JBC -- Table of Contents (Jun 6 2003, 278, (23))

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Peter Devreotes and Chris Janetopoulos: Eukaryotic Chemotaxis: Distinctions between Directional Sensing and Polarization
J. Biol. Chem. 2003 278: 20445-20448. First Published on April 2, 2003; doi:10.1074/jbc.R300010200 [Abstract] [Full Text] [PDF]

Accelerated Publications:

Tip W. Loo, M. Claire Bartlett, and David M. Clarke: Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site
J. Biol. Chem. 2003 278: 20449-20452. First Published on April 23, 2003; doi:10.1074/jbc.C300154200 [Abstract] [Full Text] [PDF]

Shing-Leng Chan, Mei Chin Lee, Kuan Onn Tan, Lay-Kien Yang, Alex S. Y. Lee, Horst Flotow, Nai Yang Fu, Mark S. Butler, Doel D. Soejarto, Antony D. Buss, and Victor C. Yu: Identification of Chelerythrine as an Inhibitor of BclXL Function
J. Biol. Chem. 2003 278: 20453-20456. First Published on April 17, 2003; doi:10.1074/jbc.C300138200 [Abstract] [Full Text] [PDF] Supplemental Data

Hiroyuki Kubota, Tohru Obata, Kazuhisa Ota, Takuma Sasaki, and Takashi Ito: Rapamycin-induced Translational Derepression of GCN4 mRNA Involves a Novel Mechanism for Activation of the eIF2 ${alpha}$ Kinase GCN2
J. Biol. Chem. 2003 278: 20457-20460. First Published on April 2, 2003; doi:10.1074/jbc.C300133200 [Abstract] [Full Text] [PDF]

DNA: Replication Repair and Recombination:

Rory J. O'Neill, Olga V. Vorob'eva, Hassan Shahbakhti, Erik Zmuda, Ashok S. Bhagwat, and Geoffrey S. Baldwin: Mismatch Uracil Glycosylase from Escherichia coli: A GENERAL MISMATCH OR A SPECIFIC DNA GLYCOSYLASE?
J. Biol. Chem. 2003 278: 20526-20532. First Published on March 31, 2003; doi:10.1074/jbc.M210860200 [Abstract] [Full Text] [PDF]

Jun Hayakawa, Chantal Depatie, Masahide Ohmichi, and Dan Mercola: The Activation of c-Jun NH₂-terminal Kinase (JNK) by DNA-damaging Agents Serves to Promote Drug Resistance via Activating Transcription Factor 2 (ATF2)-dependent Enhanced DNA Repair
J. Biol. Chem. 2003 278: 20582-20592. First Published on March 27, 2003; doi:10.1074/jbc.M210992200 [Abstract] [Full Text] [PDF]

Yulong Shen, Xiao-Feng Tang, and Ikuo Matsui: Subunit Interaction and Regulation of Activity through Terminal Domains of the Family D DNA Polymerase from Pyrococcus horikoshii
J. Biol. Chem. 2003 278: 21247-21257. First Published on March 24, 2003; doi:10.1074/jbc.M212286200 [Abstract] [Full Text] [PDF] Data Supplement

Laurence Fourrier, Peter Brooks, and Jean-Marc Malinge: Binding Discrimination of MutS to a Set of Lesions and Compound Lesions (Base Damage and Mismatch) Reveals Its Potential Role as a Cisplatin-damaged DNA Sensing Protein
J. Biol. Chem. 2003 278: 21267-21275. First Published on March 24, 2003; doi:10.1074/jbc.M301390200 [Abstract] [Full Text] [PDF]

Paul D. Chastain, II, Alexander M. Makhov, Nancy G. Nossal, and Jack Griffith: Architecture of the Replication Complex and DNA Loops at the Fork Generated by the Bacteriophage T4 Proteins
J. Biol. Chem. 2003 278: 21276-21285. First Published on March 20, 2003; doi:10.1074/jbc.M301573200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

Sigrid Harendza, David H. Lovett, Ulf Panzer, Zoltan Lukacs, Peter Kühnl, and Rolf A. K. Stahl: Linked Common Polymorphisms in the Gelatinase A Promoter Are Associated with Diminished Transcriptional Response to Estrogen and Genetic Fitness
J. Biol. Chem. 2003 278: 20490-20499. First Published on March 25, 2003; doi:10.1074/jbc.M211536200 [Abstract] [Full Text] [PDF]

Yi Liu, Zhenqi Shi, Alexandra Silveira, Jianzhong Liu, Michele Sawadogo, Hongmei Yang, and Xu Feng: Involvement of Upstream Stimulatory Factors 1 and 2 in RANKL-induced Transcription of Tartrate-resistant Acid Phosphatase Gene during Osteoclast Differentiation
J. Biol. Chem. 2003 278: 20603-20611. First Published on March 27, 2003; doi:10.1074/jbc.M212093200 [Abstract] [Full Text] [PDF]

Sebastian Oltean and Ruma Banerjee: Nutritional Modulation of Gene Expression and Homocysteine Utilization by Vitamin B₁₂
J. Biol. Chem. 2003 278: 20778-20784. First Published on April 1, 2003; doi:10.1074/jbc.M300845200 [Abstract] [Full Text] [PDF]

Nancy Detich, Stefan Hamm, George Just, J. David Knox, and Moshe Szyf: The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA: A CANDIDATE NOVEL MECHANISM FOR THE PHARMACOLOGICAL EFFECTS OF S-ADENOSYLMETHIONINE
J. Biol. Chem. 2003 278: 20812-20820. First Published on April 3, 2003; doi:10.1074/jbc.M211813200 [Abstract] [Full Text] [PDF]

Kengo Morohashi, Masayoshi Minami, Hisabumi Takase, Yasuo Hotta, and Kazuyuki Hiratsuka: Isolation and Characterization of a Novel GRAS Gene That Regulates Meiosis-associated Gene Expression
J. Biol. Chem. 2003 278: 20865-20873. First Published on March 25, 2003; doi:10.1074/jbc.M301712200 [Abstract] [Full Text] [PDF]

