Minireviews

Andrew E. Wurmser, Jonathan D. Gary, and Scott D. Emr

Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways
1999 274: 9129-9132. [Full Text] [PDF]

Communications

Daniela Brodbeck, Peter Cron, and Brian A. Hemmings

A Human Protein Kinase B with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain
1999 274: 9133-9136. [Abstract] [Full Text] [PDF]

Shaun Snyders and Bruce D. Kohorn

TAKs, Thylakoid Membrane Protein Kinases Associated with Energy Transduction
1999 274: 9137-9140. [Abstract] [Full Text] [PDF]

Carbohydrates, Lipids, and Other Natural Products

Satoshi Fukumoto, Hiroshi Miyazaki, George Goto, Takeshi Urano, Keiko Furukawa, and Koichi Furukawa

Expression Cloning of Mouse cDNA of CMP-NeuAc:Lactosylceramide 2,3-Sialyltransferase, an Enzyme That Initiates the Synthesis of Gangliosides
1999 274: 9271-9276. [Abstract] [Full Text] [PDF]

Minoru Ujita, Joseph McAuliffe, Misa Suzuki, Ole Hindsgaul, Henrik Clausen, Michiko N. Fukuda, and Minoru Fukuda

Regulation of I-Branched Poly-N-Acetyllactosamine Synthesis. CONCERTED ACTIONS BY i-EXTENSION ENZYME, I-BRANCHING ENZYME, AND 1,4-GALACTOSYLTRANSFERASE I
1999 274: 9296-9304. [Abstract] [Full Text] [PDF]

Kee-Hong Kim and George M. Carman

Phosphorylation and Regulation of Choline Kinase from Saccharomyces cerevisiae by Protein Kinase A
1999 274: 9531-9538. [Abstract] [Full Text] [PDF]

Sherry M. Carty, Kodangattil R. Sreekumar, and Christian R. H. Raetz

Effect of Cold Shock on Lipid A Biosynthesis in Escherichia coli. INDUCTION AT 12 °C OF AN ACYLTRANSFERASE SPECIFIC FOR PALMITOLEOYL-ACYL CARRIER PROTEIN
1999 274: 9677-9685. [Abstract] [Full Text] [PDF]

Kay-Hooi Khoo, Elke Jarboe, Adam Barker, Jordi Torrelles, Chu-Wei Kuo, and Delphi Chatterjee

Altered Expression Profile of the Surface Glycopeptidolipids in Drug-resistant Clinical Isolates of Mycobacterium avium Complex
1999 274: 9778-9785. [Abstract] [Full Text] [PDF]

Cell Biology and Metabolism

Bernd Stahl, Anke Diehlmann, and Thomas C. Südhof

Direct Interaction of Alzheimer's Disease-related Presenilin 1 with Armadillo Protein p0071
1999 274: 9141-9148. [Abstract] [Full Text] [PDF]

Carla Chinni, Michael R. de Niese, Deborah J. Tew, Alison L. Jenkins, Stephen P. Bottomley, and Eleanor J. Mackie

Thrombin, a Survival Factor for Cultured Myoblasts
1999 274: 9169-9174. [Abstract] [Full Text] [PDF]

David A. Suhy, Kathryn D. Simon, Daniel I. H. Linzer, and Thomas V. O'Halloran

Metallothionein Is Part of a Zinc-scavenging Mechanism for Cell Survival under Conditions of Extreme Zinc Deprivation
1999 274: 9183-9192. [Abstract] [Full Text] [PDF]

Noel D. Horton, Shyam S. Biswal, Lucindra L. Corrigan, Julie Bratta, and James P. Kehrer

Acrolein Causes Inhibitor B-independent Decreases in Nuclear Factor B Activation in Human Lung Adenocarcinoma (A549) Cells
1999 274: 9200-9206. [Abstract] [Full Text] [PDF]

Rachid El Kouhen, Odile Maestri-El Kouhen, Ping-Yee Law, and Horace H. Loh

The Absence of a Direct Correlation between the Loss of [D-Ala²,MePhe⁴,Gly⁵-ol]Enkephalin Inhibition of Adenylyl Cyclase Activity and Agonist-induced µ-Opioid Receptor Phosphorylation
1999 274: 9207-9215. [Abstract] [Full Text] [PDF]

Jacob M. Jones, Katja Nau, Michael T. Geraghty, Ralf Erdmann, and Stephen J. Gould

Identification of Peroxisomal Acyl-CoA Thioesterases in Yeast and Humans
1999 274: 9216-9223. [Abstract] [Full Text] [PDF]

