Minireviews:

Robert E. Rhoads

Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis
J. Biol. Chem. 1999 274: 30337-30340. First Published ; 10.1074/jbc.274.43.30337 [Full Text] [PDF]  

Communications:

Zhiwei Feng and Alan G. Porter

NF-B/Rel Proteins Are Required for Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells
J. Biol. Chem. 1999 274: 30341-30344. First Published ; 10.1074/jbc.274.43.30341 [Abstract] [Full Text] [PDF]  

Juanjuan Qi, Kathryn W. Peters, Chongguang Liu, Jun-Min Wang, Robert S. Edinger, John P. Johnson, Simon C. Watkins, and Raymond A. Frizzell

Regulation of the Amiloride-sensitive Epithelial Sodium Channel by Syntaxin 1A
J. Biol. Chem. 1999 274: 30345-30348. First Published ; 10.1074/jbc.274.43.30345 [Abstract] [Full Text] [PDF]  

Hadara Rubinfeld, Tamar Hanoch, and Rony Seger

Identification of a Cytoplasmic-Retention Sequence in ERK2
J. Biol. Chem. 1999 274: 30349-30352. First Published ; 10.1074/jbc.274.43.30349 [Abstract] [Full Text] [PDF]  

Hiroaki Sakurai, Hiroaki Chiba, Hidetaka Miyoshi, Takahisa Sugita, and Wataru Toriumi

IB Kinases Phosphorylate NF-B p65 Subunit on Serine 536 in the Transactivation Domain
J. Biol. Chem. 1999 274: 30353-30356. First Published ; 10.1074/jbc.274.43.30353 [Abstract] [Full Text] [PDF]  

Laura J. Juszczak and Joel M. Friedman

UV Resonance Raman Spectra of Ligand Binding Intermediates of Sol-Gel Encapsulated Hemoglobin
J. Biol. Chem. 1999 274: 30357-30360. First Published ; 10.1074/jbc.274.43.30357 [Abstract] [Full Text] [PDF] Supplemental Data  

Markus Essler, Michaela Retzer, Markus Bauer, Johan W. Heemskerk, Martin Aepfelbacher, and Wolfgang Siess

Mildly Oxidized Low Density Lipoprotein Induces Contraction of Human Endothelial Cells through Activation of Rho/Rho Kinase and Inhibition of Myosin Light Chain Phosphatase
J. Biol. Chem. 1999 274: 30361-30364. First Published ; 10.1074/jbc.274.43.30361 [Abstract] [Full Text] [PDF]  

Carbohydrates, Lipids, and Other Natural Products:

Pierre-André Trinel, Yves Plancke, Peter Gerold, Thierry Jouault, Florence Delplace, Ralph T. Schwarz, Gérard Strecker, and Daniel Poulain

The Candida albicans Phospholipomannan Is a Family of Glycolipids Presenting Phosphoinositolmannosides with Long Linear Chains of -1,2-Linked Mannose Residues
J. Biol. Chem. 1999 274: 30520-30526. First Published ; 10.1074/jbc.274.43.30520 [Abstract] [Full Text] [PDF]  

Tetsuya Okajima, Satoshi Fukumoto, Hiromi Ito, Makoto Kiso, Yoshio Hirabayashi, Takeshi Urano, Keiko Furukawa, and Koichi Furukawa

Molecular Cloning of Brain-specific GD1 Synthase (ST6GalNAc V) Containing CAG/Glutamine Repeats
J. Biol. Chem. 1999 274: 30557-30562. First Published ; 10.1074/jbc.274.43.30557 [Abstract] [Full Text] [PDF]  

Rexford L. Thomas, Jr., Christopher M. Matsko, Michael T. Lotze, and Andrew A. Amoscato

Mass Spectrometric Identification of Increased C16 Ceramide Levels During Apoptosis
J. Biol. Chem. 1999 274: 30580-30588. First Published ; 10.1074/jbc.274.43.30580 [Abstract] [Full Text] [PDF]  

Birgitta Lindahl, Camilla Westling, Guillermo Giménez-Gallego, Ulf Lindahl, and Markku Salmivirta

Common Binding Sites for -Amyloid Fibrils and Fibroblast Growth Factor-2 in Heparan Sulfate from Human Cerebral Cortex
J. Biol. Chem. 1999 274: 30631-30635. First Published ; 10.1074/jbc.274.43.30631 [Abstract] [Full Text] [PDF]  

Ryu-ichi Tozawa, Shun Ishibashi, Jun-ichi Osuga, Hiroaki Yagyu, Teruaki Oka, Zhong Chen, Ken Ohashi, Stéphane Perrey, Futoshi Shionoiri, Naoya Yahagi, Kenji Harada, Takanari Gotoda, Yoshio Yazaki, and Nobuhiro Yamada

Embryonic Lethality and Defective Neural Tube Closure in Mice Lacking Squalene Synthase
J. Biol. Chem. 1999 274: 30843-30848. First Published ; 10.1074/jbc.274.43.30843 [Abstract] [Full Text] [PDF]  

Cell Biology and Metabolism:

Karon Abe, Ian P. Whitehead, John P. O'Bryan, and Channing J. Der

Involvement of NH₂-terminal Sequences in the Negative Regulation of Vav Signaling and Transforming Activity
J. Biol. Chem. 1999 274: 30410-30418. First Published ; 10.1074/jbc.274.43.30410 [Abstract] [Full Text] [PDF]  

Huidong Yuan, Junhao Mao, Lin Li, and Dianqing Wu

Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation
J. Biol. Chem. 1999 274: 30419-30423. First Published ; 10.1074/jbc.274.43.30419 [Abstract] [Full Text] [PDF]  

Bernard Knoops, André Clippe, Cédric Bogard, Karim Arsalane, Ruddy Wattiez, Cédric Hermans, Elee Duconseille, Paul Falmagne, and Alfred Bernard

