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 Table of Contents: Dec 8 2000; 275 (49)   [Index by Author]  [Cover Figure and Caption]
       Accelerated Publications
       DNA: Replication Repair and Recombination
       Genes: Structure and Regulation
       RNA: Structure Metabolism and Catalysis
       Protein Synthesis Post-Translation Modification and Degradation
       Genomics Proteomics and Bioinformatics
       Protein Structure and Folding
       Enzyme Catalysis and Regulation
       Metabolism and Bioenergetics
       Glycobiology and Extracellular Matrices
       Lipids and Lipoproteins
       Membrane Transport Structure Function and Biogenesis
       Mechanisms Of Signal Transduction
       Molecular Basis Of Cell and Developmental Biology
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Accelerated Publications:

Daniel M. Williams, Dongxia Wang, and Philip A. Cole
Chemical Rescue of a Mutant Protein-tyrosine Kinase
J. Biol. Chem. 2000 275: 38127-38130. First Published on September 26, 2000; 10.1074/jbc.C000606200 [Abstract] [Full Text] [PDF]  

Wenhong Cao, Louis M. Luttrell, Alexander V. Medvedev, Kristen L. Pierce, Kiefer W. Daniel, Tonya M. Dixon, Robert J. Lefkowitz, and Sheila Collins
Direct Binding of Activated c-Src to the beta 3-Adrenergic Receptor Is Required for MAP Kinase Activation
J. Biol. Chem. 2000 275: 38131-38134. First Published on September 29, 2000; 10.1074/jbc.C000592200 [Abstract] [Full Text] [PDF]  

Anthony P. West, Jr., Melanie J. Bennett, Vera M. Sellers, Nancy C. Andrews, Caroline A. Enns, and Pamela J. Bjorkman
Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE
J. Biol. Chem. 2000 275: 38135-38138. First Published on October 10, 2000; 10.1074/jbc.C000664200 [Abstract] [Full Text] [PDF]  

DNA: Replication Repair and Recombination:

Leah E. Mechanic, Brenda A. Frankel, and Steven W. Matson
Escherichia coli MutL Loads DNA Helicase II onto DNA
J. Biol. Chem. 2000 275: 38337-38346. First Published on September 12, 2000; 10.1074/jbc.M006268200 [Abstract] [Full Text] [PDF]  

Hans Ullrich Barthelmes, Pernille Grue, Silke Feineis, Tobias Straub, and Fritz Boege
Active DNA Topoisomerase IIalpha Is a Component of the Salt-stable Centrosome Core
J. Biol. Chem. 2000 275: 38823-38830. First Published on September 26, 2000; 10.1074/jbc.M007044200 [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

Patricia Stanhope-Baker and Bryan R. G. Williams
Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation
J. Biol. Chem. 2000 275: 38139-38150. First Published on September 5, 2000; 10.1074/jbc.M004901200 [Abstract] [Full Text] [PDF]  

Arie B. Brinkman, Isabell Dahlke, Judith E. Tuininga, Torsten Lammers, Valerie Dumay, Edwin de Heus, Joyce H. G. Lebbink, Michael Thomm, Willem M. de Vos, and John van der Oost
An Lrp-like Transcriptional Regulator from the Archaeon Pyrococcus furiosus Is Negatively Autoregulated
J. Biol. Chem. 2000 275: 38160-38169. First Published on September 5, 2000; 10.1074/jbc.M005916200 [Abstract] [Full Text] [PDF]  

Ji-Sook Hahn, So-Young Oh, Keith F. Chater, You-Hee Cho, and Jung-Hye Roe
H2O2-sensitive Fur-like Repressor CatR Regulating the Major Catalase Gene in Streptomyces coelicolor
J. Biol. Chem. 2000 275: 38254-38260. First Published on September 15, 2000; 10.1074/jbc.M006079200 [Abstract] [Full Text] [PDF]  

Yushi Nakayama, Tao Peng, Jeff M. Sands, and Serena M. Bagnasco
The TonE/TonEBP Pathway Mediates Tonicity-responsive Regulation of UT-A Urea Transporter Expression
J. Biol. Chem. 2000 275: 38275-38280. First Published on September 19, 2000; 10.1074/jbc.M004678200 [Abstract] [Full Text] [PDF]  

Jingcheng Yu and Ronald J. Koenig
Regulation of Hepatocyte Thyroxine 5'-Deiodinase by T3 and Nuclear Receptor Coactivators as a Model of the Sick Euthyroid Syndrome
J. Biol. Chem. 2000 275: 38296-38301. First Published on September 19, 2000; 10.1074/jbc.M004866200 [Abstract] [Full Text] [PDF]  

José Perdomo, Melissa Holmes, Beng Chong, and Merlin Crossley
Eos and Pegasus, Two Members of the Ikaros Family of Proteins with Distinct DNA Binding Activities
J. Biol. Chem. 2000 275: 38347-38354. First Published on September 7, 2000; 10.1074/jbc.M005457200 [Abstract] [Full Text] [PDF]  

Prabhat C. Goswami, Jamie Sheren, Lee D. Albee, Azemat Parsian, Julia E. Sim, Lisa A. Ridnour, Ryuji Higashikubo, David Gius, Clayton R. Hunt, and Douglas R. Spitz
Cell Cycle-coupled Variation in Topoisomerase IIalpha mRNA Is Regulated by the 3'-Untranslated Region. POSSIBLE ROLE OF REDOX-SENSITIVE PROTEIN BINDING IN mRNA ACCUMULATION
J. Biol. Chem. 2000 275: 38384-38392. First Published on September 13, 2000; 10.1074/jbc.M005298200 [Abstract] [Full Text] [PDF]  

Paul A. Wielowieyski, Serdal Sevinc, Rosa Guzzo, Maysoon Salih, Jeffrey T. Wigle, and Balwant S. Tuana
Alternative Splicing, Expression, and Genomic Structure of the 3' Region of the Gene Encoding the Sarcolemmal-associated Proteins (SLAPs) Defines a Novel Class of Coiled-coil Tail-anchored Membrane Proteins
J. Biol. Chem. 2000 275: 38474-38481. First Published on September 13, 2000; 10.1074/jbc.M007682200 [Abstract] [Full Text] [PDF]  

