Editorials:

In Celebration of 100 Years of Publication
J. Biol. Chem. 2001 276: 1. [Full Text] [PDF]  

Reflections:

Arthur Kornberg

Remembering Our Teachers
J. Biol. Chem. 2000 276: 3-11. [Full Text] [PDF]  

Accelerated Publications:

Hiroshi Tauchi, Junya Kobayashi, Ken-ichi Morishima, Shinya Matsuura, Asako Nakamura, Takahiro Shiraishi, Emi Ito, Debora Masnada, Domenico Delia, and Kenshi Komatsu

The Forkhead-associated Domain of NBS1 Is Essential for Nuclear Foci Formation after Irradiation but Not Essential for hRAD50·hMRE11·NBS1 Complex DNA Repair Activity
J. Biol. Chem. 2000 276: 12-15. First Published on November 2, 2000; 10.1074/jbc.C000578200 [Abstract] [Full Text] [PDF]  

Stefano Bruno, Francesca Schiaretti, Peter Burkhard, Jan P. Kraus, Miroslav Janosik, and Andrea Mozzarelli

Functional Properties of the Active Core of Human Cystathionine -Synthase Crystals
J. Biol. Chem. 2000 276: 16-19. First Published on October 19, 2000; 10.1074/jbc.C000588200 [Abstract] [Full Text] [PDF]  

DNA: Replication Repair and Recombination:

Valerie L. Gerlach, William J. Feaver, Paula L. Fischhaber, and Errol C. Friedberg

Purification and Characterization of pol, a DNA Polymerase Encoded by the Human DINB1 Gene
J. Biol. Chem. 2000 276: 92-98. First Published on October 6, 2000; 10.1074/jbc.M004413200 [Abstract] [Full Text] [PDF]  

Frank G. Harmon and Stephen C. Kowalczykowski

Biochemical Characterization of the DNA Helicase Activity of the Escherichia coli RecQ Helicase
J. Biol. Chem. 2000 276: 232-243. First Published on October 6, 2000; 10.1074/jbc.M006555200 [Abstract] [Full Text] [PDF]  

Genes: Structure and Regulation:

Frank Wu and Amy S. Lee

YY1 as a Regulator of Replication-dependent Hamster Histone H3.2 Promoter and an Interactive Partner of AP-2
J. Biol. Chem. 2000 276: 28-34. First Published on October 3, 2000; 10.1074/jbc.M006074200 [Abstract] [Full Text] [PDF]  

Chun Li Zhang, Timothy A. McKinsey, Jian-rong Lu, and Eric N. Olson

Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor
J. Biol. Chem. 2000 276: 35-39. First Published on October 5, 2000; 10.1074/jbc.M007364200 [Abstract] [Full Text] [PDF]  

Xiaoya Zeng, Hunjoo Lee, Qinghong Zhang, and Hua Lu

p300 Does Not Require Its Acetylase Activity to Stimulate p73 Function
J. Biol. Chem. 2000 276: 48-52. First Published on November 13, 2000; 10.1074/jbc.C000722200 [Abstract] [Full Text] [PDF]  

George M. Yousef, Andreas Scorilas, Klaus Jung, Linda K. Ashworth, and Eleftherios P. Diamandis

Molecular Cloning of the Human Kallikrein 15 Gene (KLK15). UP-REGULATION IN PROSTATE CANCER
J. Biol. Chem. 2000 276: 53-61. First Published on September 28, 2000; 10.1074/jbc.M005432200 [Abstract] [Full Text] [PDF]  

Robert H. Harrington and Arun Sharma

Transcription Factors Recognizing Overlapping C1-A2 Binding Sites Positively Regulate Insulin Gene Expression
J. Biol. Chem. 2000 276: 104-113. First Published on October 6, 2000; 10.1074/jbc.M008415200 [Abstract] [Full Text] [PDF]  

Takahiro Nakamura, Masaru Ohta, Masahiro Sugiura, and Mamoru Sugita

Chloroplast Ribonucleoproteins Function as a Stabilizing Factor of Ribosome-free mRNAs in the Stroma
J. Biol. Chem. 2000 276: 147-152. First Published on October 18, 2000; 10.1074/jbc.M008817200 [Abstract] [Full Text] [PDF]  

Christopher Johnson, Geraldine Glover, and Jonathan Arias

Regulation of DNA Binding and trans-Activation by a Xenobiotic Stress-activated Plant Transcription Factor
J. Biol. Chem. 2000 276: 172-178. First Published on October 16, 2000; 10.1074/jbc.M005143200 [Abstract] [Full Text] [PDF]  

Cynthia A. Pise-Masison, Renaud Mahieux, Michael Radonovich, Hua Jiang, and John N. Brady

Human T-lymphotropic Virus Type I Tax Protein Utilizes Distinct Pathways for p53 Inhibition That Are Cell Type-dependent
J. Biol. Chem. 2000 276: 200-205. First Published on October 17, 2000; 10.1074/jbc.M005601200 [Abstract] [Full Text] [PDF]  

Sanjay D'Souza, Hong Xin, Scott Walter, and Divaker Choubey

The Gene Encoding p202, an Interferon-inducible Negative Regulator of the p53 Tumor Suppressor, Is a Target of p53-mediated Transcriptional Repression
J. Biol. Chem. 2000 276: 298-305. First Published on September 29, 2000; 10.1074/jbc.M007155200 [Abstract] [Full Text] [PDF]  

Qingfang He, Nadia Dolganov, Olle Björkman, and Arthur R. Grossman

The High Light-inducible Polypeptides in Synechocystis PCC6803. EXPRESSION AND FUNCTION IN HIGH LIGHT
J. Biol. Chem. 2000 276: 306-314. First Published on October 6, 2000; 10.1074/jbc.M008686200 [Abstract] [Full Text] [PDF]  

Chien Chen, Mark C. K. Yang, and Thomas P. Yang

Evidence That Silencing of the HPRT Promoter by DNA Methylation Is Mediated by Critical CpG Sites
J. Biol. Chem. 2000 276: 320-328. First Published on September 29, 2000; 10.1074/jbc.M007096200 [Abstract] [Full Text] [PDF]  

Christopher P. Mack, Avril V. Somlyo, Martina Hautmann, Andrew P. Somlyo, and Gary K. Owens