Cloning and Characterization of AOEB166, a Novel Mammalian Antioxidant Enzyme of the Peroxiredoxin Family
J. Biol. Chem. 1999 274: 30451-30458. First Published ; 10.1074/jbc.274.43.30451 [Abstract] [Full Text] [PDF]  

Bernardo Yusta, Romel Somwar, Feng Wang, Donald Munroe, Sergio Grinstein, Amira Klip, and Daniel J. Drucker

Identification of Glucagon-like Peptide-2 (GLP-2)-activated Signaling Pathways in Baby Hamster Kidney Fibroblasts Expressing the Rat GLP-2 Receptor
J. Biol. Chem. 1999 274: 30459-30467. First Published ; 10.1074/jbc.274.43.30459 [Abstract] [Full Text] [PDF]  

Mini P. Sajan, Mary L. Standaert, Gautam Bandyopadhyay, Michael J. Quon, Terrence R. Burke, Jr., and Robert V. Farese

Protein Kinase C- and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat Adipocytes
J. Biol. Chem. 1999 274: 30495-30500. First Published ; 10.1074/jbc.274.43.30495 [Abstract] [Full Text] [PDF]  

Markus G. Rudolph, Christoph Weise, Susanne Mirold, Bernhard Hillenbrand, Benjamin Bader, Alfred Wittinghofer, and Wolf-Dietrich Hardt

Biochemical Analysis of SopE from Salmonella typhimurium, a Highly Efficient Guanosine Nucleotide Exchange Factor for RhoGTPases
J. Biol. Chem. 1999 274: 30501-30509. First Published ; 10.1074/jbc.274.43.30501 [Abstract] [Full Text] [PDF]  

Brian V. Geisbrecht and Stephen J. Gould

The Human PICD Gene Encodes a Cytoplasmic and Peroxisomal NADP⁺-dependent Isocitrate Dehydrogenase
J. Biol. Chem. 1999 274: 30527-30533. First Published ; 10.1074/jbc.274.43.30527 [Abstract] [Full Text] [PDF]  

Svetlana Ermakova-Gerdes and Wim Vermaas

Inactivation of the Open Reading Frame slr0399 in Synechocystis sp. PCC 6803 Functionally Complements Mutations near the Q_A Niche of Photosystem II. A POSSIBLE ROLE OF Slr0399 AS A CHAPERONE FOR QUINONE BINDING
J. Biol. Chem. 1999 274: 30540-30549. First Published ; 10.1074/jbc.274.43.30540 [Abstract] [Full Text] [PDF]  

Laura Fraser Cotlin, Masood A. Siddiqui, Fiona Simpson, and James F. Collawn

Casein Kinase II Activity Is Required for Transferrin Receptor Endocytosis
J. Biol. Chem. 1999 274: 30550-30556. First Published ; 10.1074/jbc.274.43.30550 [Abstract] [Full Text] [PDF]  

France Bertrand, Christèle Desbois-Mouthon, Axelle Cadoret, Céline Prunier, Hélène Robin, Jacqueline Capeau, Azeddine Atfi, and Gisèle Cherqui

Insulin Antiapoptotic Signaling Involves Insulin Activation of the Nuclear Factor B-dependent Survival Genes Encoding Tumor Necrosis Factor Receptor-associated Factor 2 and Manganese-superoxide Dismutase
J. Biol. Chem. 1999 274: 30596-30602. First Published ; 10.1074/jbc.274.43.30596 [Abstract] [Full Text] [PDF]  

Wen-Hui Hu, Holly Johnson, and Hong-Bing Shu

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors Signal NF-B and JNK Activation and Apoptosis through Distinct Pathways
J. Biol. Chem. 1999 274: 30603-30610. First Published ; 10.1074/jbc.274.43.30603 [Abstract] [Full Text] [PDF]  

Min Ding, Xianglin Shi, Zigang Dong, Fei Chen, YongJu Lu, Vince Castranova, and Val Vallyathan

Freshly Fractured Crystalline Silica Induces Activator Protein-1 Activation through ERKs and p38 MAPK
J. Biol. Chem. 1999 274: 30611-30616. First Published ; 10.1074/jbc.274.43.30611 [Abstract] [Full Text] [PDF]  

Saobo Lei, Wei-Yang Lu, Zhi-Gang Xiong, Beverley Anne Orser, Carlos Fernando Valenzuela, and John Ferguson MacDonald

Platelet-derived Growth Factor Receptor-induced Feed-forward Inhibition of Excitatory Transmission between Hippocampal Pyramidal Neurons
J. Biol. Chem. 1999 274: 30617-30623. First Published ; 10.1074/jbc.274.43.30617 [Abstract] [Full Text] [PDF]  

Chieko Mineo, Gordon N. Gill, and Richard G. W. Anderson

Regulated Migration of Epidermal Growth Factor Receptor from Caveolae
J. Biol. Chem. 1999 274: 30636-30643. First Published ; 10.1074/jbc.274.43.30636 [Abstract] [Full Text] [PDF]  

Andrew Craxton, Aimin Jiang, Tomohiro Kurosaki, and Edward A. Clark

Syk and Bruton's Tyrosine Kinase Are Required for B Cell Antigen Receptor-mediated Activation of the Kinase Akt
J. Biol. Chem. 1999 274: 30644-30650. First Published ; 10.1074/jbc.274.43.30644 [Abstract] [Full Text] [PDF]  

Beni B. Wolf, Martin Schuler, Fernando Echeverri, and Douglas R. Green

Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation
J. Biol. Chem. 1999 274: 30651-30656. First Published ; 10.1074/jbc.274.43.30651 [Abstract] [Full Text] [PDF]  

Shailendra Kumar, Shalom Avraham, Ajit Bharti, Jaya Goyal, Pramod Pandey, and Surender Kharbanda

