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Table of Contents: May 9 2003; 278 (19)   [Index by Author]  [Cover Figure and Caption]
       Reflections
       Accelerated Publications
       DNA: Replication Repair and Recombination
       Genes: Structure and Regulation
       RNA: Structure Metabolism and Catalysis
       Protein Synthesis Post-Translation Modification and Degradation
       Genomics Proteomics and Bioinformatics
       Protein Structure and Folding
       Enzyme Catalysis and Regulation
       Metabolism and Bioenergetics
       Glycobiology and Extracellular Matrices
       Lipids and Lipoproteins
       Membrane Transport Structure Function and Biogenesis
       Mechanisms Of Signal Transduction
       Molecular Basis Of Cell and Developmental Biology
       Additions and Corrections
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Reflections:

E. C. Slater
Keilin, Cytochrome, and the Respiratory Chain
J. Biol. Chem. 2003 278: 16455-16461. First Published on January 30, 2003; doi:10.1074/jbc.X200011200 [Full Text] [PDF]  


Accelerated Publications:

Tadato Ban, Daizo Hamada, Kazuhiro Hasegawa, Hironobu Naiki, and Yuji Goto
Direct Observation of Amyloid Fibril Growth Monitored by Thioflavin T Fluorescence
J. Biol. Chem. 2003 278: 16462-16465. First Published on March 18, 2003; doi:10.1074/jbc.C300049200 [Abstract] [Full Text] [PDF] Supplemental Movie  

David W. Chang, Dara Ditsworth, Hongtu Liu, Srinivasa M. Srinivasula, Emad S. Alnemri, and Xiaolu Yang
Oligomerization Is a General Mechanism for the Activation of Apoptosis Initiator and Inflammatory Procaspases
J. Biol. Chem. 2003 278: 16466-16469. First Published on March 13, 2003; doi:10.1074/jbc.C300089200 [Abstract] [Full Text] [PDF]  

Anna Y. Kornilova, Chittaranjan Das, and Michael S. Wolfe
Differential Effects of Inhibitors on the gamma -Secretase Complex. MECHANISTIC IMPLICATIONS
J. Biol. Chem. 2003 278: 16470-16473. First Published on March 18, 2003; doi:10.1074/jbc.C300019200 [Abstract] [Full Text] [PDF]  

Keiro Shirotani, Dieter Edbauer, Anja Capell, Julia Schmitz, Harald Steiner, and Christian Haass
gamma -Secretase Activity Is Associated with a Conformational Change of Nicastrin
J. Biol. Chem. 2003 278: 16474-16477. First Published on March 18, 2003; doi:10.1074/jbc.C300095200 [Abstract] [Full Text] [PDF]  

Thomas Grewal, Iñaki de Diego, Matthias F. Kirchhoff, Francesc Tebar, Joerg Heeren, Franz Rinninger, and Carlos Enrich
High Density Lipoprotein-induced Signaling of the MAPK Pathway Involves Scavenger Receptor Type BI-mediated Activation of Ras
J. Biol. Chem. 2003 278: 16478-16481. First Published on March 7, 2003; doi:10.1074/jbc.C300085200 [Abstract] [Full Text] [PDF]  


DNA: Replication Repair and Recombination:

Pavel E. Pestryakov, Klaus Weisshart, Bernhard Schlott, Svetlana N. Khodyreva, Elisabeth Kremmer, Frank Grosse, Olga I. Lavrik, and Heinz-Peter Nasheuer
Human Replication Protein A. THE C-TERMINAL RPA70 AND THE CENTRAL RPA32 DOMAINS ARE INVOLVED IN THE INTERACTIONS WITH THE 3'-END OF A PRIMER-TEMPLATE DNA
J. Biol. Chem. 2003 278: 17515-17524. First Published on February 24, 2003; doi:10.1074/jbc.M301265200 [Abstract] [Full Text] [PDF] Supplemental Data  


Genes: Structure and Regulation:

Patrice Filée, Christelle Vreuls, Raphaël Herman, Iris Thamm, Tony Aerts, Peter P. De Deyn, Jean-Marie Frère, and Bernard Joris
Dimerization and DNA Binding Properties of the Bacillus licheniformis 749/I BlaI Repressor
J. Biol. Chem. 2003 278: 16482-16487. First Published on March 3, 2003; doi:10.1074/jbc.M210887200 [Abstract] [Full Text] [PDF]  

Haiyan Wang, Pierre Maechler, Peter A. Antinozzi, Laura Herrero, Kerstin A. Hagenfeldt-Johansson, Anneli Björklund, and Claes B. Wollheim
The Transcription Factor SREBP-1c Is Instrumental in the Development of beta -Cell Dysfunction
J. Biol. Chem. 2003 278: 16622-16629. First Published on February 24, 2003; doi:10.1074/jbc.M212488200 [Abstract] [Full Text] [PDF]  

Betsy J. Barnes, Ann E. Field, and Paula M. Pitha-Rowe
Virus-induced Heterodimer Formation between IRF-5 and IRF-7 Modulates Assembly of the IFNA Enhanceosome in Vivo and Transcriptional Activity of IFNA Genes
J. Biol. Chem. 2003 278: 16630-16641. First Published on February 24, 2003; doi:10.1074/jbc.M212609200 [Abstract] [Full Text] [PDF]  

Yihong Ma, Jing Yuan, Mei Huang, Richard Jove, and W. Douglas Cress
Regulation of the Cyclin D3 Promoter by E2F1
J. Biol. Chem. 2003 278: 16770-16776. First Published on February 28, 2003; doi:10.1074/jbc.M212702200 [Abstract] [Full Text] [PDF]  

Lars Jöres and Rolf Wagner
Essential Steps in the ppGpp-dependent Regulation of Bacterial Ribosomal RNA Promoters Can Be Explained by Substrate Competition
J. Biol. Chem. 2003 278: 16834-16843. First Published on March 5, 2003; doi:10.1074/jbc.M300196200 [Abstract] [Full Text] [PDF]  

Rebecca E. Schweppe, Alexis A. Melton, Kelley S. Brodsky, Lauren D. Aveline, Katheryn A. Resing, Natalie G. Ahn, and Arthur Gutierrez-Hartmann
Purification and Mass Spectrometric Identification of GA-binding Protein (GABP) as the Functional Pituitary Ets Factor Binding to the Basal Transcription Element of the Prolactin Promoter
J. Biol. Chem. 2003 278: 16863-16872. First Published on March 4, 2003; doi:10.1074/jbc.M213063200 [Abstract] [Full Text] [PDF]  

Ann Sutton, Wei-Jong Shia, David Band, Paul D. Kaufman, Shigehiro Osada, Jerry L. Workman, and Rolf Sternglanz
Sas4 and Sas5 Are Required for the Histone Acetyltransferase Activity of Sas2 in the SAS Complex
J. Biol. Chem. 2003 278: 16887-16892. First Published on March 6, 2003; doi:10.1074/jbc.M210709200 [Abstract] [Full Text] [PDF]  

Yuxin Li, Mingxing Xie, Xiulong Song, Sarah Gragen, Karuna Sachdeva, Yinsheng Wan, and Bingfang Yan
DEC1 Negatively Regulates the Expression of DEC2 through Binding to the E-box in the Proximal Promoter
J. Biol. Chem. 2003 278: 16899-16907. First Published on March 6, 2003; doi:10.1074/jbc.M300596200 [Abstract] [Full Text] [PDF]  

Meredith L. Moore, Edwards A. Park, and Jeanie B. McMillin
Upstream Stimulatory Factor Represses the Induction of Carnitine Palmitoyltransferase-Ibeta Expression by PGC-1
J. Biol. Chem. 2003 278: 17263-17268. First Published on February 28, 2003; doi:10.1074/jbc.M210486200 [Abstract] [Full Text] [PDF]  

Jodi M. Maglich, Derek J. Parks, Linda B. Moore, Jon L. Collins, Bryan Goodwin, Andrew N. Billin, Catherine A. Stoltz, Steven A. Kliewer, Millard H. Lambert, Timothy M. Willson, and John T. Moore
Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes
J. Biol. Chem. 2003 278: 17277-17283. First Published on February 27, 2003; doi:10.1074/jbc.M300138200 [Abstract] [Full Text] [PDF]  

Michael Stock, Henning Schäfer, Sigmar Stricker, Gerhard Gross, Stefan Mundlos, and Florian Otto
Expression of Galectin-3 in Skeletal Tissues Is Controlled by Runx2
J. Biol. Chem. 2003 278: 17360-17367. First Published on February 25, 2003; doi:10.1074/jbc.M207631200 [Abstract] [Full Text] [PDF]  

