Minireviews

Stephen M. Prescott

A Thematic Series on Kinases and Phosphatases That Regulate Lipid Signaling
J. Biol. Chem. 1999 274: 8345-8346. [Full Text] [PDF]  

Lucia E. Rameh and Lewis C. Cantley

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
J. Biol. Chem. 1999 274: 8347-8350. [Full Text] [PDF]  

Communications

Kathleen M. Holtz, Boguslaw Stec, and Evan R. Kantrowitz

A Model of the Transition State in the Alkaline Phosphatase Reaction
J. Biol. Chem. 1999 274: 8351-8354. [Abstract] [Full Text] [PDF]  

Quan Zhao and Frank S. Lee

Mitogen-activated Protein Kinase/ERK Kinase Kinases 2 and 3 Activate Nuclear Factor-B through IB Kinase- and IB Kinase-
J. Biol. Chem. 1999 274: 8355-8358. [Abstract] [Full Text] [PDF]  

Henning R. Stennicke, Quinn L. Deveraux, Eric W. Humke, John C. Reed, Vishva M. Dixit, and Guy S. Salvesen

Caspase-9 Can Be Activated without Proteolytic Processing
J. Biol. Chem. 1999 274: 8359-8362. [Abstract] [Full Text] [PDF]  

Nadia Cervoni, Sanjoy Bhattacharya, and Moshe Szyf

DNA Demethylase Is a Processive Enzyme
J. Biol. Chem. 1999 274: 8363-8366. [Abstract] [Full Text] [PDF]  

Torsten Crass, Robert S. Ames, Henry M. Sarau, Mark A. Tornetta, James J. Foley, Jörg Köhl, Andreas Klos, and Wilfried Bautsch

Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88)
J. Biol. Chem. 1999 274: 8367-8370. [Abstract] [Full Text] [PDF]  

Ronit Vogt Sionov, Eli Moallem, Michael Berger, Anat Kazaz, Offer Gerlitz, Yinon Ben-Neriah, Moshe Oren, and Ygal Haupt

c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53
J. Biol. Chem. 1999 274: 8371-8374. [Abstract] [Full Text] [PDF]  

Joost G. J. Hoenderop, Annemiete W. C. M. van der Kemp, Anita Hartog, Stan F. J. van de Graaf, Carel H. van Os, Peter H. G. M. Willems, and René J. M. Bindels

Molecular Identification of the Apical Ca²⁺ Channel in 1,25-Dihydroxyvitamin D₃-responsive Epithelia
J. Biol. Chem. 1999 274: 8375-8378. [Abstract] [Full Text] [PDF]  

James C. Otto, Edward Kim, Stephen G. Young, and Patrick J. Casey

Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease
J. Biol. Chem. 1999 274: 8379-8382. [Abstract] [Full Text] [PDF]  

Carbohydrates, Lipids, and Other Natural Products

Andreas Peschel, Michael Otto, Ralph W. Jack, Hubert Kalbacher, Günther Jung, and Friedrich Götz

Inactivation of the dlt Operon in Staphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides
J. Biol. Chem. 1999 274: 8405-8410. [Abstract] [Full Text] [PDF]  

Ken Karasawa, Xiaoyun Qiu, and Ten-ching Lee

Purification and Characterization from Rat Kidney Membranes of a Novel Platelet-activating Factor (PAF)-dependent Transacetylase That Catalyzes the Hydrolysis of PAF, Formation of PAF Analogs, and C₂-ceramide
J. Biol. Chem. 1999 274: 8655-8661. [Abstract] [Full Text] [PDF]  

Hironobu Komori, Shinichi Ichikawa, Yoshio Hirabayashi, and Makoto Ito

Regulation of Intracellular Ceramide Content in B16 Melanoma Cells. BIOLOGICAL IMPLICATIONS OF CERAMIDE GLYCOSYLATION
J. Biol. Chem. 1999 274: 8981-8987. [Abstract] [Full Text] [PDF]  

Cell Biology and Metabolism

Sean P. Collins and Michael D. Uhler

Cyclic AMP- and Cyclic GMP-dependent Protein Kinases Differ in Their Regulation of Cyclic AMP Response Element-dependent Gene Transcription
J. Biol. Chem. 1999 274: 8391-8404. [Abstract] [Full Text] [PDF]  

Quintin Pan and Robert U. Simpson

c-myc Intron Element-binding Proteins Are Required for 1,25-Dihydroxyvitamin D₃ Regulation of c-myc during HL-60 Cell Differentiation and the Involvement of HOXB4
J. Biol. Chem. 1999 274: 8437-8444. [Abstract] [Full Text] [PDF]  

Menelas N. Pangalos, Jean-Marc Neefs, Marijke Somers, Peter Verhasselt, Mariette Bekkers, Liesbet van der Helm, Erwin Fraiponts, David Ashton, and Robert D. Gordon