Negative Regulation of PYK2/Related Adhesion Focal Tyrosine Kinase Signal Transduction by Hematopoietic Tyrosine Phosphatase SHPTP1
J. Biol. Chem. 1999 274: 30657-30663. First Published ; 10.1074/jbc.274.43.30657 [Abstract] [Full Text] [PDF]  

Claire A. Gaudry, Elisabetta Verderio, Daniel Aeschlimann, Anne Cox, Colin Smith, and Martin Griffin

Cell Surface Localization of Tissue Transglutaminase Is Dependent on a Fibronectin-binding Site in Its N-terminal -Sandwich Domain
J. Biol. Chem. 1999 274: 30707-30714. First Published ; 10.1074/jbc.274.43.30707 [Abstract] [Full Text] [PDF]  

C. Alan Fu, Mary Shen, Betty C. B. Huang, Joe Lasaga, Donald G. Payan, and Ying Luo

TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton
J. Biol. Chem. 1999 274: 30729-30737. First Published ; 10.1074/jbc.274.43.30729 [Abstract] [Full Text] [PDF]  

Tadashi Igishi, Shigetomo Fukuhara, Vyomesh Patel, Ben-Zion Katz, Kenneth M. Yamada, and J. Silvio Gutkind

Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades. EVIDENCE FOR A ROLE OF PAXILLIN IN c-Jun NH₂-TERMINAL KINASE ACTIVATION
J. Biol. Chem. 1999 274: 30738-30746. First Published ; 10.1074/jbc.274.43.30738 [Abstract] [Full Text] [PDF]  

Carol A. de la Motte, Vincent C. Hascall, Anthony Calabro, Belinda Yen-Lieberman, and Scott A. Strong

Mononuclear Leukocytes Preferentially Bind via CD44 to Hyaluronan on Human Intestinal Mucosal Smooth Muscle Cells after Virus Infection or Treatment with Poly(I·C)
J. Biol. Chem. 1999 274: 30747-30755. First Published ; 10.1074/jbc.274.43.30747 [Abstract] [Full Text] [PDF]  

Shigeki Saito, Noboru Yamaji, Kunio Yasunaga, Tetsu Saito, Shun-ichiro Matsumoto, Masao Katoh, Seiji Kobayashi, and Yasuhiko Masuho

The Fibronectin Extra Domain A Activates Matrix Metalloproteinase Gene Expression by an Interleukin-1-dependent Mechanism
J. Biol. Chem. 1999 274: 30756-30763. First Published ; 10.1074/jbc.274.43.30756 [Abstract] [Full Text] [PDF]  

Antonella Alberici, Daniele Moratto, Luisa Benussi, Laura Gasparini, Roberta Ghidoni, Luisa Benerini Gatta, Dario Finazzi, Giovanni Battista Frisoni, Marco Trabucchi, John H. Growdon, Roger M. Nitsch, and Giuliano Binetti

Presenilin 1 Protein Directly Interacts with Bcl-2
J. Biol. Chem. 1999 274: 30764-30769. First Published ; 10.1074/jbc.274.43.30764 [Abstract] [Full Text] [PDF]  

Loretta Dorstyn, Stuart H. Read, Leonie M. Quinn, Helena Richardson, and Sharad Kumar

DECAY, a Novel Drosophila Caspase Related to Mammalian Caspase-3 and Caspase-7
J. Biol. Chem. 1999 274: 30778-30783. First Published ; 10.1074/jbc.274.43.30778 [Abstract] [Full Text] [PDF]  

Georges Rawadi, Jose-Luis Zugaza, Brigitte Lemercier, Jean Christophe Marvaud, Michel Popoff, Jacques Bertoglio, and Sergio Roman-Roman

Involvement of Small GTPases in Mycoplasma fermentans Membrane Lipoproteins-mediated Activation of Macrophages
J. Biol. Chem. 1999 274: 30794-30798. First Published ; 10.1074/jbc.274.43.30794 [Abstract] [Full Text] [PDF]  

Birgitte Ursø, Diane L. Cope, Heidi E. Kalloo-Hosein, Amanda C. Hayward, Jon P. Whitehead, Stephen O'Rahilly, and Kenneth Siddle

Differences in Signaling Properties of the Cytoplasmic Domains of the Insulin Receptor and Insulin-like Growth Factor Receptor in 3T3-L1 Adipocytes
J. Biol. Chem. 1999 274: 30864-30873. First Published ; 10.1074/jbc.274.43.30864 [Abstract] [Full Text] [PDF]  

Stuart D. Shumway, Masatoshi Maki, and Shigeki Miyamoto

The PEST Domain of IB Is Necessary and Sufficient for in Vitro Degradation by µ-Calpain
J. Biol. Chem. 1999 274: 30874-30881. First Published ; 10.1074/jbc.274.43.30874 [Abstract] [Full Text] [PDF]  

Marcjanna Bartkiewicz, Adam Houghton, and Roland Baron

Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl. A ROLE IN c-Cbl's TYROSINE PHOSPHORYLATION AND ITS ASSOCIATION WITH EPIDERMAL GROWTH FACTOR RECEPTOR
J. Biol. Chem. 1999 274: 30887-30895. First Published ; 10.1074/jbc.274.43.30887 [Abstract] [Full Text] [PDF]  

Nina Jones, Zubin Master, Jamie Jones, Denis Bouchard, Yuji Gunji, Hiroki Sasaki, Roger Daly, Kari Alitalo, and Daniel J. Dumont

Identification of Tek/Tie2 Binding Partners. BINDING TO A MULTIFUNCTIONAL DOCKING SITE MEDIATES CELL SURVIVAL AND MIGRATION
J. Biol. Chem. 1999 274: 30896-30905. First Published ; 10.1074/jbc.274.43.30896 [Abstract] [Full Text] [PDF]  