Pilar Lara, Luis Oñate-Sánchez, Zamira Abraham, Cristina Ferrándiz, Isabel Díaz, Pilar Carbonero, and Jesús Vicente-Carbajosa: Synergistic Activation of Seed Storage Protein Gene Expression in Arabidopsis by ABI3 and Two bZIPs Related to OPAQUE2
J. Biol. Chem. 2003 278: 21003-21011. First Published on March 25, 2003; doi:10.1074/jbc.M210538200 [Abstract] [Full Text] [PDF]

Yosuke Okada, Aldemar Montero, Xuxia Zhang, Takanori Sobue, Joseph Lorenzo, Thomas Doetschman, J. Douglas Coffin, and Marja M. Hurley: Impaired Osteoclast Formation in Bone Marrow Cultures of Fgf2 Null Mice in Response to Parathyroid Hormone
J. Biol. Chem. 2003 278: 21258-21266. First Published on March 28, 2003; doi:10.1074/jbc.M302113200 [Abstract] [Full Text] [PDF]

RNA: Structure Metabolism and Catalysis:

Rut Valgardsdottir and Hans Prydz: Transport Signals and Transcription-dependent Nuclear Localization of the Putative DEAD-box Helicase MDDX28
J. Biol. Chem. 2003 278: 21146-21154. First Published on March 27, 2003; doi:10.1074/jbc.M300888200 [Abstract] [Full Text] [PDF] Data Supplement

Protein Synthesis Post-Translation Modification and Degradation:

Julie M. Stevens, Oliver Daltrop, Christopher W. Higham, and Stuart J. Ferguson: Interaction of Heme with Variants of the Heme Chaperone CcmE Carrying Active Site Mutations and a Cleavable N-terminal His Tag
J. Biol. Chem. 2003 278: 20500-20506. First Published on March 25, 2003; doi:10.1074/jbc.M212925200 [Abstract] [Full Text] [PDF]

Dora Chin-Yen Koh, Sek-Man Wong, and Ding Xiang Liu: Synergism of the 3'-Untranslated Region and an Internal Ribosome Entry Site Differentially Enhances the Translation of a Plant Virus Coat Protein
J. Biol. Chem. 2003 278: 20565-20573. First Published on March 27, 2003; doi:10.1074/jbc.M210212200 [Abstract] [Full Text] [PDF]

Bedabrata Sarkar, Jin-Yu Lu, and Robert J. Schneider: Nuclear Import and Export Functions in the Different Isoforms of the AUF1/Heterogeneous Nuclear Ribonucleoprotein Protein Family
J. Biol. Chem. 2003 278: 20700-20707. First Published on March 31, 2003; doi:10.1074/jbc.M301176200 [Abstract] [Full Text] [PDF]

Jaana H. Toikkanen, Karl Juha Miller, Hans Söderlund, Jussi Jäntti, and Sirkka Keränen: The ${beta}$ Subunit of the Sec61p Endoplasmic Reticulum Translocon Interacts with the Exocyst Complex in Saccharomyces cerevisiae
J. Biol. Chem. 2003 278: 20946-20953. First Published on March 28, 2003; doi:10.1074/jbc.M213111200 [Abstract] [Full Text] [PDF]

Protein Structure and Folding:

T. Regan Baird and Peter N. Walsh: Factor XI, but Not Prekallikrein, Blocks High Molecular Weight Kininogen Binding to Human Umbilical Vein Endothelial Cells
J. Biol. Chem. 2003 278: 20618-20623. First Published on March 27, 2003; doi:10.1074/jbc.M300224200 [Abstract] [Full Text] [PDF]

Ian J. Clifton, Linh X. Doan, Mark C. Sleeman, Maya Topf, Hikokazu Suzuki, Rupert C. Wilmouth, and Christopher J. Schofield: Crystal Structure of Carbapenem Synthase (CarC)
J. Biol. Chem. 2003 278: 20843-20850. First Published on February 28, 2003; doi:10.1074/jbc.M213054200 [Abstract] [Full Text] [PDF]

Mack R. Kuo, Hector R. Morbidoni, David Alland, Scott F. Sneddon, Brian B. Gourlie, Mark M. Staveski, Marina Leonard, Jill S. Gregory, Andrew D. Janjigian, Christopher Yee, James M. Musser, Barry Kreiswirth, Hiroyuki Iwamoto, Remo Perozzo, William R. Jacobs, Jr., James C. Sacchettini, and David A. Fidock: Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase: COMPOUND ACTIVITY AND STRUCTURAL DATA
J. Biol. Chem. 2003 278: 20851-20859. First Published on February 26, 2003; doi:10.1074/jbc.M211968200 [Abstract] [Full Text] [PDF]

Shigeyuki Tsutsui, Satoshi Tasumi, Hiroaki Suetake, and Yuzuru Suzuki: Lectins Homologous to Those of Monocotyledonous Plants in the Skin Mucus and Intestine of Pufferfish, Fugu rubripes
J. Biol. Chem. 2003 278: 20882-20889. First Published on March 24, 2003; doi:10.1074/jbc.M301038200 [Abstract] [Full Text] [PDF]

Sergio G. Peisajovich, Stephen A. Gallo, Robert Blumenthal, and Yechiel Shai: C-terminal Octylation Rescues an Inactive T20 Mutant: IMPLICATIONS FOR THE MECHANISM OF HIV/SIMIAN IMMUNODEFICIENCY VIRUS-INDUCED MEMBRANE FUSION
J. Biol. Chem. 2003 278: 21012-21017. First Published on March 19, 2003; doi:10.1074/jbc.M212773200 [Abstract] [Full Text] [PDF]

Joshua A. Maurer and Dennis A. Dougherty: Generation and Evaluation of a Large Mutational Library from the Escherichia coli Mechanosensitive Channel of Large Conductance, MscL: IMPLICATIONS FOR CHANNEL GATING AND EVOLUTIONARY DESIGN
J. Biol. Chem. 2003 278: 21076-21082. First Published on April 1, 2003; doi:10.1074/jbc.M302892200 [Abstract] [Full Text] [PDF] Supplemental Data

