Early Edition Articles (date view)

September 4, 2020

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Molecular Biophysics - Protein Structure and Folding:

Pamela A. Naulin,
Benjamin Lozano,
Christian Fuentes,
Yu Liu,
Carla Schmidt,
Jorge E. Contreras,
and Nelson P. Barrera

Polydisperse molecular architecture of connexin 26/30 heteromeric hemichannels revealed by AFM imaging J. Biol. Chem. jbc.RA119.012128. doi:10.1074/jbc.RA119.012128

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JBC Reviews - Signal Transduction - Cell Biology:

Julia M.D. Grandjean and
R Luke Wiseman

Small molecule strategies to harness the unfolded protein response: where do we go from here? J. Biol. Chem. jbc.REV120.010218. doi:10.1074/jbc.REV120.010218

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Molecular Bases of Disease - Gene Regulation:

Ji Young Kim,
Yuntao Bai,
Laura A Jayne,
Ferdos Abdulkader,
Megha Gandhi,
Tayla Perreau,
Samir V Parikh,
David S Gardner,
Alan J Davidson,
Veronika Sander,
Min-Ae Song,
Amandeep Bajwa,
and Navjot Singh Pabla

SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells J. Biol. Chem. jbc.RA120.015110. doi:10.1074/jbc.RA120.015110

September 3, 2020

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Cell Biology - Molecular Bases of Disease:

Abigail Allen,
David Gau,
Paul Francoeur,
Jordan Sturm,
Yue Wang,
Ryan Martin,
Jodi Maranchie,
Anette Duensing,
Adam Kaczorowski,
Stefan Duensing,
Lily Wu,
Michael T. Lotze,
David Koes,
Walter J. Storkus,
and Partha Roy

Actin-binding protein Profilin1 promotes aggressiveness of clear cell renal cell carcinoma cells J. Biol. Chem. jbc.RA120.013963. doi:10.1074/jbc.RA120.013963

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Glycobiology and Extracellular Matrices - Microbiology:

Miralda Madar Johansson,
Eva Bélurier,
Anastassios C. Papageorgiou,
Anders P. Sundin,
Jani Rahkila,
Teemu Kallonen,
Ulf J. Nilsson,
Santeri Maatsola,
Thomas K.M. Nyholm,
Jarmo Käpylä,
Jukka Corander,
Reko Leino,
Jukka Finne,
Susann Teneberg,
and Sauli Haataja

The binding mechanism of the virulence factor Streptococcus suis adhesin P subtype to globotetraosylceramide is associated with systemic disease J. Biol. Chem. jbc.RA120.014818. doi:10.1074/jbc.RA120.014818

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Methods and Resources - RNA:

Samantha J. Mascuch,
Sara Fakhretaha-Aval,
Jessica C. Bowman,
Minh Thu H. Ma,
Gwendell Thomas,
Bettina Bommarius,
Chieri Ito,
Liangjun Zhao,
Gary P. Newnam,
Kavita R. Matange,
Hem R. Thapa,
Brett Barlow,
Rebecca K. Donegan,
Nguyet A. Nguyen,
Emily G. Saccuzzo,
Chiamaka T. Obianyor,
Suneesh C. Karunakaran,
Pamela Pollet,
Brooke Rothschild-Mancinelli,
Santi Mestre-Fos,
Rebecca Guth-Metzler,
Anton V. Bryksin,
Anton S. Petrov,
Mallory Hazell,
Carolyn B. Ibberson,
Petar I. Penev,
Robert G. Mannino,
Wilbur A. Lam,
Andrés J. García,
Julia M. Kubanek,
Vinayak Agarwal,
Nicholas V. Hud,
Jennifer B Glass,
Loren Dean Williams,
and Raquel L. Lieberman

A blueprint for academic labs to produce SARS-CoV-2 RT-qPCR test kits J. Biol. Chem. jbc.RA120.015434. doi:10.1074/jbc.RA120.015434

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Enzymology - Protein Structure and Folding:

Markel Martínez-Carranza,
Venkateswara Rao Jonna,
Daniel Lundin,
Margareta Sahlin,
Lars-Anders Carlson,
Newal Jemal,
Martin Högbom,
Britt-Marie Sjöberg,
Pål Stenmark,
and Anders Hofer

A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site J. Biol. Chem. jbc.RA120.014895. doi:10.1074/jbc.RA120.014895

September 2, 2020

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DNA and Chromosomes - Protein Structure and Folding:

Alyssa A. Rodriguez,
Jessica L Wojtaszek,
Briana H. Greer,
Tuhin Haldar,
Kent S. Gates,
R. Scott Williams,
and Brandt F. Eichman

An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3 J. Biol. Chem. jbc.RA120.015541. doi:10.1074/jbc.RA120.015541

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Membrane Biology - Molecular Bases of Disease:

Wenting Guo,
Bo Sun,
John Paul Estillore,
Ruiwu Wang,
and S.R. Wayne Chen

The Central Domain of Cardiac Ryanodine Receptor Governs Channel Activation, Regulation, and Stability J. Biol. Chem. jbc.RA120.013512. doi:10.1074/jbc.RA120.013512

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Signal Transduction - Metabolism:

Dipsikha Biswas,
Khoi T. Dao,
Angella Mercer,
Andrew M. Cowie,
Luke Duffley,
Yassine El Hiani,
Petra C Kienesberger,
and Thomas Pulinilkunnil

Branched-chain ketoacid overload inhibits insulin action in the muscle J. Biol. Chem. jbc.RA120.013121. doi:10.1074/jbc.RA120.013121

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Protein Synthesis and Degradation - Cell Biology:

Sha Sun and
Malaiyalam Mariappam

C-terminal tail length guides insertion and assembly of membrane proteins J. Biol. Chem. jbc.RA120.012992. doi:10.1074/jbc.RA120.012992

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Microbiology - Protein Structure and Folding:

Michael J. Rudolph,
Simon A. Davis,
Nilgun E. Tumer,
and Xiao-Ping Li

Structural basis for the interaction of Shiga toxin 2a with a C-terminal peptide of ribosomal P stalk proteins J. Biol. Chem. jbc.AC120.015070. doi:10.1074/jbc.AC120.015070

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Protein Structure and Folding - Enzymology:

Cecilia Piergentili,
Jennifer Ross,
Didi He,
Kelly J. Gallagher,
Will A. Stanley,
Laurène Adam,
C. Logan Mackay,
Arnaud Baslé,
Kevin J. Waldron,
David J. Clarke,
and Jon Marles-Wright

Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins J. Biol. Chem. jbc.RA120.014502. doi:10.1074/jbc.RA120.014502

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DNA and Chromosomes:

Onyekachi E Ononye,
Christopher W. Sausen,
Lata Balakrishnan,
and Matthew L. Bochman

Lysine Acetylation Regulates the Activity of Nuclear Pif1 J. Biol. Chem. jbc.RA120.015164. doi:10.1074/jbc.RA120.015164

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Genomics and Proteomics - Protein Structure and Folding:

Sarah A. Peck Justice,
Monica P. Barron,
Guihong D Qi,
H. R. Sagara Wijeratne,
José F. Victorino,
Edward R. Simpson,
Jonah Z. Vilseck,
Aruna B. Wijeratne,
and Amber L. Mosley

Mutant thermal proteome profiling for characterization of missense protein variants and their associated phenotypes within the proteome J. Biol. Chem. jbc.RA120.014576. doi:10.1074/jbc.RA120.014576

September 1, 2020

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Glycobiology and Extracellular Matrices - Protein Structure and Folding:

Daisuke Hira,
Takuya Onoue,
and Takuji Oka

Structural basis for the core-mannan biosynthesis of cell wall fungal-type galactomannan in Aspergillus fumigatus J. Biol. Chem. jbc.RA120.013742. doi:10.1074/jbc.RA120.013742

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Lipids - Metabolism:

Linda D Thomas,
Sepalika Bandara,
Vipul M Parmar,
Ramkumar Srinivasagan,
Nimesh Khadka,
Marcin Golczak,
Philip D Kiser,
and Johannes von Lintig

The human mitochondrial enzyme BCO2 exhibits catalytic activity towards carotenoids and apocarotenoids J. Biol. Chem. jbc.RA120.015515. doi:10.1074/jbc.RA120.015515

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Microbiology - Molecular Bases of Disease:

Ryan P. Staudt and
Thomas E. Smithgall

Nef Homodimers Downregulate SERINC5 by AP-2-Mediated Endocytosis to Promote HIV-1 Infectivity J. Biol. Chem. jbc.RA120.014668. doi:10.1074/jbc.RA120.014668

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DNA and Chromosomes - Cell Biology:

Rujuta Yashodhan Gadgil,
Eric J. Romer,
Caitlin C. Goodman,
S. Dean Rider Jr.,
French J. Damewood IV,
Joanna R. Barthelemy,
Kazuo Shin-ya,
Helmut Hanenberg,
and Michael Leffak

Replication stress at microsatellites causes DNA double strand breaks and break induced replication J. Biol. Chem. jbc.RA120.013495. doi:10.1074/jbc.RA120.013495

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Lipids - Plant Biology:

Simon Jeppson,
Helena Mattisson,
Kamil Demski,
and Ida Lager

A predicted transmembrane region in plant diacylglycerol acyltransferase 2 regulates specificity towards very long chain acyl-CoAs. J. Biol. Chem. jbc.RA120.013755. doi:10.1074/jbc.RA120.013755

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JBC Reviews - Plant Biology:

Joseph M. Jez

Plants in the real world: an introduction to the JBC Reviews thematic series J. Biol. Chem. jbc.REV120.015446. doi:10.1074/jbc.REV120.015446

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Cell Biology - Molecular Biophysics:

William Schmidt,
Aditi Madan,
D. Brian Foster,
and Anthony Cammarato

Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity J. Biol. Chem. jbc.RA120.015277. doi:10.1074/jbc.RA120.015277

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Molecular Biophysics - Computational Biology:

Julia M C Busch,
Minos-Timotheos Matsoukas,
Maria Musgaard,
Georgios A Spyroulias,
Philip C. Biggin,
and Ioannis Vakonakis

Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerisation J. Biol. Chem. jbc.RA120.014780. doi:10.1074/jbc.RA120.014780

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Enzymology - Metabolism:

Dayana Benchoam,
Jonathan A. Semelak,
Ernesto Cuevasanta,
Mauricio Mastrogiovanni,
Juan S. Grassano,
Gerardo Ferrer-Sueta,
Ari Zeida,
Madia Trujillo,
Matías N. Möller,
Dario A. Estrin,
and Beatriz Alvarez

Acidity and nucleophilic reactivity of glutathione persulfide J. Biol. Chem. jbc.RA120.014728. doi:10.1074/jbc.RA120.014728

August 31, 2020

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Cell Biology - Signal Transduction:

Simon Diering,
Konstantina Stathopoulou,
Mara Goetz,
Laura Rathjens,
Sönke Harder,
Angelika Piasecki,
Janice Raabe,
Steven Schulz,
Mona Brandt,
Julia Pflaumenbaum,
Ulrike Fuchs,
Sonia Donzelli,
Sakthivel Sadayappan,
Viacheslav O Nikolaev,
Frederik Flenner,
Elisabeth Ehler,
and Friederike Cuello

Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents J. Biol. Chem. jbc.RA120.014467. doi:10.1074/jbc.RA120.014467

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Cell Biology - Molecular Biophysics:

Majdouline Abou-Ghali,
Remy Kusters,
Sarah Körber,
John Manzi,
Jan Faix,
Cecile Sykes,
and Julie Plastino

Capping protein is dispensable for polarized actin network growth and actin-based motility J. Biol. Chem. jbc.RA120.015009. doi:10.1074/jbc.RA120.015009

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Developmental Biology - Gene Regulation:

Yuta Chiba,
Keigo Yoshizaki,
Kan Saito,
Tomoko Ikeuchi,
Tsutomu Iwamoto,
Craig Rhodes,
Takashi Nakamura,
Susana de Vega,
Robert J. Morell,
Erich T. Boger,
Daniel Martin,
Ryoko Hino,
Hiroyuki Inuzuka,
Christopher K.E. Bleck,
Aya Yamada,
Yoshihiko Yamada,
and Satoshi Fukumoto

G-protein coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts J. Biol. Chem. jbc.RA120.014281. doi:10.1074/jbc.RA120.014281

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JBC Reviews - Cell Biology - Methods and Resources:

Ross W Cheloha,
Thibault J Harmand,
Charlotte Wijne,
Thomas U Schwartz,
and Hidde L Ploegh

Exploring cellular biochemistry with nanobodies J. Biol. Chem. jbc.REV120.012960. doi:10.1074/jbc.REV120.012960

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JBC Reviews - Plant Biology - Glycobiology and Extracellular Matrices:

Nicholas C. Carpita and
Maureen C McCann

Redesigning plant cell walls for the biomass-based bioeconomy J. Biol. Chem. jbc.REV120.014561. doi:10.1074/jbc.REV120.014561

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Neurobiology - Molecular Bases of Disease:

Mahua Maulik,
Lakshmy Vasan,
Abhishek Bose,
Saikat Dutta Chowdhury,
Neelanjana Sengupta,
and Jayasri Das Sarma

Amyloid-β regulates gap junction protein Connexin 43 trafficking in cultured primary astrocytes J. Biol. Chem. jbc.RA120.013705. doi:10.1074/jbc.RA120.013705

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Signal Transduction - Cell Biology:

Sarah J Russell and
Martin F Schneider

Alternative signaling pathways from IGF1 or Insulin to Akt activation and Foxo1 nuclear efflux in adult skeletal muscle fibers J. Biol. Chem. jbc.RA120.013634. doi:10.1074/jbc.RA120.013634

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August 29, 2020

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JBC Reviews - Microbiology - Protein Structure and Folding:

Ryan P. Staudt,
John J. Alvarado,
Lori A. Emert-Sedlak,
Haibin Shi,
Sherry T. Shu,
Thomas E. Wales,
John R. Engen,
and Thomas E. Smithgall

Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes J. Biol. Chem. jbc.REV120.012317. doi:10.1074/jbc.REV120.012317

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August 28, 2020

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Enzymology - Protein Structure and Folding:

Manjunath Goolyam Basavaraj and
Sriram Krishnaswamy

Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex J. Biol. Chem. jbc.RA120.015325. doi:10.1074/jbc.RA120.015325

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Protein Synthesis and Degradation - Methods and Resources:

Bomie Han

A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by hetero-bifunctional ligands J. Biol. Chem. jbc.RA120.014715. doi:10.1074/jbc.RA120.014715

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Computational Biology - Bioenergetics:

Neeraj Manhas,
Quynh V Duong,
Pilhwa Lee,
Joshua D Richardson,
John D Robertson,
Michael A Moxley,
and Jason N Bazil

Computationally modeling mammalian succinate dehydrogenase kinetics identifies the origins and primary determinants of ROS production J. Biol. Chem. jbc.RA120.014483. doi:10.1074/jbc.RA120.014483

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Molecular Biophysics - Microbiology:

Christine Chrissian,
Emma Camacho,
John E Kelly,
Hsin Wang,
Arturo Casadevall,
and Ruth E. Stark

Solid-state NMR spectroscopy identifies three classes of lipids in C. neoformans melanized cell walls and whole fungal cells J. Biol. Chem. jbc.RA120.015201. doi:10.1074/jbc.RA120.015201

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Molecular Biophysics - Membrane Biology:

Ana Filipa Santos Seiça,
Cristina V. Iancu,
Benedikt Pfeilschifter,
M. Gregor Madej,
Jun-Yong Choe,
and Petra Hellwig

Asp22 drives the protonation state of the Staphylococcus epidermidis glucose/H⁺ symporter J. Biol. Chem. jbc.RA120.014069. doi:10.1074/jbc.RA120.014069

August 27, 2020

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Protein Synthesis and Degradation:

Felix A Ebner,
Carolin Sailer,
Daniela Eichbichler,
Jasmin Jansen,
Anna Sladewska-Marquardt,
Florian Stengel,
and Martin Scheffner

A ubiquitin variant-based affinity approach selectively identifies substrates of the ubiquitin ligase E6AP in complex with HPV-11 E6 or HPV-16 E6 J. Biol. Chem. jbc.RA120.015603. doi:10.1074/jbc.RA120.015603

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Molecular Bases of Disease - Signal Transduction:

Fariborz Parandeh,
Stefan Amisten,
Gaurav Verma,
Israa mohammed Al-Amily,
Pontus Dunér,
and Albert Salehi

Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion J. Biol. Chem. jbc.RA120.012929. doi:10.1074/jbc.RA120.012929

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Microbiology - Cell Biology:

Sujayita Roy,
Arun Kapoor,
Fei Zhu,
Rupkatha Mukhopadhyay,
Ayan Kumar Ghosh,
Hyun Lee,
Jennifer Mazzone,
Gary H Posner,
and Ravit Arav-Boger

Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition J. Biol. Chem. jbc.RA120.014116. doi:10.1074/jbc.RA120.014116

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Enzymology - Molecular Biophysics:

Bosko M Stojanovski,
Leslie A Pelc,
Xiaobing Zuo,
and Enrico Di Cera

Zymogen and activated protein C have similar structural architecture J. Biol. Chem. jbc.RA120.014789. doi:10.1074/jbc.RA120.014789

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Bioenergetics - Gene Regulation:

Laurent Vergnes,
Jason Y Lin,
Graeme R Davies,
Christopher D Church,
and Karen Reue

Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation J. Biol. Chem. jbc.RA120.013322. doi:10.1074/jbc.RA120.013322

August 26, 2020

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Molecular Bases of Disease - Signal Transduction:

Lucas Borges Pereira,
Samantha J. Thomas,
Amanda L. A. Silva,
Paula J. Bartlett,
Andrew P. Thomas,
and Celia R. S. Garcia

The genetic Ca2+ sensor GCaMP3 reveals multiple Ca2+ stores differentially coupled to Ca2+ entry in the human malaria parasite Plasmodium falciparum J. Biol. Chem. jbc.RA120.014906. doi:10.1074/jbc.RA120.014906