Gang Liu, Tian Xia, and Xinbin Chen
The Activation Domains, the Proline-rich Domain, and the C-terminal Basic Domain in p53 Are Necessary for Acetylation of Histones on the Proximal p21 Promoter and Interaction with p300/CREB-binding Protein
J. Biol. Chem. 2003 278: 17557-17565. First Published on February 27, 2003; doi:10.1074/jbc.M210696200 [Abstract] [Full Text] [PDF]  


RNA: Structure Metabolism and Catalysis:

Baohua Gu, Victor K. Johnston, Lester L. Gutshall, Tammy T. Nguyen, Richard R. Gontarek, Michael G. Darcy, Rosanna Tedesco, Dashyant Dhanak, Kevin J. Duffy, C. Cheng Kao, and Robert T. Sarisky
Arresting Initiation of Hepatitis C Virus RNA Synthesis Using Heterocyclic Derivatives
J. Biol. Chem. 2003 278: 16602-16607. First Published on January 27, 2003; doi:10.1074/jbc.M210891200 [Abstract] [Full Text] [PDF]  

Yukihide Tomari, Narumi Hino, Takashi Nagaike, Tsutomu Suzuki, and Takuya Ueda
Decreased CCA-addition in Human Mitochondrial tRNAs Bearing a Pathogenic A4317G or A10044G Mutation
J. Biol. Chem. 2003 278: 16828-16833. First Published on March 5, 2003; doi:10.1074/jbc.M213216200 [Abstract] [Full Text] [PDF]  

Uwe Kühn, Anne Nemeth, Sylke Meyer, and Elmar Wahle
The RNA Binding Domains of the Nuclear poly(A)-binding Protein
J. Biol. Chem. 2003 278: 16916-16925. First Published on March 7, 2003; doi:10.1074/jbc.M209886200 [Abstract] [Full Text] [PDF] Data Supplement  


Protein Synthesis Post-Translation Modification and Degradation:

Michael P. Malakhov, Keun Il Kim, Oxana A. Malakhova, Barbara S. Jacobs, Ernest C. Borden, and Dong-Er Zhang
High-throughput Immunoblotting. UBIQUITIN-LIKE PROTEIN ISG15 MODIFIES KEY REGULATORS OF SIGNAL TRANSDUCTION
J. Biol. Chem. 2003 278: 16608-16613. First Published on February 11, 2003; doi:10.1074/jbc.M208435200 [Abstract] [Full Text] [PDF]  

Sven Sadtler, Bodo Laube, Alhassan Lashub, Annette Nicke, Heinrich Betz, and Günther Schmalzing
A Basic Cluster Determines Topology of the Cytoplasmic M3-M4 Loop of the Glycine Receptor alpha 1 Subunit
J. Biol. Chem. 2003 278: 16782-16790. First Published on February 28, 2003; doi:10.1074/jbc.M213077200 [Abstract] [Full Text] [PDF]  

Michael Seeger, Rasmus Hartmann-Petersen, Caroline R. M. Wilkinson, Mairi Wallace, Itaru Samejima, Martin S. Taylor, and Colin Gordon
Interaction of the Anaphase-promoting Complex/Cyclosome and Proteasome Protein Complexes with Multiubiquitin Chain-binding Proteins
J. Biol. Chem. 2003 278: 16791-16796. First Published on March 3, 2003; doi:10.1074/jbc.M208281200 [Abstract] [Full Text] [PDF]  

Cheng-Gang Zou and Ruma Banerjee
Tumor Necrosis Factor-alpha -induced Targeted Proteolysis of Cystathionine beta -Synthase Modulates Redox Homeostasis
J. Biol. Chem. 2003 278: 16802-16808. First Published on March 3, 2003; doi:10.1074/jbc.M212376200 [Abstract] [Full Text] [PDF]  

Yuko Hirano, Shigeo Murata, Keiji Tanaka, Makoto Shimizu, and Ryuichiro Sato
Sterol Regulatory Element-binding Proteins Are Negatively Regulated through SUMO-1 Modification Independent of the Ubiquitin/26 S Proteasome Pathway
J. Biol. Chem. 2003 278: 16809-16819. First Published on March 2, 2003; doi:10.1074/jbc.M212448200 [Abstract] [Full Text] [PDF]  

Olivier Boutaud, Junyu Li, Irene Zagol, Elizabeth A. Shipp, Sean S. Davies, L. Jackson Roberts, II, and John A. Oates
Levuglandinyl Adducts of Proteins Are Formed via a Prostaglandin H2 Synthase-dependent Pathway after Platelet Activation
J. Biol. Chem. 2003 278: 16926-16928. First Published on March 11, 2003; doi:10.1074/jbc.M300940200 [Abstract] [Full Text] [PDF]  

Caroline Houde, Sophie Roy, Nelly Leung, Donald W. Nicholson, and Nicole Beauchemin
The Cell Adhesion Molecule CEACAM1-L Is a Substrate of Caspase-3-mediated Cleavage in Apoptotic Mouse Intestinal Cells
J. Biol. Chem. 2003 278: 16929-16935. First Published on March 11, 2003; doi:10.1074/jbc.M301842200 [Abstract] [Full Text] [PDF]  

Jason T. Huse, Damani Byant, Yaxiong Yang, Donald S. Pijak, Ian D'Souza, James J. Lah, Virginia M.-Y. Lee, Robert W. Doms, and David G. Cook
Endoproteolysis of beta -Secretase (beta -Site Amyloid Precursor Protein-cleaving Enzyme) within Its Catalytic Domain. A POTENTIAL MECHANISM FOR REGULATION
J. Biol. Chem. 2003 278: 17141-17149. First Published on January 27, 2003; doi:10.1074/jbc.M213303200 [Abstract] [Full Text] [PDF]  

Patricia M-J. Lievens and Elio Liboi
The Thanatophoric Dysplasia Type II Mutation Hampers Complete Maturation of Fibroblast Growth Factor Receptor 3 (FGFR3), Which Activates Signal Transducer and Activator of Transcription 1 (STAT1) from the Endoplasmic Reticulum
J. Biol. Chem. 2003 278: 17344-17349. First Published on March 6, 2003; doi:10.1074/jbc.M212710200 [Abstract] [Full Text] [PDF]  

Jessica Martinez, Ines Moeller, Hediye Erdjument-Bromage, Paul Tempst, and Brett Lauring
Parkinson's Disease-associated alpha -Synuclein Is a Calmodulin Substrate
J. Biol. Chem. 2003 278: 17379-17387. First Published on February 27, 2003; doi:10.1074/jbc.M209020200 [Abstract] [Full Text] [PDF]  


Genomics Proteomics and Bioinformatics:

Ana P. Yatsuda, Jeroen Krijgsveld, Albert W. C. A. Cornelissen, Albert J. R. Heck, and Erik de Vries
Comprehensive Analysis of the Secreted Proteins of the Parasite Haemonchus contortus Reveals Extensive Sequence Variation and Differential Immune Recognition
J. Biol. Chem. 2003 278: 16941-16951. First Published on February 7, 2003; doi:10.1074/jbc.M212453200 [Abstract] [Full Text] [PDF] Supplemental Data  

Karsten Suhre and Jean-Michel Claverie
Genomic Correlates of Hyperthermostability, an Update
J. Biol. Chem. 2003 278: 17198-17202. First Published on February 24, 2003; doi:10.1074/jbc.M301327200 [Abstract] [Full Text] [PDF]  


Protein Structure and Folding:

Inga-Maria Frick, Per Åkesson, Magnus Rasmussen, Artur Schmidtchen, and Lars Björck
SIC, a Secreted Protein of Streptococcus pyogenes That Inactivates Antibacterial Peptides
J. Biol. Chem. 2003 278: 16561-16566. First Published on March 5, 2003; doi:10.1074/jbc.M301995200 [Abstract] [Full Text] [PDF]  

Stefaan Rossenu, Shirley Leyman, Daisy Dewitte, Danny Peelaers, Veronique Jonckheere, Marleen Van Troys, Joël Vandekerckhove, and Christophe Ampe
A Phage Display-based Method for Determination of Relative Affinities of Mutants. APPLICATION TO THE ACTIN-BINDING MOTIFS IN THYMOSIN beta 4 AND THE VILLIN HEADPIECE
J. Biol. Chem. 2003 278: 16642-16650. First Published on February 26, 2003; doi:10.1074/jbc.M208311200 [Abstract] [Full Text] [PDF]  