Yvonne L. Kapila, Shaohui Wang, and Paul W. Johnson

Mutations in the Heparin Binding Domain of Fibronectin in Cooperation with the V Region Induce Decreases in pp125^FAK Levels Plus Proteoglycan-mediated Apoptosis via Caspases
J. Biol. Chem. 1999 274: 30906-30913. First Published ; 10.1074/jbc.274.43.30906 [Abstract] [Full Text] [PDF]  

Hiroshi Kawabe, Yutaka Hata, Masakazu Takeuchi, Nobuyuki Ide, Akira Mizoguchi, and Yoshimi Takai

nArgBP2, a Novel Neural Member of Ponsin/ArgBP2/Vinexin Family That Interacts with Synapse-associated Protein 90/Postsynaptic Density-95-associated Protein (SAPAP)
J. Biol. Chem. 1999 274: 30914-30918. First Published ; 10.1074/jbc.274.43.30914 [Abstract] [Full Text] [PDF]  

José A. Solís-Herruzo, Richard A. Rippe, Laura W. Schrum, Paz de la Torre, Inmaculada García, John J. Jeffrey, Teresa Muñoz-Yagüe, and David A. Brenner

Interleukin-6 Increases Rat Metalloproteinase-13 Gene Expression through Stimulation of Activator Protein 1 Transcription Factor in Cultured Fibroblasts
J. Biol. Chem. 1999 274: 30919-30926. First Published ; 10.1074/jbc.274.43.30919 [Abstract] [Full Text] [PDF]  

Luc Bertrand, Dario R. Alessi, Johan Deprez, Maria Deak, Eric Viaene, Mark H. Rider, and Louis Hue

Heart 6-Phosphofructo-2-kinase Activation by Insulin Results from Ser-466 and Ser-483 Phosphorylation and Requires 3-Phosphoinositide-dependent Kinase-1, but Not Protein Kinase B
J. Biol. Chem. 1999 274: 30927-30933. First Published ; 10.1074/jbc.274.43.30927 [Abstract] [Full Text] [PDF]  

Tetsuo Moriguchi, Kaoru Kawachi, Sachiko Kamakura, Norihisa Masuyama, Hiroaki Yamanaka, Kunihiro Matsumoto, Akira Kikuchi, and Eisuke Nishida

Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates
J. Biol. Chem. 1999 274: 30957-30962. First Published ; 10.1074/jbc.274.43.30957 [Abstract] [Full Text] [PDF]  

Terry P. Moynihan, Helen C. Ardley, Ulrike Nuber, Stephen A. Rose, Pamela F. Jones, Alexander F. Markham, Martin Scheffner, and Philip A. Robinson

The Ubiquitin-conjugating Enzymes UbcH7 and UbcH8 Interact with RING Finger/IBR Motif-containing Domains of HHARI and H7-AP1
J. Biol. Chem. 1999 274: 30963-30968. First Published ; 10.1074/jbc.274.43.30963 [Abstract] [Full Text] [PDF]  

Andrew P. Feranchak, Richard M. Roman, R. Brian Doctor, Kelli D. Salter, Alex Toker, and J. Gregory Fitz

The Lipid Products of Phosphoinositide 3-Kinase Contribute to Regulation of Cholangiocyte ATP and Chloride Transport
J. Biol. Chem. 1999 274: 30979-30986. First Published ; 10.1074/jbc.274.43.30979 [Abstract] [Full Text] [PDF]  

James B. Hoying, Moying Yin, Ronald Diebold, Ilona Ormsby, Ann Becker, and Thomas Doetschman

Transforming Growth Factor 1 Enhances Platelet Aggregation through a Non-transcriptional Effect on the Fibrinogen Receptor
J. Biol. Chem. 1999 274: 31008-31013. First Published ; 10.1074/jbc.274.43.31008 [Abstract] [Full Text] [PDF]  

Ilona Jaspers, James M. Samet, and William Reed

Arsenite Exposure of Cultured Airway Epithelial Cells Activates B-dependent Interleukin-8 Gene Expression in the Absence of Nuclear Factor-B Nuclear Translocation
J. Biol. Chem. 1999 274: 31025-31033. First Published ; 10.1074/jbc.274.43.31025 [Abstract] [Full Text] [PDF]  

Robin Kundra and Stuart Kornfeld

Asparagine-linked Oligosaccharides Protect Lamp-1 and Lamp-2 from Intracellular Proteolysis
J. Biol. Chem. 1999 274: 31039-31046. First Published ; 10.1074/jbc.274.43.31039 [Abstract] [Full Text] [PDF]  

Pascal N. Bernatchez, Shay Soker, and Martin G. Sirois

Vascular Endothelial Growth Factor Effect on Endothelial Cell Proliferation, Migration, and Platelet-activating Factor Synthesis Is Flk-1-dependent
J. Biol. Chem. 1999 274: 31047-31054. First Published ; 10.1074/jbc.274.43.31047 [Abstract] [Full Text] [PDF]  

Cheh Peng Lim and Xinmin Cao

Serine Phosphorylation and Negative Regulation of Stat3 by JNK
J. Biol. Chem. 1999 274: 31055-31061. First Published ; 10.1074/jbc.274.43.31055 [Abstract] [Full Text] [PDF]  

Michael J. Orsini, Jean-Luc Parent, Stuart J. Mundell, and Jeffrey L. Benovic

Trafficking of the HIV Coreceptor CXCR4. ROLE OF ARRESTINS AND IDENTIFICATION OF RESIDUES IN THE C-TERMINAL TAIL THAT MEDIATE RECEPTOR INTERNALIZATION
J. Biol. Chem. 1999 274: 31076-31086. First Published ; 10.1074/jbc.274.43.31076 [Abstract] [Full Text] [PDF]  

Zixu Mao and Marcus Wiedmann

Calcineurin Enhances MEF2 DNA Binding Activity in Calcium-dependent Survival of Cerebellar Granule Neurons
J. Biol. Chem. 1999 274: 31102-31107. First Published ; 10.1074/jbc.274.43.31102 [Abstract] [Full Text] [PDF]  

