JBC -- Table of Contents (Nov 5 2004, 279, (45))

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Larissa Tskhovrebova and John Trinick: Properties of Titin Immunoglobulin and Fibronectin-3 Domains
J. Biol. Chem. 2004 279: 46351-46354. First Published on August 18, 2004; doi:10.1074/jbc.R400023200 [Full Text] [PDF]

Accelerated Publications:

Thomas Lykke-Møller Sørensen, Johannes D. Clausen, Anne-Marie Lund Jensen, Bente Vilsen, Jesper Vuust Møller, Jens Peter Andersen, and Poul Nissen: Localization of a K⁺-binding Site Involved in Dephosphorylation of the Sarcoplasmic Reticulum Ca²+-ATPase
J. Biol. Chem. 2004 279: 46355-46358. First Published on September 21, 2004; doi:10.1074/jbc.C400414200 [Abstract] [Full Text] [PDF]

Zhenkun Lou, Benjamin Ping-Chi Chen, Aroumougame Asaithamby, Katherine Minter-Dykhouse, David J. Chen, and Junjie Chen: MDC1 Regulates DNA-PK Autophosphorylation in Response to DNA Damage
J. Biol. Chem. 2004 279: 46359-46362. First Published on September 17, 2004; doi:10.1074/jbc.C400375200 [Abstract] [Full Text] [PDF] Supplemental Data

Rakez Kayed, Yuri Sokolov, Brian Edmonds, Theresa M. McIntire, Saskia C. Milton, James E. Hall, and Charles G. Glabe: Permeabilization of Lipid Bilayers Is a Common Conformation-dependent Activity of Soluble Amyloid Oligomers in Protein Misfolding Diseases
J. Biol. Chem. 2004 279: 46363-46366. First Published on September 21, 2004; doi:10.1074/jbc.C400260200 [Abstract] [Full Text] [PDF] Supplemental Data

DNA: Replication, Repair, and Recombination:

Daniel A. Di Giusto and Garry C. King: Construction, Stability, and Activity of Multivalent Circular Anticoagulant Aptamers
J. Biol. Chem. 2004 279: 46483-46489. First Published on August 18, 2004; doi:10.1074/jbc.M408037200 [Abstract] [Full Text] [PDF]

Satoshi Nakajima, Li Lan, Shin-ichiro Kanno, Masashi Takao, Kazuo Yamamoto, Andre P. M. Eker, and Akira Yasui: UV Light-induced DNA Damage and Tolerance for the Survival of Nucleotide Excision Repair-deficient Human Cells
J. Biol. Chem. 2004 279: 46674-46677. First Published on September 1, 2004; doi:10.1074/jbc.M406070200 [Abstract] [Full Text] [PDF]

Raymond C. Manuel, Kenichi Hitomi, Andrew S. Arvai, Paul G. House, Andrew J. Kurtz, M. L. Dodson, Amanda K. McCullough, John A. Tainer, and R. Stephen Lloyd: Reaction Intermediates in the Catalytic Mechanism of Escherichia coli MutY DNA Glycosylase
J. Biol. Chem. 2004 279: 46930-46939. First Published on August 23, 2004; doi:10.1074/jbc.M403944200 [Abstract] [Full Text] [PDF]

Aditi Das, Lavanya Rajagopalan, Venkatarajan S. Mathura, Samuel J. Rigby, Sankar Mitra, and Tapas K. Hazra: Identification of a Zinc Finger Domain in the Human NEIL2 (Nei-like-2) Protein
J. Biol. Chem. 2004 279: 47132-47138. First Published on August 31, 2004; doi:10.1074/jbc.M406224200 [Abstract] [Full Text] [PDF]

Jeffrey Zheng-Sheng Ye, Jill R. Donigian, Megan van Overbeek, Diego Loayza, Yan Luo, Andrew N. Krutchinsky, Brian T. Chait, and Titia de Lange: TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres
J. Biol. Chem. 2004 279: 47264-47271. First Published on August 16, 2004; doi:10.1074/jbc.M409047200 [Abstract] [Full Text] [PDF]