Kristoffer Brännström, Bo Segerman, and Martin Gullberg
Molecular Dissection of GTP Exchange and Hydrolysis within the Ternary Complex of Tubulin Heterodimers and Op18/Stathmin Family Members
J. Biol. Chem. 2003 278: 16651-16657. First Published on February 26, 2003; doi:10.1074/jbc.M300131200 [Abstract] [Full Text] [PDF]  

Birgit Leitinger
Molecular Analysis of Collagen Binding by the Human Discoidin Domain Receptors, DDR1 and DDR2. IDENTIFICATION OF COLLAGEN BINDING SITES IN DDR2
J. Biol. Chem. 2003 278: 16761-16769. First Published on February 28, 2003; doi:10.1074/jbc.M301370200 [Abstract] [Full Text] [PDF]  

Min Zhu and Anthony L. Fink
Lipid Binding Inhibits alpha -Synuclein Fibril Formation
J. Biol. Chem. 2003 278: 16873-16877. First Published on March 5, 2003; doi:10.1074/jbc.M210136200 [Abstract] [Full Text] [PDF]  

Jay M. Janz, Jonathan F. Fay, and David L. Farrens
Stability of Dark State Rhodopsin Is Mediated by a Conserved Ion Pair in Intradiscal Loop E-2
J. Biol. Chem. 2003 278: 16982-16991. First Published on January 23, 2003; doi:10.1074/jbc.M210567200 [Abstract] [Full Text] [PDF]  

Gabriele S. V. Campanella, Elizabeth M. J. Lee, Jieti Sun, and Andrew D. Luster
CXCR3 and Heparin Binding Sites of the Chemokine IP-10 (CXCL10)
J. Biol. Chem. 2003 278: 17066-17074. First Published on February 5, 2003; doi:10.1074/jbc.M212077200 [Abstract] [Full Text] [PDF]  

Frank S. Cordes, Kaoru Komoriya, Eric Larquet, Shixin Yang, Edward H. Egelman, Ariel Blocker, and Susan M. Lea
Helical Structure of the Needle of the Type III Secretion System of Shigella flexneri
J. Biol. Chem. 2003 278: 17103-17107. First Published on February 5, 2003; doi:10.1074/jbc.M300091200 [Abstract] [Full Text] [PDF]  

Laila J. Reigstad, Hege M. Sande, Øystein Fluge, Ove Bruland, Arturo Muga, Jan Erik Varhaug, Aurora Martínez, and Johan R. Lillehaug
Platelet-derived Growth Factor (PDGF)-C, a PDGF Family Member with a Vascular Endothelial Growth Factor-like Structure
J. Biol. Chem. 2003 278: 17114-17120. First Published on February 20, 2003; doi:10.1074/jbc.M301728200 [Abstract] [Full Text] [PDF]  

Santosh Kumar, Emily E. Scott, Hong Liu, and James R. Halpert
A Rational Approach to Re-engineer Cytochrome P450 2B1 Regioselectivity Based on the Crystal Structure of Cytochrome P450 2C5
J. Biol. Chem. 2003 278: 17178-17184. First Published on February 27, 2003; doi:10.1074/jbc.M212515200 [Abstract] [Full Text] [PDF]  

Bing-Hao Luo, Timothy A. Springer, and Junichi Takagi
High Affinity Ligand Binding by Integrins Does Not Involve Head Separation
J. Biol. Chem. 2003 278: 17185-17189. First Published on February 24, 2003; doi:10.1074/jbc.M301516200 [Abstract] [Full Text] [PDF]  

Gregor P. Lotz, Hongying Lin, Anja Harst, and Wolfgang M. J. Obermann
Aha1 Binds to the Middle Domain of Hsp90, Contributes to Client Protein Activation, and Stimulates the ATPase Activity of the Molecular Chaperone
J. Biol. Chem. 2003 278: 17228-17235. First Published on February 24, 2003; doi:10.1074/jbc.M212761200 [Abstract] [Full Text] [PDF]  

Brett M. Collins, Liza Cubeddu, Nishen Naidoo, Stephen J. Harrop, Geoff D. Kornfeld, Ian W. Dawes, Paul M. G. Curmi, and Bridget C. Mabbutt
Homomeric Ring Assemblies of Eukaryotic Sm Proteins Have Affinity for Both RNA and DNA. CRYSTAL STRUCTURE OF AN OLIGOMERIC COMPLEX OF YEAST SmF
J. Biol. Chem. 2003 278: 17291-17298. First Published on March 4, 2003; doi:10.1074/jbc.M211826200 [Abstract] [Full Text] [PDF]  

Joyce Cheung-Flynn, Patricia J. Roberts, Daniel L. Riggs, and David F. Smith
C-terminal Sequences outside the Tetratricopeptide Repeat Domain of FKBP51 and FKBP52 Cause Differential Binding to Hsp90
J. Biol. Chem. 2003 278: 17388-17394. First Published on February 27, 2003; doi:10.1074/jbc.M300955200 [Abstract] [Full Text] [PDF]  

Kevin J. Barnham, William J. McKinstry, Gerd Multhaup, Denise Galatis, Craig J. Morton, Cyril C. Curtain, Nicholas A. Williamson, Anthony R. White, Mark G. Hinds, Raymond S. Norton, Konrad Beyreuther, Colin L. Masters, Michael W. Parker, and Roberto Cappai
Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain. A REGULATOR OF NEURONAL COPPER HOMEOSTASIS
J. Biol. Chem. 2003 278: 17401-17407. First Published on February 28, 2003; doi:10.1074/jbc.M300629200 [Abstract] [Full Text] [PDF]  

Carlos A. Cunha, Sofia Macieira, João M. Dias, Gabriela Almeida, Luisa L. Gonçalves, Cristina Costa, Jorge Lampreia, Robert Huber, José J. G. Moura, Isabel Moura, and Maria João Romão
Cytochrome c Nitrite Reductase from Desulfovibrio desulfuricans ATCC 27774. THE RELEVANCE OF THE TWO CALCIUM SITES IN THE STRUCTURE OF THE CATALYTIC SUBUNIT (NrfA)
J. Biol. Chem. 2003 278: 17455-17465. First Published on March 4, 2003; doi:10.1074/jbc.M211777200 [Abstract] [Full Text] [PDF]  


Enzyme Catalysis and Regulation:

Ross McC. Lilley, XueQin Wang, Elmars Krausz, and T. John Andrews
Complete Spectra of the Far-red Chemiluminescence of the Oxygenase Reaction of Mn2+-activated Ribulose-bisphosphate Carboxylase/Oxygenase Establish Excited Mn2+ as the Source
J. Biol. Chem. 2003 278: 16488-16493. First Published on February 25, 2003; doi:10.1074/jbc.M212402200 [Abstract] [Full Text] [PDF]  

Keiji Nogami, Hironao Wakabayashi, and Philip J. Fay
Mechanisms of Factor Xa-catalyzed Cleavage of the Factor VIIIa A1 Subunit Resulting in Cofactor Inactivation
J. Biol. Chem. 2003 278: 16502-16509. First Published on February 26, 2003; doi:10.1074/jbc.M213044200 [Abstract] [Full Text] [PDF]  

Andreas Weihofen, Marius K. Lemberg, Elena Friedmann, Heinrich Rueeger, Albert Schmitz, Paolo Paganetti, Giorgio Rovelli, and Bruno Martoglio
Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with gamma -Secretase Inhibitors
J. Biol. Chem. 2003 278: 16528-16533. First Published on March 5, 2003; doi:10.1074/jbc.M301372200 [Abstract] [Full Text] [PDF]  

Frederik Pauwels, Bjorn Vergauwen, Frank Vanrobaeys, Bart Devreese, and Jozef J. Van Beeumen
Purification and Characterization of a Chimeric Enzyme from Haemophilus influenzae Rd That Exhibits Glutathione-dependent Peroxidase Activity
J. Biol. Chem. 2003 278: 16658-16666. First Published on February 26, 2003; doi:10.1074/jbc.M300157200 [Abstract] [Full Text] [PDF]  

Catherine Gaille, Cornelia Reimmann, and Dieter Haas
Isochorismate Synthase (PchA), the First and Rate-limiting Enzyme in Salicylate Biosynthesis of Pseudomonas aeruginosa
J. Biol. Chem. 2003 278: 16893-16898. First Published on March 6, 2003; doi:10.1074/jbc.M212324200 [Abstract] [Full Text] [PDF]  