Michael P. Scheid, Kathryn M. Schubert, and Vincent Duronio

Regulation of Bad Phosphorylation and Association with Bcl-x_L by the MAPK/Erk Kinase
J. Biol. Chem. 1999 274: 31108-31113. First Published ; 10.1074/jbc.274.43.31108 [Abstract] [Full Text] [PDF]  

Enzymology:

Paulo C. Almeida, Iseli L. Nantes, Cláudia C. A. Rizzi, Wagner A. S. Júdice, Jair R. Chagas, Luiz Juliano, Helena B. Nader, and Ivarne L. S. Tersariol

Cysteine Proteinase Activity Regulation. A POSSIBLE ROLE OF HEPARIN AND HEPARIN-LIKE GLYCOSAMINOGLYCANS
J. Biol. Chem. 1999 274: 30433-30438. First Published ; 10.1074/jbc.274.43.30433 [Abstract] [Full Text] [PDF]  

Kirsten M. Edwards, Chih-Min Kam, James C. Powers, and Joseph A. Trapani

The Human Cytotoxic T Cell Granule Serine Protease Granzyme H Has Chymotrypsin-like (Chymase) Activity and Is Taken Up into Cytoplasmic Vesicles Reminiscent of Granzyme B-containing Endosomes
J. Biol. Chem. 1999 274: 30468-30473. First Published ; 10.1074/jbc.274.43.30468 [Abstract] [Full Text] [PDF]  

Maria Waldhoer, Alan Wise, Graeme Milligan, Michael Freissmuth, and Christian Nanoff

Kinetics of Ternary Complex Formation with Fusion Proteins Composed of the A₁-Adenosine Receptor and G Protein -Subunits
J. Biol. Chem. 1999 274: 30571-30579. First Published ; 10.1074/jbc.274.43.30571 [Abstract] [Full Text] [PDF]  

Simon Daff, Ikuko Sagami, and Toru Shimizu

The 42-Amino Acid Insert in the FMN Domain of Neuronal Nitric-oxide Synthase Exerts Control over Ca²⁺/Calmodulin-dependent Electron Transfer
J. Biol. Chem. 1999 274: 30589-30595. First Published ; 10.1074/jbc.274.43.30589 [Abstract] [Full Text] [PDF]  

Jürgen Moser, Stefan Lorenz, Christian Hubschwerlen, Alexandra Rompf, and Dieter Jahn

Methanopyrus kandleri Glutamyl-tRNA Reductase
J. Biol. Chem. 1999 274: 30679-30685. First Published ; 10.1074/jbc.274.43.30679 [Abstract] [Full Text] [PDF]  

Shayne K. Morris and Janet E. Lindsley

Yeast Topoisomerase II Is Inhibited by Etoposide After Hydrolyzing the First ATP and Before Releasing the Second ADP
J. Biol. Chem. 1999 274: 30690-30696. First Published ; 10.1074/jbc.274.43.30690 [Abstract] [Full Text] [PDF]  

Paul R. Thompson, Jeffrey Schwartzenhauer, Donald W. Hughes, Albert M. Berghuis, and Gerard D. Wright

The COOH Terminus of Aminoglycoside Phosphotransferase (3')-IIIa Is Critical for Antibiotic Recognition and Resistance
J. Biol. Chem. 1999 274: 30697-30706. First Published ; 10.1074/jbc.274.43.30697 [Abstract] [Full Text] [PDF]  

Peter Borowski, Julian Schulze zur Wiesch, Kerstin Resch, Hubert Feucht, Rainer Laufs, and Herbert Schmitz

Protein Kinase C Recognizes the Protein Kinase A-binding Motif of Nonstructural Protein 3 of Hepatitis C Virus
J. Biol. Chem. 1999 274: 30722-30728. First Published ; 10.1074/jbc.274.43.30722 [Abstract] [Full Text] [PDF]  

Cyrus Munshi, Daniel J. Thiel, Irimpan I. Mathews, Robert Aarhus, Timothy F. Walseth, and Hon Cheung Lee

Characterization of the Active Site of ADP-ribosyl Cyclase
J. Biol. Chem. 1999 274: 30770-30777. First Published ; 10.1074/jbc.274.43.30770 [Abstract] [Full Text] [PDF]  

Guang W. Wong, Yinzi Tang, Eric Feyfant, Lixin Li, Yong Li, Chifu Huang, Daniel S. Friend, Steven A. Krilis, and Richard L. Stevens

Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension
J. Biol. Chem. 1999 274: 30784-30793. First Published ; 10.1074/jbc.274.43.30784 [Abstract] [Full Text] [PDF]  

A. Brent Carter, Kevin L. Knudtson, Martha M. Monick, and Gary W. Hunninghake

The p38 Mitogen-activated Protein Kinase Is Required for NF-B-dependent Gene Expression. THE ROLE OF TATA-BINDING PROTEIN (TBP)
J. Biol. Chem. 1999 274: 30858-30863. First Published ; 10.1074/jbc.274.43.30858 [Abstract] [Full Text] [PDF]  

Membranes and Bioenergetics:

Eberhard Schlodder and Horst Tobias Witt

Stoichiometry of Proton Release from the Catalytic Center in Photosynthetic Water Oxidation. REEXAMINATION BY A GLASS ELECTRODE STUDY AT pH 5.5-7.2
J. Biol. Chem. 1999 274: 30387-30392. First Published ; 10.1074/jbc.274.43.30387 [Abstract] [Full Text] [PDF]  

Chia-Yuan Hu, Wei Chen, and Wayne D. Frasch

Metal Ligation by Walker Homology B Aspartate D262 at Site 3 of the Latent but Not Activated Form of the Chloroplast F₁-ATPase from Chlamydomonas reinhardtii
J. Biol. Chem. 1999 274: 30481-30486. First Published ; 10.1074/jbc.274.43.30481 [Abstract] [Full Text] [PDF]  