Richard T. Waldron, Teresa Iglesias, and Enrique Rozengurt

The Pleckstrin Homology Domain of Protein Kinase D Interacts Preferentially with the  Isoform of Protein Kinase C
1999 274: 9224-9230. [Abstract] [Full Text] [PDF]

Mohammad H. Ghahremani, Peihua Cheng, Paola M. C. Lembo, and Paul R. Albert

Distinct Roles for G_i2, G_i3, and G in Modulation of Forskolin- or G_s-mediated cAMP Accumulation and Calcium Mobilization by Dopamine D2S Receptors
1999 274: 9238-9245. [Abstract] [Full Text] [PDF]

Angelika Hausser, Peter Storz, Gisela Link, Hartmut Stoll, Yun-Cai Liu, Amnon Altman, Klaus Pfizenmaier, and Franz-Josef Johannes

Protein Kinase C µ Is Negatively Regulated by 14-3-3 Signal Transduction Proteins
1999 274: 9258-9264. [Abstract] [Full Text] [PDF]

Damien Freyssenet, Martino Di Carlo, and David A. Hood

Calcium-dependent Regulation of Cytochrome c Gene Expression in Skeletal Muscle Cells. IDENTIFICATION OF A PROTEIN KINASE C-DEPENDENT PATHWAY
1999 274: 9305-9311. [Abstract] [Full Text] [PDF]

Andrei E. Medvedev, Jorge C. G. Blanco, Nilofer Qureshi, and Stefanie N. Vogel

Limited Role of Ceramide in Lipopolysaccharide-mediated Mitogen-activated Protein Kinase Activation, Transcription Factor Induction, and Cytokine Release
1999 274: 9342-9350. [Abstract] [Full Text] [PDF]

Jinping Li, Kathryn DeFea, and Richard A. Roth

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation by an Akt/Phosphatidylinositol 3-Kinase Pathway
1999 274: 9351-9356. [Abstract] [Full Text] [PDF]

Kid Törnquist, Anna-Maria Malm, Michael Pasternack, Robert Kronqvist, Sonja Björklund, Raimo Tuominen, and J. Peter Slotte

Tumor Necrosis Factor-, Sphingomyelinase, and Ceramide Inhibit Store-operated Calcium Entry in Thyroid FRTL-5 Cells
1999 274: 9370-9377. [Abstract] [Full Text] [PDF]

Herman Lambert, Steve J. Charette, André F. Bernier, Alain Guimond, and Jacques Landry

HSP27 Multimerization Mediated by Phosphorylation-sensitive Intermolecular Interactions at the Amino Terminus
1999 274: 9378-9385. [Abstract] [Full Text] [PDF]

Giovanni Manfredi, Nihaar Gupta, Martel E. Vazquez-Memije, James E. Sadlock, Antonella Spinazzola, Darryl C. De Vivo, and Eric A. Schon

Oligomycin Induces a Decrease in the Cellular Content of a Pathogenic Mutation in the Human Mitochondrial ATPase 6 Gene
1999 274: 9386-9391. [Abstract] [Full Text] [PDF]

Irina Baburina and Suzanne Jackowski

Cellular Responses to Excess Phospholipid
1999 274: 9400-9408. [Abstract] [Full Text] [PDF]

Jianying Shi, Hongfa Zhu, Dennis N. Arvidson, and Gebre Woldegiorgis

A Single Amino Acid Change (Substitution of Glutamate 3 with Alanine) in the N-terminal Region of Rat Liver Carnitine Palmitoyltransferase I Abolishes Malonyl-CoA Inhibition and High Affinity Binding
1999 274: 9421-9426. [Abstract] [Full Text] [PDF]

Susanne Mohr, Hazem Hallak, Alexander de Boitte, Eduardo G. Lapetina, and Bernhard Brüne

Nitric Oxide-induced S-Glutathionylation and Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase
1999 274: 9427-9430. [Abstract] [Full Text] [PDF]

Carola Förster, Maria A. Santos, Susanne Ruffert, Reinhard Krämer, and José L. Revuelta

Physiological Consequence of Disruption of the VMA1 Gene in the Riboflavin Overproducer Ashbya gossypii
1999 274: 9442-9448. [Abstract] [Full Text] [PDF]

Xiaomei Sui, Kelli S. Bramlett, Michael C. Jorge, David A. Swanson, Andrew C. von Eschenbach, and Guido Jenster