Izumi Sugimoto, Hiroshi Murakami, Yuko Tonami, Akihiko Moriyama, and Makoto Nakanishi: DNA Replication Checkpoint Control Mediated by the Spindle Checkpoint Protein Mad2p in Fission Yeast
J. Biol. Chem. 2004 279: 47372-47378. First Published on September 2, 2004; doi:10.1074/jbc.M403231200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

Hitoshi Nagato, Noritaka Matsuo, Hideaki Sumiyoshi, Keiko Sakata-Takatani, Masaru Nasu, and Hidekatsu Yoshioka: The Transcription Factor CCAAT-binding Factor CBF/NF-Y and Two Repressors Regulate the Core Promoter of the Human Pro- ${alpha}$ 3(V) Collagen Gene (COL5A3)
J. Biol. Chem. 2004 279: 46373-46383. First Published on August 16, 2004; doi:10.1074/jbc.M406069200 [Abstract] [Full Text] [PDF] Supplemental Data

Eric R. Hines, Olga I. Kolek, Marci D. Jones, Samantha H. Serey, Nafisseh B. Sirjani, Pawel R. Kiela, Peter W. Jurutka, Mark R. Haussler, James F. Collins, and Fayez K. Ghishan: 1,25-Dihydroxyvitamin D₃ Down-regulation of PHEX Gene Expression Is Mediated by Apparent Repression of a 110 kDa Transfactor That Binds to a Polyadenine Element in the Promoter
J. Biol. Chem. 2004 279: 46406-46414. First Published on August 25, 2004; doi:10.1074/jbc.M404278200 [Abstract] [Full Text] [PDF]

Chun Sung Kim, Cheol Kyu Hwang, Hack Sun Choi, Kyu Young Song, Ping-Yee Law, Li-Na Wei, and Horace H. Loh: Neuron-restrictive Silencer Factor (NRSF) Functions as a Repressor in Neuronal Cells to Regulate the µ Opioid Receptor Gene
J. Biol. Chem. 2004 279: 46464-46473. First Published on August 18, 2004; doi:10.1074/jbc.M403633200 [Abstract] [Full Text] [PDF]

Angela M. Avery, Sylvia A. Willetts, and Simon V. Avery: Genetic Dissection of the Phospholipid Hydroperoxidase Activity of Yeast Gpx3 Reveals Its Functional Importance
J. Biol. Chem. 2004 279: 46652-46658. First Published on August 27, 2004; doi:10.1074/jbc.M408340200 [Abstract] [Full Text] [PDF]

Zhiyong Mi, Hongtao Guo, Philip Y. Wai, Chengjiang Gao, Junping Wei, and Paul C. Kuo: Differential Osteopontin Expression in Phenotypically Distinct Subclones of Murine Breast Cancer Cells Mediates Metastatic Behavior
J. Biol. Chem. 2004 279: 46659-46667. First Published on August 30, 2004; doi:10.1074/jbc.M407952200 [Abstract] [Full Text] [PDF]

Unni M. Chandrasekharan, Lin Yang, Alicia Walters, Philip Howe, and Paul E. DiCorleto: Role of CL-100, a Dual Specificity Phosphatase, in Thrombin-induced Endothelial Cell Activation
J. Biol. Chem. 2004 279: 46678-46685. First Published on August 31, 2004; doi:10.1074/jbc.M406441200 [Abstract] [Full Text] [PDF]

Feng Wang, Ruixue Zhang, Timothy V. Beischlag, Christian Muchardt, Moshe Yaniv, and Oliver Hankinson: Roles of Brahma and Brahma/SWI2-Related Gene 1 in Hypoxic Induction of the Erythropoietin Gene
J. Biol. Chem. 2004 279: 46733-46741. First Published on September 3, 2004; doi:10.1074/jbc.M409002200 [Abstract] [Full Text] [PDF]

