The cover figure shows that G_D3 (NeuAc2-3Gal1-4Glc-ceramide) is sorted into cholesterol-laden lysosomes in human fibroblasts. Cholesterol-depleted normal human fibroblasts incubated in low density lipoproteins (LDL) for 24 h were immunostained for G_D3 (green and stained with filipin blue for cholesterol localization. G_D3 immunostaining of the plasma membrane profiles the two cells. Intracellular G_D3 co-localizes with lysosomal cholesterol as indicated by the aqua color resulting from the green and blue color merge. Cellular uptake of LDL-cholesterol modulates the sorting of glycolipids between a Niemann-Pick C1-containing late endosomal compartment and lysosomes. Details can be found in the article by Zhang et al., pages 3417-3425.3417.