Adrienne E. Dubin, Rene Huvar, Michael R. D'Andrea, Jayashree Pyati, Jessica Y. Zhu, K. C. Joy, Sandy J. Wilson, Jose E. Galindo, Charles A. Glass, Lin Luo, Michael R. Jackson, Timothy W. Lovenberg, and Mark G. Erlander

The Pharmacological and Functional Characteristics of the Serotonin 5-HT_3A Receptor Are Specifically Modified by a 5-HT_3B Receptor Subunit
J. Biol. Chem. 1999 274: 30799-30810. First Published ; 10.1074/jbc.274.43.30799 [Abstract] [Full Text] [PDF]  

Mark M. Fleischmann, Stéphane Ravanel, René Delosme, Jacqueline Olive, Francesca Zito, Francis-André Wollman, and Jean-David Rochaix

Isolation and Characterization of Photoautotrophic Mutants of Chlamydomonas reinhardtii Deficient in State Transition
J. Biol. Chem. 1999 274: 30987-30994. First Published ; 10.1074/jbc.274.43.30987 [Abstract] [Full Text] [PDF]  

Naoko Yokota, Toshiro Kuroda, Shin-ichi Matsuyama, and Hajime Tokuda

Characterization of the LolA-LolB System as the General Lipoprotein Localization Mechanism of Escherichia coli
J. Biol. Chem. 1999 274: 30995-30999. First Published ; 10.1074/jbc.274.43.30995 [Abstract] [Full Text] [PDF]  

Hirofumi Suzuki, Ken-ichi Nishiyama, and Hajime Tokuda

Increases in Acidic Phospholipid Contents Specifically Restore Protein Translocation in a Cold-sensitive secA or secG Null Mutant
J. Biol. Chem. 1999 274: 31020-31024. First Published ; 10.1074/jbc.274.43.31020 [Abstract] [Full Text] [PDF]  

Matthew Revington, Derek T. McLachlin, Gary S. Shaw, and Stanley D. Dunn

The Dimerization Domain of the b Subunit of the Escherichia coli F₁F₀-ATPase
J. Biol. Chem. 1999 274: 31094-31101. First Published ; 10.1074/jbc.274.43.31094 [Abstract] [Full Text] [PDF]  

Nucleic Acids, Protein Synthesis, and Molecular Genetics:

Hymavathi K. Tirupati, Lynn C. Shaw, and Alfred S. Lewin

An RNA Binding Motif in the Cbp2 Protein Required for Protein-stimulated RNA Catalysis
J. Biol. Chem. 1999 274: 30393-30401. First Published ; 10.1074/jbc.274.43.30393 [Abstract] [Full Text] [PDF]  

Dolly M. Foti, Ajith Welihinda, Randal J. Kaufman, and Amy S. Lee

Conservation and Divergence of the Yeast and Mammalian Unfolded Protein Response. ACTIVATION OF SPECIFIC MAMMALIAN ENDOPLASMIC RETICULUM STRESS ELEMENT OF THE grp78/BiP PROMOTER BY YEAST Hac1
J. Biol. Chem. 1999 274: 30402-30409. First Published ; 10.1074/jbc.274.43.30402 [Abstract] [Full Text] [PDF]  

Kulwant S. Aulak, Rangnath Mishra, Lingyin Zhou, Susannah L. Hyatt, Wouter de Jonge, Wouter Lamers, Martin Snider, and Maria Hatzoglou

Post-transcriptional Regulation of the Arginine Transporter Cat-1 by Amino Acid Availability
J. Biol. Chem. 1999 274: 30424-30432. First Published ; 10.1074/jbc.274.43.30424 [Abstract] [Full Text] [PDF]  

Vincent Coulon, Jean-Luc Veyrune, Nikolaï Tourkine, Annick Vié, Robert A. Hipskind, and Jean-Marie Blanchard

A Novel Calcium Signaling Pathway Targets the c-fos Intragenic Transcriptional Pausing Site
J. Biol. Chem. 1999 274: 30439-30446. First Published ; 10.1074/jbc.274.43.30439 [Abstract] [Full Text] [PDF]  

Arhonda Gogos and Neil D. Clarke

Characterization of an 8-Oxoguanine DNA Glycosylase from Methanococcus jannaschii
J. Biol. Chem. 1999 274: 30447-30450. First Published ; 10.1074/jbc.274.43.30447 [Abstract] [Full Text] [PDF]  

Changhua Ji, Yun Chen, Thomas L. McCarthy, and Michael Centrella

Cloning the Promoter for Transforming Growth Factor- Type III Receptor. BASAL AND CONDITIONAL EXPRESSION IN FETAL RAT OSTEOBLASTS
J. Biol. Chem. 1999 274: 30487-30494. First Published ; 10.1074/jbc.274.43.30487 [Abstract] [Full Text] [PDF]  

Rhett J. Michelson, Michael W. Collard, Amy J. Ziemba, Jim Persinger, Blaine Bartholomew, and Jodi I. Huggenvik

Nuclear DEAF-1-related (NUDR) Protein Contains a Novel DNA Binding Domain and Represses Transcription of the Heterogeneous Nuclear Ribonucleoprotein A2/B1 Promoter
J. Biol. Chem. 1999 274: 30510-30519. First Published ; 10.1074/jbc.274.43.30510 [Abstract] [Full Text] [PDF]  

Yang-Min Ning and Diane M. Robins

AML3/CBF1 Is Required for Androgen-specific Activation of the Enhancer of the Mouse Sex-limited Protein (Slp) Gene
J. Biol. Chem. 1999 274: 30624-30630. First Published ; 10.1074/jbc.274.43.30624 [Abstract] [Full Text] [PDF]  

Taeil Kim, Tae Young Kim, Young-Hwa Song, Irene M. Min, Jeongbin Yim, and Tae Kook Kim