Isolation and Expression of Novel Human Glutamate Carboxypeptidases with N-Acetylated -Linked Acidic Dipeptidase and Dipeptidyl Peptidase IV Activity
J. Biol. Chem. 1999 274: 8470-8483. [Abstract] [Full Text] [PDF]  

Wannian Yang, Qiong Lin, Jun-Lin Guan, and Richard A. Cerione

Activation of the Cdc42-associated Tyrosine Kinase-2 (ACK-2) by Cell Adhesion via Integrin ₁
J. Biol. Chem. 1999 274: 8524-8530. [Abstract] [Full Text] [PDF]  

Michio Tamatani, Yong Ho Che, Hideo Matsuzaki, Satoshi Ogawa, Haruo Okado, Shin-ichi Miyake, Tatsunori Mizuno, and Masaya Tohyama

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFB Activation in Primary Hippocampal Neurons
J. Biol. Chem. 1999 274: 8531-8538. [Abstract] [Full Text] [PDF]  

Vukic Soskic, Elke Nyakatura, Martin Roos, Werner Müller-Esterl, and Jasminka Godovac-Zimmermann

Correlations in Palmitoylation and Multiple Phosphorylation of Rat Bradykinin B₂ Receptor in Chinese Hamster Ovary Cells
J. Biol. Chem. 1999 274: 8539-8545. [Abstract] [Full Text] [PDF]  

Robert P. Doornbos, Marga Theelen, Paul C. J. van der Hoeven, Wim J. van Blitterswijk, Arie J. Verkleij, and Paul M. P. van Bergen en Henegouwen

Protein Kinase C Is a Negative Regulator of Protein Kinase B Activity
J. Biol. Chem. 1999 274: 8589-8596. [Abstract] [Full Text] [PDF]  

Viviane Martin, Philippe Ronde, David Unett, Angela Wong, Trevor L. Hoffman, Aimee L. Edinger, Robert W. Doms, and Colin D. Funk

Leukotriene Binding, Signaling, and Analysis of HIV Coreceptor Function in Mouse and Human Leukotriene B₄ Receptor-transfected Cells
J. Biol. Chem. 1999 274: 8597-8603. [Abstract] [Full Text] [PDF]  

Pramod Pandey, Shalom Avraham, Andrew Place, Vijay Kumar, Pradip K. Majumder, Keding Cheng, Atsuko Nakazawa, Satya Saxena, and Surender Kharbanda

Bcl-x_L Blocks Activation of Related Adhesion Focal Tyrosine Kinase/Proline-rich Tyrosine Kinase 2 and Stress-activated Protein Kinase/c-Jun N-terminal Protein Kinase in the Cellular Response to Methylmethane Sulfonate
J. Biol. Chem. 1999 274: 8618-8623. [Abstract] [Full Text] [PDF]  

Caterina Bianco, Subha Kannan, Marta De Santis, Masaharu Seno, Careen K. Tang, Isabel Martinez-Lacaci, Nancy Kim, Brenda Wallace-Jones, Marc E. Lippman, Andreas D. Ebert, Christian Wechselberger, and David S. Salomon

Cripto-1 Indirectly Stimulates the Tyrosine Phosphorylation of erb B-4 through a Novel Receptor
J. Biol. Chem. 1999 274: 8624-8629. [Abstract] [Full Text] [PDF]  

Suling Li, Kajsa M. Paulsson, Hans-Olov Sjögren, and Ping Wang

Peptide-bound Major Histocompatibility Complex Class I Molecules Associate with Tapasin before Dissociation from Transporter Associated with Antigen Processing
J. Biol. Chem. 1999 274: 8649-8654. [Abstract] [Full Text] [PDF]  

Stephen J. Yarwood, Elizabeth M. Sale, Graham J. Sale, Miles D. Houslay, Elaine Kilgour, and Neil G. Anderson

Growth Hormone-dependent Differentiation of 3T3-F442A Preadipocytes Requires Janus Kinase/Signal Transducer and Activator of Transcription but Not Mitogen-activated Protein Kinase or p70 S6 Kinase Signaling
J. Biol. Chem. 1999 274: 8662-8668. [Abstract] [Full Text] [PDF]  

Christopher H. George, Jonathan M. Kendall, and W. Howard Evans

Intracellular Trafficking Pathways in the Assembly of Connexins into Gap Junctions
J. Biol. Chem. 1999 274: 8678-8685. [Abstract] [Full Text] [PDF]  

Margaret A. Cascieri, Gregory E. Koch, Elzbieta Ber, Sharon J. Sadowski, Donna Louizides, Stephen E. de Laszlo, Candice Hacker, William K. Hagmann, Malcolm MacCoss, Gary G. Chicchi, and Pasquale P. Vicario