Marina Fasolini, Xiaoqiu Wu, Maria Flocco, Jean-Yves Trosset, Udo Oppermann, and Stefan Knapp: Hot Spots in Tcf4 for the Interaction with ${beta}$ -Catenin
J. Biol. Chem. 2003 278: 21092-21098. First Published on March 25, 2003; doi:10.1074/jbc.M301781200 [Abstract] [Full Text] [PDF]

Alexei Yu. Denisov, Murthy S. R. Madiraju, Gang Chen, Abdelkrim Khadir, Pierre Beauparlant, Giorgio Attardo, Gordon C. Shore, and Kalle Gehring: Solution Structure of Human BCL-w: MODULATION OF LIGAND BINDING BY THE C-TERMINAL HELIX
J. Biol. Chem. 2003 278: 21124-21128. First Published on March 21, 2003; doi:10.1074/jbc.M301798200 [Abstract] [Full Text] [PDF]

Daping Fan, Yu Zheng, Daiwen Yang, and Jianjun Wang: NMR Solution Structure and Dynamics of an Exchangeable Apolipoprotein, Locusta migratoria Apolipophorin III
J. Biol. Chem. 2003 278: 21212-21220. First Published on March 4, 2003; doi:10.1074/jbc.M208486200 [Abstract] [Full Text] [PDF]

Ewa M. Ciszak, Lioubov G. Korotchkina, Paulina M. Dominiak, Sukhdeep Sidhu, and Mulchand S. Patel: Structural Basis for Flip-Flop Action of Thiamin Pyrophosphate-dependent Enzymes Revealed by Human Pyruvate Dehydrogenase
J. Biol. Chem. 2003 278: 21240-21246. First Published on March 21, 2003; doi:10.1074/jbc.M300339200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Tianyun Wu, Victoria Yankovskaya, and William S. McIntire: Cloning, Sequencing, and Heterologous Expression of the Murine Peroxisomal Flavoprotein, N¹-Acetylated Polyamine Oxidase
J. Biol. Chem. 2003 278: 20514-20525. First Published on March 26, 2003; doi:10.1074/jbc.M302149200 [Abstract] [Full Text] [PDF]

Csaba Bagyinka, Judit Ösz, and Sándor Száraz: Autocatalytic Oscillations in the Early Phase of the Photoreduced Methyl Viologen-initiated Fast Kinetic Reaction of Hydrogenase
J. Biol. Chem. 2003 278: 20624-20627. First Published on March 27, 2003; doi:10.1074/jbc.M300623200 [Abstract] [Full Text] [PDF]

Uwe Heinz, Rogert Bauer, Sandra Wommer, Wolfram Meyer-Klaucke, Cyril Papamichaels, John Bateson, and Hans-Werner Adolph: Coordination Geometries of Metal Ions in D- or L-Captopril-inhibited Metallo- ${beta}$ -lactamases
J. Biol. Chem. 2003 278: 20659-20666. First Published on March 31, 2003; doi:10.1074/jbc.M212581200 [Abstract] [Full Text] [PDF]

Olof Björnberg, Jan Neuhard, and Per Olof Nyman: A Bifunctional dCTP Deaminase-dUTP Nucleotidohydrolase from the Hyperthermophilic Archaeon Methanocaldococcus jannaschii
J. Biol. Chem. 2003 278: 20667-20672. First Published on March 31, 2003; doi:10.1074/jbc.M213010200 [Abstract] [Full Text] [PDF]

Stéphane Priet, Jean-Marc Navarro, Gilles Quérat, and Joséphine Sire: Reversion of the Lethal Phenotype of an HIV-1 Integrase Mutant Virus by Overexpression of the Same Integrase Mutant Protein
J. Biol. Chem. 2003 278: 20724-20730. First Published on March 31, 2003; doi:10.1074/jbc.M301768200 [Abstract] [Full Text] [PDF]

Silke Leimkühler, Rachael Hodson, Graham N. George, and K. V. Rajagopalan: Recombinant Rhodobacter capsulatus Xanthine Dehydrogenase, a Useful Model System for the Characterization of Protein Variants Leading to Xanthinuria I in Humans
J. Biol. Chem. 2003 278: 20802-20811. First Published on April 1, 2003; doi:10.1074/jbc.M303091200 [Abstract] [Full Text] [PDF]

Nicole M. Koropatkin, Hung-wen Liu, and Hazel M. Holden: High Resolution X-ray Structure of Tyvelose Epimerase from Salmonella typhi
J. Biol. Chem. 2003 278: 20874-20881. First Published on March 17, 2003; doi:10.1074/jbc.M301948200 [Abstract] [Full Text] [PDF]

Bryan D. Smith, Matthew B. Soellner, and Ronald T. Raines: Potent Inhibition of Ribonuclease A by Oligo(vinylsulfonic Acid)
J. Biol. Chem. 2003 278: 20934-20938. First Published on March 20, 2003; doi:10.1074/jbc.M301852200 [Abstract] [Full Text] [PDF]

Daniel A. Kopp, Eric A. Berg, Catherine E. Costello, and Stephen J. Lippard: Structural Features of Covalently Cross-linked Hydroxylase and Reductase Proteins of Soluble Methane Monooxygenase as Revealed by Mass Spectrometric Analysis
J. Biol. Chem. 2003 278: 20939-20945. First Published on March 26, 2003; doi:10.1074/jbc.M301581200 [Abstract] [Full Text] [PDF] Supplemental Data

Jennifer Stine Elam, Kevin Malek, Jorge A. Rodriguez, Peter A. Doucette, Alexander B. Taylor, Lawrence J. Hayward, Diane E. Cabelli, Joan Selverstone Valentine, and P. John Hart: An Alternative Mechanism of Bicarbonate-mediated Peroxidation by Copper-Zinc Superoxide Dismutase: RATES ENHANCED VIA PROPOSED ENZYME-ASSOCIATED PEROXYCARBONATE INTERMEDIATE
J. Biol. Chem. 2003 278: 21032-21039. First Published on March 20, 2003; doi:10.1074/jbc.M300484200 [Abstract] [Full Text] [PDF]