Dan-Sung C. Cho, Weidong Yang, Joshua T. Lee, Ramin Shiekhattar, John M. Murray, and Kazuko Nishikura
Requirement of Dimerization for RNA Editing Activity of Adenosine Deaminases Acting on RNA
J. Biol. Chem. 2003 278: 17093-17102. First Published on March 4, 2003; doi:10.1074/jbc.M213127200 [Abstract] [Full Text] [PDF]  

Emily I. Chen, Weizhong Li, Adam Godzik, Eric W. Howard, and Jeffrey W. Smith
A Residue in the S2 Subsite Controls Substrate Selectivity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9
J. Biol. Chem. 2003 278: 17158-17163. First Published on February 18, 2003; doi:10.1074/jbc.M210324200 [Abstract] [Full Text] [PDF]  

John A. Pezza, Kyung H. Choi, Tanya Z. Berardini, Peter T. Beernink, Karen N. Allen, and Dean R. Tolan
Spatial Clustering of Isozyme-specific Residues Reveals Unlikely Determinants of Isozyme Specificity in Fructose-1,6-bisphosphate Aldolase
J. Biol. Chem. 2003 278: 17307-17313. First Published on February 28, 2003; doi:10.1074/jbc.M209185200 [Abstract] [Full Text] [PDF]  

Chiu-Yueh Chen, Shih-Chi Luo, Chih-Feng Kuo, Yee-Shin Lin, Jiunn-Jong Wu, Ming T. Lin, Ching-Chuan Liu, Wen-Yih Jeng, and Woei-Jer Chuang
Maturation Processing and Characterization of Streptopain
J. Biol. Chem. 2003 278: 17336-17343. First Published on March 5, 2003; doi:10.1074/jbc.M209038200 [Abstract] [Full Text] [PDF]  

Douglas M. Swank, Aileen F. Knowles, William A. Kronert, Jennifer A. Suggs, George E. Morrill, Massoud Nikkhoy, Gracielle G. Manipon, and Sanford I. Bernstein
Variable N-terminal Regions of Muscle Myosin Heavy Chain Modulate ATPase Rate and Actin Sliding Velocity
J. Biol. Chem. 2003 278: 17475-17482. First Published on February 26, 2003; doi:10.1074/jbc.M212727200 [Abstract] [Full Text] [PDF]  


Metabolism and Bioenergetics:

Andrea Montalvetti, Alexis Fernandez, John M. Sanders, Subhash Ghosh, Erin Van Brussel, Eric Oldfield, and Roberto Docampo
Farnesyl Pyrophosphate Synthase Is an Essential Enzyme in Trypanosoma brucei. IN VITRO RNA INTERFERENCE AND IN VIVO INHIBITION STUDIES
J. Biol. Chem. 2003 278: 17075-17083. First Published on March 4, 2003; doi:10.1074/jbc.M210467200 [Abstract] [Full Text] [PDF]  

Daniel Bach, Sara Pich, Francesc X. Soriano, Nathalie Vega, Bernhard Baumgartner, Josep Oriola, Jens R. Daugaard, Jorge Lloberas, Marta Camps, Juleen R. Zierath, Rémi Rabasa-Lhoret, Harriet Wallberg-Henriksson, Martine Laville, Manuel Palacín, Hubert Vidal, Francisca Rivera, Martin Brand, and Antonio Zorzano
Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism. A NOVEL REGULATORY MECHANISM ALTERED IN OBESITY
J. Biol. Chem. 2003 278: 17190-17197. First Published on February 21, 2003; doi:10.1074/jbc.M212754200 [Abstract] [Full Text] [PDF]  

Leh-Miauh Buu, Yee-Chun Chen, and Fang-Jen S. Lee
Functional Characterization and Localization of Acetyl-CoA Hydrolase, Ach1p, in Saccharomyces cerevisiae
J. Biol. Chem. 2003 278: 17203-17209. First Published on February 26, 2003; doi:10.1074/jbc.M213268200 [Abstract] [Full Text] [PDF]  


Glycobiology and Extracellular Matrices:

Paul D. Rick, Kathleen Barr, Krishnan Sankaran, Junko Kajimura, Jeffrey S. Rush, and Charles J. Waechter
Evidence That the wzxE Gene of Escherichia coli K-12 Encodes a Protein Involved in the Transbilayer Movement of a Trisaccharide-Lipid Intermediate in the Assembly of Enterobacterial Common Antigen
J. Biol. Chem. 2003 278: 16534-16542. First Published on March 5, 2003; doi:10.1074/jbc.M301750200 [Abstract] [Full Text] [PDF]  

Alex Gentle, Yanyan Liu, Jennifer E. Martin, Giada L. Conti, and Neville A. McBrien
Collagen Gene Expression and the Altered Accumulation of Scleral Collagen during the Development of High Myopia
J. Biol. Chem. 2003 278: 16587-16594. First Published on February 26, 2003; doi:10.1074/jbc.M300970200 [Abstract] [Full Text] [PDF]  

Zhengliang L. Wu, Lijuan Zhang, Tomio Yabe, B. Kuberan, David L. Beeler, Andre Love, and Robert D. Rosenberg
The Involvement of Heparan Sulfate (HS) in FGF1/HS/FGFR1 Signaling Complex
J. Biol. Chem. 2003 278: 17121-17129. First Published on February 25, 2003; doi:10.1074/jbc.M212590200 [Abstract] [Full Text] [PDF]  

Maurizio Mongiat, Jian Fu, Rachel Oldershaw, Robert Greenhalgh, Allen M. Gown, and Renato V. Iozzo
Perlecan Protein Core Interacts with Extracellular Matrix Protein 1 (ECM1), a Glycoprotein Involved in Bone Formation and Angiogenesis
J. Biol. Chem. 2003 278: 17491-17499. First Published on February 25, 2003; doi:10.1074/jbc.M210529200 [Abstract] [Full Text] [PDF]  

David A. Carrino, Patrik Önnerfjord, John D. Sandy, Gabriella Cs-Szabo, Paul G. Scott, J. Michael Sorrell, Dick Heinegård, and Arnold I. Caplan
Age-related Changes in the Proteoglycans of Human Skin. SPECIFIC CLEAVAGE OF DECORIN TO YIELD A MAJOR CATABOLIC FRAGMENT IN ADULT SKIN
J. Biol. Chem. 2003 278: 17566-17572. First Published on March 5, 2003; doi:10.1074/jbc.M300124200 [Abstract] [Full Text] [PDF]  


Lipids and Lipoproteins:

Huiyong Yin, Christine M. Havrilla, Ling Gao, Jason D. Morrow, and Ned A. Porter
Mechanisms for the Formation of Isoprostane Endoperoxides from Arachidonic Acid. "DIOXETANE" INTERMEDIATE VERSUS beta -FRAGMENTATION OF PEROXYL RADICALS
J. Biol. Chem. 2003 278: 16720-16725. First Published on February 27, 2003; doi:10.1074/jbc.M300604200 [Abstract] [Full Text] [PDF]  

Urule Igbavboa, Justine M. Pidcock, Leslie N. A. Johnson, Todd M. Malo, Ann E. Studniski, Su Yu, Grace Y. Sun, and W. Gibson Wood
Cholesterol Distribution in the Golgi Complex of DITNC1 Astrocytes Is Differentially Altered by Fresh and Aged Amyloid beta -Peptide-(1-42)
J. Biol. Chem. 2003 278: 17150-17157. First Published on February 12, 2003; doi:10.1074/jbc.M301150200 [Abstract] [Full Text] [PDF]  


Membrane Transport Structure Function and Biogenesis:

Keiko Uchida, Hiroshi Miyauchi, Teiichi Furuichi, Takayuki Michikawa, and Katsuhiko Mikoshiba
Critical Regions for Activation Gating of the Inositol 1,4,5-Trisphosphate Receptor
J. Biol. Chem. 2003 278: 16551-16560. First Published on March 5, 2003; doi:10.1074/jbc.M300646200 [Abstract] [Full Text] [PDF]  

Kirk L. Hamilton, Colin A. Syme, and Daniel C. Devor
Molecular Localization of the Inhibitory Arachidonic Acid Binding Site to the Pore of hIK1
J. Biol. Chem. 2003 278: 16690-16697. First Published on February 27, 2003; doi:10.1074/jbc.M212959200 [Abstract] [Full Text] [PDF]  

Lihua He and John J. Lemasters
Heat Shock Suppresses the Permeability Transition in Rat Liver Mitochondria
J. Biol. Chem. 2003 278: 16755-16760. First Published on February 28, 2003; doi:10.1074/jbc.M300153200 [Abstract] [Full Text] [PDF]  