Smooth Muscle Differentiation Marker Gene Expression Is Regulated by RhoA-mediated Actin Polymerization
J. Biol. Chem. 2000 276: 341-347. First Published on October 16, 2000; 10.1074/jbc.M005505200 [Abstract] [Full Text] [PDF]  

Wendy Cannon, María-Trinidad Gallegos, and Martin Buck

DNA Melting within a Binary ⁵⁴-Promoter DNA Complex
J. Biol. Chem. 2000 276: 386-394. First Published on October 17, 2000; 10.1074/jbc.M007779200 [Abstract] [Full Text] [PDF]  

Akiko Kobayashi, Tsuyoshi Miyake, Yoshifumi Ohyama, Masashi Kawaichi, and Tetsuro Kokubo

Mutations in the TATA-binding Protein, Affecting Transcriptional Activation, Show Synthetic Lethality with the TAF145 Gene Lacking the TAF N-terminal Domain in Saccharomyces cerevisiae
J. Biol. Chem. 2000 276: 395-405. First Published on October 16, 2000; 10.1074/jbc.M008208200 [Abstract] [Full Text] [PDF]  

Christelle Bertrand, Arnaud Chatonnet, Christina Takke, YiLin Yan, John Postlethwait, Jean-Pierre Toutant, and Xavier Cousin

Zebrafish Acetylcholinesterase Is Encoded by a Single Gene Localized on Linkage Group 7. GENE STRUCTURE AND POLYMORPHISM; MOLECULAR FORMS AND EXPRESSION PATTERN DURING DEVELOPMENT
J. Biol. Chem. 2000 276: 464-474. First Published on October 2, 2000; 10.1074/jbc.M006308200 [Abstract] [Full Text] [PDF]  

Daisuke Nagata, Etsu Suzuki, Hiroaki Nishimatsu, Hiroshi Satonaka, Atsuo Goto, Masao Omata, and Yasunobu Hirata

Transcriptional Activation of the cyclin D1 Gene Is Mediated by Multiple Cis-Elements, Including SP1 Sites and a cAMP-responsive Element in Vascular Endothelial Cells
J. Biol. Chem. 2000 276: 662-669. First Published on October 9, 2000; 10.1074/jbc.M005522200 [Abstract] [Full Text] [PDF]  

Federico Giannoni, Hans-Michael Müller, Jacopo Vizioli, Flaminia Catteruccia, Fotis C. Kafatos, and Andrea Crisanti

Nuclear Factors Bind to a Conserved DNA Element That Modulates Transcription of Anopheles gambiae Trypsin Genes
J. Biol. Chem. 2000 276: 700-707. First Published on October 2, 2000; 10.1074/jbc.M005540200 [Abstract] [Full Text] [PDF]  

Rachel Zamostiano, Albert Pinhasov, Edgar Gelber, Ruth A. Steingart, Eyal Seroussi, Eliezer Giladi, Merav Bassan, Yoram Wollman, Helen J. Eyre, John C. Mulley, Douglas E. Brenneman, and Illana Gozes

Cloning and Characterization of the Human Activity-dependent Neuroprotective Protein
J. Biol. Chem. 2000 276: 708-714. First Published on September 29, 2000; 10.1074/jbc.M007416200 [Abstract] [Full Text] [PDF]  

Tonya M. Dixon, Kiefer W. Daniel, Stephen R. Farmer, and Sheila Collins

CCAAT/Enhancer-binding Protein Is Required for Transcription of the ₃-Adrenergic Receptor Gene during Adipogenesis
J. Biol. Chem. 2000 276: 722-728. First Published on October 6, 2000; 10.1074/jbc.M008440200 [Abstract] [Full Text] [PDF]  

Pavel L. Katsel and Robert J. Greenstein

Identification of Overlapping AP-2/NF-B-responsive Elements on the Rat Cholecystokinin Gene Promoter
J. Biol. Chem. 2000 276: 752-758. First Published on October 5, 2000; 10.1074/jbc.M007553200 [Abstract] [Full Text] [PDF]  

Jane L. Ko and Horace H. Loh

Single-stranded DNA-binding Complex Involved in Transcriptional Regulation of Mouse µ-Opioid Receptor Gene
J. Biol. Chem. 2000 276: 788-795. First Published on October 10, 2000; 10.1074/jbc.M004279200 [Abstract] [Full Text] [PDF]  

Dina Ellsworth, Renee L. Finnen, and S. J. Flint

Superimposed Promoter Sequences of the Adenoviral E2 Early RNA Polymerase III and RNA Polymerase II Transcription Units
J. Biol. Chem. 2000 276: 827-834. First Published on October 12, 2000; 10.1074/jbc.M007036200 [Abstract] [Full Text] [PDF]  

Xingming Shi, Shuting Bai, Lina Li, and Xu Cao

Hoxa-9 Represses Transforming Growth Factor--induced Osteopontin Gene Transcription
J. Biol. Chem. 2000 276: 850-855. First Published on October 19, 2000; 10.1074/jbc.M005955200 [Abstract] [Full Text] [PDF]  

RNA: Structure Metabolism and Catalysis:

Chun-Hong Chen, Wei-Yü Tsai, Hau-Ren Chen, Ching-Hung Wang, and Soo-Chen Cheng

Identification and Characterization of Two Novel Components of The Prp19p-associated Complex, Ntc30p and Ntc20p
J. Biol. Chem. 2000 276: 488-494. First Published on October 3, 2000; 10.1074/jbc.M006958200 [Abstract] [Full Text] [PDF]  

Kathleen E. Glover, David F. Spencer, and Michael W. Gray

Identification and Structural Characterization of Nucleus-encoded Transfer RNAs Imported into Wheat Mitochondria
J. Biol. Chem. 2000 276: 639-648. First Published on October 10, 2000; 10.1074/jbc.M007708200 [Abstract] [Full Text] [PDF]  

Protein Synthesis Post-Translation Modification and Degradation:

Jieya Shao, Nicholas Grammatikakis, Bradley T. Scroggins, Sheri Uma, Wenjun Huang, Jane-Jane Chen, Steven D. Hartson, and Robert L. Matts