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Protein Structure and Folding - Methods and Resources:

Kwabena F.M. Opuni,
Cornelia Koy,
Manuela Russ,
Maren Reepmeyer,
Bright D. Danquah,
Moritz Weresow,
Astrid Alef,
Peter Lorenz,
Hans-Juergen Thiesen,
and Michael O. Glocker

ITEM-THREE analysis of a monoclonal anti-malaria antibody reveals its assembled epitope on the pfMSP119 antigen J. Biol. Chem. jbc.RA120.014802. doi:10.1074/jbc.RA120.014802

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Cell Biology - Signal Transduction:

Fenfen Chen,
Dulguun Amgalan,
Richard N. Kitsis,
Jeffrey E. Pessin,
and Daorong Feng

ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death J. Biol. Chem. jbc.RA120.013999. doi:10.1074/jbc.RA120.013999

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Cell Biology - Protein Structure and Folding:

Ying Xie,
Zhi Yang Loh,
Jiao Xue,
Feng Zhou,
Jialin Sun,
Zhu Qiao,
Shengyang Jin,
Yinyue Deng,
Hongye Li,
Yue Wang,
Lanyuan Lu,
Yong-Gui Gao,
and Yansong Miao

Orchestrated actin nucleation by the Candida albicans polarisome complex enables filamentous growth J. Biol. Chem. jbc.RA120.013890. doi:10.1074/jbc.RA120.013890

August 25, 2020

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Plant Biology:

Keisuke Yoshida,
Kinuka Ohtaka,
Masami Yokota Hirai,
and Toru Hisabori

Biochemical insight into redox regulation of plastidial 3-phosphoglycerate dehydrogenase from Arabidopsis thaliana J. Biol. Chem. jbc.RA120.014263. doi:10.1074/jbc.RA120.014263

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Microbiology:

António T. Pedrosa,
Korinn N Murphy,
Ana T Nogueira,
Amanda J Brinkworth,
Tristan R Thwaites,
Jesse Aaron,
Teng-Leong Chew,
and Rey A. Carabeo

A post-invasion role for Chlamydia type III effector TarP in modulating the dynamics and organization of host cell focal adhesions J. Biol. Chem. jbc.RA120.015219. doi:10.1074/jbc.RA120.015219

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Metabolism - Lipids:

Antonela Lavatelli,
Diego de Mendoza,
and María Cecilia Mansilla

Defining Caenorhabditis elegans as a model system to investigate lipoic acid metabolism J. Biol. Chem. jbc.RA120.013760. doi:10.1074/jbc.RA120.013760

August 24, 2020

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Signal Transduction - Cell Biology:

Anthony O Fedele,
Valérie Carraro,
Jianling Xie,
Julien Averous,
and Christopher G. Proud

Cyclosporin A but not FK506 activates the integrated stress response in human cells J. Biol. Chem. jbc.RA120.014531. doi:10.1074/jbc.RA120.014531

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Signal Transduction - Cell Biology:

Xianlong Gao,
You-Hong Cheng,
Garrett A Enten,
Anthony J DeSantis,
Vadim Gaponenko,
and Matthias Majetschak

Regulation of the thrombin/protease-activated receptor 1 axis by chemokine (C-X-C motif) receptor 4 J. Biol. Chem. jbc.RA120.015355. doi:10.1074/jbc.RA120.015355

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Cell Biology:

Dong Young Kim,
Mi Jin Choi,
Tae Kyung Ko,
Na Hyun Lee,
Ok-Hee Kim,
and Hyae Gyeong Cheon

Angiotensin AT₁ receptor antagonism by losartan stimulates adipocyte browning via induction of apelin J. Biol. Chem. jbc.RA120.013834. doi:10.1074/jbc.RA120.013834

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August 23, 2020

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RNA - Metabolism:

Elizabeth T. Abshire,
Kelsey L. Hughes,
Rucheng Diao,
Sarah Pearce,
Shreekara Gopalakrishna,
Raymond C. Trievel,
Joanna Rorbach,
Peter L. Freddolino,
and Aaron C. Goldstrohm

Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors J. Biol. Chem. jbc.RA120.012618. doi:10.1074/jbc.RA120.012618

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Cell Biology - RNA:

Kaori Nakazawa,
Yuichi Shichino,
Shintaro Iwasaki,
and Nobuyuki Shiina

Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation J. Biol. Chem. jbc.RA120.012715. doi:10.1074/jbc.RA120.012715

August 21, 2020

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Cell Biology - Membrane Biology:

Xiuping Sun,
Hieng Chiong Tie,
Bing Chen,
and Lei Lu

Glycans function as a Golgi export signal to promote the constitutive exocytic trafficking J. Biol. Chem. jbc.RA120.014476. doi:10.1074/jbc.RA120.014476

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Bioenergetics - Metabolism:

Leon Chang,
Xiaochen Liu,
Christine P Diggle,
John P Boyle,
Philip M. Hopkins,
Marie-Anne Shaw,
and Paul D. Allen

Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia J. Biol. Chem. jbc.RA120.013537. doi:10.1074/jbc.RA120.013537

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Membrane Biology - Protein Synthesis and Degradation:

Eva Zöller,
Janina Laborenz,
Lena Krämer,
Felix Boos,
Markus Räschle,
R. Todd Alexander,
and Johannes M Herrmann

The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor J. Biol. Chem. jbc.RA120.014247. doi:10.1074/jbc.RA120.014247

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Computational Biology - Enzymology:

Serina L. Robinson,
Barbara R. Terlouw,
Megan D. Smith,
Sacha J. Pidot,
Timothy P. Stinear,
Marnix H Medema,
and Lawrence P. Wackett

Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia J. Biol. Chem. jbc.RA120.013528. doi:10.1074/jbc.RA120.013528

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Protein Structure and Folding - Signal Transduction:

Sharidan Brown,
Colin C. Gauvin,
Alexander A. Charbonneau,
Nathaniel Burman,
and C. Martin Lawrence

Csx3 is a cyclic oligonucleotide phosphodiesterase associated with type-III CRISPR-Cas that degrades the second messenger cA4 J. Biol. Chem. jbc.RA120.014099. doi:10.1074/jbc.RA120.014099

August 20, 2020

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Protein Structure and Folding - Glycobiology and Extracellular Matrices:

Haley E. Stubbs,
Barbara A. Bensing,
Izumi Yamakawa,
Pankaj Sharma,
Hai Yu,
Xi Chen,
Paul M. Sullam,
and T. M. Iverson

Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects J. Biol. Chem. jbc.RA120.014177. doi:10.1074/jbc.RA120.014177

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Molecular Biophysics - Protein Structure and Folding:

Suhaila Rahman and
Hassane S. Mchaourab

ATP-dependent interactions of a cargo protein with the transmembrane domain of a polypeptide processing and secretion ABC transporter J. Biol. Chem. jbc.RA120.014934. doi:10.1074/jbc.RA120.014934

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Cell Biology - DNA and Chromosomes:

Hazheen K Shirnekhi,
Jacob A Herman,
Patrick J Paddison,
and Jennifer G. DeLuca

BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis J. Biol. Chem. jbc.RA120.013598. doi:10.1074/jbc.RA120.013598

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Cell Biology - Signal Transduction:

Takashi Yamazoe,
Tomoaki Nagai,
Shinya Umeda,
Yuko Sugaya,
and Kensaku Mizuno

Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling J. Biol. Chem. jbc.RA120.013334. doi:10.1074/jbc.RA120.013334

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Membrane Biology - Neurobiology:

Bettina Kolen,
Daniel Kortzak,
Arne Franzen,
and Christoph Fahlke

An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates J. Biol. Chem. jbc.RA120.013704. doi:10.1074/jbc.RA120.013704

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Membrane Biology - Molecular Biophysics:

Nourdine Chakouri,
Johanna Diaz,
Philemon S Yang,
and Manu Ben-Johny

Ca_V channels reject signaling from a second CaM in eliciting Ca²⁺-dependent feedback regulation J. Biol. Chem. jbc.RA120.013777. doi:10.1074/jbc.RA120.013777

August 19, 2020

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Accelerated Communications - Genomics and Proteomics - Metabolism:

Minervo Perez,
Daniel W. Bak,
Sarah E. Bergholtz,
Daniel R Crooks,
Bhargav Srinivas Arimilli,
Youfeng Yang,
Eranthie Weerapana,
W. Marston Linehan,
and Jordan L. Meier

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite J. Biol. Chem. jbc.AC120.014993. doi:10.1074/jbc.AC120.014993

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Glycobiology and Extracellular Matrices - Signal Transduction:

Shinako Kakuda,
Rachel K. Lopilato,
Atsuko Ito,
and Robert S. Haltiwanger

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2 J. Biol. Chem. jbc.RA120.014407. doi:10.1074/jbc.RA120.014407

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Protein Structure and Folding:

Sachiko Toma Fukai,
Ryota Hibi,
Takao Naganuma,
Makishito Sakai,
Shinya Saijo,
Nobutaka Shimizu,
Michihiro Matsumoto,
and Toshiyuki Shimizu

Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure J. Biol. Chem. jbc.RA120.013431. doi:10.1074/jbc.RA120.013431

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Plant Biology:

Mark F Fisher,
Colton D Payne,
Thaveshini Chetty,
Darren M. Crayn,
Oliver Berkowitz,
James Whelan,
K. Johan Rosengren,
and Joshua S. Mylne

The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides J. Biol. Chem. jbc.RA120.014781. doi:10.1074/jbc.RA120.014781

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Immunology - Gene Regulation:

Vincent Peng,
Constantin Georgescu,
Anna Bakowska,
Aneta Pankow,
Liangyue Qian,
Jonathan D. Wren,
and Xiao-Hong Sun

E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem. jbc.RA120.013806. doi:10.1074/jbc.RA120.013806

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Microbiology - Molecular Bases of Disease:

Sizhu Duan,
Shiqi Wang,
Yanan Song,
Nan Gao,
Lina Meng,
Yanxin Gai,
Ying Zhang,
Song Wang,
Chu Wang,
Bin Yu,
Jiaxin Wu,
and Xianghui Yu

A novel HIV-1 inhibitor that blocks viral replication and rescues APOBEC3s by interrupting Vif/CBFβ interaction J. Biol. Chem. jbc.RA120.013404. doi:10.1074/jbc.RA120.013404

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Molecular Biophysics - Protein Structure and Folding:

Marieke J Bloemink,
Karen H Hsu,
Michael A Geeves,
and Sanford I Bernstein

Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain J. Biol. Chem. jbc.RA120.014684. doi:10.1074/jbc.RA120.014684

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Protein Structure and Folding - Bioenergetics:

Shashank Ranjan Srivastava and
Radhakrishnan Mahalakshmi

Evolutionary selection of a 19-stranded mitochondrial β-barrel scaffold bears structural and functional significance J. Biol. Chem. jbc.RA120.014366. doi:10.1074/jbc.RA120.014366

August 18, 2020

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Enzymology - Molecular Biophysics:

Akihiko Nakamura,
Daiki Ishiwata,
Akasit Visootsat,
Taku Uchiyama,
Kenji Mizutani,
Satoshi Kaneko,
Takeshi Murata,
Kiyohiko Igarashi,
and Ryota Iino

Domain architecture divergence leads to functional divergence in binding and catalytic domains of bacterial and fungal cellobiohydrolases J. Biol. Chem. jbc.RA120.014792. doi:10.1074/jbc.RA120.014792

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Glycobiology and Extracellular Matrices - Membrane Biology:

Lilian Stapane,
Nathalie Le Roy,
Jacky Ezagal,
Alejandro B. Rodriguez-Navarro,
Valérie Labas,
Lucie Combes-Soia,
Maxwell T. Hincke,
and Joël Gautron

Avian eggshell formation reveals a new paradigm for vertebrate mineralization via vesicular amorphous calcium carbonate. J. Biol. Chem. jbc.RA120.014542. doi:10.1074/jbc.RA120.014542

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Glycobiology and Extracellular Matrices - Lipids:

Gun-Hee Lee,
Morihisa Fujita,
Hideki Nakanishi,
Haruhiko Miyata,
Masahito Ikawa,
Yusuke Maeda,
Yoshiko Murakami,
and Taroh Kinoshita

PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins J. Biol. Chem. jbc.RA120.014643. doi:10.1074/jbc.RA120.014643

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August 17, 2020

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JBC Reviews - Plant Biology:

Adam R Bentham,
Juan Carlos De la Concepcion,
Nitika Mukhi,
Rafał Zdrzałek,
Markus Draeger,
Danylo Gorenkin,
Richard K. Hughes,
and Mark J. Banfield

A molecular roadmap to the plant immune system J. Biol. Chem. jbc.REV120.010852. doi:10.1074/jbc.REV120.010852

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JBC Reviews - Cell Biology:

Filip Zmuda and
Luke H. Chamberlain

Regulatory Effects of Post-Translational Modifications on zDHHC S-acyltransferases J. Biol. Chem. jbc.REV120.014717. doi:10.1074/jbc.REV120.014717

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Protein Structure and Folding:

Wei He,
Jiayin Zhang,
Veronika Sachsenhauser,
Lili Wang,
James C. A. Bardwell,
and Shu Quan

Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity J. Biol. Chem. jbc.RA119.012300. doi:10.1074/jbc.RA119.012300

August 14, 2020

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Methods and Resources - Signal Transduction:

Martin J. Baker,
Mariana Cooke,
Gabriel Kreider-Letterman,
Rafael Garcia-Mata,
Paul A Janmey,
and Marcelo G. Kazanietz

Evaluation of active Rac1 levels in cancer cells: a case of misleading conclusions from immunofluorescence analysis J. Biol. Chem. jbc.RA120.013919. doi:10.1074/jbc.RA120.013919

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Protein Synthesis and Degradation - Molecular Bases of Disease:

Annika N. Boehm,
Johanna Bialas,
Nicola Catone,
Almudena Sacristán-Reviriego,
Jacqueline van der Spuy,
Marcus Groettrup,
and Annette Aichem

The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation J. Biol. Chem. jbc.RA120.013873. doi:10.1074/jbc.RA120.013873

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Immunology - Protein Structure and Folding:

Wael Awad,
Erin W. Meermeier,
Maria L. Sandoval-Romero,
Jerome Le Nours,
Aneta H. Worley,
Megan D. Null,
Ligong Liu,
James McCluskey,
David P Fairlie,
David M. Lewinsohn,
and Jamie Rossjohn

Atypical TRAV1-2- T cell receptor recognition of the antigen-presenting molecule MR1 J. Biol. Chem. jbc.RA120.015292. doi:10.1074/jbc.RA120.015292

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Glycobiology and Extracellular Matrices - Microbiology:

John F Kelly,
Evgeny Vinogradov,
Jacek Stupak,
Anna C Robotham,
Susan M Logan,
Alison Berezuk,
Cezar M Khursigara,
and Ken Jarrell

Identification of a novel N-linked glycan on the Archaellins and S-layer protein of the thermophilic methanogen, Methanothermococcus thermolithotrophicus J. Biol. Chem. jbc.RA120.012790. doi:10.1074/jbc.RA120.012790

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JBC Reviews - RNA - DNA and Chromosomes:

Tina Y. Liu and
Jennifer A. Doudna

Chemistry of Class 1 CRISPR-Cas effectors: binding, editing, and regulation J. Biol. Chem. jbc.REV120.007034. doi:10.1074/jbc.REV120.007034

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Methods and Resources - Molecular Bases of Disease:

Charlotta Preger,
Edvard Wigren,
Elena Ossipova,
Carolyn Marks,
Johan Lengqvist,
Camilla Hofström,
Oskar Andersson,
Per-Johan Jakobsson,
Susanne Gräslund,
and Helena Persson

Generation and validation of recombinant antibodies to study human aminoacyl tRNA synthetases J. Biol. Chem. jbc.RA120.012893. doi:10.1074/jbc.RA120.012893

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Protein Structure and Folding:

Stepan S. Denisov,
Mercedes Ramírez-Escudero,
Alexandra C.A. Heinzmann,
Johannes H. Ippel,
Philip E Dawson,
Rory R. Koenen,
Tilman M. Hackeng,
Bert J.C. Janssen,
and Ingrid Dijkgraaf

Structural characterization of anti-CCL5 activity of the tick salivary protein Evasin-4 J. Biol. Chem. jbc.RA120.013891. doi:10.1074/jbc.RA120.013891

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DNA and Chromosomes:

Anh Ha,
Yunfeng Lin,
and Shan Yan

A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage J. Biol. Chem. jbc.RA120.014228. doi:10.1074/jbc.RA120.014228

August 13, 2020

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RNA - Cell Biology:

Santi Mestre-Fos,
Chieri Ito,
Courtney M. Moore,
Amit R. Reddi,
and Loren Dean Williams

Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability J. Biol. Chem. jbc.RA120.014332. doi:10.1074/jbc.RA120.014332

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Immunology - Microbiology:

Sweety Samal,
Tripti Shrivastava,
Praveen Sonkusre,
Zaigham Abbas Rizvi,
Rajesh Kumar,
Shubbir Ahmed,
Preeti Vishwakarma,
Naveen Yadav,
Manish Bansal,
Kanchana Chauhan,
Sebanta Pokhrel,
Supratik Das,
Padmakar Tambare,
and Amit Awasthi

Tetramerizing tGCN4 Domain Facilitates Production of Influenza A H1N1 M2e Higher Order Soluble Oligomers that Show Enhanced Immunogenicity In vivo J. Biol. Chem. jbc.RA120.013233. doi:10.1074/jbc.RA120.013233

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Molecular Bases of Disease - Methods and Resources:

Silvia Nitschke,
Sara Petkovic,
Saija Ahonen,
Berge A. Minassian,
and Felix Nitschke

Sensitive quantification of α-glucans in mouse tissues, cell cultures, and human cerebrospinal fluid J. Biol. Chem. jbc.RA120.015061. doi:10.1074/jbc.RA120.015061

Abstract
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Glycobiology and Extracellular Matrices - Immunology:

Mariano Malamud,
Gustavo Cavallero,
Adriana C Casabuono,
Bernd Lepenies,
María de los Angeles Serradell,
and Alicia S. Couto

Immunostimulation by Lactobacillus kefiri S-layer proteins with distinct glycosylation patterns requires different lectin partners J. Biol. Chem. jbc.RA120.013934. doi:10.1074/jbc.RA120.013934

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RNA - Molecular Bases of Disease:

Samantha Sarni,
Banhi Biswas,
Shuohui Liu,
Erik D Olson,
Jonathan P Kitzrow,
Alan Rein,
Vicki H. Wysocki,
and Karin Musier-Forsyth

HIV-1 Gag protein with or without p6 specifically dimerizes on the viral RNA packaging signal J. Biol. Chem. jbc.RA120.014835. doi:10.1074/jbc.RA120.014835

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JBC Reviews - Metabolism - Methods and Resources:

Ankit M. Shah and
Fredric E. Wondisford

Tracking the carbons supplying gluconeogenesis J. Biol. Chem. jbc.REV120.012758. doi:10.1074/jbc.REV120.012758

Abstract
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August 12, 2020

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JBC Reviews - Plant Biology - Protein Synthesis and Degradation:

Katrina J Linden and
Judy Callis

The ubiquitin system affects agronomic plant traits J. Biol. Chem. jbc.REV120.011303. doi:10.1074/jbc.REV120.011303

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DNA and Chromosomes - Protein Structure and Folding:

Janani Prahlad,
Yifeng Yuan,
Jiusheng Lin,
Chou-Wei Chang,
Dirk Iwata-Reuyl,
Yilun Liu,
Valérie de Crécy-Lagard,
and Mark A. Wilson

The DUF328 family member YaaA is a DNA-binding protein with a novel fold J. Biol. Chem. jbc.RA120.015055. doi:10.1074/jbc.RA120.015055

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JBC Reviews - Microbiology - Protein Structure and Folding:

Emmanuelle V. LeBlanc,
Elizabeth J. Polvi,
Amanda O. Veri,
Gilbert G. Privé,
and Leah E. Cowen

Structure-guided approaches to targeting stress responses in human fungal pathogens J. Biol. Chem. jbc.REV120.013731. doi:10.1074/jbc.REV120.013731

Abstract
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JBC Reviews - Metabolism - Molecular Bases of Disease:

Rachel J. Perry and
Gerald I. Shulman

Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks J. Biol. Chem. jbc.REV120.008387. doi:10.1074/jbc.REV120.008387

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Signal Transduction - Immunology:

Zhaoqing Hu,
Lin Li,
Banghui Zhu,
Yi Huang,
Xinran Wang,
Xiaolei Lin,
Maoxia Li,
Peipei Xu,
Xuerui Zhang,
Jing Zhang,
and Zichun Hua

Annexin A5 is essential for PKCθ translocation during T-cell activation J. Biol. Chem. jbc.RA120.015143. doi:10.1074/jbc.RA120.015143

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Cell Biology:

Songbo Xie,
Linlin Zhang,
Dan Dong,
Ruixin Ge,
Qianqian He,
Cunxian Fan,
Wei Xie,
Jun Zhou,
Dengwen Li,
and Min Liu

HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21 J. Biol. Chem. jbc.RA119.011006. doi:10.1074/jbc.RA119.011006

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Immunology - Signal Transduction:

Timo Oosenbrug,
Michel J. van de Graaff,
Mariëlle C. Haks,
Sander van Kasteren,
and Maaike E. Ressing

An alternative model for type I interferon induction downstream of human TLR2 J. Biol. Chem. jbc.RA120.015283. doi:10.1074/jbc.RA120.015283

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DNA and Chromosomes - RNA:

Olga M Mazina,
Srinivas Somarowthu,
Lyudmila Y. Kadyrova,
Andrey G. Baranovskiy,
Tahir H. Tahirov,
Farid A Kadyrov,
and Alexander V. Mazin

Replication protein A binds RNA and promotes R-loop formation J. Biol. Chem. jbc.RA120.013812. doi:10.1074/jbc.RA120.013812

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Enzymology - Protein Structure and Folding:

Soon Goo Lee,
Kate Harline,
Orchid Abar,
Sakirat O. Akadri,
Alexander G. Bastian,
Hui-Yuan S. Chen,
Michael Duan,
Caroline M. Focht,
Amanda R. Groziak,
Jesse Kao,
Jagdeesh S. Kottapalli,
Matthew C. Leong,
Joy J. Lin,
Regina Liu,
Joanna E. Luo,
Christine M. Meyer,
Albert F. Mo,
Seong Ho Pahng,
Vinay Penna,
Chris D. Raciti,
Abhinav Srinath,
Shwetha Sudhakar,
Joseph D. Tang,
Brian R. Cox,
Cynthia K. Holland,
Barrie Cascella,
Wilhelm Cruz,
Sheri A. McClerklin,
Barbara N. Kunkel,
and Joseph M. Jez

The plant pathogen enzyme AldC is a long-chain aliphatic aldehyde dehydrogenase J. Biol. Chem. jbc.RA120.014747. doi:10.1074/jbc.RA120.014747

August 11, 2020

August 7, 2020

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Molecular Bases of Disease:

Qin Cao,
Daniel H Anderson,
Wilson Y. Liang,
Joshua A Chou,
and Lorena Saelices

The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin J. Biol. Chem. jbc.RA120.013440. doi:10.1074/jbc.RA120.013440

August 6, 2020

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Signal Transduction - Cell Biology:

Chi Ben,
Xiaojing Wu,
Atsushi Takahashi-Kanemitsu,
Christopher Takaya Knight,
Takeru Hayashi,
and Masanori Hatakeyama

Alternative splicing reverses the cell-intrinsic and cell-extrinsic prooncogenic potentials of YAP1 J. Biol. Chem. jbc.RA120.013820. doi:10.1074/jbc.RA120.013820

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DNA and Chromosomes - RNA:

Eduardo E Laverde,
Yanhao Lai,
Fenfei Leng,
Lata Balakrishnan,
Catherine H Freudenreich,
and Yuan Liu

R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities J. Biol. Chem. jbc.RA120.014161. doi:10.1074/jbc.RA120.014161

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Glycobiology and Extracellular Matrices - Cell Biology:

Ayodele Akintayo,
Joshua Mayoral,
Masahiro Asada,
Jian Tang,
Subha Sundaram,
and Pamela Stanley

Point Mutations that Inactivate MGAT4D-L, an Inhibitor of MGAT1 and Complex N-Glycan Synthesis J. Biol. Chem. jbc.RA120.014784. doi:10.1074/jbc.RA120.014784

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Glycobiology and Extracellular Matrices - Cell Biology:

Katie L Alexander,
Carolina A Serrano,
Asmi Chakraborty,
Marie Nearing,
Leona N Council,
Arnoldo Riquelme,
Marcelo Garrido,
Susan L. Bellis,
Lesley E Smythies,
and Phillip D Smith

Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover J. Biol. Chem. jbc.RA120.014887. doi:10.1074/jbc.RA120.014887

Abstract
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Cell Biology - DNA and Chromosomes:

Bhavika Nagareddy,
Arafat Khan,
and Hyungjin Kim

Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation J. Biol. Chem. jbc.RA120.015288. doi:10.1074/jbc.RA120.015288

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Microbiology:

Min Zheng,
Evan Peter Williams,
R. K. Subbarao Malireddi,
Rajendra Karki,
Balaji Banoth,
Amanda Burton,
Richard Webby,
Rudragouda Channappanavar,
Colleen Beth Jonsson,
and Thirumala-Devi Kanneganti

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection J. Biol. Chem. jbc.RA120.015036. doi:10.1074/jbc.RA120.015036

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JBC Reviews - Signal Transduction - Protein Structure and Folding:

Alexander Vizurraga,
Rashmi Adhikari,
Jennifer Yeung,
Maiya Yu,
and Gregory G Tall

Mechanisms of Adhesion G protein Coupled Receptor Activation J. Biol. Chem. jbc.REV120.007423. doi:10.1074/jbc.REV120.007423

August 5, 2020

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Gene Regulation - RNA:

Kathrin Bajak,
Kevin Leiss,
Christine Clayton,
and Esteban Erben

A potential role for a novel ZC3H5 complex in regulating mRNA translation in Trypanosoma brucei J. Biol. Chem. jbc.RA120.014346. doi:10.1074/jbc.RA120.014346

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Molecular Bases of Disease - Neurobiology:

Shotaro Shimonaka,
Shin-Ei Matsumoto,
Montasir Elahi,
Koichi Ishiguro,
Masato Hasegawa,
Nobutaka Hattori,
and Yumiko Motoi

Asparagine residue 368 is involved in Alzheimer’s disease tau strain-specific aggregation J. Biol. Chem. jbc.RA120.013271. doi:10.1074/jbc.RA120.013271

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Developmental Biology - Gene Regulation:

Jeong Su Byun,
Mihee Oh,
Seonha Lee,
Jung-Eun Gil,
Yeajin Mo,
Bonsu Ku,
Won Kon Kim,
Kyoung-Jin Oh,
Eun-Woo Lee,
Kwang-Hee Bae,
Sang Chul Lee,
and Baek-Soo Han

