach,
    • Zuguo Liu,
    • and Wei Li
    Ectodysplasin A promotes corneal epithelial cell proliferation J. Biol. Chem. jbc.M117.803809. doi:10.1074/jbc.M117.803809
    Cell Biology:
    • Jamila Hirbawi,
    • Katarzyna Bialkowska,
    • Kamila M. Bledzka,
    • Jianmin Liu,
    • Koichi Fukuda,
    • Jun Qin,
    • and Edward F. Plow
    The Extreme C-terminal Region of Kindlin-2 Is Critical to its Regulation of Integrin Activation J. Biol. Chem. jbc.M117.776195. doi:10.1074/jbc.M117.776195
    Cell Biology - Molecular Bases of Disease:
    • Claudia-Gabriela Mitrofan,
    • Sarah L Appleby,
    • Gerard B Nash,
    • Ziad Mallat,
    • Edwin R Chilvers,
    • Paul D. Upton,
    • and Nicholas W. Morrell
    Bone morphogenetic protein (BMP) 9 and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J. Biol. Chem. jbc.M117.778506. doi:10.1074/jbc.M117.778506
    Cell Biology - Molecular Biophysics:
    • Andrea Teréz Vig,
    • István Földi,
    • Szilárd Szikora,
    • Ede Migh,
    • Rita Gombos,
    • Mónika Ágnes Tóth,
    • Tamás Huber,
    • Réka Pintér,
    • Gábor Csaba Talián,
    • József Mihály,
    • and Beáta Bugyi
    The activities of the c-terminal regions of the formin protein disheveled-associated activator of morphogenesis (daam) in actin dynamics J. Biol. Chem. jbc.M117.799247. doi:10.1074/jbc.M117.799247
    Cell Biology - Signal Transduction:
    • Vinita Yadav,
    • Xing-Huang Gao,
    • Belinda Willard,
    • Maria Hatzoglou,
    • Ruma Banerjee,
    • and Omer Kabil
    Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress response pathway J. Biol. Chem. jbc.M117.778654. doi:10.1074/jbc.M117.778654
    Cell Biology - Molecular Bases of Disease:
    • Beth A. Rose,
    • Tomohiro Yokota,
    • Vishnu Chintalgattu,
    • Shuxun Ren,
    • Luisa Iruela-Arispe,
    • Aarif Y. Khakoo,
    • Susumu Minamisawa,
    • and Yibin Wang
    Cardiac Myocyte p38α Kinase Regulates Angiogenesis via Myocyte-Endothelial Cell Cross-talk During Stress-Induced Remodeling in Heart J. Biol. Chem. jbc.M117.784553. doi:10.1074/jbc.M117.784553
    Cell Biology - Metabolism:
    • Filip Liebsch,
    • Mark R. P. Aurousseau,
    • Tobias Bethge,
    • Hugo McGuire,
    • Silvia Scolari,
    • Andreas Herrmann,
    • Rikard Blunck,
    • Derek Bowie,
    • and Gerd Multhaup
    Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization J. Biol. Chem. jbc.M117.779165. doi:10.1074/jbc.M117.779165
    Cell Biology - Genomics and Proteomics:
    • Qian Wang,
    • Yiman Tang,
    • Yue Xu,
    • Shilei Xu,
    • Yong Jiang,
    • Qiuping Dong,
    • Yongsheng Zhou,
    • and Wenshu Ge
    The X-linked Deubiquitinase USP9X Is an Integral Component of Centrosome J. Biol. Chem. jbc.M116.769943. doi:10.1074/jbc.M116.769943
    Cell Biology:
    • Arunkumar S Upadhyay,
    • Oliver Stehling,
    • Christakis Panayiotou,
    • Ralf Rösser,
    • Roland Lill,
    • and Anna K Överby
    Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin J. Biol. Chem. jbc.M117.780122. doi:10.1074/jbc.M117.780122
    Cell Biology - Protein Structure and Folding:
    • Xin Gu,
    • Yan Yan,
    • Scott J. Novick,
    • Amanda Kovich,
    • Devrishi Goswami,
    • Jiyuan Ke,
    • M. H. Eileen Tan,
    • Lili Wang,
    • Xiaodan Li,
    • Parker de Waal,
    • Martin R. Webb,
    • Patrick R. Griffin,
    • H. Eric Xu,
    • and Karsten Melcher
    Deconvoluting AMP-dependent kinase (AMPK) adenine nucleotide binding and sensing J. Biol. Chem. jbc.M117.793018. doi:10.1074/jbc.M117.793018
    Cell Biology - Immunology:
    • Yuanzheng Peng,
    • Juanjuan Yuan,
    • Zhenchao Zhang,
    • and Xing Chang
    Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells J. Biol. Chem. jbc.M117.794834. doi:10.1074/jbc.M117.794834
    Cell Biology - Gene Regulation:
    • Shoichiro Kokabu,
    • Chihiro Nakatomi,
    • Takuma Matsubara,
    • Yusuke Ono,
    • William N Addison,
    • Jonathan W Lowery,
    • Mariko Urata,
    • Aaron M Hudnall,
    • Suzuro Hitomi,
    • Mitsushiro Nakatomi,
    • Tsuyoshi Sato,
    • Kenji Osawa,
    • Tetsuya Yoda,
    • Vicki Rosen,
    • and Eijiro Jimi
    The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor J. Biol. Chem. jbc.M116.774570. doi:10.1074/jbc.M116.774570
    Cell Biology - Microbiology:
    • Smriti Parashar and
    • Amitabha Mukhopadhyay
    GTPase Sar1 regulates the trafficking and secretion of the virulence factor gp63 in Leishmania J. Biol. Chem. jbc.M117.784033. doi:10.1074/jbc.M117.784033
    Cell Biology - Signal Transduction:
    • Wee K Lin,
    • Emma L Bolton,
    • Wilian A Cortopassi,
    • Yanwen Wang,
    • Fiona O'Brien,
    • Matylda Maciejewska,
    • Matthew P Jacobson,
    • Clive Garnham,
    • Margarida Ruas,
    • John Parrington,
    • Ming Lei,
    • Rebecca Sitsapesan,
    • Antony Galione,
    • and Derek A Terrar
    Synthesis of the Ca2+-mobilizing messengers, NAADP and cADPR, by intracellular CD38 enzyme in mouse heart: role in β-adrenoceptor signaling J. Biol. Chem. jbc.M117.789347. doi:10.1074/jbc.M117.789347
    Cell Biology - Neurobiology:
    • Hans Zempel,
    • Frank Dennissen,
    • Yatender Kumar,
    • Julia Luedtke,
    • Jacek Biernat,
    • Eva-Maria Mandelkow,
    • and Eckhard Mandelkow
    Axodendritic sorting and pathological missorting of Tau is isoform specific and determined by axon initial segment architecture J. Biol. Chem. jbc.M117.784702. doi:10.1074/jbc.M117.784702
    Developmental Biology - Cell Biology:
    • Taylor McClatchie,
    • Megan Meredith,
    • Mariame O. Ouédraogo,
    • Sandy Slow,
    • Michael Lever,
    • Mellissa R. W. Mann,
    • Steven H. Zeisel,
    • Jacquetta M. Trasler,
    • and Jay M. Baltz
    Betaine is accumulated via transient choline dehydrogenase activation during Mouse oocyte meiotic maturation J. Biol. Chem. jbc.M117.803080. doi:10.1074/jbc.M117.803080
    Developmental Biology - Cell Biology:
    • Zan Zhang,
    • Anhua Lei,
    • Liyang Xu,
    • Lu Chen,
    • Yonglong Chen,
    • Xuena Zhang,
    • Yan Gao,
    • Xiaoli Yang,
    • Min Zhang,
    • and Ying Cao
    Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells J. Biol. Chem. jbc.M117.785865. doi:10.1074/jbc.M117.785865
    Developmental Biology - Cell Biology:
    • Miranda L. Xu,
    • Cathy W. C. Bi,
    • Etta Y. L. Liu,
    • Tina T. X. Dong,
    • and Karl W. K. Tsim
    Wnt3a Induces the Expression of Acetylcholinesterase during Osteoblast Differentiation via the Runx2 Transcription Factor J. Biol. Chem. jbc.M117.777581. doi:10.1074/jbc.M117.777581
    Enzymology - Cell Biology:
    • Hanna Wallin,
    • Jenny Apelqvist,
    • Freddi Andersson,
    • Ulf Ekstr&oumlm,
    • and Magnus Abrahamson
    Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells J. Biol. Chem. jbc.M117.776138. doi:10.1074/jbc.M117.776138
    Gene Regulation - Cell Biology:
    • Pradeep Kumar Yadav and
    • Ram Rajasekharan
    The m6A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells J. Biol. Chem. jbc.M117.783761. doi:10.1074/jbc.M117.783761
    Genomics and Proteomics - Cell Biology:
    • Scott M. Carlson,
    • Cameron M. Soulette,
    • Ze Yang,
    • Joshua E. Elias,
    • Angela N. Brooks,
    • and Or Gozani
    RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation J. Biol. Chem. jbc.M117.784371. doi:10.1074/jbc.M117.784371
    Immunology - Cell Biology:
    • Irina Tikhanovich,
    • Jie Zhao,
    • Brian Bridges,
    • Sean Kumer,
    • Ben Roberts,
    • and Steven A Weinman
    Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300 J. Biol. Chem. jbc.M117.797928. doi:10.1074/jbc.M117.797928
    Immunology - Cell Biology:
    • Elif Eren,
    • Mesut Berber,
    • and Nesrin Özören
    NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding J. Biol. Chem. jbc.M116.769695. doi:10.1074/jbc.M116.769695
    Lipids - Cell Biology:
    • Takashi Hirama,
    • Raibatak Das,
    • Yanbo Yang,
    • Charles Ferguson,
    • Amy Won,
    • Christopher M Yip,
    • Jason G Kay,
    • Sergio Grinstein,
    • Robert G Parton,
    • and Gregory D Fairn
    Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. J. Biol. Chem. jbc.M117.791400. doi:10.1074/jbc.M117.791400
    Minireview - Cell Biology - Signal Transduction:
    • Mohammed Adnan Mohammed Hanif Qureshi,
    • Cole M. Haynes,
    • and Mark W. Pellegrino
    The mitochondrial unfolded protein response: signaling from the powerhouse J. Biol. Chem. jbc.R117.791061. doi:10.1074/jbc.R117.791061
    Minireview - Immunology - Cell Biology:
    • Daniel S. Green,
    • Howard A Young,
    • and Julio C. Valencia
    Current prospects of type II interferon gamma signaling and autoimmunity J. Biol. Chem. jbc.R116.774745. doi:10.1074/jbc.R116.774745
    Minireview - Cell Biology - Enzymology:
    • Joseph J. Braymer and
    • Roland Lill
    Iron-Sulfur Cluster Biogenesis and Trafficking in Mitochondria J. Biol. Chem. jbc.R117.787101. doi:10.1074/jbc.R117.787101
    Minireview - Neurobiology - Cell Biology:
    • Aram Asatryan and
    • Nicolas G. Bazan
    Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection J. Biol. Chem. jbc.R117.783076. doi:10.1074/jbc.R117.783076
    Minireview - Cell Biology:
    • Sharleen V. Menezes,
    • Sumit Sahni,
    • Zaklina Kovacevic,
    • and Des R. Richardson
    Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling J. Biol. Chem. jbc.R117.776393. doi:10.1074/jbc.R117.776393
    Minireview - Cell Biology - Metabolism:
    • Caroline C. Philpott,
    • Moon-Suhn Ryu,
    • Avery G. Frey,
    • and Sarju Patel
    Cytosolic iron chaperones: proteins delivering iron cofactors in the cytosol of mammalian cells. J. Biol. Chem. jbc.R117.791962. doi:10.1074/jbc.R117.791962
    Minireview - Metabolism - Cell Biology:
    • Mitchell D. Knutson
    Iron Transport Proteins: Gateways of Cellular and Systemic Iron Homeostasis J. Biol. Chem. jbc.R117.786632. doi:10.1074/jbc.R117.786632
    Minireview - Metabolism - Cell Biology:
    • Richard Coffey and
    • Tomas Ganz
    Iron Homeostasis--an Anthropocentric Perspective J. Biol. Chem. jbc.R117.781823. doi:10.1074/jbc.R117.781823
    Molecular Bases of Disease - Cell Biology:
    • Ling Li,
    • Ronald Zviti,
    • Catherine Ha,
    • Zhao V Wang,
    • Joseph A. Hill,
    • and Fangming Lin
    Forkhead Box O3 (FoxO3) Regulates Kidney Tubular Autophagy Following Urinary Tract Obstruction J. Biol. Chem. jbc.M117.791483. doi:10.1074/jbc.M117.791483
    Molecular Bases of Disease - Cell Biology:
    • Yin Liu,
    • Yulong Chen,
    • Jinlong Zhang,
    • Yulan Liu,
    • Yanjie Zhang,
    • and Zhiguang Su
    Retinoic acid receptor-related orphan receptor alpha stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress J. Biol. Chem. jbc.M117.782391. doi:10.1074/jbc.M117.782391
    Molecular Bases of Disease - Cell Biology:
    • Carlos Vaamonde-Garcia,
    • Alice Courties,
    • Audrey Pigenet,
    • Marie-Charlotte Laiguillon,
    • Alain Sautet,
    • Xavier Houard,
    • Saadia Kerdine-Römer,
    • Rosa Meijide,
    • Francis Berenbaum,
    • and Jérémie Sellam
    The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis J. Biol. Chem. jbc.M117.802157. doi:10.1074/jbc.M117.802157
    Molecular Bases of Disease - Cell Biology:
    • Jing Yang,
    • William C Kasberg,
    • Angela Celo,
    • Zhong Liang,
    • Kristal Quispe,
    • and M. Sharon Stack
    Post-Translational Modification of the Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Cytoplasmic Tail Impacts Ovarian Cancer Multicellular Aggregate Dynamics J. Biol. Chem. jbc.M117.800904. doi:10.1074/jbc.M117.800904
    Molecular Bases of Disease - Cell Biology:
    • Guochang Huang,
    • Andrew J Kaufman,
    • Ke Xu,
    • Katia Manova,
    • and Bhuvanesh Singh
    SCCRO neddylates Cul3 to selectively promote midbody localization and activity of Cul3KLHL21 during abscission J. Biol. Chem. jbc.M117.778530. doi:10.1074/jbc.M117.778530
    Molecular Bases of Disease - Cell Biology:
    • Stefano Zanotti,
    • Jungeun Yu,
    • Archana Sanjay,
    • Lauren Schilling,
    • Chris Schoenherr,
    • Aris N. Economides,
    • and Ernesto Canalis
    Sustained Notch2 Signaling in Osteoblasts, but no in Osteoclasts, is Linked to Osteopenia in a Mouse Model of Hajdu-Cheney Syndrome J. Biol. Chem. jbc.M117.786129. doi:10.1074/jbc.M117.786129
    Molecular Biophysics - Cell Biology:
    • Pedro A Gutierrez,
    • Bryce E Ackermann,
    • Michael Vershinin,
    • and Richard J McKenney
    Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility J. Biol. Chem. jbc.M117.790048. doi:10.1074/jbc.M117.790048
    Neurobiology - Cell Biology:
    • Menglong Rui,
    • Jinjun Qian,
    • Lijuan Liu,
    • Yihan Cai,
    • Huihui Lv,
    • Junhai Han,
    • Zhengping Jia,
    • and Wei Xie
    The Neuronal Protein Neurexin Directly Interacts with the Scribble-Pix Complex to Stimulate F-actin Assembly for Synaptic Vesicle Clustering J. Biol. Chem. jbc.M117.794040. doi:10.1074/jbc.M117.794040
    Neurobiology - Cell Biology:
    • Ana Jorge-Finnigan,
    • Rune Kleppe,
    • Kunwar Jung-KC,
    • Ming Ying,
    • Michael Marie,
    • Ivan Rios-Mondragon,
    • Michael F. Salvatore,
    • Jaakko Saraste,
    • and Aurora Martinez
    Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules J. Biol. Chem. jbc.M116.762344. doi:10.1074/jbc.M116.762344
    Signal Transduction - Cell Biology:
    • Rachit Badolia,
    • Vaishali Inamdar,
    • Bhanu Kanth Manne,
    • Carol Dangelmaier,
    • and Satya P. Kunapuli
    Gq pathway regulates proximal C-type lectin-like receptor 2 (CLEC-2) signaling in platelets J. Biol. Chem. jbc.M117.791012. doi:10.1074/jbc.M117.791012
    Signal Transduction - Cell Biology:
    • Liangshuai Yuan,
    • Yun Mao,
    • Wei Luo,
    • Weiwei Wu,
    • Hao Xu,
    • Xing Li Wang,
    • and Ying H Shen
    Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling J. Biol. Chem. jbc.M117.804005. doi:10.1074/jbc.M117.804005
    Signal Transduction - Cell Biology:
    • Shuvomoy Banerjee,
    • Pushpak Bhattacharjee,
    • Juni Chakraborty,
    • Abir K. Panda,
    • Arnab Bandyopadhyay,
    • Suman K. Banik,
    • and Gaurisankar Sa
    Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis J. Biol. Chem. jbc.M117.784868. doi:10.1074/jbc.M117.784868
    Signal Transduction - Cell Biology:
    • Conggang Zhang,
    • Zeyu Liu,
    • Eric Bunker,
    • Adrian Ramirez,
    • Schuyler Lee,
    • Yinghua Peng,
    • Aik Choon Tan,
    • S Gail Eckhardt,
    • Douglas A Chapnick,
    • and Xuedong Liu
    Sorafenib Targets the Mitochondrial Electron Transport Chain Complexes and ATP Synthase to Activate the PINK1-Parkin Pathway and Modulate Cellular Drug Response J. Biol. Chem. jbc.M117.783175. doi:10.1074/jbc.M117.783175
    Signal Transduction - Cell Biology:
    • Taner Dogan,
    • Florian Gnad,
    • Jocelyn Chan,
    • Lilian Phu,
    • Amy Young,
    • Mark J Chen,
    • Sophia Doll,
    • Matthew P Stokes,
    • Marcia Belvin,
    • Lori S Friedman,
    • Donald S Kirkpatrick,
    • Klaus P Hoeflich,
    • and Georgia Hatzivassiliou
    Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling to the cell cycle J. Biol. Chem. jbc.M117.792754. doi:10.1074/jbc.M117.792754
    Signal Transduction - Cell Biology:
    • Kátia M Lima,
    • Juliana P Vago,
    • Thaís R Caux,
    • Graziele Letícia Negreiros-Lima,
    • Michelle A Sugimoto,
    • Luciana P Tavares,
    • Raquel G Arribada,
    • Aline Alves F Carmo,
    • Izabela Galvão,
    • Bruno Rocha C Costa,
    • Frederico M Soriani,
    • Vanessa Pinho,
    • Egle Solito,
    • Mauro Perretti,
    • Mauro M Teixeira,
    • and Lirlândia P Sousa
    The resolution of acute Inflammation induced by cyclic AMP is dependent on annexin A1 J. Biol. Chem. jbc.M117.800391. doi:10.1074/jbc.M117.800391
    Signal Transduction - Cell Biology:
    • Thomas H Smith,
    • Julia G Li,
    • Michael R Dores,
    • and JoAnn Trejo
    Protease-activated receptor-4 and P2Y12 Dimerize, Co-Internalize and Activate Akt Signaling via Endosomal Recruitment of β-arrestin J. Biol. Chem. jbc.M117.782359. doi:10.1074/jbc.M117.782359
    Signal Transduction - Cell Biology:
    • Subhashree Pradhan,
    • Tanvir Khatlani,
    • Angus C. Nairn,
    • and K Vinod Vijayan
    The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein coupled receptor signaling in platelets J. Biol. Chem. jbc.M117.796656. doi:10.1074/jbc.M117.796656
    Signal Transduction - Cell Biology:
    • Magda Nohemí Hernández-Vásquez,
    • Sendi Rafael Adame-García,
    • Noumeira Hamoud,
    • Rony Chidiac,
    • Guadalupe Reyes-Cruz,
    • Jean Philippe Gratton,
    • Jean-François Côté,
    • and José Vázquez-Prado
    Cell adhesion controlled by adhesion G-protein coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising Intersectins and Elmo/Dock J. Biol. Chem. jbc.M117.780304. doi:10.1074/jbc.M117.780304
    Signal Transduction - Cell Biology:
    • Abhishek Roy,
    • Shabbir A. Ansari,
    • Kaushik Das,
    • Ramesh Prasad,
    • Anindita Bhattacharya,
    • Suman Mallik,
    • Asis Mukherjee,
    • and Prosenjit Sen
    Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to β-catenin accumulation via the AKT/GSK3β pathway and contributes to breast cancer progression J. Biol. Chem. jbc.M116.764670. doi:10.1074/jbc.M116.764670