Specific Androgen Receptor Activation by an Artificial Coactivator
1999 274: 9449-9454. [Abstract] [Full Text] [PDF]

Stefan I. Liochev, Ludmil Benov, Daniele Touati, and Irwin Fridovich

Induction of the soxRS Regulon of Escherichia coli by Superoxide
1999 274: 9479-9481. [Abstract] [Full Text] [PDF]

James F. Fleming, Gary M. Spitsen, To Y. Hui, Lisa Olivier, Emma Z. Du, Martin Raabe, and Roger A. Davis

Chinese Hamster Ovary Cells Require the Coexpression of Microsomal Triglyceride Transfer Protein and Cholesterol 7-Hydroxylase for the Assembly and Secretion of Apolipoprotein B-containing Lipoproteins
1999 274: 9509-9514. [Abstract] [Full Text] [PDF]

Marthe Moldes, Bruno Fève, and Jacques Pairault

Molecular Cloning of a Major mRNA Species in Murine 3T3 Adipocyte Lineage. DIFFERENTIATION-DEPENDENT EXPRESSION, REGULATION, AND IDENTIFICATION AS SEMICARBAZIDE-SENSITIVE AMINE OXIDASE
1999 274: 9515-9523. [Abstract] [Full Text] [PDF]

Gregory T. Baxter, Richard C. Kuo, Orla J. Jupp, Peter Vandenabeele, and David J. MacEwan

Tumor Necrosis Factor- Mediates Both Apoptotic Cell Death and Cell Proliferation in a Human Hematopoietic Cell Line Dependent on Mitotic Activity and Receptor Subtype Expression
1999 274: 9539-9547. [Abstract] [Full Text] [PDF]

Larisa Gheber, Scot C. Kuo, and M. Andrew Hoyt

Motile Properties of the Kinesin-related Cin8p Spindle Motor Extracted from Saccharomyces cerevisiae Cells
1999 274: 9564-9572. [Abstract] [Full Text] [PDF]

Sandeep Mahajan, Sutapa Ghosh, Elise A. Sudbeck, Yaguo Zheng, Suzanne Downs, Michael Hupke, and Fatih M. Uckun

Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK), LFM-A13 [-Cyano--Hydroxy--Methyl-N-(2,5-Dibromophenyl)Propenamide]
1999 274: 9587-9599. [Abstract] [Full Text] [PDF]

Edward B. Neufeld, Meryl Wastney, Shutish Patel, Sundar Suresh, Adele M. Cooney, Nancy K. Dwyer, Calvin F. Roff, Kousaku Ohno, Jill A. Morris, Eugene D. Carstea, John P. Incardona, Jerome F. Strauss III, Marie T. Vanier, Marc C. Patterson, Roscoe O. Brady, Peter G. Pentchev, and E. Joan Blanchette-Mackie

The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo
1999 274: 9627-9635. [Abstract] [Full Text] [PDF]

Liz Svensson, Attila Aszódi, Finn P. Reinholt, Reinhard Fässler, Dick Heinegård, and Åke Oldberg

Fibromodulin-null Mice Have Abnormal Collagen Fibrils, Tissue Organization, and Altered Lumican Deposition in Tendon
1999 274: 9636-9647. [Abstract] [Full Text] [PDF]

Mark L. Day, Xin Zhao, Christopher J. Vallorosi, Mathew Putzi, C. Thomas Powell, Christopher Lin, and Kathleen C. Day

E-cadherin Mediates Aggregation-dependent Survival of Prostate and Mammary Epithelial Cells through the Retinoblastoma Cell Cycle Control Pathway
1999 274: 9656-9664. [Abstract] [Full Text] [PDF]

Lenka Bittova, Marius Sumandea, and Wonhwa Cho

A Structure-Function Study of the C2 Domain of Cytosolic Phospholipase A₂. IDENTIFICATION OF ESSENTIAL CALCIUM LIGANDS AND HYDROPHOBIC MEMBRANE BINDING RESIDUES
1999 274: 9665-9672. [Abstract] [Full Text] [PDF]

Aurélio V. Graça-Souza, Mário A. C. Silva-Neto, and Pedro L. Oliveira

Urate Synthesis in the Blood-sucking Insect Rhodnius prolixus. STIMULATION BY HEMIN IS MEDIATED BY PROTEIN KINASE C
1999 274: 9673-9676. [Abstract] [Full Text] [PDF]

Wenmei Li, Chandrasekharam N. Nagineni, Hong Ge, Bassey Efiok, Ana B. Chepelinsky, and Charles E. Egwuagu