Ernesto J. Fuentes, Antoine E. Karnoub, Michelle A. Booden, Channing J. Der, and Sharon L. Campbell: Critical Role of the Pleckstrin Homology Domain in Dbs Signaling and Growth Regulation
J. Biol. Chem. 2003 278: 21188-21196. First Published on March 13, 2003; doi:10.1074/jbc.M211792200 [Abstract] [Full Text] [PDF]

Tadashi Ogishima, Jun-ya Kinoshita, Fumiko Mitani, Makoto Suematsu, and Akio Ito: Identification of Outer Mitochondrial Membrane Cytochrome b₅ as a Modulator for Androgen Synthesis in Leydig Cells
J. Biol. Chem. 2003 278: 21204-21211. First Published on March 31, 2003; doi:10.1074/jbc.M301698200 [Abstract] [Full Text] [PDF]

Xiao-Ping Shi, Katherine Tugusheva, James E. Bruce, Adam Lucka, Guo-Xin Wu, Elizabeth Chen-Dodson, Eric Price, Yueming Li, Min Xu, Qian Huang, Mohinder K. Sardana, and Daria J. Hazuda: ${beta}$ -Secretase Cleavage at Amino Acid Residue 34 in the Amyloid ${beta}$ Peptide Is Dependent upon ${gamma}$ -Secretase Activity
J. Biol. Chem. 2003 278: 21286-21294. First Published on March 27, 2003; doi:10.1074/jbc.M209859200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Jeffrey A. Gralnick and Diana M. Downs: The YggX Protein of Salmonella enterica Is Involved in Fe(II) Trafficking and Minimizes the DNA Damage Caused by Hydroxyl Radicals: RESIDUE CYS-7 IS ESSENTIAL FOR YggX FUNCTION
J. Biol. Chem. 2003 278: 20708-20715. First Published on March 31, 2003; doi:10.1074/jbc.M301577200 [Abstract] [Full Text] [PDF]

Eoin P. Quinlivan, Sanja Roje, Gilles Basset, Yair Shachar-Hill, Jesse F. Gregory, III, and Andrew D. Hanson: The Folate Precursor p-Aminobenzoate Is Reversibly Converted to Its Glucose Ester in the Plant Cytosol
J. Biol. Chem. 2003 278: 20731-20737. First Published on March 31, 2003; doi:10.1074/jbc.M302894200 [Abstract] [Full Text] [PDF]

Markéta Zácková, Eva Skobisová, Eva Urbánková, and Petr Jezek: Activating ${omega}$ -6 Polyunsaturated Fatty Acids and Inhibitory Purine Nucleotides Are High Affinity Ligands for Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3
J. Biol. Chem. 2003 278: 20761-20769. First Published on April 1, 2003; doi:10.1074/jbc.M212850200 [Abstract] [Full Text] [PDF]

Takeshi Murata, Ignacio Arechaga, Ian M. Fearnley, Yoshimi Kakinuma, Ichiro Yamato, and John E. Walker: The Membrane Domain of the Na⁺-motive V-ATPase from Enterococcus hirae Contains a Heptameric Rotor
J. Biol. Chem. 2003 278: 21162-21167. First Published on March 21, 2003; doi:10.1074/jbc.M301620200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Marcelo Guerin and Armando J. Parodi: The UDP-glucose:Glycoprotein Glucosyltransferase Is Organized in at Least Two Tightly Bound Domains from Yeast to Mammals
J. Biol. Chem. 2003 278: 20540-20546. First Published on March 20, 2003; doi:10.1074/jbc.M300891200 [Abstract] [Full Text] [PDF]

Andrew P. Spicer, Adriane Joo, and Rodney A. Bowling, Jr.: A Hyaluronan Binding Link Protein Gene Family Whose Members Are Physically Linked Adjacent to Chrondroitin Sulfate Proteoglycan Core Protein Genes: THE MISSING LINKS
J. Biol. Chem. 2003 278: 21083-21091. First Published on March 27, 2003; doi:10.1074/jbc.M213100200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Karina Rodriguez Capote, Francis X. McCormack, and Fred Possmayer: Pulmonary Surfactant Protein-A (SP-A) Restores the Surface Properties of Surfactant after Oxidation by a Mechanism That Requires the Cys⁶ Interchain Disulfide Bond and the Phospholipid Binding Domain
J. Biol. Chem. 2003 278: 20461-20474. First Published on February 24, 2003; doi:10.1074/jbc.M212697200 [Abstract] [Full Text] [PDF]

Laurent Kremer, Lynn G. Dover, Hector R. Morbidoni, Catherine Vilchèze, William N. Maughan, Alain Baulard, Shiao-Chun Tu, Nadine Honoré, Vojo Deretic, James C. Sacchettini, Camille Locht, William, R. Jacobs, Jr., and Gurdyal S. Besra: Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria
J. Biol. Chem. 2003 278: 20547-20554. First Published on March 24, 2003; doi:10.1074/jbc.M302435200 [Abstract] [Full Text] [PDF]

Avula Sreenivas and George M. Carman: Phosphorylation of the Yeast Phospholipid Synthesis Regulatory Protein Opi1p by Protein Kinase A
J. Biol. Chem. 2003 278: 20673-20680. First Published on March 31, 2003; doi:10.1074/jbc.M300132200 [Abstract] [Full Text] [PDF]

Tae-Sik Park, Daniel J. O'Brien, and George M. Carman: Phosphorylation of CTP Synthetase on Ser³⁶, Ser³³⁰, Ser³⁵⁴, and Ser⁴⁵⁴ Regulates the Levels of CTP and Phosphatidylcholine Synthesis in Saccharomyces cerevisiae
J. Biol. Chem. 2003 278: 20785-20794. First Published on April 1, 2003; doi:10.1074/jbc.M301394200 [Abstract] [Full Text] [PDF]