Sin-Hyeog Im, Axel Hueber, Silvia Monticelli, Kyu-Ho Kang, and Anjana Rao: Chromatin-level Regulation of the IL10 Gene in T Cells
J. Biol. Chem. 2004 279: 46818-46825. First Published on August 19, 2004; doi:10.1074/jbc.M401722200 [Abstract] [Full Text] [PDF]

Zhiyuan Yu and Bruce C. Kone: Hypermethylation of the Inducible Nitric-oxide Synthase Gene Promoter Inhibits Its Transcription
J. Biol. Chem. 2004 279: 46954-46961. First Published on August 11, 2004; doi:10.1074/jbc.M407192200 [Abstract] [Full Text] [PDF]

Chuan-ju Liu, Lisa Prazak, Marc Fajardo, Shuang Yu, Neetu Tyagi, and Paul E. Di Cesare: Leukemia/Lymphoma-related Factor, a POZ Domain-containing Transcriptional Repressor, Interacts with Histone Deacetylase-1 and Inhibits Cartilage Oligomeric Matrix Protein Gene Expression and Chondrogenesis
J. Biol. Chem. 2004 279: 47081-47091. First Published on August 26, 2004; doi:10.1074/jbc.M405288200 [Abstract] [Full Text] [PDF]

Xiangli Yang and Gerard Karsenty: ATF4, the Osteoblast Accumulation of Which Is Determined Post-translationally, Can Induce Osteoblast-specific Gene Expression in Non-osteoblastic Cells
J. Biol. Chem. 2004 279: 47109-47114. First Published on September 16, 2004; doi:10.1074/jbc.M410010200 [Abstract] [Full Text] [PDF]

James S. Friedman, Hemant Khanna, Prabodh K. Swain, Raphael DeNicola, Hong Cheng, Kenneth P. Mitton, Christian H. Weber, David Hicks, and Anand Swaroop: The Minimal Transactivation Domain of the Basic Motif-Leucine Zipper Transcription Factor NRL Interacts with TATA-binding Protein
J. Biol. Chem. 2004 279: 47233-47241. First Published on August 24, 2004; doi:10.1074/jbc.M408298200 [Abstract] [Full Text] [PDF]

Protein Synthesis, Post-Translation Modification, and Degradation:

Sara Tokarz, Catherine Berset, Janna La Rue, Kevin Friedman, Kei-Ichi Nakayama, Keiko Nakayama, Dong-Er Zhang, and Stefan Lanker: The ISG15 Isopeptidase UBP43 Is Regulated by Proteolysis via the SCF^Skp2 Ubiquitin Ligase
J. Biol. Chem. 2004 279: 46424-46430. First Published on September 1, 2004; doi:10.1074/jbc.M403189200 [Abstract] [Full Text] [PDF]

Hiroshi Hasegawa, Nobuo Sanjo, Fusheng Chen, Yong-Jun Gu, Cortney Shier, Agnes Petit, Toshitaka Kawarai, Taiichi Katayama, Stephen D. Schmidt, Paul M. Mathews, Gerold Schmitt-Ulms, Paul E. Fraser, and Peter St George-Hyslop: Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes
J. Biol. Chem. 2004 279: 46455-46463. First Published on August 17, 2004; doi:10.1074/jbc.M406289200 [Abstract] [Full Text] [PDF]

Jérôme Delplanque, Ghislain Delpierre, Fred R. Opperdoes, and Emile Van Schaftingen: Tissue Distribution and Evolution of Fructosamine 3-Kinase and Fructosamine 3-Kinase-related Protein
J. Biol. Chem. 2004 279: 46606-46613. First Published on August 25, 2004; doi:10.1074/jbc.M407678200 [Abstract] [Full Text] [PDF]

K. G. Suresh Kumar, John J. Krolewski, and Serge Y. Fuchs: Phosphorylation and Specific Ubiquitin Acceptor Sites Are Required for Ubiquitination and Degradation of the IFNAR1 Subunit of Type I Interferon Receptor
J. Biol. Chem. 2004 279: 46614-46620. First Published on August 26, 2004; doi:10.1074/jbc.M407082200 [Abstract] [Full Text] [PDF]