Hsp90 Regulates p50^cdc37 Function during the Biogenesis of the Active Conformation of the Heme-regulated eIF2 Kinase
J. Biol. Chem. 2000 276: 206-214. First Published on October 17, 2000; 10.1074/jbc.M007583200 [Abstract] [Full Text] [PDF]  

Tümay Basar, Vladimír Havlíek, Silvia Bezouková, Murray Hackett, and Peter ebo

Acylation of Lysine 983 Is Sufficient for Toxin Activity of Bordetella pertussis Adenylate Cyclase. SUBSTITUTIONS OF ALANINE 140 MODULATE ACYLATION SITE SELECTIVITY OF THE TOXIN ACYLTRANSFERASE CyaC
J. Biol. Chem. 2000 276: 348-354. First Published on October 12, 2000; 10.1074/jbc.M006463200 [Abstract] [Full Text] [PDF]  

Rasha Hammamieh and David C. H. Yang

Magnesium Ion-mediated Binding to tRNA by an Amino-terminal Peptide of a Class II tRNA Synthetase
J. Biol. Chem. 2000 276: 428-433. First Published on October 16, 2000; 10.1074/jbc.M007570200 [Abstract] [Full Text] [PDF]  

Inga Pinnix, Usha Musunuru, Han Tun, Arati Sridharan, Todd Golde, Christopher Eckman, Chewki Ziani-Cherif, Luisa Onstead, and Kumar Sambamurti

A Novel -Secretase Assay Based on Detection of the Putative C-terminal Fragment- of Amyloid Protein Precursor
J. Biol. Chem. 2000 276: 481-487. First Published on October 16, 2000; 10.1074/jbc.M005968200 [Abstract] [Full Text] [PDF]  

Min S. Lee, Yong Lian Zhu, Jane E. Chang, and Priscilla S. Dannies

Acquisition of Lubrol Insolubility, a Common Step for Growth Hormone and Prolactin in the Secretory Pathway of Neuroendocrine Cells
J. Biol. Chem. 2000 276: 715-721. First Published on October 6, 2000; 10.1074/jbc.M008530200 [Abstract] [Full Text] [PDF]  

Takashi Okamoto, Kiminori Toyooka, and Takao Minamikawa

Identification of a Membrane-associated Cysteine Protease with Possible Dual Roles in the Endoplasmic Reticulum and Protein Storage Vacuole
J. Biol. Chem. 2000 276: 742-751. First Published on October 5, 2000; 10.1074/jbc.M003078200 [Abstract] [Full Text] [PDF]  

Germán Andrés, Alí Alejo, Carmen Simón-Mateo, and María L. Salas

African Swine Fever Virus Protease, a New Viral Member of the SUMO-1-specific Protease Family
J. Biol. Chem. 2000 276: 780-787. First Published on October 12, 2000; 10.1074/jbc.M006844200 [Abstract] [Full Text] [PDF]  

Genomics Proteomics and Bioinformatics:

Valerie Haurie, Michel Perrot, Thierry Mini, Paul Jenö, Francis Sagliocco, and Helian Boucherie

The Transcriptional Activator Cat8p Provides a Major Contribution to the Reprogramming of Carbon Metabolism during the Diauxic Shift in Saccharomyces cerevisiae
J. Biol. Chem. 2000 276: 76-85. First Published on October 6, 2000; 10.1074/jbc.M008752200 [Abstract] [Full Text] [PDF]  

Protein Structure and Folding:

Fabiana A. Carneiro, Artur S. Ferradosa, and Andrea T. Da Poian

Low pH-induced Conformational Changes in Vesicular Stomatitis Virus Glycoprotein Involve Dramatic Structure Reorganization
J. Biol. Chem. 2000 276: 62-67. First Published on October 6, 2000; 10.1074/jbc.M008753200 [Abstract] [Full Text] [PDF]  

Iseli L. Nantes, Maria R. Zucchi, Otaciro R. Nascimento, and Adelaide Faljoni-Alario

Effect of Heme Iron Valence State on the Conformation of Cytochrome c and Its Association with Membrane Interfaces. A CD AND EPR INVESTIGATION
J. Biol. Chem. 2000 276: 153-158. First Published on October 10, 2000; 10.1074/jbc.M006338200 [Abstract] [Full Text] [PDF]  

Stephen B. Hawley, Taka-aki Tamura, and Lindsey A. Miles

Purification, Cloning, and Characterization of a Profibrinolytic Plasminogen-binding Protein, TIP49a
J. Biol. Chem. 2000 276: 179-186. First Published on October 10, 2000; 10.1074/jbc.M004919200 [Abstract] [Full Text] [PDF]  

Todd P. Primm and Hiram F. Gilbert

Hormone Binding by Protein Disulfide Isomerase, a High Capacity Hormone Reservoir of the Endoplasmic Reticulum
J. Biol. Chem. 2000 276: 281-286. First Published on October 16, 2000; 10.1074/jbc.M007670200 [Abstract] [Full Text] [PDF]  

Wolfram R. Zückert, Tatiana A. Kerentseva, Catherine L. Lawson, and Alan G. Barbour

Structural Conservation of Neurotropism-associated VspA within the Variable Borrelia Vsp-OspC Lipoprotein Family
J. Biol. Chem. 2000 276: 457-463. First Published on October 3, 2000; 10.1074/jbc.M008449200 [Abstract] [Full Text] [PDF]  

Kenji Tokita, Simon J. Hocart, Tatsuro Katsuno, Samuel A. Mantey, David H. Coy, and Robert T. Jensen

Tyrosine 220 in the 5th Transmembrane Domain of the Neuromedin B Receptor Is Critical for the High Selectivity of the Peptoid Antagonist PD168368
J. Biol. Chem. 2000 276: 495-504. First Published on September 29, 2000; 10.1074/jbc.M006059200 [Abstract] [Full Text] [PDF]  

Larissa M. Podust, Andrzej M. Krezel, and Youngchang Kim

Crystal Structure of the CCAAT Box/Enhancer-binding Protein Activating Transcription Factor-4 Basic Leucine Zipper Heterodimer in the Absence of DNA
J. Biol. Chem. 2000 276: 505-513. First Published on October 3, 2000; 10.1074/jbc.M005594200 [Abstract] [Full Text] [PDF]  