Protein Synthesis and Degradation

    Cell Biology - Protein Synthesis and Degradation:
    • Narmadha Reddy Gangula and
    • Subbareddy Maddika
    Interplay between the phosphatase PHLPP1 and an E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1 J. Biol. Chem. jbc.M117.782896. doi:10.1074/jbc.M117.782896
    Enzymology - Protein Synthesis and Degradation:
    • Sungjin Park,
    • Peter K Foote,
    • David T Krist,
    • Sarah E Rice,
    • and Alexander V Statsyuk
    UbMES and UbFluor: Novel Probes For RBR E3 Ubiquitin Ligase PARKIN J. Biol. Chem. jbc.M116.773200. doi:10.1074/jbc.M116.773200
    Membrane Biology - Protein Synthesis and Degradation:
    • Kana Marunaka,
    • Chisa Furukawa,
    • Naoko Fujii,
    • Toru Kimura,
    • Takumi Furuta,
    • Toshiyuki Matsunaga,
    • Satoshi Endo,
    • Hajime Hasegawa,
    • Naohiko Anzai,
    • Yasuhiro Yamazaki,
    • Masahiko Yamaguchi,
    • and Akira Ikari
    The RING Finger- and PDZ Domain-Containing Protein PDZRN3 Controls Localization of the Mg2+ Regulator Claudin-16 in Renal Tube Epithelial Cells J. Biol. Chem. jbc.M117.779405. doi:10.1074/jbc.M117.779405
    Molecular Bases of Disease - Protein Synthesis and Degradation:
    • Brighid M. O'Donnell,
    • Timothy D. Mackie,
    • Arohan R. Subramanya,
    • and Jeffrey L. Brodsky
    Endoplasmic Reticulum-Associated Degradation of the Renal Potassium Channel, ROMK, Leads to Type II Bartter Syndrome J. Biol. Chem. jbc.M117.786376. doi:10.1074/jbc.M117.786376
    Protein Synthesis and Degradation - Signal Transduction:
    • Jeffrey A. Willy,
    • Sara K. Young,
    • Amber L. Mosley,
    • Samer Gawrieh,
    • James L. Stevens,
    • Howard C. Masuoka,
    • and Ronald C. Wek
    Function of Inhibitor of Brutons Tyrosine Kinase Isoform α (IBTKα) in Nonalcoholic Steatohepatitis links Autophagy and the Unfolded Protein Response J. Biol. Chem. jbc.M117.799304. doi:10.1074/jbc.M117.799304
    Protein Synthesis and Degradation - Gene Regulation:
    • Oscar Perez-Leal,
    • Carlos Alberto Barrero,
    • and Salim Merali
    Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses J. Biol. Chem. jbc.M116.770925. doi:10.1074/jbc.M116.770925
    Protein Synthesis and Degradation - Signal Transduction:
    • Shinwon Ha,
    • Seol-Hwa Jeong,
    • Kyungrim Yi,
    • Kyung Min Chung,
    • Caroline Jeeyeon Hong,
    • Seong Who Kim,
    • Eun-Kyoung Kim,
    • and Seong-Woon Yu
    Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells J. Biol. Chem. jbc.M117.780874. doi:10.1074/jbc.M117.780874
    Protein Synthesis and Degradation - DNA and Chromosomes:
    • Hee-Jung Kim,
    • Jae-Jin Lee,
    • Jin-Hwan Cho,
    • Jaeho Jeong,
    • A Young Park,
    • Wonmo Kang,
    • and Kong-Joo Lee
    Heterogeneous nuclear ribonucleoprotein K inhibits heat shock-induced transcriptional activity of heat shock factor 1 J. Biol. Chem. jbc.M117.774992. doi:10.1074/jbc.M117.774992
    Protein Synthesis and Degradation - Molecular Bases of Disease:
    • Taishi Yonezawa,
    • Hirotaka Takahashi,
    • Shiori Shikata,
    • Xiaoxiao Liu,
    • Moe Tamura,
    • Shuhei Asada,
    • Tsuyoshi Fukushima,
    • Tomofusa Fukuyama,
    • Yosuke Tanaka,
    • Tatsuya Sawasaki,
    • Toshio Kitamura,
    • and Susumu Goyama
    The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1 J. Biol. Chem. jbc.M117.785675. doi:10.1074/jbc.M117.785675