Activation of Interferon Regulatory Factor 3 in Response to DNA-damaging Agents
J. Biol. Chem. 1999 274: 30686-30689. First Published ; 10.1074/jbc.274.43.30686 [Abstract] [Full Text] [PDF]  

Krishna Sinha, Karthika Perumal, Yahua Chen, and Ram Reddy

Post-transcriptional Adenylation of Signal Recognition Particle RNA Is Carried Out by an Enzyme Different from mRNA Poly(A) Polymerase
J. Biol. Chem. 1999 274: 30826-30831. First Published ; 10.1074/jbc.274.43.30826 [Abstract] [Full Text] [PDF]  

Dharmesh R. Vyas, John J. McCarthy, and Richard W. Tsika

Nuclear Protein Binding at the -Myosin Heavy Chain A/T-rich Element Is Enriched following Increased Skeletal Muscle Activity
J. Biol. Chem. 1999 274: 30832-30842. First Published ; 10.1074/jbc.274.43.30832 [Abstract] [Full Text] [PDF]  

Brigitta M. N. Brinkman, Jean-Baptiste Telliez, Andrea R. Schievella, Lih-Ling Lin, and Anne E. Goldfeld

Engagement of Tumor Necrosis Factor (TNF) Receptor 1 Leads to ATF-2- and p38 Mitogen-activated Protein Kinase-dependent TNF- Gene Expression
J. Biol. Chem. 1999 274: 30882-30886. First Published ; 10.1074/jbc.274.43.30882 [Abstract] [Full Text] [PDF]  

Donald G. McEwen, Rebecca P. Green, Michael C. Naski, Dwight A. Towler, and David M. Ornitz

Fibroblast Growth Factor Receptor 3 Gene Transcription Is Suppressed by Cyclic Adenosine 3',5'-Monophosphate. IDENTIFICATION OF A CHONDROCYTIC REGULATORY ELEMENT
J. Biol. Chem. 1999 274: 30934-30942. First Published ; 10.1074/jbc.274.43.30934 [Abstract] [Full Text] [PDF]  

Pernille Sorensen and Erhard Wintersberger

Sp1 and NF-Y Are Necessary and Sufficient for Growth-dependent Regulation of the Hamster Thymidine Kinase Promoter
J. Biol. Chem. 1999 274: 30943-30949. First Published ; 10.1074/jbc.274.43.30943 [Abstract] [Full Text] [PDF]  

Vaiju Pethe and P. V. Malathy Shekhar

Estrogen Inducibility of c-Ha-ras Transcription in Breast Cancer Cells. IDENTIFICATION OF FUNCTIONAL ESTROGEN-RESPONSIVE TRANSCRIPTIONAL REGULATORY ELEMENTS IN EXON 1/INTRON 1 OF THE c-Ha-ras GENE
J. Biol. Chem. 1999 274: 30969-30978. First Published ; 10.1074/jbc.274.43.30969 [Abstract] [Full Text] [PDF]  

Eugene Lutsenko and Ashok S. Bhagwat

The Role of the Escherichia coli Mug Protein in the Removal of Uracil and 3,N⁴-Ethenocytosine from DNA
J. Biol. Chem. 1999 274: 31034-31038. First Published ; 10.1074/jbc.274.43.31034 [Abstract] [Full Text] [PDF]  

John A. Alberta, Kurt R. Auger, David Batt, Palma Iannarelli, Grace Hwang, Heidi L. Elliott, Rebecca Duke, Thomas M. Roberts, and Charles D. Stiles

Platelet-derived Growth Factor Stimulation of Monocyte Chemoattractant Protein-1 Gene Expression Is Mediated by Transient Activation of the Phosphoinositide 3-Kinase Signal Transduction Pathway
J. Biol. Chem. 1999 274: 31062-31067. First Published ; 10.1074/jbc.274.43.31062 [Abstract] [Full Text] [PDF]  

Anne Dupressoir, Willy Barbot, Marie-Paule Loireau, and Thierry Heidmann

Characterization of a Mammalian Gene Related to the Yeast CCR4 General Transcription Factor and Revealed by Transposon Insertion
J. Biol. Chem. 1999 274: 31068-31075. First Published ; 10.1074/jbc.274.43.31068 [Abstract] [Full Text] [PDF]  

Protein Chemistry and Structure:

Marie-Thérèse Giudici-Orticoni, Françoise Guerlesquin, Mireille Bruschi, and Wolfgang Nitschke

Interaction-induced Redox Switch in the Electron Transfer Complex Rusticyanin-Cytochrome c₄
J. Biol. Chem. 1999 274: 30365-30369. First Published ; 10.1074/jbc.274.43.30365 [Abstract] [Full Text] [PDF]  

Yves Bourne, Jacques Grassi, Pierre E. Bougis, and Pascale Marchot

Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X-ray Crystallography
J. Biol. Chem. 1999 274: 30370-30376. First Published ; 10.1074/jbc.274.43.30370 [Abstract] [Full Text] [PDF]  

Michele Marinò, Joel A. Friedlander, Robert T. McCluskey, and David Andrews

Identification of a Heparin-binding Region of Rat Thyroglobulin Involved in Megalin Binding
J. Biol. Chem. 1999 274: 30377-30386. First Published ; 10.1074/jbc.274.43.30377 [Abstract] [Full Text] [PDF]  

Yovka van Santen, Jacques A. E. Benen, Klaus-Hasso Schröter, Kor H. Kalk, Sylvie Armand, Jaap Visser, and Bauke W. Dijkstra

1.68-Å Crystal Structure of Endopolygalacturonase II from Aspergillus niger and Identification of Active Site Residues by Site-directed Mutagenesis
J. Biol. Chem. 1999 274: 30474-30480. First Published ; 10.1074/jbc.274.43.30474 [Abstract] [Full Text] [PDF]  

