The cover figure shows the C1b domain of PKC- complexed with the phospholipid bilayer. In our study we probed the role of the hydrophobic residues illustrated in magenta for lipid interaction and ligand binding. The ligand is illustrated in green. Positive and negative residues are shown in gold. Neutral hydrophilic residues are shown in gray. For details see the article by Wang et al., pages 19580-19587.19580.