Ryan Barry, Susan Moore, Alicia Alonso, Juan Ausió, and J. Thomas Buckley

The Channel-forming Protein Proaerolysin Remains a Dimer at Low Concentrations in Solution
J. Biol. Chem. 2000 276: 551-554. First Published on October 2, 2000; 10.1074/jbc.M008097200 [Abstract] [Full Text] [PDF]  

Fernando P. Molina-Heredia, Manuel Hervás, José A. Navarro, and Miguel A. De la Rosa

A Single Arginyl Residue in Plastocyanin and in Cytochrome c₆ from the Cyanobacterium Anabaena sp. PCC 7119 Is Required for Efficient Reduction of Photosystem I
J. Biol. Chem. 2000 276: 601-605. First Published on September 29, 2000; 10.1074/jbc.M007081200 [Abstract] [Full Text] [PDF]  

Christopher Davies, Stephen W. White, and Robert A. Nicholas

Crystal Structure of a Deacylation-defective Mutant of Penicillin-binding Protein 5 at 2.3-Å Resolution
J. Biol. Chem. 2000 276: 616-623. First Published on August 30, 2000; 10.1074/jbc.M004471200 [Abstract] [Full Text] [PDF]  

Enzyme Catalysis and Regulation:

Regine Heller, Anett Unbehaun, Berit Schellenberg, Bernd Mayer, Gabriele Werner-Felmayer, and Ernst R. Werner

L-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin
J. Biol. Chem. 2000 276: 40-47. First Published on October 5, 2000; 10.1074/jbc.M004392200 [Abstract] [Full Text] [PDF]  

Lynn M. Skinner, Malgorzata Sudol, Amy L. Harper, and Michael Katzman

Nucleophile Selection for the Endonuclease Activities of Human, Ovine, and Avian Retroviral Integrases
J. Biol. Chem. 2000 276: 114-124. First Published on October 6, 2000; 10.1074/jbc.M007032200 [Abstract] [Full Text] [PDF]  

Timothy M. Dwyer, K. Sudhindra Rao, Jonna B. Westover, Jung-Ja P. Kim, and Frank E. Frerman

The Function of Arg-94 in the Oxidation and Decarboxylation of Glutaryl-CoA by Human Glutaryl-CoA Dehydrogenase
J. Biol. Chem. 2000 276: 133-138. First Published on October 6, 2000; 10.1074/jbc.M007672200 [Abstract] [Full Text] [PDF]  

Mary Arlandson, Troy Decker, Vikram A. Roongta, Leo Bonilla, Kevin H. Mayo, Jennifer C. MacPherson, Stanley L. Hazen, and Arne Slungaard

Eosinophil Peroxidase Oxidation of Thiocyanate. CHARACTERIZATION OF MAJOR REACTION PRODUCTS AND A POTENTIAL SULFHYDRYL-TARGETED CYTOTOXICITY SYSTEM
J. Biol. Chem. 2000 276: 215-224. First Published on September 29, 2000; 10.1074/jbc.M004881200 [Abstract] [Full Text] [PDF]  

Chin-Chuan Wei, Zhi-Qiang Wang, Qian Wang, Abigail L. Meade, Craig Hemann, Russ Hille, and Dennis J. Stuehr

Rapid Kinetic Studies Link Tetrahydrobiopterin Radical Formation to Heme-dioxy Reduction and Arginine Hydroxylation in Inducible Nitric-oxide Synthase
J. Biol. Chem. 2000 276: 315-319. First Published on October 4, 2000; 10.1074/jbc.M008441200 [Abstract] [Full Text] [PDF]  

Monica Emanuelli, Francesco Carnevali, Franca Saccucci, Francesca Pierella, Adolfo Amici, Nadia Raffaelli, and Giulio Magni

Molecular Cloning, Chromosomal Localization, Tissue mRNA Levels, Bacterial Expression, and Enzymatic Properties of Human NMN Adenylyltransferase
J. Biol. Chem. 2000 276: 406-412. First Published on October 10, 2000; 10.1074/jbc.M008700200 [Abstract] [Full Text] [PDF]  

Kristin M. Rusche and Michael A. Marletta

Reconstitution of Pterin-free Inducible Nitric-oxide Synthase
J. Biol. Chem. 2000 276: 421-427. First Published on October 5, 2000; 10.1074/jbc.M006860200 [Abstract] [Full Text] [PDF]  

Pekka Pohjanjoki, Igor P. Fabrichniy, Vladimir N. Kasho, Barry S. Cooperman, Adrian Goldman, Alexander A. Baykov, and Reijo Lahti

Probing Essential Water in Yeast Pyrophosphatase by Directed Mutagenesis and Fluoride Inhibition Measurements
J. Biol. Chem. 2000 276: 434-441. First Published on October 12, 2000; 10.1074/jbc.M007360200 [Abstract] [Full Text] [PDF]  

Ulrich Hengst, Hugo Albrecht, Daniel Hess, and Denis Monard

The Phosphatidylethanolamine-binding Protein Is the Prototype of a Novel Family of Serine Protease Inhibitors
J. Biol. Chem. 2000 276: 535-540. First Published on October 16, 2000; 10.1074/jbc.M002524200 [Abstract] [Full Text] [PDF]  

Zheng Yang and James J. Champoux

The Role of Histidine 632 in Catalysis by Human Topoisomerase I
J. Biol. Chem. 2000 276: 677-685. First Published on October 9, 2000; 10.1074/jbc.M007593200 [Abstract] [Full Text] [PDF]  

Xin-Sheng Chen and Colin D. Funk

The N-terminal "-Barrel" Domain of 5-Lipoxygenase Is Essential for Nuclear Membrane Translocation
J. Biol. Chem. 2000 276: 811-818. First Published on October 19, 2000; 10.1074/jbc.M008203200 [Abstract] [Full Text] [PDF]  

Metabolism and Bioenergetics:

Jerzy Kruk and Kazimierz Strzalka

Redox Changes of Cytochrome b₅₅₉ in the Presence of Plastoquinones
J. Biol. Chem. 2000 276: 86-91. First Published on October 5, 2000; 10.1074/jbc.M003602200 [Abstract] [Full Text] [PDF]  