Vishwajeet Puri, John R. Jefferson, Raman Deep Singh, Christine L. Wheatley, David L. Marks, and Richard E. Pagano: Sphingolipid Storage Induces Accumulation of Intracellular Cholesterol by Stimulating SREBP-1 Cleavage
J. Biol. Chem. 2003 278: 20961-20970. First Published on March 25, 2003; doi:10.1074/jbc.M300304200 [Abstract] [Full Text] [PDF]

Yoshichika Kawai, Akiko Saito, Noriyuki Shibata, Makio Kobayashi, Satoshi Yamada, Toshihiko Osawa, and Koji Uchida: Covalent Binding of Oxidized Cholesteryl Esters to Protein: IMPLICATIONS FOR OXIDATIVE MODIFICATION OF LOW DENSITY LIPOPROTEIN AND ATHEROSCLEROSIS
J. Biol. Chem. 2003 278: 21040-21049. First Published on March 27, 2003; doi:10.1074/jbc.M212426200 [Abstract] [Full Text] [PDF] Supplemental Data

Membrane Transport Structure Function and Biogenesis:

Jodi L. Kreiling, James C. Byrd, Robert J. Deisz, Ikuko F. Mizukami, Robert F. Todd, III, and Richard G. MacDonald: Binding of Urokinase-type Plasminogen Activator Receptor (uPAR) to the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor: CONTRASTING INTERACTIONS OF FULL-LENGTH AND SOLUBLE FORMS OF uPAR
J. Biol. Chem. 2003 278: 20628-20637. First Published on March 27, 2003; doi:10.1074/jbc.M302249200 [Abstract] [Full Text] [PDF]

Tavan Janvilisri, Henrietta Venter, Sanjay Shahi, Galya Reuter, Lekshmy Balakrishnan, and Hendrik W. van Veen: Sterol Transport by the Human Breast Cancer Resistance Protein (ABCG2) Expressed in Lactococcus lactis
J. Biol. Chem. 2003 278: 20645-20651. First Published on March 28, 2003; doi:10.1074/jbc.M301358200 [Abstract] [Full Text] [PDF]

Karsten R. O. Hazlett, Frank Rusnak, David G. Kehres, Scott W. Bearden, Carson J. La Vake, Morgan E. La Vake, Michael E. Maguire, Robert D. Perry, and Justin D. Radolf: The Treponema pallidum tro Operon Encodes a Multiple Metal Transporter, a Zinc-dependent Transcriptional Repressor, and a Semi-autonomously Expressed Phosphoglycerate Mutase
J. Biol. Chem. 2003 278: 20687-20694. First Published on March 31, 2003; doi:10.1074/jbc.M300781200 [Abstract] [Full Text] [PDF] Supplemental Data

Pijun Wang, Richard B. Kim, J. Roy Chowdhury, and Allan W. Wolkoff: The Human Organic Anion Transport Protein SLC21A6 Is Not Sufficient for Bilirubin Transport
J. Biol. Chem. 2003 278: 20695-20699. First Published on March 31, 2003; doi:10.1074/jbc.M301100200 [Abstract] [Full Text] [PDF]

Wooin Ahn, Min Goo Lee, Kyung Hwan Kim, and Shmuel Muallem: Multiple Effects of SERCA2b Mutations Associated with Darier's Disease
J. Biol. Chem. 2003 278: 20795-20801. First Published on April 1, 2003; doi:10.1074/jbc.M301638200 [Abstract] [Full Text] [PDF]

Eleri Hughes and David A. Middleton: Solid-state NMR Reveals Structural Changes in Phospholamban Accompanying the Functional Regulation of Ca²⁺-ATPase
J. Biol. Chem. 2003 278: 20835-20842. First Published on January 29, 2003; doi:10.1074/jbc.M212208200 [Abstract] [Full Text] [PDF]

Ning Lee, Jian Chen, Lucy Sun, Shujian Wu, Kevin R. Gray, Adam Rich, Minxue Huang, Jun-Hsiang Lin, John N. Feder, Evan B. Janovitz, Paul C. Levesque, and Michael A. Blanar: Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3)
J. Biol. Chem. 2003 278: 20890-20897. First Published on April 2, 2003; doi:10.1074/jbc.M211232200 [Abstract] [Full Text] [PDF]

Jiusheng Yan and William A. Cramer: Functional Insensitivity of the Cytochrome b₆ f Complex to Structure Changes in the Hinge Region of the Rieske Iron-Sulfur Protein
J. Biol. Chem. 2003 278: 20925-20933. First Published on April 2, 2003; doi:10.1074/jbc.M212616200 [Abstract] [Full Text] [PDF]

Joshua H. Lipschutz, Vishwanath R. Lingappa, and Keith E. Mostov: The Exocyst Affects Protein Synthesis by Acting on the Translocation Machinery of the Endoplasmic Reticulum
J. Biol. Chem. 2003 278: 20954-20960. First Published on March 28, 2003; doi:10.1074/jbc.M213210200 [Abstract] [Full Text] [PDF]

Niv Papo, Michal Shahar, Lea Eisenbach, and Yechiel Shai: A Novel Lytic Peptide Composed of DL-Amino Acids Selectively Kills Cancer Cells in Culture and in Mice
J. Biol. Chem. 2003 278: 21018-21023. First Published on March 19, 2003; doi:10.1074/jbc.M211204200 [Abstract] [Full Text] [PDF]

Ionita Ghiran, Lloyd B. Klickstein, and Anne Nicholson-Weller: Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule
J. Biol. Chem. 2003 278: 21024-21031. First Published on March 19, 2003; doi:10.1074/jbc.M302306200 [Abstract] [Full Text] [PDF]

Andrew D. Paterson, Robert G. Parton, Charles Ferguson, Jennifer L. Stow, and Alpha S. Yap: Characterization of E-cadherin Endocytosis in Isolated MCF-7 and Chinese Hamster Ovary Cells: THE INITIAL FATE OF UNBOUND E-CADHERIN
J. Biol. Chem. 2003 278: 21050-21057. First Published on March 25, 2003; doi:10.1074/jbc.M300082200 [Abstract] [Full Text] [PDF]