Wei-Zhong Zeng, Xin-Ji Li, Donald W. Hilgemann, and Chou-Long Huang
Protein Kinase C Inhibits ROMK1 Channel Activity via a Phosphatidylinositol 4,5-Bisphosphate-dependent Mechanism
J. Biol. Chem. 2003 278: 16852-16856. First Published on March 3, 2003; doi:10.1074/jbc.M300619200 [Abstract] [Full Text] [PDF]  

Katrin Philippar, Kai Büchsenschütz, Maike Abshagen, Ines Fuchs, Dietmar Geiger, Benoit Lacombe, and Rainer Hedrich
The K+ Channel KZM1 Mediates Potassium Uptake into the Phloem and Guard Cells of the C4 Grass Zea mays
J. Biol. Chem. 2003 278: 16973-16981. First Published on February 27, 2003; doi:10.1074/jbc.M212720200 [Abstract] [Full Text] [PDF]  

Clemens Stockklausner and Nikolaj Klöcker
Surface Expression of Inward Rectifier Potassium Channels Is Controlled by Selective Golgi Export
J. Biol. Chem. 2003 278: 17000-17005. First Published on February 27, 2003; doi:10.1074/jbc.M212243200 [Abstract] [Full Text] [PDF]  

Juliette Morlon-Guyot, Mohamed Helmy, Sophie Lombard-Frasca, David Pignol, Gérard Piéroni, and Bruno Beaumelle
Identification of the Ricin Lipase Site and Implication in Cytotoxicity
J. Biol. Chem. 2003 278: 17006-17011. First Published on February 28, 2003; doi:10.1074/jbc.M209516200 [Abstract] [Full Text] [PDF]  

Xiaoling Li and Stephen J. Gould
The Dynamin-like GTPase DLP1 Is Essential for Peroxisome Division and Is Recruited to Peroxisomes in Part by PEX11
J. Biol. Chem. 2003 278: 17012-17020. First Published on March 4, 2003; doi:10.1074/jbc.M212031200 [Abstract] [Full Text] [PDF]  

James S. Wiley, Lan-Phuong Dao-Ung, Changping Li, Anne N. Shemon, Ben J. Gu, Megan L. Smart, Stephen J. Fuller, Julian A. Barden, Steven Petrou, and Ronald Sluyter
An Ile-568 to Asn Polymorphism Prevents Normal Trafficking and Function of the Human P2X7 Receptor
J. Biol. Chem. 2003 278: 17108-17113. First Published on February 13, 2003; doi:10.1074/jbc.M212759200 [Abstract] [Full Text] [PDF]  

Karima Taouil, Jocelyne Hinnrasky, Coralie Hologne, Pascal Corlieu, Jean-Michel Klossek, and Edith Puchelle
Stimulation of beta 2-Adrenergic Receptor Increases Cystic Fibrosis Transmembrane Conductance Regulator Expression in Human Airway Epithelial Cells through a cAMP/Protein Kinase A-independent Pathway
J. Biol. Chem. 2003 278: 17320-17327. First Published on March 5, 2003; doi:10.1074/jbc.M212227200 [Abstract] [Full Text] [PDF]  

Alan S. L. Yu, Alissa H. Enck, Wayne I. Lencer, and Eveline E. Schneeberger
Claudin-8 Expression in Madin-Darby Canine Kidney Cells Augments the Paracellular Barrier to Cation Permeation
J. Biol. Chem. 2003 278: 17350-17359. First Published on March 2, 2003; doi:10.1074/jbc.M213286200 [Abstract] [Full Text] [PDF]  

Lindsay M. Watson, Anthony K. C. Chan, Leslie R. Berry, Jun Li, Sudesh K. Sood, Jeffrey G. Dickhout, Ling Xu, Geoff H. Werstuck, Laszlo Bajzar, Henry J. Klamut, and Richard C. Austin
Overexpression of the 78-kDa Glucose-regulated Protein/Immunoglobulin-binding Protein (GRP78/BiP) Inhibits Tissue Factor Procoagulant Activity
J. Biol. Chem. 2003 278: 17438-17447. First Published on March 5, 2003; doi:10.1074/jbc.M301006200 [Abstract] [Full Text] [PDF]  

Yuk M. Leung, Youhou Kang, Xiaodong Gao, Fuzhen Xia, Huanli Xie, Laura Sheu, Sharon Tsuk, Ilana Lotan, Robert G. Tsushima, and Herbert Y. Gaisano
Syntaxin 1A Binds to the Cytoplasmic C Terminus of Kv2.1 to Regulate Channel Gating and Trafficking
J. Biol. Chem. 2003 278: 17532-17538. First Published on March 5, 2003; doi:10.1074/jbc.M213088200 [Abstract] [Full Text] [PDF]  

Valérie C. Simonet, Arnaud Baslé, Karl E. Klose, and Anne H. Delcour
The Vibrio cholerae Porins OmpU and OmpT Have Distinct Channel Properties
J. Biol. Chem. 2003 278: 17539-17545. First Published on February 25, 2003; doi:10.1074/jbc.M301202200 [Abstract] [Full Text] [PDF]  


Mechanisms Of Signal Transduction:

Whaseon Lee-Kwon, Kazuya Kawano, Jung Woong Choi, Jae Ho Kim, and Mark Donowitz
Lysophosphatidic Acid Stimulates Brush Border Na+/H+ Exchanger 3 (NHE3) Activity by Increasing Its Exocytosis by an NHE3 Kinase A Regulatory Protein-dependent Mechanism
J. Biol. Chem. 2003 278: 16494-16501. First Published on February 20, 2003; doi:10.1074/jbc.M300580200 [Abstract] [Full Text] [PDF]  

Barbara Bedogni, Giovambattista Pani, Renata Colavitti, Antonella Riccio, Silvia Borrello, Mike Murphy, Robin Smith, Maria Luisa Eboli, and Tommaso Galeotti
Redox Regulation of cAMP-responsive Element-binding Protein and Induction of Manganous Superoxide Dismutase in Nerve Growth Factor-dependent Cell Survival
J. Biol. Chem. 2003 278: 16510-16519. First Published on February 27, 2003; doi:10.1074/jbc.M301089200 [Abstract] [Full Text] [PDF]  

Yuhong Chen, Renren Wen, Shoua Yang, James Schuman, Eric E. Zhang, Taolin Yi, Gen-Sheng Feng, and Demin Wang
Identification of Shp-2 as a Stat5A Phosphatase
J. Biol. Chem. 2003 278: 16520-16527. First Published on March 3, 2003; doi:10.1074/jbc.M210572200 [Abstract] [Full Text] [PDF]  

Ronald E. Laliberte, David G. Perregaux, Lise R. Hoth, Philip J. Rosner, Crystal K. Jordan, Kevin M. Peese, James. F. Eggler, Mark A. Dombroski, Kieran F. Geoghegan, and Christopher A. Gabel
Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1beta Posttranslational Processing
J. Biol. Chem. 2003 278: 16567-16578. First Published on March 6, 2003; doi:10.1074/jbc.M211596200 [Abstract] [Full Text] [PDF]  

Celia Quevedo, Matilde Salinas, and Alberto Alcázar
Initiation Factor 2B Activity Is Regulated by Protein Phosphatase 1, Which Is Activated by the Mitogen-activated Protein Kinase-dependent Pathway in Insulin-like Growth Factor 1-stimulated Neuronal Cells
J. Biol. Chem. 2003 278: 16579-16586. First Published on March 6, 2003; doi:10.1074/jbc.M212936200 [Abstract] [Full Text] [PDF]  

Hiroyuki Kishimoto, Kentaro Nakagawa, Tomomi Watanabe, Daiju Kitagawa, Haruka Momose, Jungwon Seo, Gen Nishitai, Nao Shimizu, Shinya Ohata, Shuhei Tanemura, Satoshi Asaka, Takayuki Goto, Hiromichi Fukushi, Hiroki Yoshida, Akira Suzuki, Takehiko Sasaki, Teiji Wada, Josef M. Penninger, Hiroshi Nishina, and Toshiaki Katada
Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells
J. Biol. Chem. 2003 278: 16595-16601. First Published on March 6, 2003; doi:10.1074/jbc.M213182200 [Abstract] [Full Text] [PDF]  

Tao Li, Michael D. Southall, Qiaofang Yi, Yong Pei, Davina Lewis, Mohammed Al-Hassani, Dan Spandau, and Jeffrey B. Travers
The Epidermal Platelet-activating Factor Receptor Augments Chemotherapy-induced Apoptosis in Human Carcinoma Cell Lines
J. Biol. Chem. 2003 278: 16614-16621. First Published on February 24, 2003; doi:10.1074/jbc.M211287200 [Abstract] [Full Text] [PDF]  