Characterization of a Novel, Non-peptidyl Antagonist of the Human Glucagon Receptor
J. Biol. Chem. 1999 274: 8694-8697. [Abstract] [Full Text] [PDF]  

Ann M. Sheehy and Mark S. Schlissel

Overexpression of RelA Causes G₁ Arrest and Apoptosis in a Pro-B Cell Line
J. Biol. Chem. 1999 274: 8708-8716. [Abstract] [Full Text] [PDF]  

Lisa M. Ellerby, Rebecca L. Andrusiak, Cheryl L. Wellington, Abigail S. Hackam, Stephanie S. Propp, Jonathan D. Wood, Alan H. Sharp, Russell L. Margolis, Christopher A. Ross, Guy S. Salvesen, Michael R. Hayden, and Dale E. Bredesen

Cleavage of Atrophin-1 at Caspase Site Aspartic Acid 109 Modulates Cytotoxicity
J. Biol. Chem. 1999 274: 8730-8736. [Abstract] [Full Text] [PDF]  

Vanessa Nancy, Rob M. F. Wolthuis, Marie-France de Tand, Isabelle Janoueix-Lerosey, Johannes L. Bos, and Jean de Gunzburg

Identification and Characterization of Potential Effector Molecules of the Ras-related GTPase Rap2
J. Biol. Chem. 1999 274: 8737-8745. [Abstract] [Full Text] [PDF]  

Nikolai P. Skiba, Chii-Shen Yang, Tao Huang, Hyunsu Bae, and Heidi E. Hamm

The -Helical Domain of G_t Determines Specific Interaction with Regulator of G Protein Signaling 9
J. Biol. Chem. 1999 274: 8770-8778. [Abstract] [Full Text] [PDF]  

Matthias Eckhardt, Birgit Gotza, and Rita Gerardy-Schahn

Membrane Topology of the Mammalian CMP-Sialic Acid Transporter
J. Biol. Chem. 1999 274: 8779-8787. [Abstract] [Full Text] [PDF]  

Zerihun Assefa, Annelies Vantieghem, Wim Declercq, Peter Vandenabeele, Jackie R. Vandenheede, Wilfried Merlevede, Peter de Witte, and Patrizia Agostinis

The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin
J. Biol. Chem. 1999 274: 8788-8796. [Abstract] [Full Text] [PDF]  

Patrick Leahy, Deborah R. Crawford, Gregory Grossman, Richard M. Gronostajski, and Richard W. Hanson

CREB Binding Protein Coordinates the Function of Multiple Transcription Factors Including Nuclear Factor I to Regulate Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription
J. Biol. Chem. 1999 274: 8813-8822. [Abstract] [Full Text] [PDF]  

Morten S. Nielsen, Christian Jacobsen, Gunilla Olivecrona, Jørgen Gliemann, and Claus M. Petersen

Sortilin/Neurotensin Receptor-3 Binds and Mediates Degradation of Lipoprotein Lipase
J. Biol. Chem. 1999 274: 8832-8836. [Abstract] [Full Text] [PDF]  

Angela K. Loihl, Sean Whalen, Iain L. Campbell, John S. Mudgett, and Sean Murphy

Transcriptional Activation following Cerebral Ischemia in Mice of a Promoter-deleted Nitric Oxide Synthase-2 Gene
J. Biol. Chem. 1999 274: 8844-8849. [Abstract] [Full Text] [PDF]  

Christopher V. Carman, Michael P. Lisanti, and Jeffrey L. Benovic

Regulation of G Protein-coupled Receptor Kinases by Caveolin
J. Biol. Chem. 1999 274: 8858-8864. [Abstract] [Full Text] [PDF]  

Rebecca Worthylake, Lee K. Opresko, and H. Steven Wiley

ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors
J. Biol. Chem. 1999 274: 8865-8874. [Abstract] [Full Text] [PDF]  

Martin Oppermann, Matthias Mack, Amanda E. I. Proudfoot, and Heike Olbrich

Differential Effects of CC Chemokines on CC Chemokine Receptor 5 (CCR5) Phosphorylation and Identification of Phosphorylation Sites on the CCR5 Carboxyl Terminus
J. Biol. Chem. 1999 274: 8875-8885. [Abstract] [Full Text] [PDF]  

Kees Fluiter, Wolgang Sattler, Maria C. De Beer, Patrice M. Connell, Deneys R. van der Westhuyzen, and Theo J. C. van Berkel

Scavenger Receptor BI Mediates the Selective Uptake of Oxidized Cholesterol Esters by Rat Liver
J. Biol. Chem. 1999 274: 8893-8899. [Abstract] [Full Text] [PDF]  