Sean T. Coleman, Tung K. Fang, Sherry A. Rovinsky, Frank J. Turano, and W. Scott Moye-Rowley

Expression of a Glutamate Decarboxylase Homologue Is Required for Normal Oxidative Stress Tolerance in Saccharomyces cerevisiae
J. Biol. Chem. 2000 276: 244-250. First Published on October 12, 2000; 10.1074/jbc.M007103200 [Abstract] [Full Text] [PDF]  

Colleen M. Croniger, Carrie Millward, Jianqi Yang, Yumiko Kawai, Ifeanyi J. Arinze, Sha Liu, Mariko Harada-Shiba, Kaushik Chakravarty, Jacob E. Friedman, Valeria Poli, and Richard W. Hanson

Mice with a Deletion in the Gene for CCAAT/Enhancer-binding Protein Have an Attenuated Response to cAMP and Impaired Carbohydrate Metabolism
J. Biol. Chem. 2000 276: 629-638. First Published on October 6, 2000; 10.1074/jbc.M007576200 [Abstract] [Full Text] [PDF]  

Glycobiology and Extracellular Matrices:

Michael J. Cieslewicz, Dennis L. Kasper, Ying Wang, and Michael R. Wessels

Functional Analysis in Type Ia Group B Streptococcus of a Cluster of Genes Involved in Extracellular Polysaccharide Production by Diverse Species of Streptococci
J. Biol. Chem. 2000 276: 139-146. First Published on October 10, 2000; 10.1074/jbc.M005702200 [Abstract] [Full Text] [PDF]  

Jamie Fitzgerald, Matthias Mörgelin, Carly Selan, Charlotte Wiberg, Douglas R. Keene, Shireen R. Lamandé, and John F. Bateman

The N-terminal N5 Subdomain of the 3(VI) Chain Is Important for Collagen VI Microfibril Formation
J. Biol. Chem. 2000 276: 187-193. First Published on October 10, 2000; 10.1074/jbc.M008173200 [Abstract] [Full Text] [PDF]  

Koichi Honke, Masayuki Tsuda, Souichi Koyota, Yoshinao Wada, Naoko Iida-Tanaka, Ineo Ishizuka, Jun Nakayama, and Naoyuki Taniguchi

Molecular Cloning and Characterization of a Human -Gal-3'-sulfotransferase That Acts on Both Type 1 and Type 2 (Gal1-3/1-4GlcNAc-R) Oligosaccharides
J. Biol. Chem. 2000 276: 267-274. First Published on October 11, 2000; 10.1074/jbc.M005666200 [Abstract] [Full Text] [PDF]  

Daniel Mamelak and Clifford Lingwood

The ATPase Domain of hsp70 Possesses a Unique Binding Specificity for 3'-Sulfogalactolipids
J. Biol. Chem. 2000 276: 449-456. First Published on October 9, 2000; 10.1074/jbc.M006732200 [Abstract] [Full Text] [PDF]  

Takatoshi Kitada, Eiji Miyoshi, Katsuhisa Noda, Shigeki Higashiyama, Hideyuki Ihara, Nariaki Matsuura, Norio Hayashi, Sumio Kawata, Yuji Matsuzawa, and Naoyuki Taniguchi

The Addition of Bisecting N-Acetylglucosamine Residues to E-cadherin Down-regulates the Tyrosine Phosphorylation of -Catenin
J. Biol. Chem. 2000 276: 475-480. First Published on October 9, 2000; 10.1074/jbc.M006689200 [Abstract] [Full Text] [PDF]  

Louise A. Russo, Stephen P. Calabro, Tracy A. Filler, David J. Carey, and Russell M. Gardner

In Vivo Regulation of Syndecan-3 Expression in the Rat Uterus by 17-Estradiol
J. Biol. Chem. 2000 276: 686-692. First Published on October 6, 2000; 10.1074/jbc.M004106200 [Abstract] [Full Text] [PDF]  

Ken Sasai, Yoshitaka Ikeda, Takeo Tsuda, Hideyuki Ihara, Hiroaki Korekane, Kunio Shiota, and Naoyuki Taniguchi

The Critical Role of the Stem Region as a Functional Domain Responsible for the Oligomerization and Golgi Localization of N-Acetylglucosaminyltransferase V. THE INVOLVEMENT OF A DOMAIN HOMOPHILIC INTERACTION
J. Biol. Chem. 2000 276: 759-765. First Published on October 9, 2000; 10.1074/jbc.M004972200 [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Rajendra K. Tangirala, Domenico Praticó, Garret A. FitzGerald, Sam Chun, Kazuhisa Tsukamoto, Cyrille Maugeais, David C. Usher, Ellen Puré, and Daniel J. Rader

Reduction of Isoprostanes and Regression of Advanced Atherosclerosis by Apolipoprotein E
J. Biol. Chem. 2000 276: 261-266. First Published on October 9, 2000; 10.1074/jbc.M003324200 [Abstract] [Full Text] [PDF]  

Rajalakshmi Pariyarath, Hongxing Wang, John D. Aitchison, Henry N. Ginsberg, William J. Welch, Arthur E. Johnson, and Edward A. Fisher

Co-translational Interactions of Apoprotein B with the Ribosome and Translocon during Lipoprotein Assembly or Targeting to the Proteasome
J. Biol. Chem. 2000 276: 541-550. First Published on October 5, 2000; 10.1074/jbc.M007944200 [Abstract] [Full Text] [PDF]  

Ramasamy Sakthivel, Jing-Chuan Zhang, Dudley K. Strickland, Mats Gåfvels, and Keith R. McCrae

Regulation of the Ligand Binding Activity of the Human Very Low Density Lipoprotein Receptor by Protein Kinase C-dependent Phosphorylation
J. Biol. Chem. 2000 276: 555-562. First Published on September 28, 2000; 10.1074/jbc.M003953200 [Abstract] [Full Text] [PDF]  

Kristin Schwarz, Matthias Walther, Monika Anton, Christa Gerth, Ivo Feussner, and Hartmut Kuhn

Structural Basis for Lipoxygenase Specificity. CONVERSION OF THE HUMAN LEUKOCYTE 5-LIPOXYGENASE TO A 15-LIPOXYGENATING ENZYME SPECIES BY SITE-DIRECTED MUTAGENESIS
J. Biol. Chem. 2000 276: 773-779. First Published on October 10, 2000; 10.1074/jbc.M005114200 [Abstract] [Full Text] [PDF]  