Sophie Pattingre, Chantal Bauvy, and Patrice Codogno
Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells
J. Biol. Chem. 2003 278: 16667-16674. First Published on February 27, 2003; doi:10.1074/jbc.M210998200 [Abstract] [Full Text] [PDF]  

Leonard B. Maggi, Jr., Jason M. Moran, R. Mark L. Buller, and John A. Corbett
ERK Activation Is Required for Double-stranded RNA- and Virus-induced Interleukin-1 Expression by Macrophages
J. Biol. Chem. 2003 278: 16683-16689. First Published on February 27, 2003; doi:10.1074/jbc.M211744200 [Abstract] [Full Text] [PDF]  

Yali Hou, Judith Lascola, Nickolai O. Dulin, Richard D. Ye, and Darren D. Browning
Activation of cGMP-dependent Protein Kinase by Protein Kinase C
J. Biol. Chem. 2003 278: 16706-16712. First Published on February 27, 2003; doi:10.1074/jbc.M300045200 [Abstract] [Full Text] [PDF]  

Zhengfan Jiang, Maryam Zamanian-Daryoush, Huiqing Nie, Aristobolo M. Silva, Bryan R. G. Williams, and Xiaoxia Li
Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFkappa B and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR
J. Biol. Chem. 2003 278: 16713-16719. First Published on February 27, 2003; doi:10.1074/jbc.M300562200 [Abstract] [Full Text] [PDF]  

Shizuo Ikeyama, Xian-Tao Wang, Ji Li, Andrej Podlutsky, Jennifer L. Martindale, Gertrude Kokkonen, Rika van Huizen, Myriam Gorospe, and Nikki J. Holbrook
Expression of the Pro-apoptotic Gene gadd153/chop Is Elevated in Liver with Aging and Sensitizes Cells to Oxidant Injury
J. Biol. Chem. 2003 278: 16726-16731. First Published on February 27, 2003; doi:10.1074/jbc.M300677200 [Abstract] [Full Text] [PDF]  

Angus Harding, Nichole Giles, Andrew Burgess, John F. Hancock, and Brian G. Gabrielli
Mechanism of Mitosis-specific Activation of MEK1
J. Biol. Chem. 2003 278: 16747-16754. First Published on February 27, 2003; doi:10.1074/jbc.M301015200 [Abstract] [Full Text] [PDF]  

Paola Lovato, Christine Brender, Jørgen Agnholt, Jens Kelsen, Keld Kaltoft, Arne Svejgaard, Karsten Wessel Eriksen, Anders Woetmann, and Niels Ødum
Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease
J. Biol. Chem. 2003 278: 16777-16781. First Published on March 3, 2003; doi:10.1074/jbc.M207999200 [Abstract] [Full Text] [PDF]  

Jianhua Yang, Guanghui Hu, Shen-Wu Wang, Yucheng Li, Rachel Martin, Kang Li, and Zhengbin Yao
Calcineurin/Nuclear Factors of Activated T Cells (NFAT)-activating and Immunoreceptor Tyrosine-based Activation Motif (ITAM)-containing Protein (CNAIP), a Novel ITAM-containing Protein That Activates the Calcineurin/NFAT-signaling Pathway
J. Biol. Chem. 2003 278: 16797-16801. First Published on March 3, 2003; doi:10.1074/jbc.M211060200 [Abstract] [Full Text] [PDF]  

Lin Yang, Hui-Kuan Lin, Saleh Altuwaijri, Shaozhen Xie, Liang Wang, and Chawnshang Chang
APPL Suppresses Androgen Receptor Transactivation via Potentiating Akt Activity
J. Biol. Chem. 2003 278: 16820-16827. First Published on March 5, 2003; doi:10.1074/jbc.M213163200 [Abstract] [Full Text] [PDF]  

Clare L. Abram, Darren F. Seals, Ian Pass, Daniel Salinsky, Lisa Maurer, Therese M. Roth, and Sara A. Courtneidge
The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells
J. Biol. Chem. 2003 278: 16844-16851. First Published on March 3, 2003; doi:10.1074/jbc.M300267200 [Abstract] [Full Text] [PDF]  

John Carvalho and X. F. Steven Zheng
Domains of Gln3p Interacting with Karyopherins, Ure2p, and the Target of Rapamycin Protein
J. Biol. Chem. 2003 278: 16878-16886. First Published on March 5, 2003; doi:10.1074/jbc.M300429200 [Abstract] [Full Text] [PDF]  

Maria N. Garnovskaya, Yurii V. Mukhin, Tamara M. Vlasova, and John R. Raymond
Hypertonicity Activates Na+/H+ Exchange through Janus Kinase 2 and Calmodulin
J. Biol. Chem. 2003 278: 16908-16915. First Published on March 7, 2003; doi:10.1074/jbc.M209883200 [Abstract] [Full Text] [PDF]  

Tamio Iwamoto, Satoshi Okumura, Kousaku Iwatsubo, Jun-Ichi Kawabe, Koji Ohtsu, Ikuko Sakai, Yoko Hashimoto, Aki Izumitani, Kazunori Sango, Kyoko Ajiki, Yoshiyuki Toya, Satoshi Umemura, Yoshio Goshima, Nobutaka Arai, Stephen F. Vatner, and Yoshihiro Ishikawa
Motor Dysfunction in Type 5 Adenylyl Cyclase-null Mice
J. Biol. Chem. 2003 278: 16936-16940. First Published on March 28, 2003; doi:10.1074/jbc.C300075200 [Abstract] [Full Text] [PDF]  

Ikram El Yazidi-Belkoura, Eric Adriaenssens, Laurent Dollé, Simon Descamps, and Hubert Hondermarck
Tumor Necrosis Factor Receptor-associated Death Domain Protein Is Involved in the Neurotrophin Receptor-mediated Antiapoptotic Activity of Nerve Growth Factor in Breast Cancer Cells
J. Biol. Chem. 2003 278: 16952-16956. First Published on February 25, 2003; doi:10.1074/jbc.M300631200 [Abstract] [Full Text] [PDF]  

Karine Merienne, Dominique Helmlinger, Gordon R. Perkin, Didier Devys, and Yvon Trottier
Polyglutamine Expansion Induces a Protein-damaging Stress Connecting Heat Shock Protein 70 to the JNK Pathway
J. Biol. Chem. 2003 278: 16957-16967. First Published on February 21, 2003; doi:10.1074/jbc.M212049200 [Abstract] [Full Text] [PDF]  

Cécile Ancey, Andrea Küster, Serge Haan, Andreas Herrmann, Peter C. Heinrich, and Gerhard Müller-Newen
A Fusion Protein of the gp130 and Interleukin-6Ralpha Ligand-binding Domains Acts as a Potent Interleukin-6 Inhibitor
J. Biol. Chem. 2003 278: 16968-16972. First Published on March 19, 2003; doi:10.1074/jbc.C300081200 [Abstract] [Full Text] [PDF]  

A. Paul Mould, Stephanie J. Barton, Janet A. Askari, Paul A. McEwan, Patrick A. Buckley, Susan E. Craig, and Martin J. Humphries
Conformational Changes in the Integrin beta A Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement
J. Biol. Chem. 2003 278: 17028-17035. First Published on March 3, 2003; doi:10.1074/jbc.M213139200 [Abstract] [Full Text] [PDF]  

Yin Chen, Philip Thai, Yu-Hua Zhao, Ye-Shih Ho, Mary M. DeSouza, and Reen Wu
Stimulation of Airway Mucin Gene Expression by Interleukin (IL)-17 through IL-6 Paracrine/Autocrine Loop
J. Biol. Chem. 2003 278: 17036-17043. First Published on March 6, 2003; doi:10.1074/jbc.M210429200 [Abstract] [Full Text] [PDF]  

Helen R. Mott, Daniel Nietlispach, Louise J. Hopkins, Gladys Mirey, Jacques H. Camonis, and Darerca Owen
Structure of the GTPase-binding Domain of Sec5 and Elucidation of its Ral Binding Site
J. Biol. Chem. 2003 278: 17053-17059. First Published on March 6, 2003; doi:10.1074/jbc.M300155200 [Abstract] [Full Text] [PDF]  