Lily Wong, Tushar Baran Deb, Stewart A. Thompson, Alan Wells, and Gibbes R. Johnson

A Differential Requirement for the COOH-terminal Region of the Epidermal Growth Factor (EGF) Receptor in Amphiregulin and EGF Mitogenic Signaling
J. Biol. Chem. 1999 274: 8900-8909. [Abstract] [Full Text] [PDF]  

Xiong Li, Ruth C. Dy, William G. Cance, Lee M. Graves, and H. Shelton Earp

Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase
J. Biol. Chem. 1999 274: 8917-8924. [Abstract] [Full Text] [PDF]  

Duanqing Pei

Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP
J. Biol. Chem. 1999 274: 8925-8932. [Abstract] [Full Text] [PDF]  

Jean-Luc Parent, Pascale Labrecque, Michael J. Orsini, and Jeffrey L. Benovic

Internalization of the TXA₂ Receptor  and  Isoforms. ROLE OF THE DIFFERENTIALLY SPLICED COOH TERMINUS IN AGONIST-PROMOTED RECEPTOR INTERNALIZATION
J. Biol. Chem. 1999 274: 8941-8948. [Abstract] [Full Text] [PDF]  

Jason M. Haugh, Kevin Schooler, Alan Wells, H. Steven Wiley, and Douglas A. Lauffenburger

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-1 Signaling Pathway
J. Biol. Chem. 1999 274: 8958-8965. [Abstract] [Full Text] [PDF]  

Lili Zhang, Lixin Song, and Eric M. Parker

Calpain Inhibitor I Increases -Amyloid Peptide Production by Inhibiting the Degradation of the Substrate of -Secretase. EVIDENCE THAT SUBSTRATE AVAILABILITY LIMITS -AMYLOID PEPTIDE PRODUCTION
J. Biol. Chem. 1999 274: 8966-8972. [Abstract] [Full Text] [PDF]  

Peter M. Rettenberger, Kazuhiro Oka, Lars Ellgaard, Helle H. Petersen, Anni Christensen, Pia M. Martensen, Denis Monard, Michael Etzerodt, Lawrence Chan, and Peter A. Andreasen

Ligand Binding Properties of the Very Low Density Lipoprotein Receptor. ABSENCE OF THE THIRD COMPLEMENT-TYPE REPEAT ENCODED BY EXON 4 IS ASSOCIATED WITH REDUCED BINDING OF M_r 40,000 RECEPTOR-ASSOCIATED PROTEIN
J. Biol. Chem. 1999 274: 8973-8980. [Abstract] [Full Text] [PDF]  

Isabella Stefaner, Asja Praetor, and Walter Hunziker

Nonvectorial Surface Transport, Endocytosis via a Di-leucine-based Motif, and Bidirectional Transcytosis of Chimera Encoding the Cytosolic Tail of Rat FcRn Expressed in Madin-Darby Canine Kidney Cells
J. Biol. Chem. 1999 274: 8998-9005. [Abstract] [Full Text] [PDF]  

Christophe Montessuit and Andrew Thorburn

Transcriptional Activation of the Glucose Transporter GLUT1 in Ventricular Cardiac Myocytes by Hypertrophic Agonists
J. Biol. Chem. 1999 274: 9006-9012. [Abstract] [Full Text] [PDF]  

Cindy N. Roy, David M. Penny, John N. Feder, and Caroline A. Enns

The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells
J. Biol. Chem. 1999 274: 9022-9028. [Abstract] [Full Text] [PDF]  

Mika Ito, Richard N. Yu, J. Larry Jameson, and Masafumi Ito

Mutant Vasopressin Precursors That Cause Autosomal Dominant Neurohypophyseal Diabetes Insipidus Retain Dimerization and Impair the Secretion of Wild-type Proteins
J. Biol. Chem. 1999 274: 9029-9037. [Abstract] [Full Text] [PDF]  

L. Eric Huang, William G. Willmore, Jie Gu, Mark A. Goldberg, and H. Franklin Bunn

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide. IMPLICATIONS FOR OXYGEN SENSING AND SIGNALING
J. Biol. Chem. 1999 274: 9038-9044. [Abstract] [Full Text] [PDF]  

Darshan K. Koticha, Stephen J. Huddleston, Joan W. Witkin, and Giulia Baldini

Role of the Cysteine-rich Domain of the t-SNARE Component, SYNDET, in Membrane Binding and Subcellular Localization
J. Biol. Chem. 1999 274: 9053-9060. [Abstract] [Full Text] [PDF]  

Jiro Kasahara, Kohji Fukunaga, and Eishichi Miyamoto

Differential Effects of a Calcineurin Inhibitor on Glutamate-induced Phosphorylation of Ca²⁺/Calmodulin-dependent Protein Kinases in Cultured Rat Hippocampal Neurons
J. Biol. Chem. 1999 274: 9061-9067. [Abstract] [Full Text] [PDF]  

