About the Cover
The cover illustration shows a micrograph of the protein complex and DNA at the bacteriophage T4 replication fork. The double-stranded lagging strand DNA is in a loop, confirming the prediction of Bruce Albert’s "trombone model" that the new lagging strand fragment folds into a loop allowing the lagging strand polymerase to contact the leading strand proteins. The single-stranded segments on the lagging strand are in compact protein-covered structures, in contrast to the extended single-stranded DNA envisioned in the model. For details see the article by Chastain et al., pages 21276-21285.
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Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