Membrane Transport Structure Function and Biogenesis:

Vladimir Yarov-Yarovoy, Jacob Brown, Elizabeth M. Sharp, Jeff J. Clare, Todd Scheuer, and William A. Catterall

Molecular Determinants of Voltage-dependent Gating and Binding of Pore-blocking Drugs in Transmembrane Segment IIIS6 of the Na⁺ Channel Subunit
J. Biol. Chem. 2000 276: 20-27. First Published on October 9, 2000; 10.1074/jbc.M006992200 [Abstract] [Full Text] [PDF]  

Zhiyong Qiu, Debora A. Nicoll, and Kenneth D. Philipson

Helix Packing of Functionally Important Regions of the Cardiac Na⁺-Ca²⁺ Exchanger
J. Biol. Chem. 2000 276: 194-199. First Published on October 16, 2000; 10.1074/jbc.M005571200 [Abstract] [Full Text] [PDF]  

Davide Trotti, Masashi Aoki, Piera Pasinelli, Urs V. Berger, Niels C. Danbolt, Robert H. Brown, Jr., and Matthias A. Hediger

Amyotrophic Lateral Sclerosis-linked Glutamate Transporter Mutant Has Impaired Glutamate Clearance Capacity
J. Biol. Chem. 2000 276: 576-582. First Published on October 12, 2000; 10.1074/jbc.M003779200 [Abstract] [Full Text] [PDF]  

Baoxue Yang, Tonghui Ma, and A. S. Verkman

Erythrocyte Water Permeability and Renal Function in Double Knockout Mice Lacking Aquaporin-1 and Aquaporin-3
J. Biol. Chem. 2000 276: 624-628. First Published on October 16, 2000; 10.1074/jbc.M008664200 [Abstract] [Full Text] [PDF]  

Ravikumar Peri, Barbara A. Wible, and Arthur M. Brown

Mutations in the Kv2 Binding Site for NADPH and Their Effects on Kv1.4
J. Biol. Chem. 2000 276: 738-741. First Published on October 9, 2000; 10.1074/jbc.M008445200 [Abstract] [Full Text] [PDF]  

Mechanisms Of Signal Transduction:

Andrea Galli, Jane Pinaire, Monika Fischer, Ryan Dorris, and David W. Crabb

The Transcriptional and DNA Binding Activity of Peroxisome Proliferator-activated Receptor Is Inhibited by Ethanol Metabolism. A NOVEL MECHANISM FOR THE DEVELOPMENT OF ETHANOL-INDUCED FATTY LIVER
J. Biol. Chem. 2000 276: 68-75. First Published on October 5, 2000; 10.1074/jbc.M008791200 [Abstract] [Full Text] [PDF]  

Claudine N. Prowse and John Lew

Mechanism of Activation of ERK2 by Dual Phosphorylation
J. Biol. Chem. 2000 276: 99-103. First Published on October 2, 2000; 10.1074/jbc.M008137200 [Abstract] [Full Text] [PDF]  

Mike Solle, Jeff Labasi, David G. Perregaux, Ethan Stam, Nina Petrushova, Beverly H. Koller, Richard J. Griffiths, and Christopher A. Gabel

Altered Cytokine Production in Mice Lacking P2X₇ Receptors
J. Biol. Chem. 2000 276: 125-132. First Published on October 2, 2000; 10.1074/jbc.M006781200 [Abstract] [Full Text] [PDF]  

Hana Cho, Gi-Byoung Nam, Suk Ho Lee, Yung E. Earm, and Won-Kyung Ho

Phosphatidylinositol 4,5-Bisphosphate Is Acting as a Signal Molecule in ₁-Adrenergic Pathway via the Modulation of Acetylcholine-activated K⁺ Channels in Mouse Atrial Myocytes
J. Biol. Chem. 2000 276: 159-164. First Published on October 11, 2000; 10.1074/jbc.M004826200 [Abstract] [Full Text] [PDF]  

Wei-I. Wu, William F. Schwindinger, Luis F. Aparicio, and Michael A. Levine

Selective Resistance to Parathyroid Hormone Caused by a Novel Uncoupling Mutation in the Carboxyl Terminus of G_s. A CAUSE OF PSEUDOHYPOPARATHYROIDISM TYPE Ib
J. Biol. Chem. 2000 276: 165-171. First Published on October 11, 2000; 10.1074/jbc.M006032200 [Abstract] [Full Text] [PDF]  

Anna-Karin Pernestig, Öjar Melefors, and Dimitris Georgellis

Identification of UvrY as the Cognate Response Regulator for the BarA Sensor Kinase in Escherichia coli
J. Biol. Chem. 2000 276: 225-231. First Published on October 5, 2000; 10.1074/jbc.M001550200 [Abstract] [Full Text] [PDF]  

Sophie Leclerc, Matthieu Garnier, Ralph Hoessel, Doris Marko, James A. Bibb, Gretchen L. Snyder, Paul Greengard, Jacek Biernat, Yong-Zhong Wu, Eva-Maria Mandelkow, Gerhard Eisenbrand, and Laurent Meijer

Indirubins Inhibit Glycogen Synthase Kinase-3 and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease. A PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE INHIBITORS?
J. Biol. Chem. 2000 276: 251-260. First Published on September 29, 2000; 10.1074/jbc.M002466200 [Abstract] [Full Text] [PDF] Supplemental Data  

Jonathan C. Hagopian, Matthew P. Kirtley, Lisa M. Stevenson, Roxanne M. Gergis, Alicia A. Russo, Nikola P. Pavletich, Stanley M. Parsons, and John Lew

Kinetic Basis for Activation of CDK2/Cyclin A by Phosphorylation
J. Biol. Chem. 2000 276: 275-280. First Published on October 11, 2000; 10.1074/jbc.M007337200 [Abstract] [Full Text] [PDF]  

Junbo Hu, Sanjit K. Roy, Paul S. Shapiro, Scott R. Rodig, Sekhar P. M. Reddy, Leonidas C. Platanias, Robert D. Schreiber, and Dhananjaya V. Kalvakolanu