Interferon Consensus Sequence-binding Protein Is Constitutively Expressed and Differentially Regulated in the Ocular Lens
1999 274: 9686-9691. [Abstract] [Full Text] [PDF]

Alberto Papi and Sebastian L. Johnston

Rhinovirus Infection Induces Expression of Its Own Receptor Intercellular Adhesion Molecule 1 (ICAM-1) via Increased NF-B-mediated Transcription
1999 274: 9707-9720. [Abstract] [Full Text] [PDF]

Annette Schürmann, Martina Schmidt, Melanie Asmus, Silke Bayer, Frank Fliegert, Susanne Koling, Silke Maßmann, Christiane Schilf, M. Cecilia Subauste, Matthias Voß, Karl H. Jakobs, and Hans-Georg Joost

The ADP-ribosylation Factor (ARF)-related GTPase ARF-related Protein Binds to the ARF-specific Guanine Nucleotide Exchange Factor Cytohesin and Inhibits the ARF-dependent Activation of Phospholipase D
1999 274: 9744-9751. [Abstract] [Full Text] [PDF]

Hal P. Bogerd, R. Edward Benson, Ray Truant, Andrea Herold, Meranee Phingbodhipakkiya, and Bryan R. Cullen

Definition of a Consensus Transportin-specific Nucleocytoplasmic Transport Signal
1999 274: 9771-9777. [Abstract] [Full Text] [PDF]

Hsiu-Ling Li, William Davis, and Ellen Puré

Suboptimal Cross-linking of Antigen Receptor Induces Syk-dependent Activation of p70S6 Kinase through Protein Kinase C and Phosphoinositol 3-Kinase
1999 274: 9812-9820. [Abstract] [Full Text] [PDF]

Stefanie Heck, Frank Lezoualc'h, Stefanie Engert, and Christian Behl

Insulin-like Growth Factor-1-mediated Neuroprotection against Oxidative Stress Is Associated with Activation of Nuclear Factor B
1999 274: 9828-9835. [Abstract] [Full Text] [PDF]

Naoyuki Nishiya, Yasuhiko Iwabuchi, Motoko Shibanuma, Jean-François Côté, Michel L. Tremblay, and Kiyoshi Nose

Hic-5, a Paxillin Homologue, Binds to the Protein-tyrosine Phosphatase PEST (PTP-PEST) through Its LIM 3 Domain
1999 274: 9847-9853. [Abstract] [Full Text] [PDF]

Jennifer R. Henkel, Jamie L. Popovich, Gregory A. Gibson, Simon C. Watkins, and Ora A. Weisz

Selective Perturbation of Early Endosome and/or trans-Golgi Network pH but Not Lysosome pH by Dose-dependent Expression of Influenza M2 Protein
1999 274: 9854-9860. [Abstract] [Full Text] [PDF]

Arto Määttä, Panu Jaakkola, and Markku Jalkanen

Extracellular Matrix-dependent Activation of Syndecan-1 Expression in Keratinocyte Growth Factor-treated Keratinocytes
1999 274: 9891-9898. [Abstract] [Full Text] [PDF]

Osamu Saitoh, Yoshihiro Kubo, Megumi Odagiri, Masumi Ichikawa, Kanato Yamagata, and Toshiaki Sekine

RGS7 and RGS8 Differentially Accelerate G Protein-mediated Modulation of K⁺ Currents
1999 274: 9899-9904. [Abstract] [Full Text] [PDF]

Enzymology

Young Hwang, Alex Burgin Jr., and Frederic Bushman

DNA Contacts Stimulate Catalysis by a Poxvirus Topoisomerase
1999 274: 9160-9168. [Abstract] [Full Text] [PDF]

Gang Wu, Chunhong Wei, Richard J. Kulmacz, Yoichi Osawa, and Ah-lim Tsai

A Mechanistic Study of Self-inactivation of the Peroxidase Activity in Prostaglandin H Synthase-1
1999 274: 9231-9237. [Abstract] [Full Text] [PDF]

Agnieszka Banbula, Pawel Mak, Marcin Bugno, Jerzy Silberring, Adam Dubin, Daniel Nelson, James Travis, and Jan Potempa

Prolyl Tripeptidyl Peptidase from Porphyromonas gingivalis. A NOVEL ENZYME WITH POSSIBLE PATHOLOGICAL IMPLICATIONS FOR THE DEVELOPMENT OF PERIODONTITIS
1999 274: 9246-9252. [Abstract] [Full Text] [PDF]