Mar Sánchez, Arturo Calzada, and Avelino Bueno

The Cdc6 Protein Is Ubiquitinated in Vivo for Proteolysis in Saccharomyces cerevisiae
J. Biol. Chem. 1999 274: 9092-9097. [Abstract] [Full Text] [PDF]  

Manuel S. Rodriguez, Jill Thompson, Ronald T. Hay, and Catherine Dargemont

Nuclear Retention of IB Protects It from Signal-induced Degradation and Inhibits Nuclear Factor B Transcriptional Activation
J. Biol. Chem. 1999 274: 9108-9115. [Abstract] [Full Text] [PDF]  

Xiaohua Xin, Suya Yang, Joe Kowalski, and Mary E. Gerritsen

Peroxisome Proliferator-activated Receptor  Ligands Are Potent Inhibitors of Angiogenesis in Vitro and in Vivo
J. Biol. Chem. 1999 274: 9116-9121. [Abstract] [Full Text] [PDF]  

Gouri Ranganathan, Rami Kaakaji, and Philip A. Kern

Role of Protein Kinase C in the Translational Regulation of Lipoprotein Lipase in Adipocytes
J. Biol. Chem. 1999 274: 9122-9127. [Abstract] [Full Text] [PDF]  

Enzymology

James C. Hilton, Carrie A. Temple, and K. V. Rajagopalan

Re-design of Rhodobacter sphaeroides Dimethyl Sulfoxide Reductase. ENHANCEMENT OF ADENOSINE N¹-OXIDE REDUCTASE ACTIVITY
J. Biol. Chem. 1999 274: 8428-8436. [Abstract] [Full Text] [PDF]  

Ute C. Kabisch, Andrea Gräntzdörffer, Angelika Schierhorn, Karl Peter Rücknagel, Jan R. Andreesen, and Andreas Pich

Identification of D-Proline Reductase from Clostridium sticklandii as a Selenoenzyme and Indications for a Catalytically Active Pyruvoyl Group Derived from a Cysteine Residue by Cleavage of a Proprotein
J. Biol. Chem. 1999 274: 8445-8454. [Abstract] [Full Text] [PDF]  

Carolyn N. Lynch, Yi Chun Wang, Jennifer K. Lund, Yung-Wu Chen, Juan A. Leal, and Steven R. Wiley

TWEAK Induces Angiogenesis and Proliferation of Endothelial Cells
J. Biol. Chem. 1999 274: 8455-8459. [Abstract] [Full Text] [PDF]  

Kiyoshi Yamauchi, Jun-ichiro Nakajima, Hiroaki Hayashi, Ryuya Horiuchi, and Jamshed R. Tata

Xenopus Cytosolic Thyroid Hormone-binding Protein (xCTBP) Is Aldehyde Dehydrogenase Catalyzing the Formation of Retinoic Acid
J. Biol. Chem. 1999 274: 8460-8469. [Abstract] [Full Text] [PDF]  

William D. Mallender, Tivadar Szegletes, and Terrone L. Rosenberry

Organophosphorylation of Acetylcholinesterase in the Presence of Peripheral Site Ligands. DISTINCT EFFECTS OF PROPIDIUM AND FASCICULIN
J. Biol. Chem. 1999 274: 8491-8499. [Abstract] [Full Text] [PDF]  

Hartmut Stecher, Michael H. Gelb, John C. Saari, and Krzysztof Palczewski

Preferential Release of 11-cis-retinol from Retinal Pigment Epithelial Cells in the Presence of Cellular Retinaldehyde-binding Protein
J. Biol. Chem. 1999 274: 8577-8585. [Abstract] [Full Text] [PDF]  

Abolfazl Arabshahi and Perry A. Frey

Standard Free Energy for the Hydrolysis of Adenylylated T4 DNA Ligase and the Apparent pK_a of Lysine 159
J. Biol. Chem. 1999 274: 8586-8588. [Abstract] [Full Text] [PDF]  

Jared L. Cartwright and Alexander G. McLennan

The Saccharomyces cerevisiae YOR163w Gene Encodes a Diadenosine 5',5-P¹,P⁶-Hexaphosphate (Ap₆A) Hydrolase Member of the MutT Motif (Nudix Hydrolase) Family
J. Biol. Chem. 1999 274: 8604-8610. [Abstract] [Full Text] [PDF]  

Tsui-Ting Ching, Da-Sheng Wang, Ao-Lin Hsu, Pei-Jung Lu, and Ching-Shih Chen

Identification of Multiple Phosphoinositide-specific Phospholipases D as New Regulatory Enzymes for Phosphatidylinositol 3,4,5-Trisphosphate
J. Biol. Chem. 1999 274: 8611-8617. [Abstract] [Full Text] [PDF]  