Tomo Saric, Claudia I. Graef, and Alfred L. Goldberg: Pathway for Degradation of Peptides Generated by Proteasomes: A KEY ROLE FOR THIMET OLIGOPEPTIDASE AND OTHER METALLOPEPTIDASES
J. Biol. Chem. 2004 279: 46723-46732. First Published on August 24, 2004; doi:10.1074/jbc.M406537200 [Abstract] [Full Text] [PDF] Supplemental Data

Wei Liang and Peter H. Fishman: Resistance of the Human ${beta}$ ₁-Adrenergic Receptor to Agonist-induced Ubiquitination: A MECHANISM FOR IMPAIRED RECEPTOR DEGRADATION
J. Biol. Chem. 2004 279: 46882-46889. First Published on August 25, 2004; doi:10.1074/jbc.M406501200 [Abstract] [Full Text] [PDF]

Hardy J. Rideout, Paula Dietrich, Qiaohong Wang, William T. Dauer, and Leonidas Stefanis: ${alpha}$ -Synuclein Is Required for the Fibrillar Nature of Ubiquitinated Inclusions Induced by Proteasomal Inhibition in Primary Neurons
J. Biol. Chem. 2004 279: 46915-46920. First Published on August 18, 2004; doi:10.1074/jbc.M405146200 [Abstract] [Full Text] [PDF]

Genomics, Proteomics, and Bioinformatics:

Anders M. Hinsby, Jesper V. Olsen, and Matthias Mann: Tyrosine Phosphoproteomics of Fibroblast Growth Factor Signaling: A ROLE FOR INSULIN RECEPTOR SUBSTRATE-4
J. Biol. Chem. 2004 279: 46438-46447. First Published on August 16, 2004; doi:10.1074/jbc.M404537200 [Abstract] [Full Text] [PDF]

Carrie A. Vyhlidal, Peter K. Rogan, and J. Steven Leeder: Development and Refinement of Pregnane X Receptor (PXR) DNA Binding Site Model Using Information Theory: INSIGHTS INTO PXR-MEDIATED GENE REGULATION
J. Biol. Chem. 2004 279: 46779-46786. First Published on August 16, 2004; doi:10.1074/jbc.M408395200 [Abstract] [Full Text] [PDF] Supplemental Data

Dawn L. Brasaemle, Georgia Dolios, Lawrence Shapiro, and Rong Wang: Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes
J. Biol. Chem. 2004 279: 46835-46842. First Published on August 27, 2004; doi:10.1074/jbc.M409340200 [Abstract] [Full Text] [PDF]

Protein Structure and Folding:

Travis Beddoe, Simon R. Bushell, Matthew A. Perugini, Trevor Lithgow, Terrence D. Mulhern, Stephen P. Bottomley, and Jamie Rossjohn: A Biophysical Analysis of the Tetratricopeptide Repeat-rich Mitochondrial Import Receptor, Tom70, Reveals an Elongated Monomer That Is Inherently Flexible, Unstable, and Unfolds via a Multistate Pathway
J. Biol. Chem. 2004 279: 46448-46454. First Published on August 16, 2004; doi:10.1074/jbc.M405639200 [Abstract] [Full Text] [PDF]

Gabriele Weitz-Schmidt, Karl Welzenbach, Janet Dawson, and Joerg Kallen: Improved Lymphocyte Function-associated Antigen-1 (LFA-1) Inhibition by Statin Derivatives: MOLECULAR BASIS DETERMINED BY X-RAY ANALYSIS AND MONITORING OF LFA-1 CONFORMATIONAL CHANGES IN VITRO AND EX VIVO
J. Biol. Chem. 2004 279: 46764-46771. First Published on August 10, 2004; doi:10.1074/jbc.M407951200 [Abstract] [Full Text] [PDF]

Betsy L. Lytle, Francis C. Peterson, Shi-Hong Qiu, Ming Luo, Qin Zhao, John L. Markley, and Brian F. Volkman: Solution Structure of a Ubiquitin-like Domain from Tubulin-binding Cofactor B
J. Biol. Chem. 2004 279: 46787-46793. First Published on September 9, 2004; doi:10.1074/jbc.M409422200 [Abstract] [Full Text] [PDF]