Young Yang, Cheol Kyu Hwang, Eunsung Junn, Gwang Lee, and M. Maral Mouradian
ZIC2 and Sp3 Repress Sp1-induced Activation of the Human D1A Dopamine Receptor Gene
J. Biol. Chem. 2000 275: 38863-38869. First Published on September 12, 2000; 10.1074/jbc.M007906200 [Abstract] [Full Text] [PDF]  

Kathrin J. Scheidegger, Bruno Cenni, Didier Picard, and Patrick Delafontaine
Estradiol Decreases IGF-1 and IGF-1 Receptor Expression in Rat Aortic Smooth Muscle Cells. MECHANISMS FOR ITS ATHEROPROTECTIVE EFFECTS
J. Biol. Chem. 2000 275: 38921-38928. First Published on September 11, 2000; 10.1074/jbc.M004691200 [Abstract] [Full Text] [PDF]  

RNA: Structure Metabolism and Catalysis:

Jianguo Shan, Kim Moran-Jones, Trent P. Munro, Grahame J. Kidd, Donald J. Winzor, Keith S. Hoek, and Ross Smith
Binding of an RNA Trafficking Response Element to Heterogeneous Nuclear Ribonucleoproteins A1 and A2
J. Biol. Chem. 2000 275: 38286-38295. First Published on October 6, 2000; 10.1074/jbc.M007642200 [Abstract] [Full Text] [PDF]  

Klaus Brehm, Katharina Jensen, and Matthias Frosch
mRNA Trans-splicing in the Human Parasitic Cestode Echinococcus multilocularis
J. Biol. Chem. 2000 275: 38311-38318. First Published on September 5, 2000; 10.1074/jbc.M006091200 [Abstract] [Full Text] [PDF]  

Protein Synthesis Post-Translation Modification and Degradation:

Yannick Goumon, Karine Lugardon, Patrice Gadroy, Jean-Marc Strub, Ingeborg D. Welters, George B. Stefano, Dominique Aunis, and Marie-Hélène Metz-Boutigue
Processing of Proenkephalin-A in Bovine Chromaffin Cells. IDENTIFICATION OF NATURAL DERIVED FRAGMENTS BY N-TERMINAL SEQUENCING AND MATRIX-ASSISTED LASER DESORPTION IONIZATION-TIME OF FLIGHT MASS SPECTROMETRY
J. Biol. Chem. 2000 275: 38355-38362. First Published on September 14, 2000; 10.1074/jbc.M007557200 [Abstract] [Full Text] [PDF]  

Steven W. Taylor, A. Grey Craig, Wolfgang H. Fischer, Minkyu Park, and Robert I. Lehrer
Styelin D, an Extensively Modified Antimicrobial Peptide from Ascidian Hemocytes
J. Biol. Chem. 2000 275: 38417-38426. First Published on September 7, 2000; 10.1074/jbc.M006762200 [Abstract] [Full Text] [PDF]  

Taocong Jin, Yaping Gu, Gianluigi Zanusso, ManSun Sy, Anil Kumar, Mark Cohen, Pierluigi Gambetti, and Neena Singh
The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome
J. Biol. Chem. 2000 275: 38699-38704. First Published on September 1, 2000; 10.1074/jbc.M005543200 [Abstract] [Full Text] [PDF]  

Joseph L. Carlos, Mark Paetzel, Greg Brubaker, Andrew Karla, Christopher M. Ashwell, Mark O. Lively, Guoqing Cao, Patrick Bullinger, and Ross E. Dalbey
The Role of the Membrane-spanning Domain of Type I Signal Peptidases in Substrate Cleavage Site Selection
J. Biol. Chem. 2000 275: 38813-38822. First Published on September 11, 2000; 10.1074/jbc.M007093200 [Abstract] [Full Text] [PDF]  

Matthias Bäumer, Markus Künzler, Patrick Steigemann, Gerhard H. Braus, and Stefan Irniger
Yeast Ran-binding Protein Yrb1p Is Required for Efficient Proteolysis of Cell Cycle Regulatory Proteins Pds1p and Sic1p
J. Biol. Chem. 2000 275: 38929-38937. First Published on September 15, 2000; 10.1074/jbc.M007925200 [Abstract] [Full Text] [PDF]  

Genomics Proteomics and Bioinformatics:

John Svaren, Torsten Ehrig, Sarki A. Abdulkadir, Markus U. Ehrengruber, Mark A. Watson, and Jeffrey Milbrandt
EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis
J. Biol. Chem. 2000 275: 38524-38531. First Published on September 12, 2000; 10.1074/jbc.M005220200 [Abstract] [Full Text] [PDF]  

Protein Structure and Folding:

Ursula Jakob, Markus Eser, and James C. A. Bardwell
Redox Switch of Hsp33 Has a Novel Zinc-binding Motif
J. Biol. Chem. 2000 275: 38302-38310. First Published on September 6, 2000; 10.1074/jbc.M005957200 [Abstract] [Full Text] [PDF]  

Vincent C. Chen, Lee Chao, and Julie Chao
Roles of the P1, P2, and P3 Residues in Determining Inhibitory Specificity of Kallistatin toward Human Tissue Kallikrein
J. Biol. Chem. 2000 275: 38457-38466. First Published on September 18, 2000; 10.1074/jbc.M005605200 [Abstract] [Full Text] [PDF]  

Marco W. Fraaije, Robert H. H. van den Heuvel, Willem J. H. van Berkel, and Andrea Mattevi
Structural Analysis of Flavinylation in Vanillyl-Alcohol Oxidase
J. Biol. Chem. 2000 275: 38654-38658. First Published on September 12, 2000; 10.1074/jbc.M004753200 [Abstract] [Full Text] [PDF]  