Ayman S. Hussein, Matilde R. Chacón, Angela M. Smith, Rafael Tosado-Acevedo, and Murray E. Selkirk

Cloning, Expression, and Properties of a Nonneuronal Secreted Acetylcholinesterase from the Parasitic Nematode Nippostrongylus brasiliensis
1999 274: 9312-9319. [Abstract] [Full Text] [PDF]

Hideo Shimada, Shingo Nagano, Yoko Ariga, Masashi Unno, Tsuyoshi Egawa, Takako Hishiki, Yuzuru Ishimura, Futoshi Masuya, Takashi Obata, and Hiroshi Hori

Putidaredoxin-Cytochrome P450_cam Interaction. SPIN STATE OF THE HEME IRON MODULATES PUTIDAREDOXIN STRUCTURE
1999 274: 9363-9369. [Abstract] [Full Text] [PDF]

Ursula Burner, Christian Obinger, Martina Paumann, Paul G. Furtmüller, and Anthony J. Kettle

Transient and Steady-state Kinetics of the Oxidation of Substituted Benzoic Acid Hydrazides by Myeloperoxidase
1999 274: 9494-9502. [Abstract] [Full Text] [PDF]

Anand K. Ganesan, L. Mende-Mueller, Jorg Selzer, and Joseph T. Barbieri

Pseudomonas aeruginosa Exoenzyme S, a Double ADP-ribosyltransferase, Resembles Vertebrate Mono-ADP-ribosyltransferases
1999 274: 9503-9508. [Abstract] [Full Text] [PDF]

Sovitj Pou, Lori Keaton, Wanida Surichamorn, and Gerald M. Rosen

Mechanism of Superoxide Generation by Neuronal Nitric-oxide Synthase
1999 274: 9573-9580. [Abstract] [Full Text] [PDF]

Mary A. Dwyer, Arthur J. Huang, Clark Q. Pan, and Robert A. Lazarus

Expression and Characterization of a DNase I-Fc Fusion Enzyme
1999 274: 9738-9743. [Abstract] [Full Text] [PDF]

John F. Garvish and R. Stephen Lloyd

The Catalytic Mechanism of a Pyrimidine Dimer-specific Glycosylase (pdg)/Abasic Lyase, chlorella virus-pdg
1999 274: 9786-9794. [Abstract] [Full Text] [PDF]

Lokesh Joshi and Raymond J. St. Leger

Cloning, Expression, and Substrate Specificity of MeCPA, a Zinc Carboxypeptidase That Is Secreted into Infected Tissues by the Fungal Entomopathogen Metarhizium anisopliae
1999 274: 9803-9811. [Abstract] [Full Text] [PDF]

Susan O. Meakin, James I. S. MacDonald, Ela A. Gryz, Christopher J. Kubu, and Joseph M. Verdi

The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA. A MODEL FOR DISCRIMINATING PROLIFERATION AND DIFFERENTIATION
1999 274: 9861-9870. [Abstract] [Full Text] [PDF]

Membranes and Bioenergetics

Jürgen H. Nett and Bernard L. Trumpower

Intermediate Length Rieske Iron-Sulfur Protein Is Present and Functionally Active in the Cytochrome bc₁ Complex of Saccharomyces cerevisiae
1999 274: 9253-9257. [Abstract] [Full Text] [PDF]

Akemi Matsuno-Yagi and Youssef Hatefi

Ubiquinol:Cytochrome c Oxidoreductase. EFFECTS OF INHIBITORS ON REVERSE ELECTRON TRANSFER FROM THE IRON-SULFUR PROTEIN TO CYTOCHROME b
1999 274: 9283-9288. [Abstract] [Full Text] [PDF]

Howard K. Motoike, Ilona Bodi, Hitoshi Nakayama, Arnold Schwartz, and Gyula Varadi

A Region in IVS5 of the Human Cardiac L-type Calcium Channel Is Required for the Use-dependent Block by Phenylalkylamines and Benzothiazepines
1999 274: 9409-9420. [Abstract] [Full Text] [PDF]

Colleen M. Niswender, Sara C. Copeland, Katharine Herrick-Davis, Ronald B. Emeson, and Elaine Sanders-Bush

RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity
1999 274: 9472-9478. [Abstract] [Full Text] [PDF]

Lorna S. Ness and Ian R. Booth

Different Foci for the Regulation of the Activity of the KefB and KefC Glutathione-gated K⁺ Efflux Systems
1999 274: 9524-9530. [Abstract] [Full Text] [PDF]