J. David Spafford, Lina Chen, Zhong-Ping Feng, August B. Smit, and Gerald W. Zamponi: Expression and Modulation of an Invertebrate Presynaptic Calcium Channel ${alpha}$ ₁ Subunit Homolog
J. Biol. Chem. 2003 278: 21178-21187. First Published on April 2, 2003; doi:10.1074/jbc.M302212200 [Abstract] [Full Text] [PDF]

Mechanisms Of Signal Transduction:

Prasad V. Jallepalli, Christoph Lengauer, Bert Vogelstein, and Fred Bunz: The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells
J. Biol. Chem. 2003 278: 20475-20479. First Published on March 24, 2003; doi:10.1074/jbc.M213159200 [Abstract] [Full Text] [PDF]

Jinwoo Ahn, Marshall Urist, and Carol Prives: Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response
J. Biol. Chem. 2003 278: 20480-20489. First Published on March 24, 2003; doi:10.1074/jbc.M213185200 [Abstract] [Full Text] [PDF]

Marita Goodwin, Eva M. Kovacs, Molly A. Thoreson, Albert B. Reynolds, and Alpha S. Yap: Minimal Mutation of the Cytoplasmic Tail Inhibits the Ability of E-cadherin to Activate Rac but Not Phosphatidylinositol 3-Kinase: DIRECT EVIDENCE OF A ROLE FOR CADHERIN-ACTIVATED Rac SIGNALING IN ADHESION AND CONTACT FORMATION
J. Biol. Chem. 2003 278: 20533-20539. First Published on April 2, 2003; doi:10.1074/jbc.M213171200 [Abstract] [Full Text] [PDF]

Thierry Pedron, Robert Girard, and Richard Chaby: TLR4-dependent Lipopolysaccharide-induced Shedding of Tumor Necrosis Factor Receptors in Mouse Bone Marrow Granulocytes
J. Biol. Chem. 2003 278: 20555-20564. First Published on March 27, 2003; doi:10.1074/jbc.M203551200 [Abstract] [Full Text] [PDF]

Marylis Hortala, Geraldine Ferjoux, Agnes Estival, Claudine Bertrand, Stefan Schulz, Lucien Pradayrol, Christiane Susini, and François Clemente: Inhibitory Role of the Somatostatin Receptor SST2 on the Intracrine-regulated Cell Proliferation Induced by the 210-Amino Acid Fibroblast Growth Factor-2 Isoform: IMPLICATION OF JAK2
J. Biol. Chem. 2003 278: 20574-20581. First Published on March 27, 2003; doi:10.1074/jbc.M210767200 [Abstract] [Full Text] [PDF]

Nand K. Sah, Anupama Munshi, John F. Kurland, Timothy J. McDonnell, Bing Su, and Raymond E. Meyn: Translation Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) by Activating c-Jun N-terminal Kinase
J. Biol. Chem. 2003 278: 20593-20602. First Published on March 27, 2003; doi:10.1074/jbc.M211010200 [Abstract] [Full Text] [PDF]

Jeanne Fringer and Frederick Grinnell: Fibroblast Quiescence in Floating Collagen Matrices: DECREASE IN SERUM ACTIVATION OF MEK AND RAF BUT NOT RAS
J. Biol. Chem. 2003 278: 20612-20617. First Published on March 27, 2003; doi:10.1074/jbc.M212365200 [Abstract] [Full Text] [PDF]

Sharon L. Chinault and Kendall J. Blumer: The C-terminal Tail Preceding the CAAX Box of a Yeast G Protein ${gamma}$ Subunit Is Dispensable for Receptor-mediated G Protein Activation in Vivo
J. Biol. Chem. 2003 278: 20638-20644. First Published on March 28, 2003; doi:10.1074/jbc.M212701200 [Abstract] [Full Text] [PDF]

Jena J. Steinle, George W. Booz, Cynthia J. Meininger, Jonathan N. E. Day, and Harris J. Granger: ${beta}$ ₃-Adrenergic Receptors Regulate Retinal Endothelial Cell Migration and Proliferation
J. Biol. Chem. 2003 278: 20681-20686. First Published on March 31, 2003; doi:10.1074/jbc.M300368200 [Abstract] [Full Text] [PDF]

Huiyan Zeng, Dezheng Zhao, Suping Yang, Kaustubh Datta, and Debabrata Mukhopadhyay: Heterotrimeric G ${alpha}$ _q/G ${alpha}$ ₁₁ Proteins Function Upstream of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (KDR) Phosphorylation in Vascular Permeability Factor/VEGF Signaling
J. Biol. Chem. 2003 278: 20738-20745. First Published on April 1, 2003; doi:10.1074/jbc.M209712200 [Abstract] [Full Text] [PDF]

Ryan M. Young, David Holowka, and Barbara Baird: A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from Dephosphorylation
J. Biol. Chem. 2003 278: 20746-20752. First Published on April 1, 2003; doi:10.1074/jbc.M211402200 [Abstract] [Full Text] [PDF]

Kenneth W. Young, Mark S. Nash, R. A. John Challiss, and Stefan R. Nahorski: Role of Ca²⁺ Feedback on Single Cell Inositol 1,4,5-Trisphosphate Oscillations Mediated by G-protein-coupled Receptors
J. Biol. Chem. 2003 278: 20753-20760. First Published on April 1, 2003; doi:10.1074/jbc.M211555200 [Abstract] [Full Text] [PDF]

Yoshiharu Higuchi, Kinya Otsu, Kazuhiko Nishida, Shinichi Hirotani, Hiroyuki Nakayama, Osamu Yamaguchi, Shungo Hikoso, Kazunori Kashiwase, Toshihiro Takeda, Tetsuya Watanabe, Toshiaki Mano, Yasushi Matsumura, Hikaru Ueno, and Masatsugu Hori: The Small GTP-binding Protein Rac1 Induces Cardiac Myocyte Hypertrophy through the Activation of Apoptosis Signal-regulating Kinase 1 and Nuclear Factor- ${kappa}$ B
J. Biol. Chem. 2003 278: 20770-20777. First Published on April 2, 2003; doi:10.1074/jbc.M213203200 [Abstract] [Full Text] [PDF]