Molecular Bases of Disease

    Cell Biology - Molecular Bases of Disease:
    • Robert W. Button,
    • Sheridan L. Roberts,
    • Thea L. Willis,
    • C. Oliver Hanemann,
    • and Shouqing Luo
    Accumulation of autophagosomes confers cytotoxicity J. Biol. Chem. jbc.M117.782276. doi:10.1074/jbc.M117.782276
    Cell Biology - Molecular Bases of Disease:
    • Sanming Li,
    • Jing Zhou,
    • Jinghua Bu,
    • Ke Ning,
    • Liying Zhang,
    • Juan Li,
    • Yuli Guo,
    • Xin He,
    • Hui He,
    • Xiaoxin Cai,
    • Yongxiong Chen,
    • Peter Sol Reinach,
    • Zuguo Liu,
    • and Wei Li
    Ectodysplasin A promotes corneal epithelial cell proliferation J. Biol. Chem. jbc.M117.803809. doi:10.1074/jbc.M117.803809
    Cell Biology - Molecular Bases of Disease:
    • Claudia-Gabriela Mitrofan,
    • Sarah L Appleby,
    • Gerard B Nash,
    • Ziad Mallat,
    • Edwin R Chilvers,
    • Paul D. Upton,
    • and Nicholas W. Morrell
    Bone morphogenetic protein (BMP) 9 and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J. Biol. Chem. jbc.M117.778506. doi:10.1074/jbc.M117.778506
    Cell Biology - Molecular Bases of Disease:
    • Beth A. Rose,
    • Tomohiro Yokota,
    • Vishnu Chintalgattu,
    • Shuxun Ren,
    • Luisa Iruela-Arispe,
    • Aarif Y. Khakoo,
    • Susumu Minamisawa,
    • and Yibin Wang
    Cardiac Myocyte p38α Kinase Regulates Angiogenesis via Myocyte-Endothelial Cell Cross-talk During Stress-Induced Remodeling in Heart J. Biol. Chem. jbc.M117.784553. doi:10.1074/jbc.M117.784553
    DNA and Chromosomes - Molecular Bases of Disease:
    • Kyle S. Sorenson,
    • Brandi L. Mahaney,
    • Susan P. Lees-Miller,
    • and Jennifer A. Cobb
    The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 at DNA double strand breaks J. Biol. Chem. jbc.M117.796011. doi:10.1074/jbc.M117.796011
    Enzymology - Molecular Bases of Disease:
    • Eric Gonzalez and
    • F. Peter Guengerich
    Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1 J. Biol. Chem. jbc.M117.794917. doi:10.1074/jbc.M117.794917
    Enzymology - Molecular Bases of Disease:
    • Kednerlin Dornevil,
    • Ian Davis,
    • Andrew J. Fielding,
    • James R. Terrell,
    • Li Ma,
    • and Aimin Liu
    Crosslinking of Dicyclotyrosine by the Cytochrome P450 Enzyme CYP121 from Mycobacterium tuberculosis Proceeds through a Catalytic Shunt Pathway J. Biol. Chem. jbc.M117.794099. doi:10.1074/jbc.M117.794099
    Gene Regulation - Molecular Bases of Disease:
    • Sheng Tan,
    • Keshuo Ding,
    • Qing-Yun Chong,
    • Junsong Zhao,
    • Yuan Liu,
    • Yunying Shao,
    • Yuanyuan Zhang,
    • Qing Yu,
    • Zirui Xiong,
    • Weijie Zhang,
    • Min Zhang,
    • Gaopeng Li,
    • Xiaoni Li,
    • Xiangjun Kong,
    • Akhlaq Ahmad,
    • Zhengsheng Wu,
    • Qiang Wu,
    • Xiaodong Zhao,
    • Peter E Lobie,
    • and Tao Zhu
    Decreased miR26a/b and increased HuR expression post-transcriptionally upregulates ERBB2 to mediate acquired tamoxifen resistance in ER+ breast cancer cells J. Biol. Chem. jbc.M117.780973. doi:10.1074/jbc.M117.780973
    Immunology - Molecular Bases of Disease:
    • Heather Kerr,
    • Edwin Wong,
    • Elisavet Makou,
    • Yi Yang,
    • Kevin Marchbank,
    • David Kavanagh,
    • Anna Richards,
    • Andrew P Herbert,
    • and Paul N Barlow
    Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self surface-selective regulation of complement activation J. Biol. Chem. jbc.M117.795088. doi:10.1074/jbc.M117.795088
    Immunology - Molecular Bases of Disease:
    • Luis H. Franco,
    • Anna K.A. Fleuri,
    • Nat&aacutelia C. Pellison,
    • Gustavo F. S. Quirino,
    • Catarina V. Horta,
    • Renan V. H. de Carvalho,
    • Sérgio C. Oliveira,
    • and Dario S. Zamboni
    Autophagy downstream of endosomal Toll-like Receptors Signaling in Macrophages is a Key Mechanism for Resistance to Leishmania major Infection J. Biol. Chem. jbc.M117.780981. doi:10.1074/jbc.M117.780981
    Membrane Biology - Molecular Bases of Disease:
    • Benedict Reilly-O'Donnell,
    • Gavin B Robertson,
    • Angela Karumbi,
    • Connor McIntyre,
    • Wojciech Bal,
    • Miyuki Nishi,
    • Hiroshi Takeshima,
    • Alan J Stewart,
    • and Samantha J Pitt
    Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage J. Biol. Chem. jbc.M117.781708. doi:10.1074/jbc.M117.781708
    Metabolism - Molecular Bases of Disease:
    • Pranavi Koppula,
    • Yilei Zhang,
    • Jiejun Shi,
    • Wei Li,
    • and Boyi Gan
    The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate J. Biol. Chem. jbc.M117.798405. doi:10.1074/jbc.M117.798405
    Metabolism - Molecular Bases of Disease:
    • Xiao Jian Sun,
    • Soohyun Park Kim,
    • Dongming Zhang,
    • Helen Sun,
    • Qi Cao,
    • Xin Lu,
    • Zhekang Ying,
    • Liwu Li,
    • Robert R. Henry,
    • Theodore P. Ciaraldi,
    • Simeon I. Taylor,
    • and Michael J. Quon
    Deletion of interleukin 1 receptor associated kinase 1 (IRAK1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle J. Biol. Chem. jbc.M117.779108. doi:10.1074/jbc.M117.779108
    Microbiology - Molecular Bases of Disease:
    • Heather K. Kroh,
    • Ramyavardhanee Chandrasekaran,
    • Kim Rosenthal,
    • Rob Woods,
    • Xiaofang Jin,
    • Melanie D. Ohi,
    • Andrew C. Nyborg,
    • G. Jonah Rainey,
    • Paul Warrener,
    • Benjamin W. Spiller,
    • and D. Borden Lacy
    Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface J. Biol. Chem. jbc.M117.781112. doi:10.1074/jbc.M117.781112
    Microbiology - Molecular Bases of Disease:
    • Bidyottam Mittra,
    • Maria Fernanda Laranjeira-Silva,
    • Danilo Ciccone Miguel,
    • Juliana Perrone Bezerra de Menezes,
    • and Norma W Andrews
    The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence J. Biol. Chem. jbc.M116.772624. doi:10.1074/jbc.M116.772624
    Molecular Bases of Disease - Cell Biology:
    • Ling Li,
    • Ronald Zviti,
    • Catherine Ha,
    • Zhao V Wang,
    • Joseph A. Hill,
    • and Fangming Lin
    Forkhead Box O3 (FoxO3) Regulates Kidney Tubular Autophagy Following Urinary Tract Obstruction J. Biol. Chem. jbc.M117.791483. doi:10.1074/jbc.M117.791483
    Molecular Bases of Disease - Cell Biology:
    • Yin Liu,
    • Yulong Chen,
    • Jinlong Zhang,
    • Yulan Liu,
    • Yanjie Zhang,
    • and Zhiguang Su
    Retinoic acid receptor-related orphan receptor alpha stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress J. Biol. Chem. jbc.M117.782391. doi:10.1074/jbc.M117.782391
    Molecular Bases of Disease - Cell Biology:
    • Carlos Vaamonde-Garcia,
    • Alice Courties,
    • Audrey Pigenet,
    • Marie-Charlotte Laiguillon,
    • Alain Sautet,
    • Xavier Houard,
    • Saadia Kerdine-Römer,
    • Rosa Meijide,
    • Francis Berenbaum,
    • and Jérémie Sellam
    The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis J. Biol. Chem. jbc.M117.802157. doi:10.1074/jbc.M117.802157
    Molecular Bases of Disease - Protein Structure and Folding:
    • Maria Bakou,
    • Kathleen Hille,
    • Michael Kracklauer,
    • Anna Spanopoulou,
    • Christina V. Frost,
    • Eleni Malideli,
    • Li-Mei Yan,
    • Andrea Caporale,
    • Martin Zacharias,
    • and Aphrodite Kapurniotu
    Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly J. Biol. Chem. jbc.M117.774893. doi:10.1074/jbc.M117.774893
    Molecular Bases of Disease - Protein Structure and Folding:
    • Eleanna Kara,
    • Jordan D. Marks,
    • Zhanyun Fan,
    • Jacob A. Klickstein,
    • Allyson D. Roe,
    • Kelly A. Krogh,
    • Susanne Wegmann,
    • Masato Maesako,
    • Christina C. Luo,
    • Ravi Mylvaganam,
    • Oksana Berezovska,
    • Eloise Hudry,
    • and Bradley T. Hyman
    Isoform and cell type-specific structure of Apolipoprotein E lipoparticles as revealed by a novel Forster Resonance Energy Transfer assay J. Biol. Chem. jbc.M117.784264. doi:10.1074/jbc.M117.784264
    Molecular Bases of Disease - Gene Regulation:
    • Lakshmi Subramanian,
    • Abrar A Khan,
    • Prasanna K.R. Allu,
    • Malapaka Kiranmayi,
    • Bhavani S. Sahu,
    • Saurabh Sharma,
    • Madhu Khullar,
    • Ajit S. Mullasari,
    • and Nitish R. Mahapatra
    A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders J. Biol. Chem. jbc.M117.778134. doi:10.1074/jbc.M117.778134
    Molecular Bases of Disease - Lipids:
    • Birthe Trautz,
    • Hannah Wiedemann,
    • Christian L&uumlchtenborg,
    • Virginia Pierini,
    • Jan Kranich,
    • B&aumlrbel Glass,
    • Hans-Georg Kr&aumlusslich,
    • Thomas Brocker,
    • Massimo Pizzato,
    • Alessia Ruggieri,
    • Britta Br&uumlgger,
    • and Oliver T Fackler
    The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles J. Biol. Chem. jbc.M117.797332. doi:10.1074/jbc.M117.797332
    Molecular Bases of Disease - Signal Transduction:
    • Nikhlesh K. Singh,
    • Jagadeesh Janjanam,
    • and Gadiparthi N. Rao
    p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1-induced vascular smooth muscle cell migration and proliferation J. Biol. Chem. jbc.M117.777896. doi:10.1074/jbc.M117.777896
    Molecular Bases of Disease - Cell Biology:
    • Jing Yang,
    • William C Kasberg,
    • Angela Celo,
    • Zhong Liang,
    • Kristal Quispe,
    • and M. Sharon Stack
    Post-Translational Modification of the Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Cytoplasmic Tail Impacts Ovarian Cancer Multicellular Aggregate Dynamics J. Biol. Chem. jbc.M117.800904. doi:10.1074/jbc.M117.800904
    Molecular Bases of Disease - Membrane Biology:
    • Zhihui Li,
    • Daochuan Li,
    • Eun Yong Choi,
    • Rena Lapidus,
    • Lei Zhang,
    • Shiew-Mei Huang,
    • Paul Shapiro,
    • and Hongbing Wang
    Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells J. Biol. Chem. jbc.M117.783860. doi:10.1074/jbc.M117.783860
    Molecular Bases of Disease - DNA and Chromosomes:
    • Zhigang Chen,
    • Thomas L. Eggerman,
    • Alexander V. Bocharov,
    • Irina N. Baranova,
    • Tatyana G. Vishnyakova,
    • Roger Kurlander,
    • and Amy P. Patterson
    Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus J. Biol. Chem. jbc.M116.760637. doi:10.1074/jbc.M116.760637
    Molecular Bases of Disease - Protein Synthesis and Degradation:
    • Brighid M. O'Donnell,
    • Timothy D. Mackie,
    • Arohan R. Subramanya,
    • and Jeffrey L. Brodsky
    Endoplasmic Reticulum-Associated Degradation of the Renal Potassium Channel, ROMK, Leads to Type II Bartter Syndrome J. Biol. Chem. jbc.M117.786376. doi:10.1074/jbc.M117.786376
    Molecular Bases of Disease - Cell Biology:
    • Guochang Huang,
    • Andrew J Kaufman,
    • Ke Xu,
    • Katia Manova,
    • and Bhuvanesh Singh
    SCCRO neddylates Cul3 to selectively promote midbody localization and activity of Cul3KLHL21 during abscission J. Biol. Chem. jbc.M117.778530. doi:10.1074/jbc.M117.778530
    Molecular Bases of Disease - Neurobiology:
    • Richard J. Karpowicz, Jr.,
    • Conor M. Haney,
    • Tiberiu S. Mihaila,
    • Raizel M. Sandler,
    • E. James Petersson,
    • and Virginia M.-Y. Lee
    Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies J. Biol. Chem. jbc.M117.780296. doi:10.1074/jbc.M117.780296
    Molecular Bases of Disease - Genomics and Proteomics:
    • Peter Hahl,
    • Rachel Hunt,
    • Edward S. Bjes,
    • Andrew Skaff,
    • J. Andrew Keightley,
    • and Ann Smith
    Identification of oxidative modifications of hemopexin and their predicted physiological relevance J. Biol. Chem. jbc.M117.783951. doi:10.1074/jbc.M117.783951
    Molecular Bases of Disease - Cell Biology:
    • Stefano Zanotti,
    • Jungeun Yu,
    • Archana Sanjay,
    • Lauren Schilling,
    • Chris Schoenherr,
    • Aris N. Economides,
    • and Ernesto Canalis
    Sustained Notch2 Signaling in Osteoblasts, but no in Osteoclasts, is Linked to Osteopenia in a Mouse Model of Hajdu-Cheney Syndrome J. Biol. Chem. jbc.M117.786129. doi:10.1074/jbc.M117.786129
    Molecular Bases of Disease - Glycobiology and Extracellular Matrices:
    • Anke P. Willems,
    • Mehmet Gundogdu,
    • Marlies J.E. Kempers,
    • Jacques C. Giltay,
    • Rolph Pfundt,
    • Martin Elferink,
    • Bettina F. Loza,
    • Joris Fuijkschot,
    • Andrew T. Ferenbach,
    • Koen L.I. van Gassen,
    • Daan M.F. van Aalten,
    • and Dirk J. Lefeber
    Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability J. Biol. Chem. jbc.M117.790097. doi:10.1074/jbc.M117.790097
    Molecular Bases of Disease - Metabolism:
    • Hervé Lerat,
    • Mohamed Rabah Imache,
    • Jacqueline Polyte,
    • Aurore Gaudin,
    • Marion Mercey,
    • Flora Donati,
    • Camille Baudesson,
    • Martin R. Higgs,
    • Alexandre Picard,
    • Christophe Magnan,
    • Fabienne Foufelle,
    • and Jean-Michel Pawlotsky
    Hepatitis C virus induces a pre-diabetic state by directly impairing hepatic glucose metabolism in mice J. Biol. Chem. jbc.M117.785030. doi:10.1074/jbc.M117.785030
    Protein Structure and Folding - Molecular Bases of Disease:
    • Gina M Moriarty,
    • Michael P Olson,
    • Tamr B Atieh,
    • Maria K Janowska,
    • Sagar D Khare,
    • and Jean Baum
    A pH Dependent Switch Promotes β-Synuclein Fibril Formation via Glutamate Residues J. Biol. Chem. jbc.M117.780528. doi:10.1074/jbc.M117.780528
    Protein Structure and Folding - Molecular Bases of Disease:
    • Patrick Constantinescu,
    • Rebecca A Brown,
    • Amy R Wyatt,
    • Marie Ranson,
    • and Mark R Wilson
    Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones J. Biol. Chem. jbc.M117.786657. doi:10.1074/jbc.M117.786657
    Protein Structure and Folding - Molecular Bases of Disease:
    • Anke Piechotta,
    • Christoph Parthier,
    • Martin Kleinschmidt,
    • Kathrin Gnoth,
    • Thierry Pillot,
    • Inge Lues,
    • Hans-Ulrich Demuth,
    • Stephan Schilling,
    • Jens-Ulrich Rahfeld,
    • and Milton T. Stubbs II
    Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy J. Biol. Chem. jbc.M117.777839. doi:10.1074/jbc.M117.777839
    Protein Synthesis and Degradation - Molecular Bases of Disease:
    • Taishi Yonezawa,
    • Hirotaka Takahashi,
    • Shiori Shikata,
    • Xiaoxiao Liu,
    • Moe Tamura,
    • Shuhei Asada,
    • Tsuyoshi Fukushima,
    • Tomofusa Fukuyama,
    • Yosuke Tanaka,
    • Tatsuya Sawasaki,
    • Toshio Kitamura,
    • and Susumu Goyama
    The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1 J. Biol. Chem. jbc.M117.785675. doi:10.1074/jbc.M117.785675
    RNA - Molecular Bases of Disease:
    • Mi Zhou,
    • Meng Wang,
    • Ling Xue,
    • Zhi Lin,
    • Qiufen He,
    • Wenwen Shi,
    • Yaru Chen,
    • Xiaofen Jin,
    • Haiying Li,
    • Pingping Jiang,
    • and Min-Xin Guan
    A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNALeu(UUR) J. Biol. Chem. jbc.M117.787028. doi:10.1074/jbc.M117.787028
    Signal Transduction - Molecular Bases of Disease:
    • Dong An,
    • Feng Hao,
    • Fuqiang Zhang,
    • Wei Kong,
    • Jerold Chun,
    • Xuemin Xu,
    • and Mei-Zhen Cui
    CD14 Is a Key Mediator of Both Lysophosphatidic Acid and Lipopolysaccharide Induction of Foam Cell Formation J. Biol. Chem. jbc.M117.781807. doi:10.1074/jbc.M117.781807
    Signal Transduction - Molecular Bases of Disease:
    • Xiaohong Guo,
    • Tingting Li,
    • Yun Xu,
    • Xiayan Xu,
    • Zhengyi Zhu,
    • Yun Zhang,
    • Jiaqi Xu,
    • Kaihong Xu,
    • Hongqiang Cheng,
    • Xue Zhang,
    • and Yuehai Ke
    Increased levels of Gab1 and Gab2 adaptor proteins skew IL-4 signaling toward M2 macrophage-driven pulmonary fibrosis in mice J. Biol. Chem. jbc.M117.802066. doi:10.1074/jbc.M117.802066
    Signal Transduction - Molecular Bases of Disease:
    • Angela M Gocher,
    • Gissou Azabdaftari,
    • Lindsey M Euscher,
    • Shuhang Dai,
    • Loukia G Karacosta,
    • Thomas F Franke,
    • and Arthur M Edelman
    Akt Activation by Ca2+/calmodulin-dependent protein Kinase Kinase 2 (CaMKK2) in Ovarian Cancer Cells J. Biol. Chem. jbc.M117.778464. doi:10.1074/jbc.M117.778464