Naoya Sasaki, Reiko Ohkura, and Kazuo Sutoh
Insertion or Deletion of a Single Residue in the Strut Sequence of Dictyostelium Myosin II Abolishes Strong Binding to Actin
J. Biol. Chem. 2000 275: 38705-38709. First Published on September 25, 2000; 10.1074/jbc.M001966200 [Abstract] [Full Text] [PDF]  

Ananyo A. Bhattacharya, Stephen Curry, and Nicholas P. Franks
Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin. HIGH RESOLUTION CRYSTAL STRUCTURES
J. Biol. Chem. 2000 275: 38731-38738. First Published on August 11, 2000; 10.1074/jbc.M005460200 [Abstract] [Full Text] [PDF]  

Jizu Yi, Jonathan W. Arthur, Roland L. Dunbrack, Jr., and Anna Marie Skalka
An Inhibitory Monoclonal Antibody Binds at the Turn of the Helix-Turn-Helix Motif in the N-terminal Domain of HIV-1 Integrase
J. Biol. Chem. 2000 275: 38739-38748. First Published on August 31, 2000; 10.1074/jbc.M005499200 [Abstract] [Full Text] [PDF]  

Jian-Ping Xiong, Rui Li, Makram Essafi, Thilo Stehle, and M. Amin Arnaout
An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain
J. Biol. Chem. 2000 275: 38762-38767. First Published on October 16, 2000; 10.1074/jbc.C000563200 [Abstract] [Full Text] [PDF]  

John W. M. Creemers, Jan-Willem H. P. van de Loo, Evelyn Plets, Linda M. Hendershot, and Wim J. M. Van de Ven
Binding of BiP to the Processing Enzyme Lymphoma Proprotein Convertase Prevents Aggregation, but Slows Down Maturation
J. Biol. Chem. 2000 275: 38842-38847. First Published on August 29, 2000; 10.1074/jbc.M006758200 [Abstract] [Full Text] [PDF]  

Nolan R. Filipenko and David M. Waisman
Characterization of the Ca2+-binding Sites of Annexin II Tetramer
J. Biol. Chem. 2000 275: 38877-38884. First Published on September 8, 2000; 10.1074/jbc.M004125200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Valerie B. O'Donnell, Barbara Coles, Malcolm J. Lewis, Brenda C. Crews, Lawrence J. Marnett, and Bruce A. Freeman
Catalytic Consumption of Nitric Oxide by Prostaglandin H Synthase-1 Regulates Platelet Function
J. Biol. Chem. 2000 275: 38239-38244. First Published on September 18, 2000; 10.1074/jbc.M001802200 [Abstract] [Full Text] [PDF]  

Kenji Watanabe, Takashi Mie, Akitami Ichihara, Hideaki Oikawa, and Mamoru Honma
Detailed Reaction Mechanism of Macrophomate Synthase. EXTRAORDINARY ENZYME CATALYZING FIVE-STEP TRANSFORMATION FROM 2-PYRONES TO BENZOATES
J. Biol. Chem. 2000 275: 38393-38401. First Published on September 12, 2000; 10.1074/jbc.M003119200 [Abstract] [Full Text] [PDF]  

Vicky N. Jackson, Victor A. Zammit, and Nigel T. Price
Identification of Positive and Negative Determinants of Malonyl-CoA Sensitivity and Carnitine Affinity within the Amino Termini of Rat Liver- and Muscle-type Carnitine Palmitoyltransferase I
J. Biol. Chem. 2000 275: 38410-38416. First Published on August 31, 2000; 10.1074/jbc.M007722200 [Abstract] [Full Text] [PDF]  

Stefan I. Liochev and Irwin Fridovich
Copper- and Zinc-containing Superoxide Dismutase Can Act as a Superoxide Reductase and a Superoxide Oxidase
J. Biol. Chem. 2000 275: 38482-38485. First Published on September 25, 2000; 10.1074/jbc.M007891200 [Abstract] [Full Text] [PDF]  

Cary B. Bauer, Hazel M. Holden, James B. Thoden, Robert Smith, and Ivan Rayment
X-ray Structures of the Apo and MgATP-bound States of Dictyostelium discoideum Myosin Motor Domain
J. Biol. Chem. 2000 275: 38494-38499. First Published on August 22, 2000; 10.1074/jbc.M005585200 [Abstract] [Full Text] [PDF]  

Danilo S. Boskovic and Sriram Krishnaswamy
Exosite Binding Tethers the Macromolecular Substrate to the Prothrombinase Complex and Directs Cleavage at Two Spatially Distinct Sites
J. Biol. Chem. 2000 275: 38561-38570. First Published on September 12, 2000; 10.1074/jbc.M006637200 [Abstract] [Full Text] [PDF]  

Mark E. Hatley, Benjamin K. Benton, Jun Xu, John P. Manfredi, Alfred G. Gilman, and Roger K. Sunahara
Isolation and Characterization of Constitutively Active Mutants of Mammalian Adenylyl Cyclase
J. Biol. Chem. 2000 275: 38626-38632. First Published on September 11, 2000; 10.1074/jbc.M007148200 [Abstract] [Full Text] [PDF]  

Jason P. Salter, Kee-Chong Lim, Elizabeth Hansell, Ivy Hsieh, and James H. McKerrow
Schistosome Invasion of Human Skin and Degradation of Dermal Elastin Are Mediated by a Single Serine Protease
J. Biol. Chem. 2000 275: 38667-38673. First Published on September 18, 2000; 10.1074/jbc.M006997200 [Abstract] [Full Text] [PDF]  

Giedrius Vilkaitis, Aiping Dong, Elmar Weinhold, Xiaodong Cheng, and Saulius Klimasauskas
Functional Roles of the Conserved Threonine 250 in the Target Recognition Domain of HhaI DNA Methyltransferase
J. Biol. Chem. 2000 275: 38722-38730. [Abstract] [Full Text] [PDF]  