R. Todd Pickard, Beth A. Strifler, Ruth M. Kramer, and John D. Sharp

Molecular Cloning of Two New Human Paralogs of 85-kDa Cytosolic Phospholipase A₂
J. Biol. Chem. 1999 274: 8823-8831. [Abstract] [Full Text] [PDF]  

Luise Stempka, Martina Schnölzer, Susanne Radke, Gabriele Rincke, Friedrich Marks, and Michael Gschwendt

Requirements of Protein Kinase C for Catalytic Function. ROLE OF GLUTAMIC ACID 500 AND AUTOPHOSPHORYLATION ON SERINE 643
J. Biol. Chem. 1999 274: 8886-8892. [Abstract] [Full Text] [PDF]  

Steven L. Coon, Valérie Bégay, Daphne Deurloo, Jack Falcón, and David C. Klein

Two Arylalkylamine N-Acetyltransferase Genes Mediate Melatonin Synthesis in Fish
J. Biol. Chem. 1999 274: 9076-9082. [Abstract] [Full Text] [PDF]  

Membranes and Bioenergetics

William A. Frazier, Ai-Guo Gao, Julie Dimitry, Jun Chung, Eric J. Brown, Frederik P. Lindberg, and Maurine E. Linder

The Thrombospondin Receptor Integrin-associated Protein (CD47) Functionally Couples to Heterotrimeric G_i
J. Biol. Chem. 1999 274: 8554-8560. [Abstract] [Full Text] [PDF]  

Ivan H. M. Ho and R. D. Murrell-Lagnado

Molecular Determinants for Sodium-dependent Activation of G Protein-gated K⁺ Channels
J. Biol. Chem. 1999 274: 8639-8648. [Abstract] [Full Text] [PDF]  

Sudha K. Shenoy, Linda Yu, and Chang-an Yu

Identification of Quinone-binding and Heme-ligating Residues of the Smallest Membrane-anchoring Subunit (QPs3) of Bovine Heart Mitochondrial Succinate:Ubiquinone Reductase
J. Biol. Chem. 1999 274: 8717-8722. [Abstract] [Full Text] [PDF]  

Hai-Yan Qi and Harris D. Bernstein

SecA Is Required for the Insertion of Inner Membrane Proteins Targeted by the Escherichia coli Signal Recognition Particle
J. Biol. Chem. 1999 274: 8993-8997. [Abstract] [Full Text] [PDF]  

Nucleic Acids, Protein Synthesis, and Molecular Genetics

Edward Kim, Patricia Ambroziak, James C. Otto, Brigit Taylor, Matthew Ashby, Kevin Shannon, Patrick J. Casey, and Stephen G. Young

Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells
J. Biol. Chem. 1999 274: 8383-8390. [Abstract] [Full Text] [PDF]  

Olivier Gadal, George V. Shpakovski, and Pierre Thuriaux

Mutants in ABC10, a Conserved Subunit Shared by All Three Yeast RNA Polymerases, Specifically Affect RNA Polymerase I Assembly
J. Biol. Chem. 1999 274: 8421-8427. [Abstract] [Full Text] [PDF]  

Silvia Montaner, Rosario Perona, Luisa Saniger, and Juan Carlos Lacal

Activation of Serum Response Factor by RhoA Is Mediated by the Nuclear Factor-B and C/EBP Transcription Factors
J. Biol. Chem. 1999 274: 8506-8515. [Abstract] [Full Text] [PDF]  

Philippe Pourquier, Li-Ming Ueng, Jolanta Fertala, David Wang, Hyun-Ju Park, John M. Essigmann, Mary-Ann Bjornsti, and Yves Pommier

Induction of Reversible Complexes between Eukaryotic DNA Topoisomerase I and DNA-containing Oxidative Base Damages. 7,8-DIHYDRO-8-OXOGUANINE AND 5-HYDROXYCYTOSINE
J. Biol. Chem. 1999 274: 8516-8523. [Abstract] [Full Text] [PDF]  

Parisa Hanachi, John W. B. Hershey, and Hans-Peter Vornlocher

Characterization of the p33 Subunit of Eukaryotic Translation Initiation Factor-3 from Saccharomyces cerevisiae
J. Biol. Chem. 1999 274: 8546-8553. [Abstract] [Full Text] [PDF]  

Hong-Yo Kang, Shuyuan Yeh, Naohiro Fujimoto, and Chawnshang Chang

Cloning and Characterization of Human Prostate Coactivator ARA54, a Novel Protein That Associates with the Androgen Receptor
J. Biol. Chem. 1999 274: 8570-8576. [Abstract] [Full Text] [PDF]  