Gene Regulation

    Cell Biology - Gene Regulation:
    • Javier Gaytan-Cervantes,
    • Carolina Gonzalez-Torres,
    • Vilma Maldonado,
    • Cecilia Zampedri,
    • Gisela Ceballos-Cancino,
    • and Jorge Melendez-Zajgla
    Sam68 Regulates the Alternative Splicing of Survivin DEx3 J. Biol. Chem. jbc.M117.800318. doi:10.1074/jbc.M117.800318
    Cell Biology - Gene Regulation:
    • Lu Jiang,
    • Jiannan Xiong,
    • Junsi Zhan,
    • Fengjie Yuan,
    • Ming Tang,
    • Chaohua Zhang,
    • Ziyang Cao,
    • Yongcan Chen,
    • Xiaopeng Lu,
    • Yinglu Li,
    • Hui Wang,
    • Lina Wang,
    • Jiadong Wang,
    • Wei-Guo Zhu,
    • and Haiying Wang
    Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis J. Biol. Chem. jbc.M117.780130. doi:10.1074/jbc.M117.780130
    Cell Biology - Gene Regulation:
    • Shoichiro Kokabu,
    • Chihiro Nakatomi,
    • Takuma Matsubara,
    • Yusuke Ono,
    • William N Addison,
    • Jonathan W Lowery,
    • Mariko Urata,
    • Aaron M Hudnall,
    • Suzuro Hitomi,
    • Mitsushiro Nakatomi,
    • Tsuyoshi Sato,
    • Kenji Osawa,
    • Tetsuya Yoda,
    • Vicki Rosen,
    • and Eijiro Jimi
    The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor J. Biol. Chem. jbc.M116.774570. doi:10.1074/jbc.M116.774570
    Developmental Biology - Gene Regulation:
    • Sha-Sha Bian,
    • Xu-Lei Zheng,
    • Hua-Qin Sun,
    • Jian-Hui Chen,
    • Yi-Lu Lu,
    • Yun-Qiang Liu,
    • Da-Chang Tao,
    • and Yong-Xin Ma
    Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signalings in the zebrafish embryo J. Biol. Chem. jbc.M117.794289. doi:10.1074/jbc.M117.794289
    Developmental Biology - Gene Regulation:
    • Qing Xie and
    • Zhu A. Wang
    Transcriptional regulation of Nkx3.1 in prostate luminal stem cell specification and cancer initiation via its 3′ genomic region J. Biol. Chem. jbc.M117.788315. doi:10.1074/jbc.M117.788315
    Developmental Biology - Gene Regulation:
    • Xiaohua Dong,
    • Jingyun Li,
    • Luqingqing He,
    • Chun Gu,
    • Wenshuang Jia,
    • Yunyun Yue,
    • Jun Li,
    • Qinxin Zhang,
    • Lele Chu,
    • and Qingshun Zhao
    Zebrafish Znfl1s control the expression of hoxb1b in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 J. Biol. Chem. jbc.M117.777094. doi:10.1074/jbc.M117.777094
    Gene Regulation - Developmental Biology:
    • Keigo Yoshizaki,
    • Lizhi Hu,
    • Thai Nguyen,
    • Kiyoshi Sakai,
    • Masaki Ishikawa,
    • Ichiro Takahashi,
    • Satoshi Fukumoto,
    • Pamela Den Besten,
    • Daniel D. Bikle,
    • Yuko Oda,
    • and Yoshihiko Yamada
    Mediator 1 Contributes to Enamel Mineralization as a Coactivator for Notch1 Signaling and Stimulates Transcription of the Alkaline Phosphatase Gene J. Biol. Chem. jbc.M117.780866. doi:10.1074/jbc.M117.780866
    Gene Regulation - Cell Biology:
    • Pradeep Kumar Yadav and
    • Ram Rajasekharan
    The m6A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells J. Biol. Chem. jbc.M117.783761. doi:10.1074/jbc.M117.783761
    Gene Regulation - Signal Transduction:
    • Clàudia Salat-Canela,
    • Esther Paulo,
    • Laura Sánchez-Mir,
    • Mercè Carmona,
    • José Ayté,
    • Baldo Oliva,
    • and Elena Hidalgo
    Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation J. Biol. Chem. jbc.M117.794339. doi:10.1074/jbc.M117.794339
    Gene Regulation - Molecular Bases of Disease:
    • Sheng Tan,
    • Keshuo Ding,
    • Qing-Yun Chong,
    • Junsong Zhao,
    • Yuan Liu,
    • Yunying Shao,
    • Yuanyuan Zhang,
    • Qing Yu,
    • Zirui Xiong,
    • Weijie Zhang,
    • Min Zhang,
    • Gaopeng Li,
    • Xiaoni Li,
    • Xiangjun Kong,
    • Akhlaq Ahmad,
    • Zhengsheng Wu,
    • Qiang Wu,
    • Xiaodong Zhao,
    • Peter E Lobie,
    • and Tao Zhu
    Decreased miR26a/b and increased HuR expression post-transcriptionally upregulates ERBB2 to mediate acquired tamoxifen resistance in ER+ breast cancer cells J. Biol. Chem. jbc.M117.780973. doi:10.1074/jbc.M117.780973
    Gene Regulation - RNA:
    • Gilles Ponzio,
    • Roger Rezzonico,
    • Isabelle Bourget,
    • Richard Allan,
    • Nicolas Nottet,
    • Alexandra Popa,
    • Virginie Magnone,
    • Géraldine Rios,
    • Bernard Mari,
    • and Pascal Barbry
    A new long noncoding RNA (LncRNA) is induced in cutaneous squamous cell carcinoma and downregulates several anticancer and cell-differentiation genes in mouse J. Biol. Chem. jbc.M117.776260. doi:10.1074/jbc.M117.776260
    Gene Regulation - Signal Transduction:
    • Shuman Gao,
    • Zhiqiang Wang,
    • Wencai Wang,
    • Xueli Hu,
    • Peilin Chen,
    • Jiwen Li,
    • Xin Hua Feng,
    • Jiemin Wong,
    • and James X Du
    The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling J. Biol. Chem. jbc.M117.776278. doi:10.1074/jbc.M117.776278
    Gene Regulation:
    • Chien-Cheng Chen,
    • Alina P. Montalbano,
    • Imran Hussain,
    • Wan-Ru Lee,
    • and Carole R. Mendelson
    The transcriptional repressor GATAD2B mediates progesterone receptor suppression of myometrial contractile gene expression J. Biol. Chem. jbc.M117.791350. doi:10.1074/jbc.M117.791350
    Immunology - Gene Regulation:
    • Jing Chen,
    • Jennifer L Martindale,
    • Carole Cramer,
    • Myriam Gorospe,
    • Ulus Atasoy,
    • Paul D Drew,
    • and Shiguang Yu
    The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells J. Biol. Chem. jbc.M117.782771. doi:10.1074/jbc.M117.782771
    Metabolism - Gene Regulation:
    • Mark E. Corkins,
    • Stevin Wilson,
    • Jean-Christophe Cocuron,
    • Ana P. Alonso,
    • and Amanda J. Bird
    The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast J. Biol. Chem. jbc.M117.798488. doi:10.1074/jbc.M117.798488
    Metabolism - Gene Regulation:
    • Yong Xue,
    • Stefan Schmollinger,
    • Narsis Attar,
    • Oscar Campos,
    • Maria Vogelauer,
    • Michael F Carey,
    • Sabeeha S. Merchant,
    • and Siavash K Kurdistani
    Endoplasmic reticulum-mitochondria junction is required for iron homeostasis J. Biol. Chem. jbc.M117.784249. doi:10.1074/jbc.M117.784249
    Microbiology - Gene Regulation:
    • Xiaoduo Zhi,
    • Samantha Dages,
    • Kelley Dages,
    • Yingting Liu,
    • Zi-Chun Hua,
    • John Makemson,
    • and Fenfei Leng
    Transient and dynamic DNA supercoiling potently stimulates the leu-500 promoter in Escherichia coli J. Biol. Chem. jbc.M117.794628. doi:10.1074/jbc.M117.794628
    Microbiology - Gene Regulation:
    • Kristin M. Keck,
    • Stephanie A. Moquin,
    • Amanda He,
    • Samantha G. Fernandez,
    • Jessica J. Somberg,
    • Stephanie M. Liu,
    • Delsy M. Martinez,
    • and JJ L. Miranda
    BET inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps J. Biol. Chem. jbc.M116.751644. doi:10.1074/jbc.M116.751644
    Minireview - Immunology - Gene Regulation:
    • Michael A Wheeler,
    • Veit Rothhammer,
    • and Francisco J Quintana
    Control of immune-mediated pathology via the aryl hydrocarbon receptor J. Biol. Chem. jbc.R116.767723. doi:10.1074/jbc.R116.767723
    Minireview - Gene Regulation - Immunology:
    • Nicholas W Mathy and
    • Xian-Ming Chen
    LncRNAs and Their Transcriptional Control of Inflammatory Responses J. Biol. Chem. jbc.R116.760884. doi:10.1074/jbc.R116.760884
    Molecular Bases of Disease - Gene Regulation:
    • Lakshmi Subramanian,
    • Abrar A Khan,
    • Prasanna K.R. Allu,
    • Malapaka Kiranmayi,
    • Bhavani S. Sahu,
    • Saurabh Sharma,
    • Madhu Khullar,
    • Ajit S. Mullasari,
    • and Nitish R. Mahapatra
    A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders J. Biol. Chem. jbc.M117.778134. doi:10.1074/jbc.M117.778134
    Molecular Biophysics - Gene Regulation:
    • Tam Vo,
    • Shuo Wang,
    • Gregory M. K. Poon,
    • and W. David Wilson
    Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6 J. Biol. Chem. jbc.M117.792887. doi:10.1074/jbc.M117.792887
    Protein Synthesis and Degradation - Gene Regulation:
    • Oscar Perez-Leal,
    • Carlos Alberto Barrero,
    • and Salim Merali
    Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses J. Biol. Chem. jbc.M116.770925. doi:10.1074/jbc.M116.770925
    RNA - Gene Regulation:
    • Fernando A Gonzales-Zubiate,
    • Ellen K Okuda,
    • Julia PC Da Cunha,
    • and Carla Columbano Oliveira
    Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae J. Biol. Chem. jbc.M116.772376. doi:10.1074/jbc.M116.772376
    Signal Transduction - Gene Regulation:
    • Wenliang Qian,
    • Xiaoxu Gang,
    • Tianlei Zhang,
    • Ling Wei,
    • Xinxin Yang,
    • Zheng Li,
    • Yan Yang,
    • Liang Song,
    • Peng Wang,
    • Jian Peng,
    • Daojun Cheng,
    • and Qingyou Xia
    Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity J. Biol. Chem. jbc.M117.775130. doi:10.1074/jbc.M117.775130