Hilde Abrahamsen, Torkel Vang, and Kjetil Taskén
Protein Kinase A Intersects Src Signaling in Membrane Microdomains
J. Biol. Chem. 2003 278: 17170-17177. First Published on February 26, 2003; doi:10.1074/jbc.M211426200 [Abstract] [Full Text] [PDF]  

Ying Gu, You Cheng Xu, Ru Feng Wu, Fiemu E. Nwariaku, Rhonda F. Souza, Sonia C. Flores, and Lance S. Terada
p47phox Participates in Activation of RelA in Endothelial Cells
J. Biol. Chem. 2003 278: 17210-17217. First Published on March 4, 2003; doi:10.1074/jbc.M210314200 [Abstract] [Full Text] [PDF]  

Elena B. Kabotyanski and Jeffrey M. Rosen
Signal Transduction Pathways Regulated by Prolactin and Src Result in Different Conformations of Activated Stat5b
J. Biol. Chem. 2003 278: 17218-17227. First Published on March 5, 2003; doi:10.1074/jbc.M301578200 [Abstract] [Full Text] [PDF]  

Hisanori Takenobu, Ayano Yamazaki, Michinari Hirata, Toshiyuki Umata, and Eisuke Mekada
The Stress- and Inflammatory Cytokine-induced Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor Is Mediated by p38 MAPK, Distinct from the 12-O-Tetradecanoylphorbol-13-acetate- and Lysophosphatidic Acid-induced Signaling Cascades
J. Biol. Chem. 2003 278: 17255-17262. First Published on February 28, 2003; doi:10.1074/jbc.M211835200 [Abstract] [Full Text] [PDF]  

Satoshi Takida and Philip B. Wedegaertner
Heterotrimer Formation, Together with Isoprenylation, Is Required for Plasma Membrane Targeting of Gbeta gamma
J. Biol. Chem. 2003 278: 17284-17290. First Published on February 27, 2003; doi:10.1074/jbc.M213239200 [Abstract] [Full Text] [PDF]  

Yanzhong Hu and Nahid F. Mivechi
HSF-1 Interacts with Ral-binding Protein 1 in a Stress-responsive, Multiprotein Complex with HSP90 in Vivo
J. Biol. Chem. 2003 278: 17299-17306. First Published on March 5, 2003; doi:10.1074/jbc.M300788200 [Abstract] [Full Text] [PDF]  

Ingrid Chou Koo and Richard S. Stephens
A Developmentally Regulated Two-component Signal Transduction System in Chlamydia
J. Biol. Chem. 2003 278: 17314-17319. First Published on February 24, 2003; doi:10.1074/jbc.M212170200 [Abstract] [Full Text] [PDF]  

Parvathi Rudrabhatla and Ram Rajasekharan
Mutational Analysis of Stress-responsive Peanut Dual Specificity Protein Kinase. IDENTIFICATION OF TYROSINE RESIDUES INVOLVED IN REGULATION OF PROTEIN KINASE ACTIVITY
J. Biol. Chem. 2003 278: 17328-17335. First Published on March 5, 2003; doi:10.1074/jbc.M300024200 [Abstract] [Full Text] [PDF]  

Keon Wook Kang, So Yeon Choi, Min Kyung Cho, Chang Ho Lee, and Sang Geon Kim
Thrombin Induces Nitric-oxide Synthase via Galpha 12/13-coupled Protein Kinase C-dependent I-kappa Balpha Phosphorylation and JNK-mediated I-kappa Balpha Degradation
J. Biol. Chem. 2003 278: 17368-17378. First Published on February 26, 2003; doi:10.1074/jbc.M300471200 [Abstract] [Full Text] [PDF]  

Dhyan Chandra and Dean G. Tang
Mitochondrially Localized Active Caspase-9 and Caspase-3 Result Mostly from Translocation from the Cytosol and Partly from Caspase-mediated Activation in the Organelle. LACK OF EVIDENCE FOR Apaf-1-MEDIATED PROCASPASE-9 ACTIVATION IN THE MITOCHONDRIA
J. Biol. Chem. 2003 278: 17408-17420. First Published on February 28, 2003; doi:10.1074/jbc.M300750200 [Abstract] [Full Text] [PDF]  

Rozita Bagheri-Yarmand, Ratna K. Vadlamudi, and Rakesh Kumar
Activating Transcription Factor 4 Overexpression Inhibits Proliferation and Differentiation of Mammary Epithelium Resulting in Impaired Lactation and Accelerated Involution
J. Biol. Chem. 2003 278: 17421-17429. First Published on February 28, 2003; doi:10.1074/jbc.M300761200 [Abstract] [Full Text] [PDF]  

Juana M. Del Valle, Pablo Engel, and Margarita Martín
The Cell Surface Expression of SAP-binding Receptor CD229 Is Regulated via Its Interaction with Clathrin-associated Adaptor Complex 2 (AP-2)
J. Biol. Chem. 2003 278: 17430-17437. First Published on March 5, 2003; doi:10.1074/jbc.M301569200 [Abstract] [Full Text] [PDF]  

Dawn M. Kilkenny, Jonathan V. Rocheleau, James Price, Martha B. Reich, and Geraldine G. Miller
c-Src Regulation of Fibroblast Growth Factor-induced Proliferation in Murine Embryonic Fibroblasts
J. Biol. Chem. 2003 278: 17448-17454. First Published on March 5, 2003; doi:10.1074/jbc.M209698200 [Abstract] [Full Text] [PDF]  

Megan E. Williams, Phyllis Strickland, Ken Watanabe, and Lindsay Hinck
UNC5H1 Induces Apoptosis via Its Juxtamembrane Region through an Interaction with NRAGE
J. Biol. Chem. 2003 278: 17483-17490. First Published on February 21, 2003; doi:10.1074/jbc.M300415200 [Abstract] [Full Text] [PDF]  

Zohar Tiran, Asher Peretz, Bernard Attali, and Ari Elson
Phosphorylation-dependent Regulation of Kv2.1 Channel Activity at Tyrosine 124 by Src and by Protein-tyrosine Phosphatase epsilon
J. Biol. Chem. 2003 278: 17509-17514. First Published on March 1, 2003; doi:10.1074/jbc.M212766200 [Abstract] [Full Text] [PDF]  

Yuichiro J. Suzuki, Regina M. Day, Chia Chi Tan, Tor H. Sandven, Qiangrong Liang, Jeffery D. Molkentin, and Barry L. Fanburg
Activation of GATA-4 by Serotonin in Pulmonary Artery Smooth Muscle Cells
J. Biol. Chem. 2003 278: 17525-17531. First Published on March 3, 2003; doi:10.1074/jbc.M210465200 [Abstract] [Full Text] [PDF]  

Zhenglin Gu, Ping Zhong, and Zhen Yan
Activation of Muscarinic Receptors Inhibits beta -Amyloid Peptide-induced Signaling in Cortical Slices
J. Biol. Chem. 2003 278: 17546-17556. First Published on February 26, 2003; doi:10.1074/jbc.M209892200 [Abstract] [Full Text] [PDF]  

C. Christian Johansson, Maria K. Dahle, Sandra Rodrigo Blomqvist, Line M. Grønning, Einar M. Aandahl, Sven Enerbäck, and Kjetil Taskén
A Winged Helix Forkhead (FOXD2) Tunes Sensitivity to cAMP in T Lymphocytes through Regulation of cAMP-dependent Protein Kinase RIalpha
J. Biol. Chem. 2003 278: 17573-17579. First Published on March 5, 2003; doi:10.1074/jbc.M300311200 [Abstract] [Full Text] [PDF]  


Molecular Basis Of Cell and Developmental Biology:

A. Christine Engblom, Flemming F. Johansen, and Uffe Kristiansen
Actions and Interactions of Extracellular Potassium and Kainate on Expression of 13 gamma -Aminobutyric Acid Type A Receptor Subunits in Cultured Mouse Cerebellar Granule Neurons
J. Biol. Chem. 2003 278: 16543-16550. First Published on March 5, 2003; doi:10.1074/jbc.M300548200 [Abstract] [Full Text] [PDF]  

Nozomi Sakai, Tetsuo Maruyama, Rei Sakurai, Hirotaka Masuda, Yurie Yamamoto, Aki Shimizu, Ikuko Kishi, Hironori Asada, Satoshi Yamagoe, and Yasunori Yoshimura
Involvement of Histone Acetylation in Ovarian Steroid-induced Decidualization of Human Endometrial Stromal Cells
J. Biol. Chem. 2003 278: 16675-16682. First Published on February 27, 2003; doi:10.1074/jbc.M211715200 [Abstract] [Full Text] [PDF]  