Nucleic Acids, Protein Synthesis, and Molecular Genetics

Luis Oñate, Jesús Vicente-Carbajosa, Pilar Lara, Isabel Díaz, and Pilar Carbonero

Barley BLZ2, a Seed-specific bZIP Protein That Interacts with BLZ1 in Vivo and Activates Transcription from the GCN4-like motif of B-hordein Promoters in Barley Endosperm
1999 274: 9175-9182. [Abstract] [Full Text] [PDF]

Régis Blaise, Jacques Grober, Philippe Rouet, Geneviève Tavernier, Dominique Daegelen, and Dominique Langin

Testis Expression of Hormone-sensitive Lipase Is Conferred by a Specific Promoter That Contains Four Regions Binding Testicular Nuclear Proteins
1999 274: 9327-9334. [Abstract] [Full Text] [PDF]

Felipe D. Araujo, J. David Knox, Shyam Ramchandani, Richard Pelletier, Pascal Bigey, Gerald Price, Moshe Szyf, and Maria Zannis-Hadjopoulos

Identification of Initiation Sites for DNA Replication in the Human dnmt1 (DNA-methyltransferase) Locus
1999 274: 9335-9341. [Abstract] [Full Text] [PDF]

Shannon L. Stroschein, Wei Wang, and Kunxin Luo

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor -induced Smad-dependent Transcriptional Activation
1999 274: 9431-9441. [Abstract] [Full Text] [PDF]

Wei-Yü Tsai, Y-Ting Chow, Hau-Ren Chen, Kuang-Tse Huang, Rong-I Hong, Shr-Peng Jan, Nien-Yuan Kuo, Twee Y. Tsao, Chun-Hong Chen, and Soo-Chen Cheng

Cef1p Is a Component of the Prp19p-associated Complex and Essential for Pre-mRNA Splicing
1999 274: 9455-9462. [Abstract] [Full Text] [PDF]

Soha D. Idriss, Tanima Gudi, Dareen E. Casteel, Vladimir G. Kharitonov, Renate B. Pilz, and Gerry R. Boss

Nitric Oxide Regulation of Gene Transcription via Soluble Guanylate Cyclase and Type I cGMP-dependent Protein Kinase
1999 274: 9489-9493. [Abstract] [Full Text] [PDF]

Zhongmin Ma, Xiying Wang, William Nowatzke, Sasanka Ramanadham, and John Turk

Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A₂ (iPLA₂) That Arise from an Exon-skipping Mechanism of Alternative Splicing of the Transcript from the iPLA₂ Gene on Chromosome 22q13.1
1999 274: 9607-9616. [Abstract] [Full Text] [PDF]

Takahiro Narishige, Kristie L. Blade, Yuji Ishibashi, Toshio Nagai, Masayoshi Hamawaki, Donald R. Menick, Dhandapani Kuppuswamy, and George Cooper IV

Cardiac Hypertrophic and Developmental Regulation of the -Tubulin Multigene Family
1999 274: 9692-9697. [Abstract] [Full Text] [PDF]

Deborah M. Tobiason, Anne G. Lenich, and Anna C. Glasgow

Multiple DNA Binding Activities of the Novel Site-specific Recombinase, Piv, from Moraxella lacunata
1999 274: 9698-9706. [Abstract] [Full Text] [PDF]

Matthias Ernst, Ulrike Novak, Sandra E. Nicholson, Judith E. Layton, and Ashley R. Dunn

The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation. INVOLVEMENT OF STAT3
1999 274: 9729-9737. [Abstract] [Full Text] [PDF]

Yunzeng Zou, Issei Komuro, Tsutomu Yamazaki, Sumiyo Kudoh, Hiroki Uozumi, Takashi Kadowaki, and Yoshio Yazaki

Both G_s and G_i Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy
1999 274: 9760-9770. [Abstract] [Full Text] [PDF]

Igor Nikolaev, François Lenouvel, and Béatrice Felenbok

Unique DNA Binding Specificity of the Binuclear Zinc AlcR Activator of the Ethanol Utilization Pathway in Aspergillus nidulans
1999 274: 9795-9802. [Abstract] [Full Text] [PDF]

Protein Chemistry and Structure

Nicole M. Thielens, Karine Enrie, Monique Lacroix, Michel Jaquinod, Jean-François Hernandez, Alfred F. Esser, and Gérard J. Arlaud

The N-terminal CUB-Epidermal Growth Factor Module Pair of Human Complement Protease C1r Binds Ca²⁺ with High Affinity and Mediates Ca²⁺-dependent Interaction with C1s
1999 274: 9149-9159. [Abstract] [Full Text] [PDF]

