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On the cover, stimulation with hormone agonists results in protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors in addition to production of inositol 1,4,5-trisphosphate in pancreatic acinar cells. This phosphorylation alters the calcium release properties of the receptor, resulting in the production of calcium oscillations with specific temporal characteristics. These precise temporal properties likely exert control over explicit physiological processes. For details see the article by Straub et al., pages 31949-31956.