Bernard C. Cook, Amy E. Rudolph, Ravi G. Kurumbail, Rhonda Porche-Sorbet, and Joseph P. Miletich
Directed Glycosylation of Human Coagulation Factor X at Residue 333. INSIGHT INTO FACTOR Va-DEPENDENT PROTHROMBIN CATALYSIS
J. Biol. Chem. 2000 275: 38774-38779. First Published on September 19, 2000; 10.1074/jbc.M004573200 [Abstract] [Full Text] [PDF]  

Reuben K. Njau, Carter A. Herndon, and John W. Hawes
Novel beta -Hydroxyacid Dehydrogenases in Escherichia coli and Haemophilus influenzae
J. Biol. Chem. 2000 275: 38780-38786. First Published on September 7, 2000; 10.1074/jbc.M007432200 [Abstract] [Full Text] [PDF]  

Tove Hammarberg, Patrick Provost, Bengt Persson, and Olof Rådmark
The N-terminal Domain of 5-Lipoxygenase Binds Calcium and Mediates Calcium Stimulation of Enzyme Activity
J. Biol. Chem. 2000 275: 38787-38793. First Published on September 12, 2000; 10.1074/jbc.M006136200 [Abstract] [Full Text] [PDF]  

Keith Stephenson, Yasuchika Yamaguchi, and James A. Hoch
The Mechanism of Action of Inhibitors of Bacterial Two-component Signal Transduction Systems
J. Biol. Chem. 2000 275: 38900-38904. First Published on September 7, 2000; 10.1074/jbc.M006633200 [Abstract] [Full Text] [PDF]  

Wataru Morikawa, Kenji Yamamoto, Sara Ishikawa, Sumiyo Takemoto, Mayumi Ono, Jun-ichi Fukushi, Seiji Naito, Chikateru Nozaki, Sadaaki Iwanaga, and Michihiko Kuwano
Angiostatin Generation by Cathepsin D Secreted by Human Prostate Carcinoma Cells
J. Biol. Chem. 2000 275: 38912-38920. First Published on September 13, 2000; 10.1074/jbc.M005402200 [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Mónica Mendes Sousa, Anthony G. W. Norden, Christian Jacobsen, Thomas E. Willnow, Erik Ilsø Christensen, Raj V. Thakker, Pierre J. Verroust, Søren K. Moestrup, and Maria Joaõ Saraiva
Evidence for the Role of Megalin in Renal Uptake of Transthyretin
J. Biol. Chem. 2000 275: 38176-38181. First Published on September 11, 2000; 10.1074/jbc.M002886200 [Abstract] [Full Text] [PDF]  

Slavoljub Vujcic, Maria Halmekytö, Paula Diegelman, Gregory Gan, Debora L. Kramer, Juhani Jänne, and Carl W. Porter
Effects of Conditional Overexpression of Spermidine/Spermine N1-Acetyltransferase on Polyamine Pool Dynamics, Cell Growth, and Sensitivity to Polyamine Analogs
J. Biol. Chem. 2000 275: 38319-38328. First Published on September 7, 2000; 10.1074/jbc.M003270200 [Abstract] [Full Text] [PDF]  

Kunhong Xiao, Linda Yu, and Chang-An Yu
Confirmation of the Involvement of Protein Domain Movement during the Catalytic Cycle of the Cytochrome bc1 Complex by the Formation of an Intersubunit Disulfide Bond between Cytochrome b and the Iron-Sulfur Protein
J. Biol. Chem. 2000 275: 38597-38604. First Published on September 7, 2000; 10.1074/jbc.M007444200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Rajan Somasundaram, Martin Ruehl, Nikolaus Tiling, Renate Ackermann, Monika Schmid, Ernst Otto Riecken, and Detlef Schuppan
Collagens Serve as an Extracellular Store of Bioactive Interleukin 2
J. Biol. Chem. 2000 275: 38170-38175. First Published on September 11, 2000; 10.1074/jbc.M006616200 [Abstract] [Full Text] [PDF]  

Helle Hassan, Celso A. Reis, Eric Paul Bennett, Ekaterina Mirgorodskaya, Peter Roepstorff, Michael A. Hollingsworth, Joy Burchell, Joyce Taylor-Papadimitriou, and Henrik Clausen
The Lectin Domain of UDP-N-acetyl-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T4 Directs Its Glycopeptide Specificities
J. Biol. Chem. 2000 275: 38197-38205. First Published on September 12, 2000; 10.1074/jbc.M005783200 [Abstract] [Full Text] [PDF]  

Guoqing Xia, Matthias R. Evers, Hyung-Gyoo Kang, Melitta Schachner, and Jacques U. Baenziger
Molecular Cloning and Expression of the Pituitary Glycoprotein Hormone N-Acetylgalactosamine-4-O-sulfotransferase
J. Biol. Chem. 2000 275: 38402-38409. First Published on September 14, 2000; 10.1074/jbc.M007821200 [Abstract] [Full Text] [PDF]  

Hiroyuki Nakamura, Yutaka Fujii, Isao Inoki, Kotaro Sugimoto, Kazuhiko Tanzawa, Hirokazu Matsuki, Ryu Miura, Yu Yamaguchi, and Yasunori Okada
Brevican Is Degraded by Matrix Metalloproteinases and Aggrecanase-1 (ADAMTS4) at Different Sites
J. Biol. Chem. 2000 275: 38885-38890. First Published on September 13, 2000; 10.1074/jbc.M003875200 [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Conceição Egas, Nuno Lavoura, Rosa Resende, Rui M. M. Brito, Euclides Pires, Maria C. Pedroso de Lima, and Carlos Faro
The Saposin-like Domain of the Plant Aspartic Proteinase Precursor Is a Potent Inducer of Vesicle Leakage
J. Biol. Chem. 2000 275: 38190-38196. First Published on September 11, 2000; 10.1074/jbc.M006093200 [Abstract] [Full Text] [PDF]  

Regina Klose, Friedrich Fresser, Silvano Köchl, Walther Parson, Andreas Kapetanopoulos, Jamila Fruchart-Najib, Gottfried Baier, and Gerd Utermann
Mapping of a Minimal Apolipoprotein(a) Interaction Motif Conserved in Fibrin(ogen) beta - and gamma -Chains
J. Biol. Chem. 2000 275: 38206-38212. First Published on September 8, 2000; 10.1074/jbc.M003640200 [Abstract] [Full Text] [PDF]  