ERK1 and ERK2 Activate CCAAAT/Enhancer-binding Protein--dependent Gene Transcription in Response to Interferon-
J. Biol. Chem. 2000 276: 287-297. First Published on September 19, 2000; 10.1074/jbc.M004885200 [Abstract] [Full Text] [PDF]  

Debasish Maiti, Asima Bhattacharyya, and Joyoti Basu

Lipoarabinomannan from Mycobacterium tuberculosis Promotes Macrophage Survival by Phosphorylating Bad through a Phosphatidylinositol 3-Kinase/Akt Pathway
J. Biol. Chem. 2000 276: 329-333. First Published on October 4, 2000; 10.1074/jbc.M002650200 [Abstract] [Full Text] [PDF]  

Marc J. Servant, Benjamin ten Oever, Cecile LePage, Lucia Conti, Sandra Gessani, Ilkka Julkunen, Rongtuan Lin, and John Hiscott

Identification of Distinct Signaling Pathways Leading to the Phosphorylation of Interferon Regulatory Factor 3
J. Biol. Chem. 2000 276: 355-363. First Published on October 16, 2000; 10.1074/jbc.M007790200 [Abstract] [Full Text] [PDF]  

Valerie Schulte, Daniel Snell, Wolfgang Bergmeier, Hubert Zirngibl, Steve P. Watson, and Bernhard Nieswandt

Evidence for Two Distinct Epitopes within Collagen for Activation of Murine Platelets
J. Biol. Chem. 2000 276: 364-368. First Published on October 17, 2000; 10.1074/jbc.M007536200 [Abstract] [Full Text] [PDF]  

Mario Delgado and Doina Ganea

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Nuclear Factor-B-dependent Gene Activation at Multiple Levels in the Human Monocytic Cell Line THP-1
J. Biol. Chem. 2000 276: 369-380. First Published on October 11, 2000; 10.1074/jbc.M006923200 [Abstract] [Full Text] [PDF]  

Lei Deng, Yen-Chiu Lin-Lee, Francois-Xavier Claret, and M. Tien Kuo

2-Acetylaminofluorene Up-regulates Rat mdr1b Expression through Generating Reactive Oxygen Species That Activate NF-B Pathway
J. Biol. Chem. 2000 276: 413-420. First Published on October 4, 2000; 10.1074/jbc.M004551200 [Abstract] [Full Text] [PDF]  

José Lozano, Silvia Menendez, Albert Morales, Desiree Ehleiter, Wen-Chieh Liao, Rachel Wagman, Adriana Haimovitz-Friedman, Zvi Fuks, and Richard Kolesnick

Cell Autonomous Apoptosis Defects in Acid Sphingomyelinase Knockout Fibroblasts
J. Biol. Chem. 2000 276: 442-448. First Published on October 12, 2000; 10.1074/jbc.M006353200 [Abstract] [Full Text] [PDF]  

Jayshree L. Hirpara, Marie-Véronique Clément, and Shazib Pervaiz

Intracellular Acidification Triggered by Mitochondrial-derived Hydrogen Peroxide Is an Effector Mechanism for Drug-induced Apoptosis in Tumor Cells
J. Biol. Chem. 2000 276: 514-521. First Published on October 2, 2000; 10.1074/jbc.M004687200 [Abstract] [Full Text] [PDF]  

Jürgen Götz, Feng Chen, Robi Barmettler, and Roger M. Nitsch

Tau Filament Formation in Transgenic Mice Expressing P301L Tau
J. Biol. Chem. 2000 276: 529-534. First Published on September 29, 2000; 10.1074/jbc.M006531200 [Abstract] [Full Text] [PDF]  

Yan-Hong Zhang, Antoinette Heulsmann, M. Mehrdad Tondravi, Aditi Mukherjee, and Yousef Abu-Amer

Tumor Necrosis Factor- (TNF) Stimulates RANKL-induced Osteoclastogenesis via Coupling of TNF Type 1 Receptor and RANK Signaling Pathways
J. Biol. Chem. 2000 276: 563-568. First Published on October 13, 2000; 10.1074/jbc.M008198200 [Abstract] [Full Text] [PDF]  

William R. Franek, Stuart Horowitz, Leah Stansberry, Jeffrey A. Kazzaz, Hshi-Chi Koo, Yuchi Li, Yuko Arita, Jonathan M. Davis, Abraham S. Mantell, William Scott, and Lin L. Mantell

Hyperoxia Inhibits Oxidant-induced Apoptosis in Lung Epithelial Cells
J. Biol. Chem. 2000 276: 569-575. First Published on October 16, 2000; 10.1074/jbc.M004716200 [Abstract] [Full Text] [PDF]  

Yasue Fukushi, Ichiro Kato, Shin Takasawa, Tsukasa Sasaki, Boon Hooi Ong, Mika Sato, Atsushi Ohsaga, Kozo Sato, Kunio Shirato, Hiroshi Okamoto, and Yoshio Maruyama

Identification of Cyclic ADP-ribose-dependent Mechanisms in Pancreatic Muscarinic Ca²⁺ Signaling Using CD38 Knockout Mice
J. Biol. Chem. 2000 276: 649-655. First Published on September 22, 2000; 10.1074/jbc.M004469200 [Abstract] [Full Text] [PDF]  

Tomoyuki Sumi, Kunio Matsumoto, and Toshikazu Nakamura

Specific Activation of LIM kinase 2 via Phosphorylation of Threonine 505 by ROCK, a Rho-dependent Protein Kinase
J. Biol. Chem. 2000 276: 670-676. First Published on October 3, 2000; 10.1074/jbc.M007074200 [Abstract] [Full Text] [PDF]  

Gustavo Pedraza-Alva, Sansana Sawasdikosol, Yun Cai Liu, Lily Beatriz Mérida, Mario Ermesto Cruz-Muñoz, Fabian Oceguera-Yañez, Steven J. Burakoff, and Yvonne Rosenstein

Regulation of Cbl Molecular Interactions by the Co-receptor Molecule CD43 in Human T Cells
J. Biol. Chem. 2000 276: 729-737. First Published on October 6, 2000; 10.1074/jbc.M008494200 [Abstract] [Full Text] [PDF]  