The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene J. Biol. Chem. jbc.RA120.013352. doi:10.1074/jbc.RA120.013352

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Cell Biology - Molecular Bases of Disease:

Avishek Prasai,
Marketa Schmidt Cernohorska,
Klara Ruppova,
Veronika Niederlova,
Monika Andelova,
Peter Draber,
Ondrej Stepanek,
and Martina Huranova

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells J. Biol. Chem. jbc.RA120.013905. doi:10.1074/jbc.RA120.013905

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Microbiology:

Stephanie Willing,
Emma Dyer,
Olaf Schneewind,
and Dominique Missiakas

FmhA and FmhC of Staphylococcus aureus incorporate serine residues into peptidoglycan crossbridges J. Biol. Chem. jbc.RA120.014371. doi:10.1074/jbc.RA120.014371

Abstract
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RNA - Lipids:

Cuiying Chen,
Shuqi Wang,
Yu Hu,
Mei Zhang,
Xianda He,
Cuihong You,
Xiaobo Wen,
Oscar Monroig,
Douglas R. Tocher,
and Yuanyou Li

miR-26a mediates LC-PUFA biosynthesis by targeting the Lxrα-Srebp1 pathway in the marine teleost Siganus canaliculatus J. Biol. Chem. jbc.RA120.014858. doi:10.1074/jbc.RA120.014858

August 4, 2020

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Signal Transduction - Molecular Biophysics:

Ya Zhuo,
Vsevolod V. Gurevich,
Sergey A Vishnivetskiy,
Candice S Klug,
and Adriano Marchese

A non-GPCR binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling J. Biol. Chem. jbc.RA120.015074. doi:10.1074/jbc.RA120.015074

Abstract
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Signal Transduction:

Michael W. Boesgaard,
Kasper Harpsøe,
Michelle Malmberg,
Christina R. Underwood,
Asuka Inoue,
Jesper M. Mathiesen,
Gabriele M. König,
Evi Kostenis,
David E Gloriam,
and Hans Bräuner-Osborne

Delineation of molecular determinants for FR900359 inhibition of G_q/11 unlocks inhibition of Gα_s J. Biol. Chem. jbc.RA120.013002. doi:10.1074/jbc.RA120.013002

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DNA and Chromosomes:

Xiuhua Liu,
Rong Xie,
Lily L. Yu,
Shih-Hsun Chen,
Xiaoyun Yang,
Anup K. Singh,
Hongzhi Li,
Chen Wu,
and Xiaochun Yu

AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair J. Biol. Chem. jbc.RA120.012801. doi:10.1074/jbc.RA120.012801

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Enzymology - Cell Biology:

Hope Gloria Umutesi,
Hanh My Hoang,
Hope Elizabeth Johnson,
Kwangho Nam,
and Jongyun Heo

Development of Noonan syndrome by deregulation of allosteric SOS autoactivation J. Biol. Chem. jbc.RA120.013275. doi:10.1074/jbc.RA120.013275

August 3, 2020

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Microbiology - Molecular Bases of Disease:

Georg Dultz,
Tetsuro Shimakami,
Markus Schneider,
Kazuhisa Murai,
Daisuke Yamane,
Antoine Marion,
Tobias M Zeitler,
Claudia Stross,
Christian Grimm,
Rebecca M Richter,
Katrin Bäumer,
MinKyung Yi,
Ricardo M Biondi,
Stefan Zeuzem,
Robert Tampé,
Iris Antes,
Christian M Lange,
and Christoph Welsch

Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors J. Biol. Chem. jbc.RA120.013898. doi:10.1074/jbc.RA120.013898

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Bioenergetics - Metabolism:

Cody D. Smith,
Cameron A. Schmidt,
Chien-Te Lin,
Kelsey H. Fisher-Wellman,
and P. Darrell Neufer

Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure J. Biol. Chem. jbc.RA120.013899. doi:10.1074/jbc.RA120.013899

Abstract
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Neurobiology - Computational Biology:

Jan-Niklas Dohrke,
Jake F Watson,
Kristian Birchall,
and Ingo H Greger

Characterising the binding and function of TARP γ8-selective AMPA receptor modulators J. Biol. Chem. jbc.RA120.014135. doi:10.1074/jbc.RA120.014135

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Cell Biology - Gene Regulation:

Dongxu Feng,
Xiaomin Kang,
Ruiqi Wang,
He Chen,
Kun Zhang,
Weilou Feng,
Huixia Li,
Yangjun Zhu,
and Shufang Wu

Progranulin modulates cartilage-specific gene expression via sirtuin 1-mediated deacetylation of the transcription factors SOX9 and P65 J. Biol. Chem. jbc.RA119.011164. doi:10.1074/jbc.RA119.011164

July 31, 2020

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Protein Structure and Folding - Enzymology:

Kristiane R Torgeson,
Michael W Clarkson,
Genesan S Kumar,
Rebecca Page,
and Wolfgang Peti

Cooperative dynamics across distinct structural elements regulate PTP1B activity J. Biol. Chem. jbc.RA120.014652. doi:10.1074/jbc.RA120.014652

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Enzymology - Molecular Biophysics:

Elliot I Corless,
Brian Bennett,
and Edwin Antony

Substrate recognition induces sequential electron transfer across subunits in the nitrogenase-like DPOR complex J. Biol. Chem. jbc.RA120.015151. doi:10.1074/jbc.RA120.015151

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Molecular Bases of Disease - Neurobiology:

Jianlan Gu,
Wen Xu,
Nana Jin,
Longfei Li,
Yan Zhou,
Dandan Chu,
Cheng-Xin Gong,
Khalid Iqbal,
and Fei Liu

Truncation of tau selectively facilitates its pathological activities J. Biol. Chem. jbc.RA120.012587. doi:10.1074/jbc.RA120.012587

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Molecular Bases of Disease - Protein Structure and Folding:

Filippa Lo Cascio,
Stephanie Garcia,
Mauro Montalbano,
Nicha Puangmalai,
Salome McAllen,
Andrea Pace,
Antonio Palumbo Piccionello,
and Rakez Kayed

Modulating Disease-Relevant Tau Oligomeric Strains by Small Molecules J. Biol. Chem. jbc.RA120.014630. doi:10.1074/jbc.RA120.014630

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Signal Transduction - Protein Synthesis and Degradation:

Yueli Shi,
Xinyu Wang,
Zhiyong Xu,
Ying He,
Chunyi Guo,
Lingjuan He,
Caijuan Huan,
Changhong Cai,
Jiaqi Huang,
Jie Zhang,
Yiqing Li,
Chunlai Zeng,
Xue Zhang,
Linrun Wang,
Yuehai Ke,
and Hongqiang Cheng

PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells J. Biol. Chem. jbc.RA120.014976. doi:10.1074/jbc.RA120.014976

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JBC Reviews - Enzymology - Metabolism:

Si’Ana A Coggins,
Bijan Mahboubi,
Raymond F. Schinazi,
and Baek Kim

Mechanistic Crosstalk between DNA/RNA Polymerase Enzyme Kinetics and Nucleotide Substrate Availability in Cells: Implications for Polymerase Inhibitor Discovery J. Biol. Chem. jbc.REV120.013746. doi:10.1074/jbc.REV120.013746

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Gene Regulation - Developmental Biology:

Clément Immarigeon,
Sandra Bernat-Fabre,
Emmanuelle Guillou,
Alexis Verger,
Elodie Prince,
Mohamed A. Benmedjahed,
Adeline Payet,
Marie Couralet,
Didier Monte,
Vincent Villeret,
Henri-Marc Bourbon,
and Muriel Boube

Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation in vivo J. Biol. Chem. jbc.RA120.013728. doi:10.1074/jbc.RA120.013728

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Cell Biology - Lipids:

Una L. Kelly,
Daniel Grigsby,
Martha A. Cady,
Michael Landowski,
Nikolai P. Skiba,
Jian Liu,
Alan T. Remaley,
Mikael Klingeborn,
and Catherine Bowes Rickman

High density lipoproteins are a potential therapeutic target for age-related macular degeneration J. Biol. Chem. jbc.RA119.012305. doi:10.1074/jbc.RA119.012305

July 30, 2020

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Molecular Bases of Disease - Signal Transduction:

Soumya Maity,
Falguni Das,
Balakuntalam S. Kasinath,
Nandini Ghosh-Choudhury,
and Goutam Ghosh Choudhury

TGFb acts through PDGFRb to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression J. Biol. Chem. jbc.RA120.014994. doi:10.1074/jbc.RA120.014994

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Signal Transduction:

Paula J Bucko,
Irvin Garcia,
Ridhima Manocha,
Akansha Bhat,
Linda Wordeman,
and John D Scott

Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles J. Biol. Chem. jbc.RA120.014791. doi:10.1074/jbc.RA120.014791

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Cell Biology - Membrane Biology:

Nathan Nguyen,
Taryn J Olivas,
Antonio Mires,
Jiaxin Jin,
Shenliang Yu,
Lin Luan,
Shanta Nag,
Karlina J Kauffman,
and Thomas J Melia