Vincent Raussens, Michael K. H. Mah, Cyril M. Kay, Brian D. Sykes, and Robert O. Ryan
Structural Characterization of a Low Density Lipoprotein Receptor-active Apolipoprotein E Peptide, ApoE3-(126-183)
J. Biol. Chem. 2000 275: 38329-38336. First Published on September 13, 2000; 10.1074/jbc.M005732200 [Abstract] [Full Text] [PDF]  

Elizabeth E. Millard, Kalpana Srivastava, Linton M. Traub, Jean E. Schaffer, and Daniel S. Ory
Niemann-Pick Type C1 (NPC1) Overexpression Alters Cellular Cholesterol Homeostasis
J. Biol. Chem. 2000 275: 38445-38451. First Published on August 29, 2000; 10.1074/jbc.M003180200 [Abstract] [Full Text] [PDF]  

Dawn L. Brasaemle, Boris Rubin, Ingrid A. Harten, Jasmine Gruia-Gray, Alan R. Kimmel, and Constantine Londos
Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis
J. Biol. Chem. 2000 275: 38486-38493. First Published on August 17, 2000; 10.1074/jbc.M007322200 [Abstract] [Full Text] [PDF]  

Paul N. Black, Concetta C. DiRusso, David Sherin, Robert MacColl, Jens Knudsen, and James D. Weimar
Affinity Labeling Fatty Acyl-CoA Synthetase with 9-p-Azidophenoxy Nonanoic Acid and the Identification of the Fatty Acid-binding Site
J. Biol. Chem. 2000 275: 38547-38553. First Published on September 19, 2000; 10.1074/jbc.M006413200 [Abstract] [Full Text] [PDF]  

James P. Bridges, Harold W. Davis, Mamatha Damodarasamy, Yoshio Kuroki, Gabriel Howles, David Y. Hui, and Francis X. McCormack
Pulmonary Surfactant Proteins A and D Are Potent Endogenous Inhibitors of Lipid Peroxidation and Oxidative Cellular Injury
J. Biol. Chem. 2000 275: 38848-38855. First Published on August 31, 2000; 10.1074/jbc.M005322200 [Abstract] [Full Text] [PDF]  

Membrane Transport Structure Function and Biogenesis:

Carola Förster and Patricia M. Kane
Cytosolic Ca2+ Homeostasis Is a Constitutive Function of the V-ATPase in Saccharomyces cerevisiae
J. Biol. Chem. 2000 275: 38245-38253. First Published on September 15, 2000; 10.1074/jbc.M006650200 [Abstract] [Full Text] [PDF]  

Rita Barresi, Steven A. Moore, Catherine A. Stolle, Jerry R. Mendell, and Kevin P. Campbell
Expression of gamma -Sarcoglycan in Smooth Muscle and Its Interaction with the Smooth Muscle Sarcoglycan-Sarcospan Complex
J. Biol. Chem. 2000 275: 38554-38560. First Published on September 18, 2000; 10.1074/jbc.M007799200 [Abstract] [Full Text] [PDF]  

Takahiro Iwamoto, Akira Uehara, Issei Imanaga, and Munekazu Shigekawa
The Na+/Ca2+ Exchanger NCX1 Has Oppositely Oriented Reentrant Loop Domains That Contain Conserved Aspartic Acids Whose Mutation Alters Its Apparent Ca2+ Affinity
J. Biol. Chem. 2000 275: 38571-38580. First Published on August 30, 2000; 10.1074/jbc.M003788200 [Abstract] [Full Text] [PDF]  

Leah J. Siskind and Marco Colombini
The Lipids C2- and C16-Ceramide Form Large Stable Channels. IMPLICATIONS FOR APOPTOSIS
J. Biol. Chem. 2000 275: 38640-38644. First Published on October 10, 2000; 10.1074/jbc.C000587200 [Abstract] [Full Text] [PDF]  

Khaled Machaca and Shirley Haun
Store-operated Calcium Entry Inactivates at the Germinal Vesicle Breakdown Stage of Xenopus Meiosis
J. Biol. Chem. 2000 275: 38710-38715. First Published on September 15, 2000; 10.1074/jbc.M007887200 [Abstract] [Full Text] [PDF]  

Guoxiang Chu, James W. Lester, Karen B. Young, Wusheng Luo, Jing Zhai, and Evangelia G. Kranias
A Single Site (Ser16) Phosphorylation in Phospholamban Is Sufficient in Mediating Its Maximal Cardiac Responses to beta -Agonists
J. Biol. Chem. 2000 275: 38938-38943. First Published on September 14, 2000; 10.1074/jbc.M004079200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Adilson Guilherme, Masahiro Emoto, Joanne M. Buxton, Sahana Bose, Rosanna Sabini, William E. Theurkauf, John Leszyk, and Michael P. Czech
Perinuclear Localization and Insulin Responsiveness of GLUT4 Requires Cytoskeletal Integrity in 3T3-L1 Adipocytes
J. Biol. Chem. 2000 275: 38151-38159. First Published on August 18, 2000; 10.1074/jbc.M003432200 [Abstract] [Full Text] [PDF]  

Lianne B. Dale, Moshmi Bhattacharya, Pieter H. Anborgh, Barbara Murdoch, Mickie Bhatia, Shigetada Nakanishi, and Stephen S. G. Ferguson
G Protein-coupled Receptor Kinase-mediated Desensitization of Metabotropic Glutamate Receptor 1A Protects against Cell Death
J. Biol. Chem. 2000 275: 38213-38220. First Published on September 11, 2000; 10.1074/jbc.M006075200 [Abstract] [Full Text] [PDF]  