Franca Esposito, Giuseppa Chirico, Nicola Montesano Gesualdi, Inmaculada Posadas, Rosario Ammendola, Tommaso Russo, Giuseppe Cirino, and Filiberto Cimino: Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity
J. Biol. Chem. 2003 278: 20828-20834. First Published on April 7, 2003; doi:10.1074/jbc.M211841200 [Abstract] [Full Text] [PDF]

Michael C. Ashby, Cristina Camello-Almaraz, Oleg V. Gerasimenko, Ole H. Petersen, and Alexei V. Tepikin: Long Distance Communication between Muscarinic Receptors and Ca²⁺ Release Channels Revealed by Carbachol Uncaging in Cell-attached Patch Pipette
J. Biol. Chem. 2003 278: 20860-20864. First Published on March 25, 2003; doi:10.1074/jbc.M302599200 [Abstract] [Full Text] [PDF]

Ramachandra K. Reddy, Changhui Mao, Peter Baumeister, Richard C. Austin, Randal J. Kaufman, and Amy S. Lee: Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors: ROLE OF ATP BINDING SITE IN SUPPRESSION OF CASPASE-7 ACTIVATION
J. Biol. Chem. 2003 278: 20915-20924. First Published on March 28, 2003; doi:10.1074/jbc.M212328200 [Abstract] [Full Text] [PDF]

Sophie Pattingre, Luc De Vries, Chantal Bauvy, Isabelle Chantret, Françoise Cluzeaud, Eric Ogier-Denis, Alain Vandewalle, and Patrice Codogno: The G-protein Regulator AGS3 Controls an Early Event during Macroautophagy in Human Intestinal HT-29 Cells
J. Biol. Chem. 2003 278: 20995-21002. First Published on March 17, 2003; doi:10.1074/jbc.M300917200 [Abstract] [Full Text] [PDF]

Hideaki Sowa, Hiroshi Kaji, Lucie Canaff, Geoffrey N. Hendy, Tatsuo Tsukamoto, Toru Yamaguchi, Kohei Miyazono, Toshitsugu Sugimoto, and Kazuo Chihara: Inactivation of Menin, the Product of the Multiple Endocrine Neoplasia Type 1 Gene, Inhibits the Commitment of Multipotential Mesenchymal Stem Cells into the Osteoblast Lineage
J. Biol. Chem. 2003 278: 21058-21069. First Published on March 20, 2003; doi:10.1074/jbc.M302044200 [Abstract] [Full Text] [PDF]

Feng Yin, Ping Li, Ming Zheng, Li Chen, Qi Xu, Kai Chen, Yong-yu Wang, You-yi Zhang, and Chide Han: Interleukin-6 Family of Cytokines Mediates Isoproterenol-induced Delayed STAT3 Activation in Mouse Heart
J. Biol. Chem. 2003 278: 21070-21075. First Published on March 28, 2003; doi:10.1074/jbc.M211028200 [Abstract] [Full Text] [PDF]

Jason T. Snyder, Alex U. Singer, Michele R. Wing, T. Kendall Harden, and John Sondek: The Pleckstrin Homology Domain of Phospholipase C- ${beta}$ ₂ as an Effector Site for Rac
J. Biol. Chem. 2003 278: 21099-21104. First Published on March 25, 2003; doi:10.1074/jbc.M301418200 [Abstract] [Full Text] [PDF]

Craig A. Harrison, Peter C. Gray, Steven C. Koerber, Wolfgang Fischer, and Wylie Vale: Identification of a Functional Binding Site for Activin on the Type I Receptor ALK4
J. Biol. Chem. 2003 278: 21129-21135. First Published on March 28, 2003; doi:10.1074/jbc.M302015200 [Abstract] [Full Text] [PDF]

Hien T. Le, Charlene M. Schaldach, Gary L. Firestone, and Leonard F. Bjeldanes: Plant-derived 3,3'-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells
J. Biol. Chem. 2003 278: 21136-21145. First Published on March 27, 2003; doi:10.1074/jbc.M300588200 [Abstract] [Full Text] [PDF]

Bernhard Schmierer, Michael K. Schuster, Alena Shkumatava, and Karl Kuchler: Activin A Signaling Induces Smad2, but Not Smad3, Requiring Protein Kinase A Activity in Granulosa Cells from the Avian Ovary
J. Biol. Chem. 2003 278: 21197-21203. First Published on March 28, 2003; doi:10.1074/jbc.M212425200 [Abstract] [Full Text] [PDF]

Yunsun Nam, Andrew P. Weng, Jon C. Aster, and Stephen C. Blacklow: Structural Requirements for Assembly of the CSL·Intracellular Notch1·Mastermind-like 1 Transcriptional Activation Complex
J. Biol. Chem. 2003 278: 21232-21239. First Published on March 18, 2003; doi:10.1074/jbc.M301567200 [Abstract] [Full Text] [PDF]

Lisa A. Madge, Jie-Hui Li, Jaehyuk Choi, and Jordan S. Pober: Inhibition of Phosphatidylinositol 3-Kinase Sensitizes Vascular Endothelial Cells to Cytokine-initiated Cathepsin-dependent Apoptosis
J. Biol. Chem. 2003 278: 21295-21306. First Published on March 27, 2003; doi:10.1074/jbc.M212837200 [Abstract] [Full Text] [PDF]

D. Scott Witherow, Steven C. Tovey, Qiang Wang, Gary B. Willars, and Vladlen Z. Slepak: G ${beta}$ 5·RGS7 Inhibits G ${alpha}$ _q-mediated Signaling via a Direct Protein-Protein Interaction
J. Biol. Chem. 2003 278: 21307-21313. First Published on April 1, 2003; doi:10.1074/jbc.M212884200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Keith Tan, Anthony L. Shaw, Bente Madsen, Kirsten Jensen, Joyce Taylor-Papadimitriou, and Paul S. Freemont: Human PLU-1 Has Transcriptional Repression Properties and Interacts with the Developmental Transcription Factors BF-1 and PAX9
J. Biol. Chem. 2003 278: 20507-20513. First Published on March 25, 2003; doi:10.1074/jbc.M301994200 [Abstract] [Full Text] [PDF]

