The cover shows the structural response of the BRCA1 C-terminal domain to the cancer-causing missense substitution, Met-1775 Arg-1775. Arg-1775 (red surface) is flipped out of the hydrophobic pocket where the methionine (green surface) normally packs. This movement and additional rearrangements contribute to protein instability and an increased susceptibility to disease. For details see the article by Williams and Glover, pages 2630-2635.