Guoxun Chen, Hans E. Hohmeier, and Christopher B. Newgard

Expression of the Transcription Factor STAT-1 in Insulinoma Cells Protects against Cytotoxic Effects of Multiple Cytokines
J. Biol. Chem. 2000 276: 766-772. First Published on October 6, 2000; 10.1074/jbc.M008330200 [Abstract] [Full Text] [PDF]  

Nuria DeGregorio-Rocasolano, Teresa Gasull, and Ramon Trullas

Overexpression of Neuronal Pentraxin 1 Is Involved in Neuronal Death Evoked by Low K⁺ in Cerebellar Granule Cells
J. Biol. Chem. 2000 276: 796-803. First Published on October 12, 2000; 10.1074/jbc.M007967200 [Abstract] [Full Text] [PDF]  

Thomas Pomorski, Thomas F. Meyer, and Michael Naumann

Helicobacter pylori-induced Prostaglandin E₂ Synthesis Involves Activation of Cytosolic Phospholipase A₂ in Epithelial Cells
J. Biol. Chem. 2000 276: 804-810. First Published on October 16, 2000; 10.1074/jbc.M003819200 [Abstract] [Full Text] [PDF]  

Silvana A. Andric, Tatjana S. Kostic, Melanija Tomi, Taka-aki Koshimizu, and Stanko S. Stojilkovic

Dependence of Soluble Guanylyl Cyclase Activity on Calcium Signaling in Pituitary Cells
J. Biol. Chem. 2000 276: 844-849. First Published on October 12, 2000; 10.1074/jbc.M004406200 [Abstract] [Full Text] [PDF]  

Molecular Basis Of Cell and Developmental Biology:

Avital Yahalom, Tae-Houn Kim, Eitan Winter, Baruch Karniol, Albrecht G. von Arnim, and Daniel A. Chamovitz

Arabidopsis eIF3e (INT-6) Associates with Both eIF3c and the COP9 Signalosome Subunit CSN7
J. Biol. Chem. 2000 276: 334-340. First Published on October 11, 2000; 10.1074/jbc.M006721200 [Abstract] [Full Text] [PDF]  

Aixin Yu and Thomas R. Malek

The Proteasome Regulates Receptor-mediated Endocytosis of Interleukin-2
J. Biol. Chem. 2000 276: 381-385. First Published on October 13, 2000; 10.1074/jbc.M007991200 [Abstract] [Full Text] [PDF]  

Frederick K. Racke, Dongyan Wang, Zan Zaidi, Joshua Kelley, Jane Visvader, Jae-Won Soh, and Adam N. Goldfarb

A Potential Role for Protein Kinase C- in Regulating Megakaryocytic Lineage Commitment
J. Biol. Chem. 2000 276: 522-528. First Published on October 2, 2000; 10.1074/jbc.M005236200 [Abstract] [Full Text] [PDF]  

Abigail S. McElhinny, Bernhard Kolmerer, Velia M. Fowler, Siegfried Labeit, and Carol C. Gregorio

The N-terminal End of Nebulin Interacts with Tropomodulin at the Pointed Ends of the Thin Filaments
J. Biol. Chem. 2000 276: 583-592. First Published on October 2, 2000; 10.1074/jbc.M005693200 [Abstract] [Full Text] [PDF]  

Zhe Jiang, Zhong Guo, Fawzy A. Saad, James Ellis, and Eldad Zacksenhaus

Retinoblastoma Gene Promoter Directs Transgene Expression Exclusively to the Nervous System
J. Biol. Chem. 2000 276: 593-600. First Published on October 2, 2000; 10.1074/jbc.M005474200 [Abstract] [Full Text] [PDF]  

Petr Hájek, Gaetano Villani, and Giuseppe Attardi

Rate-limiting Step Preceding Cytochrome c Release in Cells Primed for Fas-mediated Apoptosis Revealed by Analysis of Cellular Mosaicism of Respiratory Changes
J. Biol. Chem. 2000 276: 606-615. First Published on October 10, 2000; 10.1074/jbc.M007871200 [Abstract] [Full Text] [PDF]  

Amit Kumar, Vladimir Novoselov, Anthony J. Celeste, Neil M. Wolfman, Peter ten Dijke, and Michael R. Kuehn

Nodal Signaling Uses Activin and Transforming Growth Factor- Receptor-regulated Smads
J. Biol. Chem. 2000 276: 656-661. First Published on October 9, 2000; 10.1074/jbc.M004649200 [Abstract] [Full Text] [PDF]  

Takanobu Nakazawa, Shoji Komai, Tohru Tezuka, Chihiro Hisatsune, Hisashi Umemori, Kentaro Semba, Masayoshi Mishina, Toshiya Manabe, and Tadashi Yamamoto

Characterization of Fyn-mediated Tyrosine Phosphorylation Sites on GluR2 (NR2B) Subunit of the N-Methyl-D-aspartate Receptor
J. Biol. Chem. 2000 276: 693-699. First Published on October 6, 2000; 10.1074/jbc.M008085200 [Abstract] [Full Text] [PDF]  

Kohsuke Kataoka, Kiyomi Yoshitomo-Nakagawa, Setsuko Shioda, and Makoto Nishizawa

A Set of Hox Proteins Interact with the Maf Oncoprotein to Inhibit Its DNA Binding, Transactivation, and Transforming Activities
J. Biol. Chem. 2000 276: 819-826. First Published on October 17, 2000; 10.1074/jbc.M007643200 [Abstract] [Full Text] [PDF]  

Michael P. Gustafson, Charles F. Thomas, Jr., Frank Rusnak, Andrew H. Limper, and Edward B. Leof

Differential Regulation of Growth and Checkpoint Control Mediated by a Cdc25 Mitotic Phosphatase from Pneumocystis carinii
J. Biol. Chem. 2000 276: 835-843. First Published on October 11, 2000; 10.1074/jbc.M007814200 [Abstract] [Full Text] [PDF]  

Additions and Corrections:

Vicki L. Schweickart, Angela Epp, Carol J. Raport, and Patrick W. Gray

CCR11 is a functional receptor for the monocyte chemoaattractant protein family of chemokines.
J. Biol. Chem. 2000 276: 856. [Full Text] [PDF]  

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