Ziyin Li and Ching C. Wang: A PHO80-like Cyclin and a B-type Cyclin Control the Cell Cycle of the Procyclic Form of Trypanosoma brucei
J. Biol. Chem. 2003 278: 20652-20658. First Published on March 28, 2003; doi:10.1074/jbc.M301635200 [Abstract] [Full Text] [PDF]

Rakesh Verma, Bryan Wharram, Iulia Kovari, Robin Kunkel, Deepak Nihalani, Kishore K. Wary, Roger C. Wiggins, Paul Killen, and Lawrence B. Holzman: Fyn Binds to and Phosphorylates the Kidney Slit Diaphragm Component Nephrin
J. Biol. Chem. 2003 278: 20716-20723. First Published on March 31, 2003; doi:10.1074/jbc.M301689200 [Abstract] [Full Text] [PDF]

Daniel Strausak, Michelle K. Howie, Stephen D. Firth, Andrea Schlicksupp, Rüdiger Pipkorn, Gerd Multhaup, and Julian F. B. Mercer: Kinetic Analysis of the Interaction of the Copper Chaperone Atox1 with the Metal Binding Sites of the Menkes Protein
J. Biol. Chem. 2003 278: 20821-20827. First Published on April 4, 2003; doi:10.1074/jbc.M212437200 [Abstract] [Full Text] [PDF]

Margaret S. Ho, Karen Carniol, and Richard Losick: Evidence in Support of a Docking Model for the Release of the Transcription Factor ${sigma}$ ^F from the Antisigma Factor SpoIIAB in Bacillus subtilis
J. Biol. Chem. 2003 278: 20898-20905. First Published on April 3, 2003; doi:10.1074/jbc.M302305200 [Abstract] [Full Text] [PDF]

Hongbin Zhang, Jane Nøhr, Charlotte H. Jensen, Rasmus K. Petersen, Elin Bachmann, Børge Teisner, Leif K. Larsen, Susanne Mandrup, and Karsten Kristiansen: Insulin-like Growth Factor-1/Insulin Bypasses Pref-1/FA1-mediated Inhibition of Adipocyte Differentiation
J. Biol. Chem. 2003 278: 20906-20914. First Published on March 21, 2003; doi:10.1074/jbc.M300022200 [Abstract] [Full Text] [PDF]

Patricia A. Ritch, Steven L. Carroll, and Harald Sontheimer: Neuregulin-1 Enhances Motility and Migration of Human Astrocytic Glioma Cells
J. Biol. Chem. 2003 278: 20971-20978. First Published on February 24, 2003; doi:10.1074/jbc.M213074200 [Abstract] [Full Text] [PDF]

Melanie B. Blevins, Ashley M. Smith, Erica M. Phillips, and Maureen A. Powers: Complex Formation among the RNA Export Proteins Nup98, Rae1/Gle2, and TAP
J. Biol. Chem. 2003 278: 20979-20988. First Published on March 13, 2003; doi:10.1074/jbc.M302061200 [Abstract] [Full Text] [PDF]

Jacqueline Banyard, Lere Bao, and Bruce R. Zetter: Type XXIII Collagen, a New Transmembrane Collagen Identified in Metastatic Tumor Cells
J. Biol. Chem. 2003 278: 20989-20994. First Published on March 18, 2003; doi:10.1074/jbc.M210616200 [Abstract] [Full Text] [PDF]

Sean P. Kessler, Preenie deS. Senanayake, Thomas S. Scheidemantel, Janette B. Gomos, Theresa M. Rowe, and Ganes C. Sen: Maintenance of Normal Blood Pressure and Renal Functions Are Independent Effects of Angiotensin-converting Enzyme
J. Biol. Chem. 2003 278: 21105-21112. First Published ; doi:10.1074/jbc.M3023472000 [Abstract] [Full Text] [PDF]

Hector Peinado, Miguel Quintanilla, and Amparo Cano: Transforming Growth Factor ${beta}$ -1 Induces Snail Transcription Factor in Epithelial Cell Lines: MECHANISMS FOR EPITHELIAL MESENCHYMAL TRANSITIONS
J. Biol. Chem. 2003 278: 21113-21123. First Published on March 28, 2003; doi:10.1074/jbc.M211304200 [Abstract] [Full Text] [PDF]

Véronique Pons, Françoise Hullin-Matsuda, Michel Nauze, Ronald Barbaras, Christine Pérès, Xavier Collet, Bertrand Perret, Hugues Chap, and Ama Gassama-Diagne: Enterophilin-1, a New Partner of Sorting Nexin 1, Decreases Cell Surface Epidermal Growth Factor Receptor
J. Biol. Chem. 2003 278: 21155-21161. First Published on March 25, 2003; doi:10.1074/jbc.M211008200 [Abstract] [Full Text] [PDF]

Keith Mikule, Somkiat Sunpaweravong, Jesse C. Gatlin, and Karl H. Pfenninger: Eicosanoid Activation of Protein Kinase C ${epsilon}$ : INVOLVEMENT IN GROWTH CONE REPELLENT SIGNALING
J. Biol. Chem. 2003 278: 21168-21177. First Published on March 28, 2003; doi:10.1074/jbc.M211828200 [Abstract] [Full Text] [PDF]

Olga Ostrovsky and Eyal Bengal: The Mitogen-activated Protein Kinase Cascade Promotes Myoblast Cell Survival by Stabilizing the Cyclin-dependent Kinase Inhibitor, p21^WAF1 Protein
J. Biol. Chem. 2003 278: 21221-21231. First Published on March 11, 2003; doi:10.1074/jbc.M211357200 [Abstract] [Full Text] [PDF]

Additions and Corrections:

Syed M. Noorwez, Vladimir Kuksa, Yoshikazu Imanishi, Li Zhu, Slawomir Filipek, Krzysztof Palczewski, and Shalesh Kaushal: Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa
J. Biol. Chem. 2003 278: 21314. [Full Text] [PDF]

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