Differentiation of photoreceptor cell types requires precise regulation of gene expression. NRL is a basic motif leucine zipper transcription factor involved in rhodopsin regulation. It is phosphorylated at multiple sites and is believed to initiate signaling pathways leading to rod photoreceptor differentiation. The cover photo is a confocal micrograph of human retina demonstrating expression of NRL in rod photoreceptor nuclei (orange but not cone nuclei (magenta). For details, see the article by Swain et al., pages 36824-36830.36824.