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The cover shows the molecular surface of the potent anti-HIV protein cyanovirin-N bound to a synthetic hexamannoside. The secondary sugar-binding site is shown in the lower right side, with hexamannoside bound. The primary site is in the upper left corner occupied by a CHES buffer molecule. Positive surface potential is illustrated in blue and negative potential in red. For details see the article by Botos et al., pages 34336-34342.