Kari R. Strand, Solveig Karlsen, Matthias Kolberg, Åsmund Kjendseth Røhr, Carl Henrik Görbitz, and K. Kristoffer Andersson: Crystal Structural Studies of Changes in the Native Dinuclear Iron Center of Ribonucleotide Reductase Protein R2 from Mouse
J. Biol. Chem. 2004 279: 46794-46801. First Published on August 17, 2004; doi:10.1074/jbc.M407346200 [Abstract] [Full Text] [PDF]

David Pettigrew, Kirstine L. Anderson, Jason Billington, Ernesto Cota, Peter Simpson, Petri Urvil, Filip Rabuzin, Pietro Roversi, Bogdan Nowicki, Laurence du Merle, Chantal Le Bouguénec, Stephen Matthews, and Susan M. Lea: High Resolution Studies of the Afa/Dr Adhesin DraE and Its Interaction with Chloramphenicol
J. Biol. Chem. 2004 279: 46851-46857. First Published on August 24, 2004; doi:10.1074/jbc.M409284200 [Abstract] [Full Text] [PDF]

Julie L. Dutton, Rosemary F. Renda, Clement Waine, Richard J. Clark, Norelle L. Daly, Cameron V. Jennings, Marilyn A. Anderson, and David J. Craik: Conserved Structural and Sequence Elements Implicated in the Processing of Gene-encoded Circular Proteins
J. Biol. Chem. 2004 279: 46858-46867. First Published on August 24, 2004; doi:10.1074/jbc.M407421200 [Abstract] [Full Text] [PDF]

Alexei V. Buevich, Teresita Silva, Barbara Brodsky, and Jean Baum: Transformation of the Mechanism of Triple-helix Peptide Folding in the Absence of a C-terminal Nucleation Domain and Its Implications for Mutations in Collagen Disorders
J. Biol. Chem. 2004 279: 46890-46895. First Published on August 5, 2004; doi:10.1074/jbc.M407061200 [Abstract] [Full Text] [PDF]

Nadine Merkley and Gary S. Shaw: Solution Structure of the Flexible Class II Ubiquitin-conjugating Enzyme Ubc1 Provides Insights for Polyubiquitin Chain Assembly
J. Biol. Chem. 2004 279: 47139-47147. First Published on August 24, 2004; doi:10.1074/jbc.M409576200 [Abstract] [Full Text] [PDF] [Papers Of The Week]

Jon López-Llano, Susana Maldonado, Marta Bueno, Anabel Lostao, Maria Ángeles-Jiménez, Mariá P. Lillo, and Javier Sancho: The Long and Short Flavodoxins: I. THE ROLE OF THE DIFFERENTIATING LOOP IN APOFLAVODOXIN STRUCTURE AND FMN BINDING
J. Biol. Chem. 2004 279: 47177-47183. First Published on August 17, 2004; doi:10.1074/jbc.M405792200 [Abstract] [Full Text] [PDF]

Jon López-Llano, Susana Maldonado, Shandya Jain, Anabel Lostao, Raquel Godoy-Ruiz, José M. Sanchez-Ruiz, Manuel Cortijo, Juan Fernández-Recio, and Javier Sancho: The Long and Short Flavodoxins: II. THE ROLE OF THE DIFFERENTIATING LOOP IN APOFLAVODOXIN STABILITY AND FOLDING MECHANISM
J. Biol. Chem. 2004 279: 47184-47191. First Published on August 17, 2004; doi:10.1074/jbc.M405791200 [Abstract] [Full Text] [PDF] Supplemental Data

Ajaybabu V. Pobbati, Adelia Razeto, Matthias Böddener, Stefan Becker, and Dirk Fasshauer: Structural Basis for the Inhibitory Role of Tomosyn in Exocytosis
J. Biol. Chem. 2004 279: 47192-47200. First Published on August 16, 2004; doi:10.1074/jbc.M408767200 [Abstract] [Full Text] [PDF] Supplemental Data [Papers Of The Week]

