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On the cover, histone H2B within the chromosomal DNA is recognized by Rad6 and its auxiliary proteins and is ubiquitinated on its lysine 123. This ubiquitination of histone H2B serves as a direct or indirect recognition signal for COMPASS, which catalyzes the methylation of the fourth lysine of histone H3, resulting in transcriptinal silencing of genes located near a chromosome telomere. Details are found in the paper by Dover et al., pages 28368-28371.