Molecular Biophysics

    Cell Biology - Molecular Biophysics:
    • Andrea Teréz Vig,
    • István Földi,
    • Szilárd Szikora,
    • Ede Migh,
    • Rita Gombos,
    • Mónika Ágnes Tóth,
    • Tamás Huber,
    • Réka Pintér,
    • Gábor Csaba Talián,
    • József Mihály,
    • and Beáta Bugyi
    The activities of the c-terminal regions of the formin protein disheveled-associated activator of morphogenesis (daam) in actin dynamics J. Biol. Chem. jbc.M117.799247. doi:10.1074/jbc.M117.799247
    Computational Biology - Molecular Biophysics:
    • Hyunbum Jang,
    • Avik Banerjee,
    • Tanmay Chavan,
    • Vadim Gaponenko,
    • and Ruth Nussinov
    Flexible-Body Motions of Calmodulin and the Farnesylated Hypervariable Region Yield a High-Affinity Interaction Enabling K-Ras4B Membrane Extraction J. Biol. Chem. jbc.M117.785063. doi:10.1074/jbc.M117.785063
    Computational Biology - Molecular Biophysics:
    • Asghar M Razavi,
    • Lucie Delemotte,
    • Joshua R Berlin,
    • Vincenzo Carnevale,
    • and Vincent A Voelz
    Molecular simulations and free-energy calculations suggest conformation-dependent anion binding to a cytoplasmic site as a mechanism for Na+/K+-ATPase ion selectivity J. Biol. Chem. jbc.M117.779090. doi:10.1074/jbc.M117.779090
    Computational Biology - Molecular Biophysics:
    • Mary Hongying Cheng,
    • Jennie Garcia-Olivares,
    • Steven Wasserman,
    • Jennifer DiPietro,
    • and Ivet Bahar
    Allosteric Modulation of Human Dopamine Transporter Activity under Conditions Promoting its Dimerization J. Biol. Chem. jbc.M116.763565. doi:10.1074/jbc.M116.763565
    Computational Biology - Molecular Biophysics:
    • David D. Mowrey,
    • Le Xu,
    • Yingwu Mei,
    • Daniel A. Pasek,
    • Gerhard Meissner,
    • and Nikolay V. Dokholyan
    Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor J. Biol. Chem. jbc.M116.760199. doi:10.1074/jbc.M116.760199
    DNA and Chromosomes - Molecular Biophysics:
    • Yufeng Qian and
    • Kenneth A. Johnson
    The human mitochondrial single strand DNA binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange J. Biol. Chem. jbc.M117.791392. doi:10.1074/jbc.M117.791392
    Enzymology - Molecular Biophysics:
    • Wan-Chen Huang,
    • Chun-Ying Lee,
    • and Tao-shih Hsieh
    Single-molecule FRET analysis discloses the dynamics of the DNA-topoisomerase II (TOP2) interaction in the presence of TOP2-targeting agents J. Biol. Chem. jbc.M117.792861. doi:10.1074/jbc.M117.792861
    Membrane Biology - Molecular Biophysics:
    • Eva Fortea,
    • Vincent Lemieux,
    • Léna Potvin,
    • Vimbai Chikwana,
    • Samantha Griffin,
    • Thimothy Hey,
    • David McCaskill,
    • Kenneth Narva,
    • Sek Yee Tan,
    • Xiaoping Xu,
    • Vincent Vachon,
    • and Jean-Louis Schwartz
    Cry6Aa1, a Bacillus thuringiensis Nematocidal and Insecticidal Toxin, Forms Pores in Planar Lipid Bilayers at Extremely Low Concentrations and Without the Need of Proteolytic Processing J. Biol. Chem. jbc.M116.765941. doi:10.1074/jbc.M116.765941
    Membrane Biology - Molecular Biophysics:
    • Bharat Ramasubramanian Iyer,
    • Punit Zadafiya,
    • Pallavi Vijay Vetal,
    • and Radhakrishnan Mahalakshmi
    Energetics of side chain partitioning of β-signal residues in unassisted folding of a transmembrane β-barrel protein J. Biol. Chem. jbc.M117.789446. doi:10.1074/jbc.M117.789446
    Minireview - Protein Structure and Folding - Molecular Biophysics:
    • Philipp Koldewey,
    • Scott Horowitz,
    • and James C. A. Bardwell
    Chaperone-client interactions: non-specificity engenders multi-functionality J. Biol. Chem. jbc.R117.796862. doi:10.1074/jbc.R117.796862
    Molecular Biophysics - Enzymology:
    • Kayla M Bell,
    • Hyo Keun Cha,
    • Charles V. Sindelar,
    • and Jared C Cochran
    The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner J. Biol. Chem. jbc.M117.797662. doi:10.1074/jbc.M117.797662
    Molecular Biophysics - Protein Structure and Folding:
    • Joel C. D. Kaufmann,
    • Benjamin S Krause,
    • Christiane Grimm,
    • Eglof Ritter,
    • Peter Hegemann,
    • and Franz J. Bartl
    Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function J. Biol. Chem. jbc.M117.779629. doi:10.1074/jbc.M117.779629
    Molecular Biophysics - Gene Regulation:
    • Tam Vo,
    • Shuo Wang,
    • Gregory M. K. Poon,
    • and W. David Wilson
    Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6 J. Biol. Chem. jbc.M117.792887. doi:10.1074/jbc.M117.792887
    Molecular Biophysics - Cell Biology:
    • Pedro A Gutierrez,
    • Bryce E Ackermann,
    • Michael Vershinin,
    • and Richard J McKenney
    Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility J. Biol. Chem. jbc.M117.790048. doi:10.1074/jbc.M117.790048
    Molecular Biophysics - Protein Structure and Folding:
    • Alexander S Moffett,
    • Kyle W Bender,
    • Steven C Huber,
    • and Diwakar Shukla
    Molecular dynamics simulations reveal the conformational dynamics of Arabidopsis thaliana BRI1 and BAK1 receptor-like kinases J. Biol. Chem. jbc.M117.792762. doi:10.1074/jbc.M117.792762
    Molecular Biophysics - Protein Structure and Folding:
    • Morgan M. Fetherolf,
    • Stefanie D. Boyd,
    • Alexander B. Taylor,
    • Hee Jong Kim,
    • James A. Wohlschlegel,
    • Ninian J. Blackburn,
    • P. John Hart,
    • Dennis R. Winge,
    • and Duane D. Winkler
    Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper-ion entry site J. Biol. Chem. jbc.M117.775981. doi:10.1074/jbc.M117.775981
    Protein Structure and Folding - Molecular Biophysics:
    • Aitor Manteca,
    • Álvaro Alonso-Caballero,
    • Marie Fertin,
    • Simon Poly,
    • David De Sancho,
    • and Raul Perez-Jimenez
    The Influence of Disulfide Bonds on the Mechanical Stability of Proteins is Context Dependent J. Biol. Chem. jbc.M117.784934. doi:10.1074/jbc.M117.784934
    Protein Structure and Folding - Molecular Biophysics:
    • Luciano Pirone,
    • Jorge Ripoll-Rozada,
    • Marilisa Leone,
    • Raffaele Ronca,
    • Fabrizio Lombardo,
    • Gabriella Fiorentino,
    • John F. Andersen,
    • Pedro José Barbosa Pereira,
    • Bruno Arcà,
    • and Emilia Pedone
    Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae J. Biol. Chem. jbc.M117.788042. doi:10.1074/jbc.M117.788042
    RNA - Molecular Biophysics:
    • Franziska Pinker,
    • Cédric Schelcher,
    • Pablo Fernández-Millán,
    • Anthony Gobert,
    • Catherine Birck,
    • Aurélien Thureau,
    • Pierre Roblin,
    • Philippe Giegé,
    • and Claude Sauter
    Biophysical analysis of Arabidopsis protein-only RNase P alone and in complex with tRNA provides a refined model of tRNA binding J. Biol. Chem. jbc.M117.782078. doi:10.1074/jbc.M117.782078
    Signal Transduction - Molecular Biophysics:
    • Hisao Tsukamoto,
    • I-Shan Chen,
    • Yoshihiro Kubo,
    • and Yuji Furutani
    A ciliary opsin in the brain of a marine annelid zooplankton is UV-sensitive and the sensitivity is tuned by a single amino acid residue J. Biol. Chem. jbc.M117.793539. doi:10.1074/jbc.M117.793539
    Signal Transduction - Molecular Biophysics:
    • Rory Sleno,
    • Dominic Devost,
    • Darlaine Pétrin,
    • Alice Zhang,
    • Kyla Bourque,
    • Yuji Shinjo,
    • Junken Aoki,
    • Asuka Inoue,
    • and Terence E. Hébert
    Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors J. Biol. Chem. jbc.M117.793877. doi:10.1074/jbc.M117.793877
    Signal Transduction - Molecular Biophysics:
    • Braden D Siempelkamp,
    • Manoj K Rathinaswamy,
    • Meredith L Jenkins,
    • and John E Burke
    Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas J. Biol. Chem. jbc.M117.789263. doi:10.1074/jbc.M117.789263

Genomics and Proteomics

    Cell Biology - Genomics and Proteomics:
    • Qian Wang,
    • Yiman Tang,
    • Yue Xu,
    • Shilei Xu,
    • Yong Jiang,
    • Qiuping Dong,
    • Yongsheng Zhou,
    • and Wenshu Ge
    The X-linked Deubiquitinase USP9X Is an Integral Component of Centrosome J. Biol. Chem. jbc.M116.769943. doi:10.1074/jbc.M116.769943
    DNA and Chromosomes - Genomics and Proteomics:
    • Rucha Kshirsagar,
    • Indrajeet Ghodke,
    • and Kalappa Muniyappa
    Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end joining activity and potentiates Hop1 promoted pairing of double-stranded DNA J. Biol. Chem. jbc.M117.796425. doi:10.1074/jbc.M117.796425
    Genomics and Proteomics - Cell Biology:
    • Scott M. Carlson,
    • Cameron M. Soulette,
    • Ze Yang,
    • Joshua E. Elias,
    • Angela N. Brooks,
    • and Or Gozani
    RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation J. Biol. Chem. jbc.M117.784371. doi:10.1074/jbc.M117.784371
    Molecular Bases of Disease - Genomics and Proteomics:
    • Peter Hahl,
    • Rachel Hunt,
    • Edward S. Bjes,
    • Andrew Skaff,
    • J. Andrew Keightley,
    • and Ann Smith
    Identification of oxidative modifications of hemopexin and their predicted physiological relevance J. Biol. Chem. jbc.M117.783951. doi:10.1074/jbc.M117.783951
    Neurobiology - Genomics and Proteomics:
    • Jason J Yi,
    • Smita R Paranjape,
    • Matthew P Walker,
    • Rajarshi Choudhury,
    • Justin M Wolter,
    • Giulia Fragola,
    • Michael J Emanuele,
    • Michael B Major,
    • and Mark J Zylka
    The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome J. Biol. Chem. jbc.M117.788448. doi:10.1074/jbc.M117.788448