Navneet Sangha, Surinder Kaur, Vandana Sharma, and M. V. Krishnasastry

Importance of the Carboxyl Terminus in the Folding and Function of -Hemolysin of Staphylococcus aureus
1999 274: 9193-9199. [Abstract] [Full Text] [PDF]

Rolf Gurezka, Rico Laage, Bettina Brosig, and Dieter Langosch

A Heptad Motif of Leucine Residues Found in Membrane Proteins Can Drive Self-assembly of Artificial Transmembrane Segments
1999 274: 9265-9270. [Abstract] [Full Text] [PDF]

Dan Ye, David C. Willhite, and Steven R. Blanke

Identification of the Minimal Intracellular Vacuolating Domain of the Helicobacter pylori Vacuolating Toxin
1999 274: 9277-9282. [Abstract] [Full Text] [PDF]

Hyun Sil Kim, Jorge Garcia, Mark Exley, Kevin W. Johnson, Steven P. Balk, and Richard S. Blumberg

Biochemical Characterization of CD1d Expression in the Absence of ₂-Microglobulin
1999 274: 9289-9295. [Abstract] [Full Text] [PDF]

Mireille Lamberty, Sarah Ades, Sandrine Uttenweiler-Joseph, Gary Brookhart, Dean Bushey, Jules A. Hoffmann, and Philippe Bulet

Insect Immunity. ISOLATION FROM THE LEPIDOPTERAN HELIOTHIS VIRESCENS OF A NOVEL INSECT DEFENSIN WITH POTENT ANTIFUNGAL ACTIVITY
1999 274: 9320-9326. [Abstract] [Full Text] [PDF]

Kristin M. Fox and P. Andrew Karplus

The Flavin Environment in Old Yellow Enzyme. AN EVALUATION OF INSIGHTS FROM SPECTROSCOPIC AND ARTIFICIAL FLAVIN STUDIES
1999 274: 9357-9362. [Abstract] [Full Text] [PDF]

Sergey I. Dikalov, Michael P. Vitek, Kirk R. Maples, and Ronald P. Mason

Amyloid  Peptides Do Not Form Peptide-derived Free Radicals Spontaneously, but Can Enhance Metal-catalyzed Oxidation of Hydroxylamines to Nitroxides
1999 274: 9392-9399. [Abstract] [Full Text] [PDF]

Barbara Driscoll, Anne T'Ang, Yi-Hui Hu, Chun Li Yan, Yue Fu, Yi Luo, Kai Jin Wu, Shumin Wen, Xiang-He Shi, Lora Barsky, Kenneth Weinberg, A. Linn Murphree, and Yuen Kai Fung

Discovery of a Regulatory Motif That Controls the Exposure of Specific Upstream Cyclin-dependent Kinase Sites That Determine Both Conformation and Growth Suppressing Activity of pRb
1999 274: 9463-9471. [Abstract] [Full Text] [PDF]

Ellie L. James, James C. Whisstock, Michael G. Gore, and Stephen P. Bottomley

Probing the Unfolding Pathway of ₁-Antitrypsin
1999 274: 9482-9488. [Abstract] [Full Text] [PDF]

Timothy R. Dafforn, Ravi Mahadeva, Peter R. Elliott, Pasupathy Sivasothy, and David A. Lomas

A Kinetic Mechanism for the Polymerization of ₁-Antitrypsin
1999 274: 9548-9555. [Abstract] [Full Text] [PDF]

Fiona M. Herr, Ellen Li, Richard B. Weinberg, Victoria R. Cook, and Judith Storch

Differential Mechanisms of Retinoid Transfer from Cellular Retinol Binding Proteins Types I and II to Phospholipid Membranes
1999 274: 9556-9563. [Abstract] [Full Text] [PDF]

Hitoshi Osaka, Siobhan Malany, Joan R. Kanter, Steven M. Sine, and Palmer Taylor

Subunit Interface Selectivity of the -Neurotoxins for the Nicotinic Acetylcholine Receptor
1999 274: 9581-9586. [Abstract] [Full Text] [PDF]

Pushkar Sharma, Peter J. Steinbach, Monica Sharma, Niranjana D. Amin, Joseph J. Barchi Jr., and Harish C. Pant

Identification of Substrate Binding Site of Cyclin-dependent Kinase 5
1999 274: 9600-9606. [Abstract] [Full Text] [PDF]