Walter J. Lukiw, Jorge Martinez, Ricardo Palacios Pelaez, and Nicolas G. Bazan

The Interleukin-1 Type 2 Receptor Gene Displays Immediate Early Gene Responsiveness in Glucocorticoid-stimulated Human Epidermal Keratinocytes
J. Biol. Chem. 1999 274: 8630-8638. [Abstract] [Full Text] [PDF]  

Brendan J. Jenkins, Fei Le, and Thomas J. Gonda

A Cell Type-specific Constitutive Point Mutant of the Common -Subunit of the Human Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Interleukin (IL)-3, and IL-5 Receptors Requires the GM-CSF Receptor -Subunit for Activation
J. Biol. Chem. 1999 274: 8669-8677. [Abstract] [Full Text] [PDF]  

Song Her, Rose Ann Bell, Allyson K. Bloom, Brenda J. Siddall, and Dona L. Wong

Phenylethanolamine N-Methyltransferase Gene Expression. SP1 AND MAZ POTENTIAL FOR TISSUE-SPECIFIC EXPRESSION
J. Biol. Chem. 1999 274: 8698-8707. [Abstract] [Full Text] [PDF]  

Rajendra K. Agrawal, Pawel Penczek, Robert A. Grassucci, Nils Burkhardt, Knud H. Nierhaus, and Joachim Frank

Effect of Buffer Conditions on the Position of tRNA on the 70 S Ribosome As Visualized by Cryoelectron Microscopy
J. Biol. Chem. 1999 274: 8723-8729. [Abstract] [Full Text] [PDF]  

Olivia Lee Schaubach and Alicia J. Dombroski

Transcription Initiation at the Flagellin Promoter by RNA Polymerase Carrying ²⁸ from Salmonella typhimurium
J. Biol. Chem. 1999 274: 8757-8763. [Abstract] [Full Text] [PDF]  

Jonathan D. Brown, Maria R. DiChiara, Keith R. Anderson, Michael A. Gimbrone Jr., and James N. Topper

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells
J. Biol. Chem. 1999 274: 8797-8805. [Abstract] [Full Text] [PDF]  

Sanjay Thakur and Carlo M. Croce

Positive Regulation of the BRCA1 Promoter
J. Biol. Chem. 1999 274: 8837-8843. [Abstract] [Full Text] [PDF]  

Jozef Nosek, L'ubomír Tomáska, Blanka Pagácová, and Hiroshi Fukuhara

Mitochondrial Telomere-binding Protein from Candida parapsilosis Suggests an Evolutionary Adaptation of a Nonspecific Single-stranded DNA-binding Protein
J. Biol. Chem. 1999 274: 8850-8857. [Abstract] [Full Text] [PDF]  

Yuji Sano, Jun Harada, Shigeki Tashiro, Ryoko Gotoh-Mandeville, Toshio Maekawa, and Shunsuke Ishii

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor- Signaling
J. Biol. Chem. 1999 274: 8949-8957. [Abstract] [Full Text] [PDF]  

Helen Dell and Margarita Hadzopoulou-Cladaras

CREB-binding Protein Is a Transcriptional Coactivator for Hepatocyte Nuclear Factor-4 and Enhances Apolipoprotein Gene Expression
J. Biol. Chem. 1999 274: 9013-9021. [Abstract] [Full Text] [PDF]  

Mark A. Perrella, Andrea Pellacani, Philippe Wiesel, Michael T. Chin, Lauren C. Foster, Maureen Ibanez, Chung-Ming Hsieh, Raymond Reeves, Shaw-Fang Yet, and Mu-En Lee

High Mobility Group-I(Y) Protein Facilitates Nuclear Factor-B Binding and Transactivation of the Inducible Nitric-oxide Synthase Promoter/Enhancer
J. Biol. Chem. 1999 274: 9045-9052. [Abstract] [Full Text] [PDF]  

François Bachand, Xian-Jian Yao, Mohammed Hrimech, Nicole Rougeau, and Éric A. Cohen

Incorporation of Vpr into Human Immunodeficiency Virus Type 1 Requires a Direct Interaction with the p6 Domain of the p55 Gag Precursor
J. Biol. Chem. 1999 274: 9083-9091. [Abstract] [Full Text] [PDF]  

Brian S. Egan, Kirk B. Lane, and Virginia L. Shepherd

PU.1 and USF Are Required for Macrophage-specific Mannose Receptor Promoter Activity
J. Biol. Chem. 1999 274: 9098-9107. [Abstract] [Full Text] [PDF]  

Protein Chemistry and Structure

Tao Yuan, Hui Ouyang, and Hans J. Vogel

Surface Exposure of the Methionine Side Chains of Calmodulin in Solution. A NITROXIDE SPIN LABEL AND TWO-DIMENSIONAL NMR STUDY
J. Biol. Chem. 1999 274: 8411-8420. [Abstract] [Full Text] [PDF]  