The insufficiency of ATG4A in macroautophagy J. Biol. Chem. jbc.RA120.013897. doi:10.1074/jbc.RA120.013897

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JBC Reviews - Plant Biology - Immunology:

John H. Herlihy,
Terri A. Long,
and John M. McDowell

Iron homeostasis and plant immune responses: recent insights and translational implications J. Biol. Chem. jbc.REV120.010856. doi:10.1074/jbc.REV120.010856

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Protein Structure and Folding:

Sonia Fieulaine,
Martin D. Witte,
Christopher S. Theile,
Maya Ayach,
Hidde L Ploegh,
Isabelle Jupin,
and Stéphane Bressanelli

Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity J. Biol. Chem. jbc.RA120.014628. doi:10.1074/jbc.RA120.014628

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Molecular Bases of Disease - Lipids:

Long Shuang Huang,
Sainath R. Kotha,
Sreedevi Avasarala,
Michelle VanScoyk,
Robert A. Winn,
Arjun Pennathur,
Puttaraju S. Yashaswini,
Mounica Bandela,
Ravi Salgia,
Yulia Y Tyurina,
Valerian E. Kagan,
Xiangdong Zhu,
Sekhar P. Reddy,
Tara Sudhadevi,
Prasanth-Kumar Punathil-Kannan,
Anantha Harijith,
Ramaswamy Ramchandran,
Rama Kamesh Bikkavilli,
and Viswanathan Natarajan

Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics J. Biol. Chem. jbc.RA120.012680. doi:10.1074/jbc.RA120.012680

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Molecular Bases of Disease - Microbiology:

Michael Ditiatkovski,
Nigora Mukhamedova,
Dragana Dragoljevic,
Anh Hoang,
Hann Low,
Tatiana Pushkarsky,
Ying Fu,
Irena Carmichael,
Andrew F Hill,
Andrew J. Murphy,
Michael Bukrinsky,
and Dmitri Sviridov

Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of APP and Tau causing neuronal dysfunction J. Biol. Chem. jbc.RA120.014642. doi:10.1074/jbc.RA120.014642

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July 29, 2020

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Cell Biology:

Kentaro Nakamura,
Tatsuro Noguchi,
Mariko Takahara,
Yoshihiro Omori,
Takahisa Furukawa,
Yohei Katoh,
and Kazuhisa Nakayama

Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the IFT machinery is required for intraciliary retrograde protein trafficking J. Biol. Chem. jbc.RA120.014142. doi:10.1074/jbc.RA120.014142

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Metabolism - Molecular Bases of Disease:

Subhashis Banerjee,
Sarbani Ghoshal,
Joseph R. Stevens,
Kyle S McCommis,
Su Gao,
Mauricio Castro-Sepulveda,
Maria L Mizgier,
Clemence Girardet,
K Ganesh Kumar,
Jose E Galgani,
Michael L. Niehoff,
Susan A Farr,
Jinsong Zhang,
and Andrew A. Butler

Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction J. Biol. Chem. jbc.RA120.014381. doi:10.1074/jbc.RA120.014381

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Signal Transduction - Molecular Biophysics:

Patrick O. Byrne,
Kalina Hristova,
and Daniel J. Leahy

EGFR forms ligand-independent oligomers that are distinct from the active state J. Biol. Chem. jbc.RA120.012852. doi:10.1074/jbc.RA120.012852

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Signal Transduction - Computational Biology:

Suzu Endo,
Akiko Suganami,
Keijo Fukushima,
Kanaho Senoo,
Yumi Araki,
John W Regan,
Masato Mashimo,
Yutaka Tamura,
and Hiromichi Fujino

15-keto-PGE₂acts as a biased/partial agonist to terminate PGE₂-evoked signaling J. Biol. Chem. jbc.RA120.013988. doi:10.1074/jbc.RA120.013988

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Molecular Bases of Disease - Microbiology:

Charles Schaub,
Joseph Verdi,
Penny Lee,
Nada Terra,
Gina Limon,
Jayne Raper,
and Russell Thomson

Cation channel conductance and pH gating of the innate immunity factor APOL1 is governed by pore lining residues within the C-terminal domain J. Biol. Chem. jbc.RA120.014201. doi:10.1074/jbc.RA120.014201

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Protein Structure and Folding - Metabolism:

Luca Martinelli,
Athanassios Adamopoulos,
Patrik Johansson,
Paul T. Wan,
Jenny Gunnarsson,
Hongwei Guo,
Helen Boyd,
Noam Zelcer,
and Titia K. Sixma

Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate binding site J. Biol. Chem. jbc.RA120.014349. doi:10.1074/jbc.RA120.014349

July 28, 2020

July 27, 2020

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Microbiology - Immunology:

Geon-Woo Kim,
Hasan Imam,
Mohsin Khan,
and Aleem Siddiqui

N6-Methyladenosine Modification of Hepatitis B and C Viral RNAs Attenuates Host Innate Immunity via RIG-I Signaling J. Biol. Chem. jbc.RA120.014260. doi:10.1074/jbc.RA120.014260

July 24, 2020

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Cell Biology - Molecular Bases of Disease:

Kangdi Li,
Ting Liu,
Jie Chen,
Huying Ni,
and Wenhua Li

Survivin in breast cancer-derived exosomes activates fibroblasts by upregulating SOD1, whose feedback promotes cancer proliferation and metastasis J. Biol. Chem. jbc.RA120.013805. doi:10.1074/jbc.RA120.013805

July 23, 2020

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Microbiology - Metabolism:

Lucas Pagura,
Evelyn Tevere,
Marcelo L Merli,
and Julia A. Cricco

A new model for Trypanosoma cruzi heme homeostasis depends on modulation of TcHTE protein expression J. Biol. Chem. jbc.RA120.014574. doi:10.1074/jbc.RA120.014574

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Molecular Bases of Disease - Glycobiology and Extracellular Matrices:

Saori Miura,
Akiomi Yoshihisa,
Tomofumi Misaka,
Takayoshi Yamaki,
Takao Kojima,
Masahiro Toyokawa,
Kazuei Ogawa,
Hiroki Shimura,
Naomasa Yamamoto,
Kohji Kasahara,
Yasuchika Takeishi,
and Shinobu Kitazume

Amyloid precursor protein 770 is specifically expressed and released from platelets J. Biol. Chem. jbc.RA120.012904. doi:10.1074/jbc.RA120.012904

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Signal Transduction - Cell Biology:

Tao Wang,
Samuel Young,
Henrike Krenz,
Frank Tüttelmann,
Albrecht Röpke,
Claudia Krallmann,
Sabine Kliesch,
Xu-Hui Zeng,
Christoph Brenker,
and Timo Strünker

The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA J. Biol. Chem. jbc.RA120.013218. doi:10.1074/jbc.RA120.013218

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Cell Biology - Signal Transduction:

Yubo Cao,
Sahil Kumar,
Yoon Namkung,
Laurence Gagnon,
Aaron Cho,
and Stéphane A. Laporte

Angiotensin II type 1 receptor variants alter endosomal receptor–β-arrestin complex stability and MAPK activation J. Biol. Chem. jbc.RA120.014330. doi:10.1074/jbc.RA120.014330

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Molecular Biophysics - Membrane Biology:

Jessica E. Besaw,
Wei-Lin Ou,
Takefumi Morizumi,
Bryan T. Eger,
Juan D. Sanchez Vasquez,
Jessica H. Y. Chu,
Andrew Harris,
Leonid S. Brown,
R. J. Dwayne Miller,
and Oliver P. Ernst

The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants J. Biol. Chem. jbc.RA120.014118. doi:10.1074/jbc.RA120.014118

July 22, 2020

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JBC Reviews - Microbiology - Gene Regulation:

Brenna J.C. Walsh and
David P. Giedroc

H2S and reactive sulfur signaling at the host bacterial pathogen interface J. Biol. Chem. jbc.REV120.011304. doi:10.1074/jbc.REV120.011304

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JBC Reviews - Cell Biology - DNA and Chromosomes:

Xing Liu,
Xu Liu,
Haowei Wang,
Zhen Dou,
Ke Ruan,
Donald L Hill,
Lin Li,
Yunyu Shi,
and Xuebiao Yao

Phase separation drives decision making in cell division J. Biol. Chem. jbc.REV120.011746. doi:10.1074/jbc.REV120.011746

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Microbiology:

Felice D. Kelly,
Khoa D. Tran,
Jess Hatfield,
Kat Schmidt,
Marco A. Sanchez,
and Scott M. Landfear

A Cytoskeletal Protein Complex is Essential for Division of Intracellular Amastigotes of Leishmania mexicana J. Biol. Chem. jbc.RA120.014065. doi:10.1074/jbc.RA120.014065

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Membrane Biology - Plant Biology:

Pengchao Hao,
Jian Xia,
Jie Liu,
Martin di Donato,
Konrad Pakula,
Aurélien Bailly,
Michał Jasiński,
and Markus Geisler

Auxin-transporting ABC transporters are defined by a conserved D/E-P motif regulated by a prolylisomerase J. Biol. Chem. jbc.RA120.014104. doi:10.1074/jbc.RA120.014104