Jason S. Carroll, Owen W. J. Prall, Elizabeth A. Musgrove, and Robert L. Sutherland
A Pure Estrogen Antagonist Inhibits Cyclin E-Cdk2 Activity in MCF-7 Breast Cancer Cells and Induces Accumulation of p130-E2F4 Complexes Characteristic of Quiescence
J. Biol. Chem. 2000 275: 38221-38229. First Published on September 15, 2000; 10.1074/jbc.M004424200 [Abstract] [Full Text] [PDF]  

James D. Joseph and Anthony R. Means
Identification and Characterization of Two Ca2+/CaM-dependent Protein Kinases Required for Normal Nuclear Division in Aspergillus nidulans
J. Biol. Chem. 2000 275: 38230-38238. First Published on September 14, 2000; 10.1074/jbc.M006422200 [Abstract] [Full Text] [PDF]  

Brian K. Law, Mary E. Waltner-Law, Amelia J. Entingh, Anna Chytil, Mary E. Aakre, Peter Nørgaard, and Harold L. Moses
Salicylate-induced Growth Arrest Is Associated with Inhibition of p70s6k and Down-regulation of c-Myc, Cyclin D1, Cyclin A, and Proliferating Cell Nuclear Antigen
J. Biol. Chem. 2000 275: 38261-38267. First Published on September 18, 2000; 10.1074/jbc.M005545200 [Abstract] [Full Text] [PDF]  

Suzanne M. Appleyard, Jay P. McLaughlin, and Charles Chavkin
Tyrosine Phosphorylation of the kappa -Opioid Receptor Regulates Agonist Efficacy
J. Biol. Chem. 2000 275: 38281-38285. First Published on September 19, 2000; 10.1074/jbc.M006756200 [Abstract] [Full Text] [PDF]  

Supriya Patil, Gary M. Wildey, Thomas L. Brown, Lisa Choy, Rik Derynck, and Philip H. Howe
Smad7 Is Induced by CD40 and Protects WEHI 231 B-lymphocytes from Transforming Growth Factor-beta -induced Growth Inhibition and Apoptosis
J. Biol. Chem. 2000 275: 38363-38370. First Published on September 19, 2000; 10.1074/jbc.M004861200 [Abstract] [Full Text] [PDF]  

Patricia Lebrun, Véronique Baron, Christof R. Hauck, David D. Schlaepfer, and Emmanuel Van Obberghen
Cell Adhesion and Focal Adhesion Kinase Regulate Insulin Receptor Substrate-1 Expression
J. Biol. Chem. 2000 275: 38371-38377. First Published on August 30, 2000; 10.1074/jbc.M006162200 [Abstract] [Full Text] [PDF]  

Shigeichi Kumazaki, Hiroshi Nakajima, Takahisa Sakaguchi, Emi Nakagawa, Hidenori Shinohara, Keitaro Yoshihara, and Shigetoshi Aono
Dissociation and Recombination between Ligands and Heme in a CO-sensing Transcriptional Activator CooA. A FLASH PHOTOLYSIS STUDY
J. Biol. Chem. 2000 275: 38378-38383. First Published on September 7, 2000; 10.1074/jbc.M005533200 [Abstract] [Full Text] [PDF]  

Yanick Paquet, Eric Trottier, Marie-Josée Beaudet, and Alan Anderson
Mutational Analysis of the CYP2B2 Phenobarbital Response Unit and Inhibitory Effect of the Constitutive Androstane Receptor on Phenobarbital Responsiveness
J. Biol. Chem. 2000 275: 38427-38436. First Published on September 18, 2000; 10.1074/jbc.M005776200 [Abstract] [Full Text] [PDF]  

Nai-Wen Chi and Harvey F. Lodish
Tankyrase Is a Golgi-associated Mitogen-activated Protein Kinase Substrate That Interacts with IRAP in GLUT4 Vesicles
J. Biol. Chem. 2000 275: 38437-38444. First Published on September 14, 2000; 10.1074/jbc.M007635200 [Abstract] [Full Text] [PDF]  

Tania Arcondéguy, David Lawson, and Mike Merrick
Two Residues in the T-loop of GlnK Determine NifL-dependent Nitrogen Control of nif Gene Expression
J. Biol. Chem. 2000 275: 38452-38456. First Published on August 21, 2000; 10.1074/jbc.M001935200 [Abstract] [Full Text] [PDF]  

Tianbao Yang and B. W. Poovaiah
An Early Ethylene Up-regulated Gene Encoding a Calmodulin-binding Protein Involved in Plant Senescence and Death
J. Biol. Chem. 2000 275: 38467-38473. First Published on August 21, 2000; 10.1074/jbc.M003566200 [Abstract] [Full Text] [PDF]  

Kersten M. Small, Susan L. Forbes, Kari M. Brown, and Stephen B. Liggett
An Asn to Lys Polymorphism in the Third Intracellular Loop of the Human alpha 2A-Adrenergic Receptor Imparts Enhanced Agonist-promoted Gi Coupling
J. Biol. Chem. 2000 275: 38518-38523. First Published on August 17, 2000; 10.1074/jbc.M004550200 [Abstract] [Full Text] [PDF]  

Kenneth W. Young, Martin D. Bootman, Deborah R. Channing, Peter Lipp, Peter R. Maycox, Jackie Meakin, R. A. John Challiss, and Stefan R. Nahorski
Lysophosphatidic Acid-induced Ca2+ Mobilization Requires Intracellular Sphingosine 1-Phosphate Production. POTENTIAL INVOLVEMENT OF ENDOGENOUS EDG-4 RECEPTORS
J. Biol. Chem. 2000 275: 38532-38539. First Published on August 22, 2000; 10.1074/jbc.M006631200 [Abstract] [Full Text] [PDF]  

Mahnaz Razandi, Ali Pedram, and Ellis R. Levin
Estrogen Signals to the Preservation of Endothelial Cell Form and Function
J. Biol. Chem. 2000 275: 38540-38546. First Published on September 14, 2000; 10.1074/jbc.M007555200 [Abstract] [Full Text] [PDF]  