Won-Chul Suh, Chi Zen Lu, and Carol A. Gross

Structural Features Required for the Interaction of the Hsp70 Molecular Chaperone DnaK with Its Cochaperone DnaJ
J. Biol. Chem. 1999 274: 30534-30539. First Published ; 10.1074/jbc.274.43.30534 [Abstract] [Full Text] [PDF]  

Marcos E. Milla, M. Anthony Leesnitzer, Marcia L. Moss, William C. Clay, H. Luke Carter, Ann B. Miller, Jui-Lan Su, Millard H. Lambert, Derril H. Willard, Douglas M. Sheeley, Thomas A. Kost, William Burkhart, Mary Moyer, R. Kevin Blackburn, Gregory L. Pahel, Justin L. Mitchell, Christine R. Hoffman, and J. David Becherer

Specific Sequence Elements Are Required for the Expression of Functional Tumor Necrosis Factor--converting Enzyme (TACE)
J. Biol. Chem. 1999 274: 30563-30570. First Published ; 10.1074/jbc.274.43.30563 [Abstract] [Full Text] [PDF]  

Craig S. Walker, Douglas Steel, Richard B. Jacobsen, Marcelina B. Lirazan, Lourdes J. Cruz, David Hooper, Reshma Shetty, Richard C. DelaCruz, Jacob S. Nielsen, Li Ming Zhou, Pradip Bandyopadhyay, A. Grey Craig, and Baldomero M. Olivera

The T-superfamily of Conotoxins
J. Biol. Chem. 1999 274: 30664-30671. First Published ; 10.1074/jbc.274.43.30664 [Abstract] [Full Text] [PDF]  

Ivo S. Ridder, Henriëtte J. Rozeboom, Kor H. Kalk, and Bauke W. Dijkstra

Crystal Structures of Intermediates in the Dehalogenation of Haloalkanoates by L-2-Haloacid Dehalogenase
J. Biol. Chem. 1999 274: 30672-30678. First Published ; 10.1074/jbc.274.43.30672 [Abstract] [Full Text] [PDF]  

Soo-Youl Kim, Philip Grant, Jeung-Hoon Lee, Harish C. Pant, and Peter M. Steinert

Differential Expression of Multiple Transglutaminases in Human Brain. INCREASED EXPRESSION AND CROSS-LINKING BY TRANSGLUTAMINASES 1 AND 2 IN ALZHEIMER'S DISEASE
J. Biol. Chem. 1999 274: 30715-30721. First Published ; 10.1074/jbc.274.43.30715 [Abstract] [Full Text] [PDF]  

Anna Roujeinikova, Svetlana Sedelnikova, Gert-Jan de Boer, Antoine R. Stuitje, Antoni R. Slabas, John B. Rafferty, and David W. Rice

Inhibitor Binding Studies on Enoyl Reductase Reveal Conformational Changes Related to Substrate Recognition
J. Biol. Chem. 1999 274: 30811-30817. First Published ; 10.1074/jbc.274.43.30811 [Abstract] [Full Text] [PDF]  

Jun-ichi Saito, Akiko Kita, Yoshiki Higuchi, Yoshiho Nagata, Akikazu Ando, and Kunio Miki

Crystal Structure of Chitosanase from Bacillus circulans MH-K1 at 1.6-Å Resolution and Its Substrate Recognition Mechanism
J. Biol. Chem. 1999 274: 30818-30825. First Published ; 10.1074/jbc.274.43.30818 [Abstract] [Full Text] [PDF]  

Catherine M. Falcon and Kathleen S. Matthews

Glycine Insertion in the Hinge Region of Lactose Repressor Protein Alters DNA Binding
J. Biol. Chem. 1999 274: 30849-30857. First Published ; 10.1074/jbc.274.43.30849 [Abstract] [Full Text] [PDF]  

Hubert Wojtasek and Walter S. Leal

Conformational Change in the Pheromone-binding Protein from Bombyx mori Induced by pH and by Interaction with Membranes
J. Biol. Chem. 1999 274: 30950-30956. First Published ; 10.1074/jbc.274.43.30950 [Abstract] [Full Text] [PDF]  

Keiji Nogami, Midori Shima, Kazuya Hosokawa, Toyoaki Suzuki, Takehiko Koide, Evgueni L. Saenko, Dorothea Scandella, Masaru Shibata, Seiki Kamisue, Ichiro Tanaka, and Akira Yoshioka

Role of Factor VIII C2 Domain in Factor VIII Binding to Factor Xa
J. Biol. Chem. 1999 274: 31000-31007. First Published ; 10.1074/jbc.274.43.31000 [Abstract] [Full Text] [PDF]  

Thomas P. Loisel, Hervé Ansanay, Lynda Adam, Stefano Marullo, Roland Seifert, Monique Lagacé, and Michel Bouvier

Activation of the ₂-Adrenergic Receptor-G_s Complex Leads to Rapid Depalmitoylation and Inhibition of Repalmitoylation of Both the Receptor and G_s
J. Biol. Chem. 1999 274: 31014-31019. First Published ; 10.1074/jbc.274.43.31014 [Abstract] [Full Text] [PDF]  

Bruce A. Posner, Alfred G. Gilman, and Bruce A. Harris

Regulators of G Protein Signaling 6 and 7. PURIFICATION OF COMPLEXES WITH G5 AND ASSESSMENT OF THEIR EFFECTS ON G PROTEIN-MEDIATED SIGNALING PATHWAYS
J. Biol. Chem. 1999 274: 31087-31093. First Published ; 10.1074/jbc.274.43.31087 [Abstract] [Full Text] [PDF]  

Additions and Corrections:

Petra Panzer, Ute Preuss, Gerard Joberty, and Hassan Y. Naim

Protein domains implicated in intracellular transport and sorting of lactase-phlorizin hydrolase.
J. Biol. Chem. 1999 274: 31114. [Full Text] [PDF]  

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