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Neurobiology - Molecular Bases of Disease:

Antigoni Katsikoudi,
Elena Ficulle,
Annalisa Cavallini,
Gary Sharman,
Amelie Guyot,
Michele Zagnoni,
Brian J Eastwood,
Michael Hutton,
and Suchira Bose

Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures J. Biol. Chem. jbc.RA120.013325. doi:10.1074/jbc.RA120.013325

July 21, 2020

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Enzymology - Microbiology:

Marco Massmig,
Edward Reijerse,
Joern Krausze,
Christoph Laurich,
Wolfgang Lubitz,
Dieter Jahn,
and Jürgen Moser

Carnitine metabolism in the human gut: Characterization of the two-component carnitine monooxygenase CntAB from Acinetobacter baumannii J. Biol. Chem. jbc.RA120.014266. doi:10.1074/jbc.RA120.014266

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Protein Structure and Folding - Enzymology:

Elfriede Dall,
Florian B Zauner,
Wai Tuck Soh,
Fatih Demir,
Sven O. Dahms,
Chiara Cabrele,
Pitter F. Huesgen,
and Hans Brandstetter

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition J. Biol. Chem. jbc.RA120.014478. doi:10.1074/jbc.RA120.014478

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Protein Structure and Folding:

Line Friis Bakmann Christensen,
Jan Stanislaw Nowak,
Thorbjørn Vincent Sønderby,
Signe Andrea Frank,
and Daniel Erik Otzen

Quantitating denaturation by formic acid: Imperfect repeats are essential to the stability of the functional amyloid protein FapC J. Biol. Chem. jbc.RA120.013396. doi:10.1074/jbc.RA120.013396

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Enzymology - Molecular Biophysics:

Pratik Rajendra Patil,
Neha Vithani,
Virender Singh,
Ashok Kumar,
and Balaji Prakash

A revised mechanism for (p)ppGpp synthesis by Rel proteins: The critical role of the 2’-OH of GTP J. Biol. Chem. jbc.RA120.013636. doi:10.1074/jbc.RA120.013636

July 20, 2020

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Microbiology - Methods and Resources:

Seiya Ozono,
Yanzhao Zhang,
Minoru Tobiume,
Satoshi Kishigami,
and Kenzo Tokunaga

Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag J. Biol. Chem. jbc.RA120.013887. doi:10.1074/jbc.RA120.013887

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Molecular Bases of Disease - Cell Biology:

Panhong Zhang,
Yutao Yang,
Kai Qian,
Lianlian Li,
Cuiping Zhang,
Xiaoyi Fu,
Xiumei Zhang,
Huan Chen,
Qiongqing Liu,
Shengnan Cao,
and Jiajun Cui

A novel tumor suppressor ZBTB1 regulates tamoxifen resistance and aerobic glycolysis through suppressing HER2 expression in breast cancer J. Biol. Chem. jbc.RA119.010759. doi:10.1074/jbc.RA119.010759

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Protein Structure and Folding - Membrane Biology:

Takuto Hayashi,
Keita Oishi,
Midori Kimura,
Kazuko Iida,
and Hidetoshi Iida

Highly conserved extracellular residues mediate interactions between pore-forming and regulatory subunits of the yeast Ca2+ channel related to the animal VGCC/NALCN family J. Biol. Chem. jbc.RA120.014378. doi:10.1074/jbc.RA120.014378

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JBC Reviews - Enzymology - Microbiology:

Raphaël Billot,
Laure Plener,
Pauline Jacquet,
Mikael Elias,
Eric Chabrière,
and David Daudé

Engineering Acyl-Homoserine Lactone-Interfering Enzymes Towards Bacterial Control J. Biol. Chem. jbc.REV120.013531. doi:10.1074/jbc.REV120.013531

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Molecular Bases of Disease - Cell Biology:

Xinlei Yao,
Kun Li,
Chen Liang,
Zilong Zhou,
Jiao Wang,
Shuyue Wang,
Lei Liu,
Chun-Lei Yu,
Zhen-Bo Song,
Yong-Li Bao,
Li-Hua Zheng,
Ying Sun,
Guannan Wang,
Yanxin Huang,
Jingwen Yi,
Luguo Sun,
and Yuxin Li

Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress J. Biol. Chem. jbc.RA120.012849. doi:10.1074/jbc.RA120.012849

July 19, 2020

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Cell Biology - Signal Transduction:

Marc R Block,
Molly Brunner,
Théo Ziegelmeyer,
Dominique Lallemand,
Mylène Pezet,
Genevieve Chevalier,
Philippe Rondé,
Cecile Gauthier-Rouviere,
Bernhard Wehrle-Haller,
and Daniel Bouvard

The mechano-sensitive response of β1 integrin promotes SRC-positive late endosome recycling and activation of Yes-associated protein J. Biol. Chem. jbc.RA120.013503. doi:10.1074/jbc.RA120.013503

July 18, 2020

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Cell Biology - Signal Transduction:

Kavisha Arora,
John R Lund,
Nevin A Naren,
Basilia Zingarelli,
and Anjaparavanda P. Naren

AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals J. Biol. Chem. jbc.RA120.013703. doi:10.1074/jbc.RA120.013703

July 16, 2020

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Cell Biology - Microbiology:

Kieu T. M. Pham,
Huiqing Hu,
and Ziyin Li

Maintenance of hook complex integrity and centrin arm assembly facilitates flagellum inheritance in Trypanosoma brucei J. Biol. Chem. jbc.RA120.014237. doi:10.1074/jbc.RA120.014237

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Cell Biology - DNA and Chromosomes:

Soichiro S. Ito,
Yosuke Nakagawa,
Masaya Matsubayashi,
Yoshihiko M. Sakaguchi,
Shinko Kobashigawa,
Takeshi K. Matsui,
Hitoki Nanaura,
Mari Nakanishi,
Fumika Kitayoshi,
Sotaro Kikuchi,
Atsuhisa Kajihara,
Shigehiro Tamaki,
Kazuma Sugie,
Genro Kashino,
Akihisa Takahashi,
Masatoshi Hasegawa,
Eiichiro Mori,
and Tadaaki Kirita

Inhibition of the ATR kinase enhances 5-FU sensitivity independently of non-homologous end-joining and homologous recombination repair pathways J. Biol. Chem. jbc.RA120.013726. doi:10.1074/jbc.RA120.013726

July 15, 2020

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Enzymology - Microbiology:

Andrew Bell,
Emmanuele Severi,
Micah O Lee,
Serena Monaco,
Dimitrios Latousakis,
Jesus Angulo,
Gavin H. Thomas,
James Naismith,
and Nathalie Juge

Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria J. Biol. Chem. jbc.RA120.014454. doi:10.1074/jbc.RA120.014454

July 14, 2020

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Signal Transduction - Immunology:

Simon Borna,
Matej Fabisik,
Kristyna Ilievova,
Tomas Dvoracek,
and Tomas Brdicka

Mechanisms determining a differential threshold for sensing Src family kinase activity by B and T cell antigen receptors J. Biol. Chem. jbc.RA120.013552. doi:10.1074/jbc.RA120.013552

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Molecular Biophysics - Microbiology:

Alexander E. Yarawsky and
Andrew B. Herr

The staphylococcal biofilm protein Aap forms a tetrameric species as a necessary intermediate before amyloidogenesis J. Biol. Chem. jbc.RA120.013936. doi:10.1074/jbc.RA120.013936

July 13, 2020

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JBC Reviews - Molecular Bases of Disease:

Ella Hartenian,
Divya Nandakumar,
Azra Lari,
Michael Ly,
Jessica M. Tucker,
and Britt A. Glaunsinger

The molecular virology of Coronaviruses J. Biol. Chem. jbc.REV120.013930. doi:10.1074/jbc.REV120.013930

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July 10, 2020

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Molecular Biophysics - Computational Biology:

Xiaoli Zhao,
Jenny (Jingxin) Tian,
Hua Yu,
Brian C. Bryksa,
John H. Dupuis,
Xiuyuan Ou,
Zhaohui Qian,
Chen Song,
Shenlin Wang,
and Rickey Y. Yada

Insights into the mechanism of membrane fusion induced by the plant defense element, Plant Specific Insert J. Biol. Chem. jbc.RA120.014311. doi:10.1074/jbc.RA120.014311

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Cell Biology - Molecular Biophysics:

Zongwei Guo,
Ting Song,
Ziqian Wang,
Donghai Lin,
Keke Cao,
Peng Liu,
Yingang Feng,
Xiaodong Zhang,
Peiran Wang,
and Zhichao Zhang

The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients J. Biol. Chem. jbc.RA120.013364. doi:10.1074/jbc.RA120.013364

June 30, 2020

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Protein Structure and Folding:

Erumbi S Rangarajan,
Marina C Primi,
Lesley A Colgan,
Krishna Chinthalapudi,
Ryohei Yasuda,
and Tina Izard

A distinct talin2 structure directs isoform specificity in cell adhesion J. Biol. Chem. jbc.RA119.010789. doi:10.1074/jbc.RA119.010789

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