Julie Lotharius and Karen L. O'Malley
The Parkinsonism-inducing Drug 1-Methyl-4-phenylpyridinium Triggers Intracellular Dopamine Oxidation. A NOVEL MECHANISM OF TOXICITY
J. Biol. Chem. 2000 275: 38581-38588. First Published on August 31, 2000; 10.1074/jbc.M005385200 [Abstract] [Full Text] [PDF]  

Kenton L. Longenecker, Baolin Zhang, Urszula Derewenda, Peter J. Sheffield, Zbigniew Dauter, J. Thomas Parsons, Yi Zheng, and Zygmunt S. Derewenda
Structure of the BH Domain from Graf and Its Implications for Rho GTPase Recognition
J. Biol. Chem. 2000 275: 38605-38610. First Published on September 11, 2000; 10.1074/jbc.M007574200 [Abstract] [Full Text] [PDF]  

Angela W. Norton, Marc R. D'Amours, Hector J. Grazio, Tracy L. Hebert, and Rick H. Cote
Mechanism of Transducin Activation of Frog Rod Photoreceptor Phosphodiesterase. ALLOSTERIC INTERACTIONS BETWEEN THE INHIBITORY gamma SUBUNIT AND THE NONCATALYTIC cGMP-BINDING SITES
J. Biol. Chem. 2000 275: 38611-38619. First Published on September 18, 2000; 10.1074/jbc.M004606200 [Abstract] [Full Text] [PDF]  

Sebastian Pons and Ignacio Torres-Aleman
Insulin-like Growth Factor-I Stimulates Dephosphorylation of Ikappa B through the Serine Phosphatase Calcineurin (Protein Phosphatase 2B)
J. Biol. Chem. 2000 275: 38620-38625. First Published on September 5, 2000; 10.1074/jbc.M004531200 [Abstract] [Full Text] [PDF]  

Akhilesh Pandey, Minerva M. Fernandez, Hanno Steen, Blagoy Blagoev, Mogens M. Nielsen, Serge Roche, Matthias Mann, and Harvey F. Lodish
Identification of a Novel Immunoreceptor Tyrosine-based Activation Motif-containing Molecule, STAM2, by Mass Spectrometry and Its Involvement in Growth Factor and Cytokine Receptor Signaling Pathways
J. Biol. Chem. 2000 275: 38633-38639. First Published on September 18, 2000; 10.1074/jbc.M007849200 [Abstract] [Full Text] [PDF]  

Rinku Dutta, Takeshi Yoshida, and Masayori Inouye
The Critical Role of the Conserved Thr247 Residue in the Functioning of the Osmosensor EnvZ, a Histidine Kinase/Phosphatase, in Escherichia coli
J. Biol. Chem. 2000 275: 38645-38653. First Published on September 5, 2000; 10.1074/jbc.M005872200 [Abstract] [Full Text] [PDF]  

Liaoyuan A. Hu, Yuting Tang, William E. Miller, Mei Cong, Anthony G. Lau, Robert J. Lefkowitz, and Randy A. Hall
beta 1-Adrenergic Receptor Association with PSD-95. INHIBITION OF RECEPTOR INTERNALIZATION AND FACILITATION OF beta 1-ADRENERGIC RECEPTOR INTERACTION WITH N-METHYL-D-ASPARTATE RECEPTORS
J. Biol. Chem. 2000 275: 38659-38666. First Published on September 19, 2000; 10.1074/jbc.M005938200 [Abstract] [Full Text] [PDF]  

Jannie W. H. Janssen, Petra H. M. Bovee-Geurts, Zan P. A. Peeters, Jim K. Bowmaker, Howard M. Cooper, Zoë K. David-Gray, Eviatar Nevo, and Willem J. DeGrip
A Fully Functional Rod Visual Pigment in a Blind Mammal. A CASE FOR ADAPTIVE FUNCTIONAL REORGANIZATION?
J. Biol. Chem. 2000 275: 38674-38679. First Published on September 12, 2000; 10.1074/jbc.M008254200 [Abstract] [Full Text] [PDF]  

Antonio González, Irene Schulz, and Andreas Schmid
Agonist-evoked Mitochondrial Ca2+ Signals in Mouse Pancreatic Acinar Cells
J. Biol. Chem. 2000 275: 38680-38686. First Published on September 19, 2000; 10.1074/jbc.M005667200 [Abstract] [Full Text] [PDF]  

Grant C. Churchill and Antony Galione
Spatial Control of Ca2+ Signaling by Nicotinic Acid Adenine Dinucleotide Phosphate Diffusion and Gradients
J. Biol. Chem. 2000 275: 38687-38692. First Published on September 26, 2000; 10.1074/jbc.M005827200 [Abstract] [Full Text] [PDF]  

Michael M. Awad, Herve Enslen, Joan M. Boylan, Roger J. Davis, and Philip A. Gruppuso
Growth Regulation via p38 Mitogen-activated Protein Kinase in Developing Liver
J. Biol. Chem. 2000 275: 38716-38721. First Published on September 19, 2000; 10.1074/jbc.M008040200 [Abstract] [Full Text] [PDF]  

Yasmin Shakur, Kazuyo Takeda, Yael Kenan, Zu-Xi Yu, Graham Rena, Daniel Brandt, Miles D. Houslay, Eva Degerman, Victor J. Ferrans, and Vicent C. Manganiello
Membrane Localization of Cyclic Nucleotide Phosphodiesterase 3 (PDE3). TWO N-TERMINAL DOMAINS ARE REQUIRED FOR THE EFFICIENT TARGETING TO, AND ASSOCIATION OF, PDE3 WITH ENDOPLASMIC RETICULUM
J. Biol. Chem. 2000 275: 38749-38761. First Published on August 21, 2000; 10.1074/jbc.M001734200 [Abstract] [Full Text] [PDF]  

Mei-Chieh Chen, Tsui-Ling Hsu, Tien-Yau Luh, and Shie-Liang Hsieh
Overexpression of Bcl-2 Enhances LIGHT- and Interferon-gamma -mediated Apoptosis in Hep3BT2 Cells
J. Biol. Chem. 2000 275: 38794-38801. First Published on September 18, 2000; 10.1074/jbc.M003292200 [Abstract] [Full Text] [PDF]  

