About the Cover
The cover shows calcium signaling and trypsinogen activation in the pancreas. Hormone stimulation can elicit either a physiological (oscillations, yellow curve) or a pathological (peak plateaus, red curve) calcium response in pancreatic exocrine cells, only the latter of which is followed by intracellular trypsinogen activation (left image). Pancreatic duct obstruction in rodents, a disease model that mimics gallstone-induced pancreatitis in man, affects both intracellular calcium signaling and intrapancreatic trypsinogen activation. For details see the article by Mooren et al., pages 9361-9369 and its Ref. 3.
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Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