Protein Structure and Folding

    Cell Biology - Protein Structure and Folding:
    • Xin Gu,
    • Yan Yan,
    • Scott J. Novick,
    • Amanda Kovich,
    • Devrishi Goswami,
    • Jiyuan Ke,
    • M. H. Eileen Tan,
    • Lili Wang,
    • Xiaodan Li,
    • Parker de Waal,
    • Martin R. Webb,
    • Patrick R. Griffin,
    • H. Eric Xu,
    • and Karsten Melcher
    Deconvoluting AMP-dependent kinase (AMPK) adenine nucleotide binding and sensing J. Biol. Chem. jbc.M117.793018. doi:10.1074/jbc.M117.793018
    Enzymology - Protein Structure and Folding:
    • David L. Nelson,
    • Gregory A. Applegate,
    • Matthew L. Beio,
    • Danielle L. Graham,
    • and David B. Berkowitz
    Human Serine Racemase Structure/Activity Relationship Studies Provide Mechanistic Insight and Point to Position-84 as a Hotspot for β-Elimination Function J. Biol. Chem. jbc.M117.777904. doi:10.1074/jbc.M117.777904
    Enzymology - Protein Structure and Folding:
    • Giulia Pontarollo,
    • Laura Acquasaliente,
    • Daniele Peterle,
    • Ilaria Artusi,
    • and Vincenzo De Filippis
    Noncanonical Proteolytic Activation of Human Prothrombin by Subtilisin from Bacillus subtilis may Shift the Procoagulant-Anticoagulant Equilibrium Toward Thrombosis J. Biol. Chem. jbc.M117.795245. doi:10.1074/jbc.M117.795245
    Enzymology - Protein Structure and Folding:
    • Christian W Johnson,
    • Derion Reid,
    • Jillian A Parker,
    • Shores Salter,
    • Ryan Knihtila,
    • Petr Kuzmic,
    • and Carla Mattos
    The small GTPases K-Ras, N-Ras and H-Ras have distinct biochemical properties determined by allosteric effects J. Biol. Chem. jbc.M117.778886. doi:10.1074/jbc.M117.778886
    Enzymology - Protein Structure and Folding:
    • Darryl R. Jones,
    • Muhammed Salah Uddin,
    • Robert J. Gruninger,
    • Thi Thanh My Pham,
    • Dallas Thomas,
    • Alisdair B. Boraston,
    • Jonathan Briggs,
    • Benjamin Pluvinage,
    • Tim A. McAllister,
    • Robert J. Forster,
    • Adrian Tsang,
    • L. Brent Selinger,
    • and D. Wade Abbott
    Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl-substrates J. Biol. Chem. jbc.M117.789008. doi:10.1074/jbc.M117.789008
    Enzymology - Protein Structure and Folding:
    • Yaozong Chen,
    • Tin Lok Li,
    • Xingbang Lin,
    • Xin Li,
    • Xiang David Li,
    • and Zhihong Guo
    Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate binding mode J. Biol. Chem. jbc.M117.790410. doi:10.1074/jbc.M117.790410
    Enzymology - Protein Structure and Folding:
    • Mayo Sato,
    • Dorothee Liebschner,
    • Yusuke Yamada,
    • Naohiro Matsugaki,
    • Takatoshi Arakawa,
    • Siobhan S. Wills,
    • Mitchell Hattie,
    • Keith A. Stubbs,
    • Tasuku Ito,
    • Toshiya Senda,
    • Hisashi Ashida,
    • and Shinya Fushinobu
    The First Crystal Structure of a Family 129 Glycoside Hydrolase from a Probiotic Bacterium Reveals Critical Residues and Metal Co-factors J. Biol. Chem. jbc.M117.777391. doi:10.1074/jbc.M117.777391
    Glycobiology and Extracellular Matrices - Protein Structure and Folding:
    • Hadar Feinberg,
    • Sabine A. F. Jégouzo,
    • Maximus J. Rex,
    • Kurt Drickamer,
    • William I. Weis,
    • and Maureen E. Taylor
    Mechanism of pathogen recognition by human dectin-2 J. Biol. Chem. jbc.M117.799080. doi:10.1074/jbc.M117.799080
    Glycobiology and Extracellular Matrices - Protein Structure and Folding:
    • Emma-Ruoqi Xu,
    • Emily E. Blythe,
    • Gerhard Fischer,
    • and Marko Hyvönen
    Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2 J. Biol. Chem. jbc.M117.788992. doi:10.1074/jbc.M117.788992
    Membrane Biology - Protein Structure and Folding:
    • Moshe Giladi,
    • Liat van Dijk,
    • Bosmat Refaeli,
    • Lior Almagor,
    • Reuben Hiller,
    • Petr Man,
    • Eric Forest,
    • and Daniel Khananshvili
    Dynamic distinctions in the sodium-calcium exchanger adopting the inward- and outward-facing conformational states J. Biol. Chem. jbc.M117.787168. doi:10.1074/jbc.M117.787168
    Minireview - Protein Structure and Folding - Molecular Biophysics:
    • Philipp Koldewey,
    • Scott Horowitz,
    • and James C. A. Bardwell
    Chaperone-client interactions: non-specificity engenders multi-functionality J. Biol. Chem. jbc.R117.796862. doi:10.1074/jbc.R117.796862
    Minireview - Protein Structure and Folding - Metabolism:
    • Tracey A Rouault and
    • Nunziata Maio
    Biogenesis and Functions of Mammalian Iron-Sulfur Proteins in the Regulation of Iron Homeostasis and Pivotal Metabolic Pathways J. Biol. Chem. jbc.R117.789537. doi:10.1074/jbc.R117.789537
    Molecular Bases of Disease - Protein Structure and Folding:
    • Maria Bakou,
    • Kathleen Hille,
    • Michael Kracklauer,
    • Anna Spanopoulou,
    • Christina V. Frost,
    • Eleni Malideli,
    • Li-Mei Yan,
    • Andrea Caporale,
    • Martin Zacharias,
    • and Aphrodite Kapurniotu
    Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly J. Biol. Chem. jbc.M117.774893. doi:10.1074/jbc.M117.774893
    Molecular Bases of Disease - Protein Structure and Folding:
    • Eleanna Kara,
    • Jordan D. Marks,
    • Zhanyun Fan,
    • Jacob A. Klickstein,
    • Allyson D. Roe,
    • Kelly A. Krogh,
    • Susanne Wegmann,
    • Masato Maesako,
    • Christina C. Luo,
    • Ravi Mylvaganam,
    • Oksana Berezovska,
    • Eloise Hudry,
    • and Bradley T. Hyman
    Isoform and cell type-specific structure of Apolipoprotein E lipoparticles as revealed by a novel Forster Resonance Energy Transfer assay J. Biol. Chem. jbc.M117.784264. doi:10.1074/jbc.M117.784264
    Molecular Biophysics - Protein Structure and Folding:
    • Joel C. D. Kaufmann,
    • Benjamin S Krause,
    • Christiane Grimm,
    • Eglof Ritter,
    • Peter Hegemann,
    • and Franz J. Bartl
    Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function J. Biol. Chem. jbc.M117.779629. doi:10.1074/jbc.M117.779629
    Molecular Biophysics - Protein Structure and Folding:
    • Alexander S Moffett,
    • Kyle W Bender,
    • Steven C Huber,
    • and Diwakar Shukla
    Molecular dynamics simulations reveal the conformational dynamics of Arabidopsis thaliana BRI1 and BAK1 receptor-like kinases J. Biol. Chem. jbc.M117.792762. doi:10.1074/jbc.M117.792762
    Molecular Biophysics - Protein Structure and Folding:
    • Morgan M. Fetherolf,
    • Stefanie D. Boyd,
    • Alexander B. Taylor,
    • Hee Jong Kim,
    • James A. Wohlschlegel,
    • Ninian J. Blackburn,
    • P. John Hart,
    • Dennis R. Winge,
    • and Duane D. Winkler
    Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper-ion entry site J. Biol. Chem. jbc.M117.775981. doi:10.1074/jbc.M117.775981
    Protein Structure and Folding - Molecular Bases of Disease:
    • Gina M Moriarty,
    • Michael P Olson,
    • Tamr B Atieh,
    • Maria K Janowska,
    • Sagar D Khare,
    • and Jean Baum
    A pH Dependent Switch Promotes β-Synuclein Fibril Formation via Glutamate Residues J. Biol. Chem. jbc.M117.780528. doi:10.1074/jbc.M117.780528
    Protein Structure and Folding:
    • Aron Broom,
    • Zachary Jacobi,
    • Kyle Trainor,
    • and Elizabeth M Meiering
    Computational tools help improve protein stability but with a solubility tradeoff J. Biol. Chem. jbc.M117.784165. doi:10.1074/jbc.M117.784165
    Protein Structure and Folding - Molecular Bases of Disease:
    • Patrick Constantinescu,
    • Rebecca A Brown,
    • Amy R Wyatt,
    • Marie Ranson,
    • and Mark R Wilson
    Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones J. Biol. Chem. jbc.M117.786657. doi:10.1074/jbc.M117.786657
    Protein Structure and Folding - Microbiology:
    • Koree W. Ahn and
    • Michael J. Root
    Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors J. Biol. Chem. jbc.M117.791731. doi:10.1074/jbc.M117.791731
    Protein Structure and Folding - Signal Transduction:
    • Dene R Littler,
    • Sheng Y Ang,
    • Danilo G Moriel,
    • Martina Kocan,
    • Oded Kleifeld,
    • Mathew D Johnson,
    • Mai T Tran,
    • Adrienne W Paton,
    • James C Paton,
    • Roger Summers,
    • Mark Schrembri,
    • Jamie Rossjohn,
    • and Travis T Beddoe
    Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins J. Biol. Chem. jbc.M117.796094. doi:10.1074/jbc.M117.796094
    Protein Structure and Folding - Neurobiology:
    • Hideaki Shimizu,
    • Asako Tosaki,
    • Noboru Ohsawa,
    • Yoshiko Ishizuka-Katsura,
    • Shisako Shoji,
    • Haruko Miyazaki,
    • Fumitaka Oyama,
    • Takaho Terada,
    • Mikako Shirouzu,
    • Shun-ichi Sekine,
    • Nobuyuki Nukina,
    • and Shigeyuki Yokoyama
    Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion J. Biol. Chem. jbc.M117.786509. doi:10.1074/jbc.M117.786509
    Protein Structure and Folding - Computational Biology:
    • Robert M. Vernon,
    • P. Andrew Chong,
    • Hong Lin,
    • Zhengrong Yang,
    • Qingxian Zhou,
    • Andrei A Aleksandrov,
    • Jennifer E Dawson,
    • John R. Riordan,
    • Christie G. Brouillette,
    • Patrick H. Thibodeau,
    • and Julie D. Forman-Kay
    Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations J. Biol. Chem. jbc.M116.772335. doi:10.1074/jbc.M116.772335
    Protein Structure and Folding - Molecular Biophysics:
    • Aitor Manteca,
    • Álvaro Alonso-Caballero,
    • Marie Fertin,
    • Simon Poly,
    • David De Sancho,
    • and Raul Perez-Jimenez
    The Influence of Disulfide Bonds on the Mechanical Stability of Proteins is Context Dependent J. Biol. Chem. jbc.M117.784934. doi:10.1074/jbc.M117.784934
    Protein Structure and Folding - Immunology:
    • Esben G.W. Schmidt,
    • Michael L. Hvam,
    • Filipa Antunes,
    • Jason Cameron,
    • Dorthe Viuff,
    • Birgitte Andersen,
    • Nanna N. Kristensen,
    • and Kenneth A. Howard
    Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin J. Biol. Chem. jbc.M117.794248. doi:10.1074/jbc.M117.794248
    Protein Structure and Folding:
    • Dan Chen,
    • Anna Jansson,
    • Daniel Sim,
    • Andreas Larsson,
    • and Pär Nordlund
    Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem. jbc.M117.787267. doi:10.1074/jbc.M117.787267
    Protein Structure and Folding - Signal Transduction:
    • Hikaru Shimizu,
    • Sachiko Toma-Fukai,
    • Shinya Saijo,
    • Nobutaka Shimizu,
    • Kenji Kontani,
    • Toshiaki Katada,
    • and Toshiyuki Shimizu
    Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding J. Biol. Chem. jbc.M117.792556. doi:10.1074/jbc.M117.792556
    Protein Structure and Folding - Molecular Bases of Disease:
    • Anke Piechotta,
    • Christoph Parthier,
    • Martin Kleinschmidt,
    • Kathrin Gnoth,
    • Thierry Pillot,
    • Inge Lues,
    • Hans-Ulrich Demuth,
    • Stephan Schilling,
    • Jens-Ulrich Rahfeld,
    • and Milton T. Stubbs II
    Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy J. Biol. Chem. jbc.M117.777839. doi:10.1074/jbc.M117.777839
    Protein Structure and Folding - Immunology:
    • Patricia A Blundell,
    • Ngoc Phuong Lan Le,
    • Joel Allen,
    • Yasunori Watanabe,
    • and Richard J Pleass
    Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors J. Biol. Chem. jbc.M117.795047. doi:10.1074/jbc.M117.795047
    Protein Structure and Folding - Enzymology:
    • Matthew Bratkowski,
    • Xin Yang,
    • and Xin Liu
    Polycomb repressive complex 2 in an autoinhibited state J. Biol. Chem. jbc.M117.787572. doi:10.1074/jbc.M117.787572
    Protein Structure and Folding:
    • Bobo Dang,
    • Sandeep Chhabra,
    • Michael W. Pennington,
    • Raymond S. Norton,
    • and Stephen B. H. Kent
    Reinvestigation of the biological activity of D-allo-ShK protein J. Biol. Chem. jbc.M117.793943. doi:10.1074/jbc.M117.793943
    Protein Structure and Folding - Molecular Biophysics:
    • Luciano Pirone,
    • Jorge Ripoll-Rozada,
    • Marilisa Leone,
    • Raffaele Ronca,
    • Fabrizio Lombardo,
    • Gabriella Fiorentino,
    • John F. Andersen,
    • Pedro José Barbosa Pereira,
    • Bruno Arcà,
    • and Emilia Pedone
    Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae J. Biol. Chem. jbc.M117.788042. doi:10.1074/jbc.M117.788042
    Protein Structure and Folding - Enzymology:
    • Zongyang Lv,
    • Lingmin Yuan,
    • James H. Atkison,
    • Grace Aldana-Masangkay,
    • Yuan Chen,
    • and Shaun K. Olsen
    Domain alternation and active site remodeling are conserved structural features of ubiquitin E1 J. Biol. Chem. jbc.M117.787622. doi:10.1074/jbc.M117.787622
    Protein Structure and Folding - Plant Biology:
    • Bastian Franke,
    • Amy M. James,
    • Mehdi Mobli,
    • Michelle L. Colgrave,
    • Joshua S. Mylne,
    • and K. Johan Rosengren
    Two Proteins for the Price of One: Structural Studies of the Dual Destiny Preproalbumin with Sunflower Trypsin Inhibitor-1 J. Biol. Chem. jbc.M117.776955. doi:10.1074/jbc.M117.776955
    Signal Transduction - Protein Structure and Folding:
    • Sergey A. Vishnivetskiy,
    • Regina J. Lee,
    • X. Edward Zhou,
    • Andreas Franz,
    • Qiuyi Xu,
    • H. Eric Xu,
    • and Vsevolod V. Gurevich
    Functional role of the three conserved cysteines in the N-domain of visual arrestin-1 J. Biol. Chem. jbc.M117.790386. doi:10.1074/jbc.M117.790386

Immunology

    Cell Biology - Immunology:
    • Yuanzheng Peng,
    • Juanjuan Yuan,
    • Zhenchao Zhang,
    • and Xing Chang
    Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells J. Biol. Chem. jbc.M117.794834. doi:10.1074/jbc.M117.794834
    Immunology - Gene Regulation:
    • Jing Chen,
    • Jennifer L Martindale,
    • Carole Cramer,
    • Myriam Gorospe,
    • Ulus Atasoy,
    • Paul D Drew,
    • and Shiguang Yu
    The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells J. Biol. Chem. jbc.M117.782771. doi:10.1074/jbc.M117.782771
    Immunology - Lipids:
    • Ashley E Shay,
    • Bastihalli T Diwakar,
    • Bo-Jhih Guan,
    • Vivek Narayan,
    • Joseph F Urban, Jr.,
    • and K. Sandeep Prabhu
    IL-4 upregulates cyclooxygenase-1 expression in macrophages J. Biol. Chem. jbc.M117.785014. doi:10.1074/jbc.M117.785014
    Immunology - Neurobiology:
    • Liraz Shmuel-Galia,
    • Yoal Klug,
    • Ziv Porat,
    • Meital Charni,
    • Batya Zarmi,
    • and Yechiel Shai
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia mediated neurodegeneration J. Biol. Chem. jbc.M117.784983. doi:10.1074/jbc.M117.784983
    Immunology:
    • Camilla De Nardis,
    • Linda J. A. Hendriks,
    • Emilie Poirier,
    • Tudor Arvinte,
    • Piet Gros,
    • Alexander B. H. Bakker,
    • and John de Kruif
    A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1 J. Biol. Chem. jbc.M117.793497. doi:10.1074/jbc.M117.793497
    Immunology - Cell Biology:
    • Irina Tikhanovich,
    • Jie Zhao,
    • Brian Bridges,
    • Sean Kumer,
    • Ben Roberts,
    • and Steven A Weinman
    Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300 J. Biol. Chem. jbc.M117.797928. doi:10.1074/jbc.M117.797928
    Immunology - Molecular Bases of Disease:
    • Heather Kerr,
    • Edwin Wong,
    • Elisavet Makou,
    • Yi Yang,
    • Kevin Marchbank,
    • David Kavanagh,
    • Anna Richards,
    • Andrew P Herbert,
    • and Paul N Barlow
    Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self surface-selective regulation of complement activation J. Biol. Chem. jbc.M117.795088. doi:10.1074/jbc.M117.795088
    Immunology - Molecular Bases of Disease:
    • Luis H. Franco,
    • Anna K.A. Fleuri,
    • Nat&aacutelia C. Pellison,
    • Gustavo F. S. Quirino,
    • Catarina V. Horta,
    • Renan V. H. de Carvalho,
    • Sérgio C. Oliveira,
    • and Dario S. Zamboni
    Autophagy downstream of endosomal Toll-like Receptors Signaling in Macrophages is a Key Mechanism for Resistance to Leishmania major Infection J. Biol. Chem. jbc.M117.780981. doi:10.1074/jbc.M117.780981
    Immunology - Metabolism:
    • Javier Traba,
    • Sarah S Geiger,
    • Miriam Kwarteng Siaw,
    • Kim Han,
    • One Hyuk Ra,
    • Richard M Siegel,
    • David Gius,
    • and Michael N Sack
    Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3 mediated activation of Superoxide Dismutase 2 J. Biol. Chem. jbc.M117.791715. doi:10.1074/jbc.M117.791715
    Immunology - Cell Biology:
    • Elif Eren,
    • Mesut Berber,
    • and Nesrin Özören
    NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding J. Biol. Chem. jbc.M116.769695. doi:10.1074/jbc.M116.769695
    Immunology - Signal Transduction:
    • Raquel Domingo-Fernández,
    • Rebecca C. Coll,
    • Jay Kearney,
    • Samuel Breit,
    • and Luke AJ. O'Neill
    The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome J. Biol. Chem. jbc.M117.797126. doi:10.1074/jbc.M117.797126
    Microbiology - Immunology:
    • Xianzhu Wu,
    • Kiran K Dayanand,
    • Ramesh P Thylur,
    • Christopher C Norbury,
    • and D. Channe Gowda
    Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes J. Biol. Chem. jbc.M116.770313. doi:10.1074/jbc.M116.770313
    Minireview - Immunology - Cell Biology:
    • Daniel S. Green,
    • Howard A Young,
    • and Julio C. Valencia
    Current prospects of type II interferon gamma signaling and autoimmunity J. Biol. Chem. jbc.R116.774745. doi:10.1074/jbc.R116.774745
    Minireview - Immunology - Gene Regulation:
    • Michael A Wheeler,
    • Veit Rothhammer,
    • and Francisco J Quintana
    Control of immune-mediated pathology via the aryl hydrocarbon receptor J. Biol. Chem. jbc.R116.767723. doi:10.1074/jbc.R116.767723
    Minireview - Gene Regulation - Immunology:
    • Nicholas W Mathy and
    • Xian-Ming Chen
    LncRNAs and Their Transcriptional Control of Inflammatory Responses J. Biol. Chem. jbc.R116.760884. doi:10.1074/jbc.R116.760884
    Protein Structure and Folding - Immunology:
    • Esben G.W. Schmidt,
    • Michael L. Hvam,
    • Filipa Antunes,
    • Jason Cameron,
    • Dorthe Viuff,
    • Birgitte Andersen,
    • Nanna N. Kristensen,
    • and Kenneth A. Howard
    Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin J. Biol. Chem. jbc.M117.794248. doi:10.1074/jbc.M117.794248
    Protein Structure and Folding - Immunology:
    • Patricia A Blundell,
    • Ngoc Phuong Lan Le,
    • Joel Allen,
    • Yasunori Watanabe,
    • and Richard J Pleass
    Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors J. Biol. Chem. jbc.M117.795047. doi:10.1074/jbc.M117.795047