Christian M. Franke, Jan Tiemersma, Gerard Venema, and Jan Kok

Membrane Topology of the Lactococcal Bacteriocin ATP-binding Cassette Transporter Protein LcnC. INVOLVEMENT OF LcnC IN LACTOCOCCIN A MATURATION
J. Biol. Chem. 1999 274: 8484-8490. [Abstract] [Full Text] [PDF]  

Edward L. G. Pryzdial, Nadine Lavigne, Nicolas Dupuis, and Garry E. Kessler

Plasmin Converts Factor X from Coagulation Zymogen to Fibrinolysis Cofactor
J. Biol. Chem. 1999 274: 8500-8505. [Abstract] [Full Text] [PDF]  

Craig A. Harrison, Mark J. Raftery, John Walsh, Paul Alewood, Siiri E. Iismaa, Soula Thliveris, and Carolyn L. Geczy

Oxidation Regulates the Inflammatory Properties of the Murine S100 Protein S100A8
J. Biol. Chem. 1999 274: 8561-8569. [Abstract] [Full Text] [PDF]  

Celia Bonaventura, Joseph Bonaventura, Daniel Tzu-bi Shih, E. Timothy Iben, and Joel Friedman

Altered Ligand Rebinding Kinetics Due to Distal-side Effects in Hemoglobin Chico (Lys⁶⁶(E10)  Thr)
J. Biol. Chem. 1999 274: 8686-8693. [Abstract] [Full Text] [PDF]  

Nicholas R. Brown, Martin E. M. Noble, Alison M. Lawrie, May C. Morris, Paul Tunnah, Gilles Divita, Louise N. Johnson, and Jane A. Endicott

Effects of Phosphorylation of Threonine 160 on Cyclin-dependent Kinase 2 Structure and Activity
J. Biol. Chem. 1999 274: 8746-8756. [Abstract] [Full Text] [PDF]  

Arianna Loregian, Maria Rosa D'Acunto, Roberto Battistutta, Alessandro Tossi, Giorgio Palù, and Giuseppe Zanotti

Crystal Structure of the B Subunit of Escherichia coli Heat-labile Enterotoxin Carrying Peptides with Anti-herpes Simplex Virus Type 1 Activity
J. Biol. Chem. 1999 274: 8764-8769. [Abstract] [Full Text] [PDF]  

Fumi Yanaga, Sachio Morimoto, and Iwao Ohtsuki

Ca²⁺ Sensitization and Potentiation of the Maximum Level of Myofibrillar ATPase Activity Caused by Mutations of Troponin T Found in Familial Hypertrophic Cardiomyopathy
J. Biol. Chem. 1999 274: 8806-8812. [Abstract] [Full Text] [PDF]  

Paul Stathakis, Angelina J. Lay, Melinda Fitzgerald, Christian Schlieker, Lisa J. Matthias, and Philip J. Hogg

Angiostatin Formation Involves Disulfide Bond Reduction and Proteolysis in Kringle 5 of Plasmin
J. Biol. Chem. 1999 274: 8910-8916. [Abstract] [Full Text] [PDF]  

Timothy M. Ritty, Thomas Broekelmann, Clarina Tisdale, Dianna M. Milewicz, and Robert P. Mecham

Processing of the Fibrillin-1 Carboxyl-terminal Domain
J. Biol. Chem. 1999 274: 8933-8940. [Abstract] [Full Text] [PDF]  

Holger Notbohm, Minna Nokelainen, Johanna Myllyharju, Peter P. Fietzek, Peter K. Müller, and Kari I. Kivirikko

Recombinant Human Type II Collagens with Low and High Levels of Hydroxylysine and Its Glycosylated Forms Show Marked Differences in Fibrillogenesis in Vitro
J. Biol. Chem. 1999 274: 8988-8992. [Abstract] [Full Text] [PDF]  

Sabine Strahl-Bolsinger and Alexandra Scheinost

Transmembrane Topology of Pmt1p, a Member of an Evolutionarily Conserved Family of Protein O-Mannosyltransferases
J. Biol. Chem. 1999 274: 9068-9075. [Abstract] [Full Text] [PDF]  

Additions and Corrections

Elena Dibrov, Stanley Fu, and Bernard D. Lemire

Additions and Corrections to The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II).
J. Biol. Chem. 1999 274: 9128. [Full Text] [PDF]  

Dennis R. Warner, Rianna Romanowski, Shuhua Yu, and Lee S. Weinstein

Additions and Corrections to Mutagenesis of the conserved residue Glu²⁵⁹ of G_s demonstrates the importance of interactions between switches 2 and 3 for activation.
J. Biol. Chem. 1999 274: 9128. [Full Text] [PDF]  

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