About the Cover
The cover illustrates the structure of a naturally occurring circular peptide (SFTI-1) derived from sunflower seeds that is one of the most potent trypsin inhibitors known. Marx et al. have shown that a synthetic linear form of SFTI-1 has its ends sufficiently close together in one of its conformations (illustrated in the sky) that they may be efficiently stitched together by trypsin to form the circular peptide. In this case trypsin operates in the reverse direction to its normal role as a proteolytic enzyme. For details see the article by Marx et al., pages 21782-21789.
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Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