Neurobiology

    Cell Biology - Neurobiology:
    • Hans Zempel,
    • Frank Dennissen,
    • Yatender Kumar,
    • Julia Luedtke,
    • Jacek Biernat,
    • Eva-Maria Mandelkow,
    • and Eckhard Mandelkow
    Axodendritic sorting and pathological missorting of Tau is isoform specific and determined by axon initial segment architecture J. Biol. Chem. jbc.M117.784702. doi:10.1074/jbc.M117.784702
    Immunology - Neurobiology:
    • Liraz Shmuel-Galia,
    • Yoal Klug,
    • Ziv Porat,
    • Meital Charni,
    • Batya Zarmi,
    • and Yechiel Shai
    Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia mediated neurodegeneration J. Biol. Chem. jbc.M117.784983. doi:10.1074/jbc.M117.784983
    Metabolism - Neurobiology:
    • Jennifer R. Chao,
    • Kaitlen Knight,
    • Abbi L. Engel,
    • Connor Jankowski,
    • Yekai Wang,
    • Megan A. Manson,
    • Haiwei Gu,
    • Danijel Djukovic,
    • Daniel Raftery,
    • James B. Hurley,
    • and Jianhai Du
    Human Retinal Pigment Epithelium Cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side J. Biol. Chem. jbc.M117.788422. doi:10.1074/jbc.M117.788422
    Microbiology - Neurobiology:
    • Rahul Basu,
    • Abhishek Bose,
    • Deepthi Thomas,
    • and Jayasri Das Sarma
    Microtubule assisted altered trafficking of Astrocytic Gap Junction Protein Connexin 43 is associated with depletion of Connexin 47 during Mouse Hepatitis Virus infection J. Biol. Chem. jbc.M117.786491. doi:10.1074/jbc.M117.786491
    Minireview - Neurobiology - Cell Biology:
    • Aram Asatryan and
    • Nicolas G. Bazan
    Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection J. Biol. Chem. jbc.R117.783076. doi:10.1074/jbc.R117.783076
    Minireview - Neurobiology:
    • Nicolas G. Bazan and
    • George M. Carman
    Thematic minireview series on the molecular principles of the inflammatory response governed by gene transcriptional control. Inflammatory transcription instructs genes on how to talk back and confront homeostatic disruptions J. Biol. Chem. jbc.R117.801753. doi:10.1074/jbc.R117.801753
    Molecular Bases of Disease - Neurobiology:
    • Richard J. Karpowicz, Jr.,
    • Conor M. Haney,
    • Tiberiu S. Mihaila,
    • Raizel M. Sandler,
    • E. James Petersson,
    • and Virginia M.-Y. Lee
    Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies J. Biol. Chem. jbc.M117.780296. doi:10.1074/jbc.M117.780296
    Neurobiology - Cell Biology:
    • Menglong Rui,
    • Jinjun Qian,
    • Lijuan Liu,
    • Yihan Cai,
    • Huihui Lv,
    • Junhai Han,
    • Zhengping Jia,
    • and Wei Xie
    The Neuronal Protein Neurexin Directly Interacts with the Scribble-Pix Complex to Stimulate F-actin Assembly for Synaptic Vesicle Clustering J. Biol. Chem. jbc.M117.794040. doi:10.1074/jbc.M117.794040
    Neurobiology - Cell Biology:
    • Ana Jorge-Finnigan,
    • Rune Kleppe,
    • Kunwar Jung-KC,
    • Ming Ying,
    • Michael Marie,
    • Ivan Rios-Mondragon,
    • Michael F. Salvatore,
    • Jaakko Saraste,
    • and Aurora Martinez
    Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules J. Biol. Chem. jbc.M116.762344. doi:10.1074/jbc.M116.762344
    Neurobiology - Genomics and Proteomics:
    • Jason J Yi,
    • Smita R Paranjape,
    • Matthew P Walker,
    • Rajarshi Choudhury,
    • Justin M Wolter,
    • Giulia Fragola,
    • Michael J Emanuele,
    • Michael B Major,
    • and Mark J Zylka
    The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome J. Biol. Chem. jbc.M117.788448. doi:10.1074/jbc.M117.788448
    Protein Structure and Folding - Neurobiology:
    • Hideaki Shimizu,
    • Asako Tosaki,
    • Noboru Ohsawa,
    • Yoshiko Ishizuka-Katsura,
    • Shisako Shoji,
    • Haruko Miyazaki,
    • Fumitaka Oyama,
    • Takaho Terada,
    • Mikako Shirouzu,
    • Shun-ichi Sekine,
    • Nobuyuki Nukina,
    • and Shigeyuki Yokoyama
    Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion J. Biol. Chem. jbc.M117.786509. doi:10.1074/jbc.M117.786509
    Signal Transduction - Neurobiology:
    • Andrew C Emery,
    • Wenqin Xu,
    • Maribeth V Eiden,
    • and Lee E Eiden
    Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells J. Biol. Chem. jbc.M117.790329. doi:10.1074/jbc.M117.790329

DNA and Chromosomes

    DNA and Chromosomes - Enzymology:
    • Christina A. Gerodimos,
    • Howard H. Y. Chang,
    • Go Watanabe,
    • and Michael R. Lieber
    Effects of DNA end configuration on XRCC4:DNA ligase IV and its stimulation of Artemis activity J. Biol. Chem. jbc.M117.798850. doi:10.1074/jbc.M117.798850
    DNA and Chromosomes - Molecular Bases of Disease:
    • Kyle S. Sorenson,
    • Brandi L. Mahaney,
    • Susan P. Lees-Miller,
    • and Jennifer A. Cobb
    The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 at DNA double strand breaks J. Biol. Chem. jbc.M117.796011. doi:10.1074/jbc.M117.796011
    DNA and Chromosomes:
    • Masako Izumi,
    • Takeshi Mizuno,
    • Ken-ichiro Yanagi,
    • Kazuto Sugimura,
    • Katsuzumi Okumura,
    • Naoko Imamoto,
    • Tomoko Abe,
    • and Fumio Hanaoka
    The Mcm2-7- interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing J. Biol. Chem. jbc.M117.779371. doi:10.1074/jbc.M117.779371
    DNA and Chromosomes:
    • Philip Nevin,
    • Carolina C Gabbai,
    • and Kenneth J Marians
    Replisome-mediated Translesion Synthesis by a Cellular Replicase J. Biol. Chem. jbc.M117.800441. doi:10.1074/jbc.M117.800441
    DNA and Chromosomes - Genomics and Proteomics:
    • Rucha Kshirsagar,
    • Indrajeet Ghodke,
    • and Kalappa Muniyappa
    Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end joining activity and potentiates Hop1 promoted pairing of double-stranded DNA J. Biol. Chem. jbc.M117.796425. doi:10.1074/jbc.M117.796425
    DNA and Chromosomes - Molecular Biophysics:
    • Yufeng Qian and
    • Kenneth A. Johnson
    The human mitochondrial single strand DNA binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange J. Biol. Chem. jbc.M117.791392. doi:10.1074/jbc.M117.791392
    DNA and Chromosomes - Signal Transduction:
    • Michael G Kemp
    DNA damage-induced ATR kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor II-H (TFIIH) J. Biol. Chem. jbc.M117.788406. doi:10.1074/jbc.M117.788406
    Microbiology - DNA and Chromosomes:
    • Russell W. Goetze,
    • Dong-Hyun Kim,
    • Raymond F. Schinazi,
    • and Baek Kim
    A CRISPR/Cas9 approach reveals that the polymerase activity of DNA Polymerase β is dispensable for HIV-1 infection in dividing and nondividing cells J. Biol. Chem. jbc.M117.793661. doi:10.1074/jbc.M117.793661
    Molecular Bases of Disease - DNA and Chromosomes:
    • Zhigang Chen,
    • Thomas L. Eggerman,
    • Alexander V. Bocharov,
    • Irina N. Baranova,
    • Tatyana G. Vishnyakova,
    • Roger Kurlander,
    • and Amy P. Patterson
    Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus J. Biol. Chem. jbc.M116.760637. doi:10.1074/jbc.M116.760637
    Protein Synthesis and Degradation - DNA and Chromosomes:
    • Hee-Jung Kim,
    • Jae-Jin Lee,
    • Jin-Hwan Cho,
    • Jaeho Jeong,
    • A Young Park,
    • Wonmo Kang,
    • and Kong-Joo Lee
    Heterogeneous nuclear ribonucleoprotein K inhibits heat shock-induced transcriptional activity of heat shock factor 1 J. Biol. Chem. jbc.M117.774992. doi:10.1074/jbc.M117.774992

Developmental Biology

    Developmental Biology - Gene Regulation:
    • Sha-Sha Bian,
    • Xu-Lei Zheng,
    • Hua-Qin Sun,
    • Jian-Hui Chen,
    • Yi-Lu Lu,
    • Yun-Qiang Liu,
    • Da-Chang Tao,
    • and Yong-Xin Ma
    Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signalings in the zebrafish embryo J. Biol. Chem. jbc.M117.794289. doi:10.1074/jbc.M117.794289
    Developmental Biology - Gene Regulation:
    • Qing Xie and
    • Zhu A. Wang
    Transcriptional regulation of Nkx3.1 in prostate luminal stem cell specification and cancer initiation via its 3′ genomic region J. Biol. Chem. jbc.M117.788315. doi:10.1074/jbc.M117.788315
    Developmental Biology - Cell Biology:
    • Taylor McClatchie,
    • Megan Meredith,
    • Mariame O. Ouédraogo,
    • Sandy Slow,
    • Michael Lever,
    • Mellissa R. W. Mann,
    • Steven H. Zeisel,
    • Jacquetta M. Trasler,
    • and Jay M. Baltz
    Betaine is accumulated via transient choline dehydrogenase activation during Mouse oocyte meiotic maturation J. Biol. Chem. jbc.M117.803080. doi:10.1074/jbc.M117.803080
    Developmental Biology - Cell Biology:
    • Zan Zhang,
    • Anhua Lei,
    • Liyang Xu,
    • Lu Chen,
    • Yonglong Chen,
    • Xuena Zhang,
    • Yan Gao,
    • Xiaoli Yang,
    • Min Zhang,
    • and Ying Cao
    Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells J. Biol. Chem. jbc.M117.785865. doi:10.1074/jbc.M117.785865
    Developmental Biology - Gene Regulation:
    • Xiaohua Dong,
    • Jingyun Li,
    • Luqingqing He,
    • Chun Gu,
    • Wenshuang Jia,
    • Yunyun Yue,
    • Jun Li,
    • Qinxin Zhang,
    • Lele Chu,
    • and Qingshun Zhao
    Zebrafish Znfl1s control the expression of hoxb1b in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 J. Biol. Chem. jbc.M117.777094. doi:10.1074/jbc.M117.777094
    Developmental Biology - Cell Biology:
    • Miranda L. Xu,
    • Cathy W. C. Bi,
    • Etta Y. L. Liu,
    • Tina T. X. Dong,
    • and Karl W. K. Tsim
    Wnt3a Induces the Expression of Acetylcholinesterase during Osteoblast Differentiation via the Runx2 Transcription Factor J. Biol. Chem. jbc.M117.777581. doi:10.1074/jbc.M117.777581
    Gene Regulation - Developmental Biology:
    • Keigo Yoshizaki,
    • Lizhi Hu,
    • Thai Nguyen,
    • Kiyoshi Sakai,
    • Masaki Ishikawa,
    • Ichiro Takahashi,
    • Satoshi Fukumoto,
    • Pamela Den Besten,
    • Daniel D. Bikle,
    • Yuko Oda,
    • and Yoshihiko Yamada
    Mediator 1 Contributes to Enamel Mineralization as a Coactivator for Notch1 Signaling and Stimulates Transcription of the Alkaline Phosphatase Gene J. Biol. Chem. jbc.M117.780866. doi:10.1074/jbc.M117.780866

Plant Biology

    Enzymology - Plant Biology:
    • Hajo Kries,
    • Franziska Kellner,
    • Mohamed Omar Kamileen,
    • and Sarah E. O'Connor
    Inverted stereocontrol of iridoid synthase in snapdragon J. Biol. Chem. jbc.M117.800979. doi:10.1074/jbc.M117.800979
    Glycobiology and Extracellular Matrices - Plant Biology:
    • Tatiana Bilova,
    • Gagan Paudel,
    • Nikita Shilyaev,
    • Rico Schmidt,
    • Dominic Brauch,
    • Elena Tarakhovskaya,
    • Svetlana Milrud,
    • Galina Smolikova,
    • Alain Tissier,
    • Thomas Vogt,
    • Andrea Sinz,
    • Wolfgang Brandt,
    • Claudia Birkemeyer,
    • Ludger A. Wessjohann,
    • and Andrej Frolov
    Global Proteomic Analysis of Advanced Glycation End Products in the Arabidopsis Proteome Provides Evidence for Age-related Glycation Hotspots J. Biol. Chem. jbc.M117.794537. doi:10.1074/jbc.M117.794537
    Plant Biology:
    • Till Myrach,
    • Anting Zhu,
    • and Claus-Peter Witte
    The assembly of the plant urease activation complex and the essential role of the urease accessory protein G (UreG) in delivery of nickel to urease J. Biol. Chem. jbc.M117.780403. doi:10.1074/jbc.M117.780403
    Plant Biology - Signal Transduction:
    • Jan Petersen,
    • Shin-ichiro Inoue,
    • Sharon M Kelly,
    • Stuart Sullivan,
    • Toshinori Kinoshita,
    • and John Mackie Christie
    Functional Characterization of a Constitutively Active Kinase Variant of Arabidopsis Phototropin 1 J. Biol. Chem. jbc.M117.799643. doi:10.1074/jbc.M117.799643
    Plant Biology - Signal Transduction:
    • Christian Orth,
    • Nils Niemann,
    • Lars Hennig,
    • Lars-Oliver Essen,
    • and Alfred Batschauer
    Hyperactivity of the Arabidopsis cryptochrome (cry1) L407F mutant is caused by a structural alteration close to the cry1 ATP-binding sit J. Biol. Chem. jbc.M117.788869. doi:10.1074/jbc.M117.788869
    Protein Structure and Folding - Plant Biology:
    • Bastian Franke,
    • Amy M. James,
    • Mehdi Mobli,
    • Michelle L. Colgrave,
    • Joshua S. Mylne,
    • and K. Johan Rosengren
    Two Proteins for the Price of One: Structural Studies of the Dual Destiny Preproalbumin with Sunflower Trypsin Inhibitor-1 J. Biol. Chem. jbc.M117.776955. doi:10.1074/jbc.M117.776955