Jing Qing, Ying Zhang, and Rik Derynck
Structural and Functional Characterization of the Transforming Growth Factor-beta -induced Smad3/c-Jun Transcriptional Cooperativity
J. Biol. Chem. 2000 275: 38802-38812. First Published on September 19, 2000; 10.1074/jbc.M004731200 [Abstract] [Full Text] [PDF]  

Charles K. Szekeres, Keqin Tang, Mohit Trikha, and Kenneth V. Honn
Eicosanoid Activation of Extracellular Signal-regulated Kinase1/2 in Human Epidermoid Carcinoma Cells
J. Biol. Chem. 2000 275: 38831-38841. First Published on August 21, 2000; 10.1074/jbc.M002673200 [Abstract] [Full Text] [PDF]  

Nicholas J. Brandon, Patrick Delmas, Josef T. Kittler, Bernard J. McDonald, Werner Sieghart, David A. Brown, Trevor G. Smart, and Stephen J. Moss
GABAA Receptor Phosphorylation and Functional Modulation in Cortical Neurons by a Protein Kinase C-dependent Pathway
J. Biol. Chem. 2000 275: 38856-38862. First Published on September 7, 2000; 10.1074/jbc.M004910200 [Abstract] [Full Text] [PDF]  

Rajani K. Bommakanti, Shaveta Vinayak, and William F. Simonds
Dual Regulation of Akt/Protein Kinase B by Heterotrimeric G Protein Subunits
J. Biol. Chem. 2000 275: 38870-38876. First Published on September 13, 2000; 10.1074/jbc.M007403200 [Abstract] [Full Text] [PDF]  

Giovanni Pani, Renata Colavitti, Barbara Bedogni, Rosanna Anzevino, Silvia Borrello, and Tommaso Galeotti
A Redox Signaling Mechanism for Density-dependent Inhibition of Cell Growth
J. Biol. Chem. 2000 275: 38891-38899. First Published on September 14, 2000; 10.1074/jbc.M007319200 [Abstract] [Full Text] [PDF]  

Han-Fei Ding, Yi-Ling Lin, Gaël McGill, Peter Juo, Hong Zhu, John Blenis, Junying Yuan, and David E. Fisher
Essential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53
J. Biol. Chem. 2000 275: 38905-38911. First Published on September 14, 2000; 10.1074/jbc.M004714200 [Abstract] [Full Text] [PDF]  

Claudia Schmauss
A Single Dose of Methamphetamine Leads to a Long Term Reversal of the Blunted Dopamine D1 Receptor-mediated Neocortical c-fos Responses in Mice Deficient for D2 and D3 Receptors
J. Biol. Chem. 2000 275: 38944-38948. First Published on September 27, 2000; 10.1074/jbc.M005064200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Bruce L. Goode, Miu Chau, Paul E. Denis, and Stuart C. Feinstein
Structural and Functional Differences between 3-Repeat and 4-Repeat Tau Isoforms. IMPLICATIONS FOR NORMAL TAU FUNCTION AND THE ONSET OF NEURODEGENERATIVE DISEASE
J. Biol. Chem. 2000 275: 38182-38189. First Published on September 12, 2000; 10.1074/jbc.M007489200 [Abstract] [Full Text] [PDF]  

Edmar T. Costa, Dorian S. Olivera, Douglas A. Meyer, Vania M. M. Ferreira, Eli E. Soto, Shanti Frausto, Daniel D. Savage, Michael D. Browning, and C. Fernando Valenzuela
Fetal Alcohol Exposure Alters Neurosteroid Modulation of Hippocampal N-Methyl-D-aspartate Receptors
J. Biol. Chem. 2000 275: 38268-38274. First Published on September 14, 2000; 10.1074/jbc.M004136200 [Abstract] [Full Text] [PDF]  

Amom Ruhikanta Meetei, Kolathur S. Ullas, and Manchanahalli R. Satyanarayana Rao
Identification of Two Novel Zinc Finger Modules and Nuclear Localization Signal in Rat Spermatidal Protein TP2 by Site-directed Mutagenesis
J. Biol. Chem. 2000 275: 38500-38507. First Published on August 28, 2000; 10.1074/jbc.M002734200 [Abstract] [Full Text] [PDF]  

Dexi Chen, R. Anne Stetler, Guodong Cao, Wei Pei, Cristine O'Horo, Xiao-Ming Yin, and Jun Chen
Characterization of the Rat DNA Fragmentation Factor 35/Inhibitor of Caspase-activated DNase (Short Form). THE ENDOGENOUS INHIBITOR OF CASPASE-DEPENDENT DNA FRAGMENTATION IN NEURONAL APOPTOSIS
J. Biol. Chem. 2000 275: 38508-38517. First Published on September 12, 2000; 10.1074/jbc.M003906200 [Abstract] [Full Text] [PDF]  

Jose A. Rodríguez and Beric R. Henderson
Identification of a Functional Nuclear Export Sequence in BRCA1
J. Biol. Chem. 2000 275: 38589-38596. First Published on September 15, 2000; 10.1074/jbc.M003851200 [Abstract] [Full Text] [PDF]  

Siu-Yuen Chan and Richard Wing-Chuen Wong
Expression of Epidermal Growth Factor in Transgenic Mice Causes Growth Retardation
J. Biol. Chem. 2000 275: 38693-38698. First Published on September 22, 2000; 10.1074/jbc.M004189200 [Abstract] [Full Text] [PDF]  

Claire Bastie, Serge Luquet, Dorte Holst, Chantal Jehl-Pietri, and Paul A. Grimaldi
Alterations of Peroxisome Proliferator-activated Receptor delta Activity Affect Fatty Acid-controlled Adipose Differentiation
J. Biol. Chem. 2000 275: 38768-38773. First Published on September 15, 2000; 10.1074/jbc.M006450200 [Abstract] [Full Text] [PDF]  

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