Benhur Lee, Matthew Sharron, Cedric Blanpain, Benjamin J. Doranz, Jalal Vakili, Pui Setoh, Ellen Berg, Gao Liu, H. Robert Guy, Stewart R. Durell, Marc Parmentier, Chung Nan Chang, Ken Price, Monica Tsang, and Robert W. Doms

Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function
1999 274: 9617-9626. [Abstract] [Full Text] [PDF]

Thomas Kieber-Emmons, Chaomei Lin, Mary H. Foster, and Thomas R. Kleyman

Antiidiotypic Antibody Recognizes an Amiloride Binding Domain within the  Subunit of the Epithelial Na⁺ Channel
1999 274: 9648-9655. [Abstract] [Full Text] [PDF]

Ta-Hsiang Chao, Julia A. Ember, Meiying Wang, Yolanda Bayon, Tony E. Hugli, and Richard D. Ye

Role of the Second Extracellular Loop of Human C3a Receptor in Agonist Binding and Receptor Function
1999 274: 9721-9728. [Abstract] [Full Text] [PDF]

Jean Labrecque, Normand Mc Nicoll, Martin Marquis, and André De Léan

A Disulfide-bridged Mutant of Natriuretic Peptide Receptor-A Displays Constitutive Activity. ROLE OF RECEPTOR DIMERIZATION IN SIGNAL TRANSDUCTION
1999 274: 9752-9759. [Abstract] [Full Text] [PDF]

Gunther Wuytens, Kristin Verschueren, Johan P. de Winter, Nadesan Gajendran, Lisette Beek, Kathleen Devos, Fons Bosman, Peter de Waele, Maria Andries, Adriana J.M. van den Eijnden-van Raaij, James C. Smith, and Danny Huylebroeck

Identification of Two Amino Acids in Activin A That Are Important for Biological Activity and Binding to the Activin Type II Receptors
1999 274: 9821-9827. [Abstract] [Full Text] [PDF]

Lining Guo, Raymond O. Fatig III, Gregory L. Orr, Barry W. Schafer, James A. Strickland, Kitisri Sukhapinda, Aaron T. Woodsworth, and James K. Petell

Photorhabdus luminescens W-14 Insecticidal Activity Consists of at Least Two Similar but Distinct Proteins. PURIFICATION AND CHARACTERIZATION OF TOXIN A AND TOXIN B
1999 274: 9836-9842. [Abstract] [Full Text] [PDF]

Linda Narhi, Stephen J. Wood, Shirley Steavenson, Yijia Jiang, Gay May Wu, Dan Anafi, Stephen A. Kaufman, Francis Martin, Karen Sitney, Paul Denis, Jean-Claude Louis, Jette Wypych, Anja Leona Biere, and Martin Citron

Both Familial Parkinson's Disease Mutations Accelerate -Synuclein Aggregation
1999 274: 9843-9846. [Abstract] [Full Text] [PDF]

T. Glen Lawson, Donna L. Gronros, Paul E. Evans, Michelle C. Bastien, Katherine M. Michalewich, Justin K. Clark, Jay H. Edmonds, Karolina H. Graber, Jonathan A. Werner, Beth A. Lurvey, and Julie M. Cate

Identification and Characterization of a Protein Destruction Signal in the Encephalomyocarditis Virus 3C Protease
1999 274: 9871-9980. [Abstract] [Full Text] [PDF]

Peter M. Steinert, Ying-Hao Chou, Veena Prahlad, David A. D. Parry, Lyuben N. Marekov, Kenneth C. Wu, Shyh-Ing Jang, and Robert D. Goldman

A High Molecular Weight Intermediate Filament-associated Protein in BHK-21 Cells Is Nestin, a Type VI Intermediate Filament Protein. LIMITED CO-ASSEMBLY IN VITRO TO FORM HETEROPOLYMERS WITH TYPE III VIMENTIN AND TYPE IV -INTERNEXIN
1999 274: 9881-9890. [Abstract] [Full Text] [PDF]

Additions and Corrections

Tadashi Suzuki, Qi Yan, and William J. Lennarz

Additions and Corrections to Complex, two-way traffic of molecules across the membrane of the endoplasmic reticulum.
1999 274: 9905. [Full Text] [PDF]

Shi-Hua Li, Seyed H. Hosseini, Claire-Anne Gutekunst, Steven M. Hersch, Robert J. Ferrante, and Xiao-Jiang Li

Additions and Corrections to A human HAP1 homologue. Cloning, expression, and interaction with Huntingtin.
1999 274: 9906. [Full Text] [PDF]

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