Lipids

    Enzymology - Lipids:
    • Natalia Mast,
    • Kyle W. Anderson,
    • Kevin M. Johnson,
    • Thanh T.N. Phan,
    • F. Peter Guengerich,
    • and Irina A. Pikuleva
    In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds J. Biol. Chem. jbc.M117.794909. doi:10.1074/jbc.M117.794909
    Immunology - Lipids:
    • Ashley E Shay,
    • Bastihalli T Diwakar,
    • Bo-Jhih Guan,
    • Vivek Narayan,
    • Joseph F Urban, Jr.,
    • and K. Sandeep Prabhu
    IL-4 upregulates cyclooxygenase-1 expression in macrophages J. Biol. Chem. jbc.M117.785014. doi:10.1074/jbc.M117.785014
    Lipids - Cell Biology:
    • Takashi Hirama,
    • Raibatak Das,
    • Yanbo Yang,
    • Charles Ferguson,
    • Amy Won,
    • Christopher M Yip,
    • Jason G Kay,
    • Sergio Grinstein,
    • Robert G Parton,
    • and Gregory D Fairn
    Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. J. Biol. Chem. jbc.M117.791400. doi:10.1074/jbc.M117.791400
    Lipids:
    • Gil-Soo Han and
    • George M. Carman
    Yeast PAH1-encoded phosphatidate phosphatase controls the expression of CHO1-encoded phosphatidylserine synthase for membrane phospholipid synthesis J. Biol. Chem. jbc.M117.801720. doi:10.1074/jbc.M117.801720
    Lipids - Membrane Biology:
    • Jennifer Prashek,
    • Samuel Bouyain,
    • Mingui Fu,
    • Yong Li,
    • Dusan Berkes,
    • and Xiaolan Yao
    Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain J. Biol. Chem. jbc.M117.780007. doi:10.1074/jbc.M117.780007
    Lipids - Metabolism:
    • Maidina Tuohetahuntila,
    • Martijn R. Molenaar,
    • Bart Spee,
    • Jos F. Brouwers,
    • Richard Wubbolts,
    • Martin Houweling,
    • Cong Yan,
    • Hong Du,
    • Brian C VanderVen,
    • Arie B. Vaandrager,
    • and J. Bernd Helms
    Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation J. Biol. Chem. jbc.M117.778472. doi:10.1074/jbc.M117.778472
    Lipids - Signal Transduction:
    • Mariangela Vessichelli,
    • Stefania Mariggi&ograve,
    • Alessia Varone,
    • Pasquale Zizza,
    • Angelomaria Di Santo,
    • Concetta Amore,
    • Giuseppe Dell'Elba,
    • Adele Cutignano,
    • Angelo Fontana,
    • Carmela Cacciapuoti,
    • Gaetano Di Costanzo,
    • Mariastella Zannini,
    • Tiziana de Cristofaro,
    • Virgilio Evangelista,
    • and Daniela Corda
    The Natural Phosphoinositide-Derivative Glycerophosphoinositol Inhibits the Lipopolysaccharide-Induced Inflammatory and Thrombotic Responses J. Biol. Chem. jbc.M116.773861. doi:10.1074/jbc.M116.773861
    Lipids - Membrane Biology:
    • Hideo Shindou,
    • Hideto Koso,
    • Junko Sasaki,
    • Hiroki Nakanishi,
    • Hiroshi Sagara,
    • Koh M. Nakagawa,
    • Yoshikazu Takahashi,
    • Daisuke Hishikawa,
    • Yoshiko Iizuka-Hishikawa,
    • Fuyuki Tokumasu,
    • Hiroshi Noguchi,
    • Sumiko Watanabe,
    • Takehiko Sasaki,
    • and Takao Shimizu
    Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells J. Biol. Chem. jbc.M117.790568. doi:10.1074/jbc.M117.790568
    Membrane Biology - Lipids:
    • Yoshiko Iizuka-Hishikawa,
    • Daisuke Hishikawa,
    • Junko Sasaki,
    • Keiyo Takubo,
    • Motohito Goto,
    • Katsuyuki Nagata,
    • Hiroki Nakanishi,
    • Hideo Shindou,
    • Tadashi Okamura,
    • Chizuru Ito,
    • Kiyotaka Toshimori,
    • Takehiko Sasaki,
    • and Takao Shimizu
    Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem. jbc.M117.791277. doi:10.1074/jbc.M117.791277
    Molecular Bases of Disease - Lipids:
    • Birthe Trautz,
    • Hannah Wiedemann,
    • Christian L&uumlchtenborg,
    • Virginia Pierini,
    • Jan Kranich,
    • B&aumlrbel Glass,
    • Hans-Georg Kr&aumlusslich,
    • Thomas Brocker,
    • Massimo Pizzato,
    • Alessia Ruggieri,
    • Britta Br&uumlgger,
    • and Oliver T Fackler
    The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles J. Biol. Chem. jbc.M117.797332. doi:10.1074/jbc.M117.797332

Glycobiology and Extracellular Matrices

    Enzymology - Glycobiology and Extracellular Matrices:
    • José Munoz-Munoz,
    • Alan Cartmell,
    • Nicolas Terrapon,
    • Arnaud Baslé,
    • Bernard Henrissat,
    • and Harry J. Gilbert
    An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins J. Biol. Chem. jbc.M117.794578. doi:10.1074/jbc.M117.794578
    Glycobiology and Extracellular Matrices - Signal Transduction:
    • Patricia Y Akinfenwa,
    • Wesley S Bond,
    • Cristhian J Ildefonso,
    • Mary Y Hurwitz,
    • and Richard L Hurwitz
    Versican G1 Domain Enhances Adenoviral-Mediated Transgene Expression and Can Be Modulated by Inhibitors of the Janus Kinase (JAK)/STAT and Src Family Kinase Pathways J. Biol. Chem. jbc.M116.773549. doi:10.1074/jbc.M116.773549
    Glycobiology and Extracellular Matrices - Protein Structure and Folding:
    • Hadar Feinberg,
    • Sabine A. F. Jégouzo,
    • Maximus J. Rex,
    • Kurt Drickamer,
    • William I. Weis,
    • and Maureen E. Taylor
    Mechanism of pathogen recognition by human dectin-2 J. Biol. Chem. jbc.M117.799080. doi:10.1074/jbc.M117.799080
    Glycobiology and Extracellular Matrices - Plant Biology:
    • Tatiana Bilova,
    • Gagan Paudel,
    • Nikita Shilyaev,
    • Rico Schmidt,
    • Dominic Brauch,
    • Elena Tarakhovskaya,
    • Svetlana Milrud,
    • Galina Smolikova,
    • Alain Tissier,
    • Thomas Vogt,
    • Andrea Sinz,
    • Wolfgang Brandt,
    • Claudia Birkemeyer,
    • Ludger A. Wessjohann,
    • and Andrej Frolov
    Global Proteomic Analysis of Advanced Glycation End Products in the Arabidopsis Proteome Provides Evidence for Age-related Glycation Hotspots J. Biol. Chem. jbc.M117.794537. doi:10.1074/jbc.M117.794537
    Glycobiology and Extracellular Matrices - Protein Structure and Folding:
    • Emma-Ruoqi Xu,
    • Emily E. Blythe,
    • Gerhard Fischer,
    • and Marko Hyvönen
    Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2 J. Biol. Chem. jbc.M117.788992. doi:10.1074/jbc.M117.788992
    Molecular Bases of Disease - Glycobiology and Extracellular Matrices:
    • Anke P. Willems,
    • Mehmet Gundogdu,
    • Marlies J.E. Kempers,
    • Jacques C. Giltay,
    • Rolph Pfundt,
    • Martin Elferink,
    • Bettina F. Loza,
    • Joris Fuijkschot,
    • Andrew T. Ferenbach,
    • Koen L.I. van Gassen,
    • Daan M.F. van Aalten,
    • and Dirk J. Lefeber
    Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability J. Biol. Chem. jbc.M117.790097. doi:10.1074/jbc.M117.790097

RNA

    Gene Regulation - RNA:
    • Gilles Ponzio,
    • Roger Rezzonico,
    • Isabelle Bourget,
    • Richard Allan,
    • Nicolas Nottet,
    • Alexandra Popa,
    • Virginie Magnone,
    • Géraldine Rios,
    • Bernard Mari,
    • and Pascal Barbry
    A new long noncoding RNA (LncRNA) is induced in cutaneous squamous cell carcinoma and downregulates several anticancer and cell-differentiation genes in mouse J. Biol. Chem. jbc.M117.776260. doi:10.1074/jbc.M117.776260
    RNA - Molecular Biophysics:
    • Franziska Pinker,
    • Cédric Schelcher,
    • Pablo Fernández-Millán,
    • Anthony Gobert,
    • Catherine Birck,
    • Aurélien Thureau,
    • Pierre Roblin,
    • Philippe Giegé,
    • and Claude Sauter
    Biophysical analysis of Arabidopsis protein-only RNase P alone and in complex with tRNA provides a refined model of tRNA binding J. Biol. Chem. jbc.M117.782078. doi:10.1074/jbc.M117.782078
    RNA - Molecular Bases of Disease:
    • Mi Zhou,
    • Meng Wang,
    • Ling Xue,
    • Zhi Lin,
    • Qiufen He,
    • Wenwen Shi,
    • Yaru Chen,
    • Xiaofen Jin,
    • Haiying Li,
    • Pingping Jiang,
    • and Min-Xin Guan
    A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNALeu(UUR) J. Biol. Chem. jbc.M117.787028. doi:10.1074/jbc.M117.787028
    RNA:
    • Aparna Kishor,
    • Elizabeth J.F. White,
    • Aerielle E. Matsangos,
    • Zisui Yan,
    • Bishal Tandukar,
    • and Gerald M. Wilson
    Hsp70's RNA-binding and mRNA-stabilizing activities are independent of its protein chaperone functions J. Biol. Chem. jbc.M117.785394. doi:10.1074/jbc.M117.785394
    RNA:
    • Luang Xu,
    • Xinyu Liu,
    • Na Sheng,
    • Kyaw Soe Oo,
    • Junxin Liang,
    • Yok Hian Chionh,
    • Juan Xu,
    • Fuzhou Ye,
    • Yong-Gui Gao,
    • Peter C Dedon,
    • and Xin-Yuan Fu
    Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans J. Biol. Chem. jbc.M117.798298. doi:10.1074/jbc.M117.798298
    RNA:
    • Subhanita Ghosh,
    • Abhinav Kaushik,
    • Sachin Khurana,
    • Aditi Varshney,
    • Avishek Kumar Singh,
    • Pradeep Dahiya,
    • Jitendra K. Thakur,
    • Shiv Kumar Sarin,
    • Dinesh Gupta,
    • Pawan Malhotra,
    • Sunil K. Mukherjee,
    • and Raj K. Bhatnagar
    An RNAi based high-throughput screening assay to identify small molecule inhibitors of Hepatitis B Virus replication J. Biol. Chem. jbc.M117.775155. doi:10.1074/jbc.M117.775155
    RNA - Gene Regulation:
    • Fernando A Gonzales-Zubiate,
    • Ellen K Okuda,
    • Julia PC Da Cunha,
    • and Carla Columbano Oliveira
    Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae J. Biol. Chem. jbc.M116.772376. doi:10.1074/jbc.M116.772376

Minireview

    Minireview - Cell Biology - Signal Transduction:
    • Mohammed Adnan Mohammed Hanif Qureshi,
    • Cole M. Haynes,
    • and Mark W. Pellegrino
    The mitochondrial unfolded protein response: signaling from the powerhouse J. Biol. Chem. jbc.R117.791061. doi:10.1074/jbc.R117.791061
    Minireview - Immunology - Cell Biology:
    • Daniel S. Green,
    • Howard A Young,
    • and Julio C. Valencia
    Current prospects of type II interferon gamma signaling and autoimmunity J. Biol. Chem. jbc.R116.774745. doi:10.1074/jbc.R116.774745
    Minireview - Protein Structure and Folding - Molecular Biophysics:
    • Philipp Koldewey,
    • Scott Horowitz,
    • and James C. A. Bardwell
    Chaperone-client interactions: non-specificity engenders multi-functionality J. Biol. Chem. jbc.R117.796862. doi:10.1074/jbc.R117.796862
    Minireview - Cell Biology - Enzymology:
    • Joseph J. Braymer and
    • Roland Lill
    Iron-Sulfur Cluster Biogenesis and Trafficking in Mitochondria J. Biol. Chem. jbc.R117.787101. doi:10.1074/jbc.R117.787101
    Minireview - Neurobiology - Cell Biology:
    • Aram Asatryan and
    • Nicolas G. Bazan
    Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection J. Biol. Chem. jbc.R117.783076. doi:10.1074/jbc.R117.783076
    Minireview - Immunology - Gene Regulation:
    • Michael A Wheeler,
    • Veit Rothhammer,
    • and Francisco J Quintana
    Control of immune-mediated pathology via the aryl hydrocarbon receptor J. Biol. Chem. jbc.R116.767723. doi:10.1074/jbc.R116.767723
    Minireview - Cell Biology:
    • Sharleen V. Menezes,
    • Sumit Sahni,
    • Zaklina Kovacevic,
    • and Des R. Richardson
    Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling J. Biol. Chem. jbc.R117.776393. doi:10.1074/jbc.R117.776393
    Minireview - Gene Regulation - Immunology:
    • Nicholas W Mathy and
    • Xian-Ming Chen
    LncRNAs and Their Transcriptional Control of Inflammatory Responses J. Biol. Chem. jbc.R116.760884. doi:10.1074/jbc.R116.760884
    Minireview - Cell Biology - Metabolism:
    • Caroline C. Philpott,
    • Moon-Suhn Ryu,
    • Avery G. Frey,
    • and Sarju Patel
    Cytosolic iron chaperones: proteins delivering iron cofactors in the cytosol of mammalian cells. J. Biol. Chem. jbc.R117.791962. doi:10.1074/jbc.R117.791962
    Minireview - Protein Structure and Folding - Metabolism:
    • Tracey A Rouault and
    • Nunziata Maio
    Biogenesis and Functions of Mammalian Iron-Sulfur Proteins in the Regulation of Iron Homeostasis and Pivotal Metabolic Pathways J. Biol. Chem. jbc.R117.789537. doi:10.1074/jbc.R117.789537
    Minireview - Neurobiology:
    • Nicolas G. Bazan and
    • George M. Carman
    Thematic minireview series on the molecular principles of the inflammatory response governed by gene transcriptional control. Inflammatory transcription instructs genes on how to talk back and confront homeostatic disruptions J. Biol. Chem. jbc.R117.801753. doi:10.1074/jbc.R117.801753
    Minireview - Metabolism - Cell Biology:
    • Mitchell D. Knutson
    Iron Transport Proteins: Gateways of Cellular and Systemic Iron Homeostasis J. Biol. Chem. jbc.R117.786632. doi:10.1074/jbc.R117.786632
    Minireview - Enzymology - Metabolism:
    • F. Peter Guengerich
    MINIREVIEW PROLOGUE Introduction: Metals in Biology 2017: Iron transport, storage, and the ramifications J. Biol. Chem. jbc.R117.801332. doi:10.1074/jbc.R117.801332
    Minireview - Metabolism - Cell Biology:
    • Richard Coffey and
    • Tomas Ganz
    Iron Homeostasis--an Anthropocentric Perspective J. Biol. Chem. jbc.R117.781823. doi:10.1074/jbc.R117.781823
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