Mark C. Hall, Matthew P. Torres, Gottfried K. Schroeder, and Christoph H. Borchers
Mnd2 and Swm1 Are Core Subunits of the Saccharomyces cerevisiae Anaphase-promoting Complex
J. Biol. Chem. 2003 278: 16698-16705. First Published on February 27, 2003; doi:10.1074/jbc.M213109200 [Abstract] [Full Text] [PDF]  

Wei Zou, Alla Amcheslavsky, and Zvi Bar-Shavit
CpG Oligodeoxynucleotides Modulate the Osteoclastogenic Activity of Osteoblasts via Toll-like Receptor 9
J. Biol. Chem. 2003 278: 16732-16740. First Published on February 28, 2003; doi:10.1074/jbc.M212473200 [Abstract] [Full Text] [PDF]  

Jay A. Grobler, Eric J. Markel, John F. Fay, Donald J. Graham, Amy L. Simcoe, Steve W. Ludmerer, Edward M. Murray, Giovanni Migliaccio, and Osvaldo A. Flores
Identification of a Key Determinant of Hepatitis C Virus Cell Culture Adaptation in Domain II of NS3 Helicase
J. Biol. Chem. 2003 278: 16741-16746. First Published on February 28, 2003; doi:10.1074/jbc.M212602200 [Abstract] [Full Text] [PDF]  

Jin Woong Chung, Suk Jin Hong, Kee Jun Kim, Daniel Goti, Monique F. Stins, Sooan Shin, Valina L. Dawson, Ted M. Dawson, and Kwang Sik Kim
37-kDa Laminin Receptor Precursor Modulates Cytotoxic Necrotizing Factor 1-mediated RhoA Activation and Bacterial Uptake
J. Biol. Chem. 2003 278: 16857-16862. First Published on March 3, 2003; doi:10.1074/jbc.M301028200 [Abstract] [Full Text] [PDF]  

Xiaolan Yi, Xiao-Ming Yin, and Zheng Dong
Inhibition of Bid-induced Apoptosis by Bcl-2. tBid INSERTION, Bax TRANSLOCATION, AND Bax/Bak OLIGOMERIZATION SUPPRESSED
J. Biol. Chem. 2003 278: 16992-16999. First Published on March 6, 2003; doi:10.1074/jbc.M300039200 [Abstract] [Full Text] [PDF]  

Siwanon Jirawatnotai, David S. Moons, Carlos O. Stocco, Roberta Franks, Dale B. Hales, Geula Gibori, and Hiroaki Kiyokawa
The Cyclin-dependent Kinase Inhibitors p27Kip1 and p21Cip1 Cooperate to Restrict Proliferative Life Span in Differentiating Ovarian Cells
J. Biol. Chem. 2003 278: 17021-17027. First Published on February 27, 2003; doi:10.1074/jbc.M301206200 [Abstract] [Full Text] [PDF]  

Candace M. Cham, Hui Xu, James P. O'Keefe, Fabiola V. Rivas, Panayiotis Zagouras, and Thomas F. Gajewski
Gene Array and Protein Expression Profiles Suggest Post-transcriptional Regulation during CD8+ T Cell Differentiation
J. Biol. Chem. 2003 278: 17044-17052. First Published on February 11, 2003; doi:10.1074/jbc.M212741200 [Abstract] [Full Text] [PDF] Supplemental Data  

Satoshi Miyake, Yuka Yanagisawa, and Yasuhito Yuasa
A Novel EID-1 Family Member, EID-2, Associates with Histone Deacetylases and Inhibits Muscle Differentiation
J. Biol. Chem. 2003 278: 17060-17065. First Published on February 13, 2003; doi:10.1074/jbc.M212212200 [Abstract] [Full Text] [PDF]  

Kuniaki Mukai, Fumiko Mitani, Hideko Nagasawa, Reiko Suzuki, Tsuneharu Suzuki, Makoto Suematsu, and Yuzuru Ishimura
An Inverse Correlation between Expression of a Preprocathepsin B-related Protein with Cysteine-rich Sequences and Steroid 11beta -Hydroxylase in Adrenocortical Cells
J. Biol. Chem. 2003 278: 17084-17092. First Published on February 24, 2003; doi:10.1074/jbc.M301477200 [Abstract] [Full Text] [PDF]  

Hirotaka Watada, David W. Scheel, Joey Leung, and Michael S. German
Distinct Gene Expression Programs Function in Progenitor and Mature Islet Cells
J. Biol. Chem. 2003 278: 17130-17140. First Published on February 25, 2003; doi:10.1074/jbc.M213196200 [Abstract] [Full Text] [PDF]  

Tali Lange, Noga Guttmann-Raviv, Limor Baruch, Marcelle Machluf, and Gera Neufeld
VEGF162, A New Heparin-binding Vascular Endothelial Growth Factor Splice Form That Is Expressed in Transformed Human Cells
J. Biol. Chem. 2003 278: 17164-17169. First Published on February 21, 2003; doi:10.1074/jbc.M212224200 [Abstract] [Full Text] [PDF]  

Chao-Neng Tseng, Lili Zhang, Michael Cascio, and Zuo-Zhong Wang
Calcium Plays a Critical Role in Determining the Acetylcholine Receptor-clustering Activities of Alternatively Spliced Isoforms of Agrin
J. Biol. Chem. 2003 278: 17236-17245. First Published on March 5, 2003; doi:10.1074/jbc.M300282200 [Abstract] [Full Text] [PDF]  

Joel W. Neal and Neil A. Clipstone
A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts
J. Biol. Chem. 2003 278: 17246-17254. First Published on February 21, 2003; doi:10.1074/jbc.M300528200 [Abstract] [Full Text] [PDF]  

James K. Wahl, III, Young J. Kim, Janet M. Cullen, Keith R. Johnson, and Margaret J. Wheelock
N-cadherin-Catenin Complexes Form Prior to Cleavage of the Proregion and Transport to the Plasma Membrane
J. Biol. Chem. 2003 278: 17269-17276. First Published on February 25, 2003; doi:10.1074/jbc.M211452200 [Abstract] [Full Text] [PDF]  

Felipe Palacios and Crislyn D'Souza-Schorey
Modulation of Rac1 and ARF6 Activation during Epithelial Cell Scattering
J. Biol. Chem. 2003 278: 17395-17400. First Published on February 27, 2003; doi:10.1074/jbc.M300998200 [Abstract] [Full Text] [PDF]  

Maike Krenz, Atsushi Sanbe, Florence Bouyer-Dalloz, James Gulick, Raisa Klevitsky, Timothy E. Hewett, Hanna E. Osinska, John N. Lorenz, Christine Brosseau, Andrea Federico, Norman R. Alpert, David M. Warshaw, M. Benjamin Perryman, Steve M. Helmke, and Jeffrey Robbins
Analysis of Myosin Heavy Chain Functionality in the Heart
J. Biol. Chem. 2003 278: 17466-17474. First Published on March 6, 2003; doi:10.1074/jbc.M210804200 [Abstract] [Full Text] [PDF]  

Karthikeyan Narayanan, Amsaveni Ramachandran, Jianjun Hao, Gen He, Kyle Won Park, Michael Cho, and Anne George
Dual Functional Roles of Dentin Matrix Protein 1. IMPLICATIONS IN BIOMINERALIZATION AND GENE TRANSCRIPTION BY ACTIVATION OF INTRACELLULAR Ca2+ STORE
J. Biol. Chem. 2003 278: 17500-17508. First Published on March 3, 2003; doi:10.1074/jbc.M212700200 [Abstract] [Full Text] [PDF]  


Additions and Corrections:

Tomoko Tominaga, Wenxiang Meng, Kazuya Togashi, Hiroko Urano, Arthur S. Alberts, and Makoto Tominaga
The Rho GTPase effector protein, mDia, inhibits the DNA binding ability of the transcription factor Pax6 and changes the pattern of neurite extension in cerebellar granule cells through its binding to Pax6.
J. Biol. Chem. 2003 278: 17580. [Full Text] [PDF]  

Osamu Kondoh, Tsuyoshi Takasuka, Mikio Arisawa, Yuko Aoki, and Takahide Watanabe
Differential sensitivity between Fks1p and Fks2p against a novel beta -1,3-glucan synthase inhibitor, aero- thricin1.
J. Biol. Chem. 2003 278: 17580. [Full Text] [PDF]  

Gareth J. Inman and Caroline S. Hill
Stoichiometry of active Smad-transcription factor complexes on DNA.
J. Biol. Chem. 2003 278: 17580. [Full Text] [PDF]  


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