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On the cover, the arh gene encodes an adaptor protein that is necessary for low density lipoprotein (LDL) endocytosis in humans. Immunohistochemistry of ARH-knockout mouse liver shows redistribution of endogenous LDL receptors from endosomal compartments to the sinusoidal surface of hepatocytes. For details see the article by Jones, et al., pages 29024-29030.