Cristina Ferrer-Orta, Armando Arias, Rosa Perez-Luque, Cristina Escarmís, Esteban Domingo, and Nuria Verdaguer: Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA
J. Biol. Chem. 2004 279: 47212-47221. First Published on August 3, 2004; doi:10.1074/jbc.M405465200 [Abstract] [Full Text] [PDF]

Mark S. Wilke, Tanya L. Hills, Hong-Zhong Zhang, Henry F. Chambers, and Natalie C. J. Strynadka: Crystal Structures of the Apo and Penicillin-acylated Forms of the BlaR1 ${beta}$ -Lactam Sensor of Staphylococcus aureus
J. Biol. Chem. 2004 279: 47278-47287. First Published on August 18, 2004; doi:10.1074/jbc.M407054200 [Abstract] [Full Text] [PDF]

Taku Yamashita, Yohei Hoashi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Tadayuki Uno: The C-helix in CooA Rolls upon CO Binding to Ferrous Heme
J. Biol. Chem. 2004 279: 47320-47325. First Published on August 23, 2004; doi:10.1074/jbc.M407766200 [Abstract] [Full Text] [PDF]

Tsuyoshi Nonaka, Masahiro Fujihashi, Akiko Kita, Katsuhisa Saeki, Susumu Ito, Koki Horikoshi, and Kunio Miki: The Crystal Structure of an Oxidatively Stable Subtilisin-like Alkaline Serine Protease, KP-43, with a C-terminal ${beta}$ -Barrel Domain
J. Biol. Chem. 2004 279: 47344-47351. First Published on September 1, 2004; doi:10.1074/jbc.M409089200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Xia Yang, Yu-Jia Chang, Shu-Wha Lin, and Peter N. Walsh: Identification of Residues Asn⁸⁹, Ile⁹⁰, and Val¹⁰⁷ of the Factor IXa Second Epidermal Growth Factor Domain That Are Essential for the Assembly of the Factor X-activating Complex on Activated Platelets
J. Biol. Chem. 2004 279: 46400-46405. First Published on August 24, 2004; doi:10.1074/jbc.M406552200 [Abstract] [Full Text] [PDF]

Jeffrey M. Boyd, Heather Ellsworth, and Scott A. Ensign: Bacterial Acetone Carboxylase Is a Manganese-dependent Metalloenzyme
J. Biol. Chem. 2004 279: 46644-46651. First Published on August 27, 2004; doi:10.1074/jbc.M407177200 [Abstract] [Full Text] [PDF]

Anthony C. B. Lim, Zhibo Hou, Choon-Peng Goh, and Robert Z. Qi: Protein Kinase CK2 Is an Inhibitor of the Neuronal Cdk5 Kinase
J. Biol. Chem. 2004 279: 46668-46673. First Published on September 1, 2004; doi:10.1074/jbc.M404760200 [Abstract] [Full Text] [PDF]

Boris Bleijlevens, Thorsten Buhrke, Eddy van der Linden, Bärbel Friedrich, and Simon P. J. Albracht: The Auxiliary Protein HypX Provides Oxygen Tolerance to the Soluble [NiFe]-Hydrogenase of Ralstonia eutropha H16 by Way of a Cyanide Ligand to Nickel
J. Biol. Chem. 2004 279: 46686-46691. First Published on August 31, 2004; doi:10.1074/jbc.M406942200 [Abstract] [Full Text] [PDF]

Lingyun Rui, Li Cao, Wilfred Chen, Kenneth F. Reardon, and Thomas K. Wood: Active Site Engineering of the Epoxide Hydrolase from Agrobacterium radiobacter AD1 to Enhance Aerobic Mineralization of cis-1,2-Dichloroethylene in Cells Expressing an Evolved Toluene ortho-Monooxygenase
J. Biol. Chem. 2004 279: 46810-46817. First Published on August 30, 2004; doi:10.1074/jbc.M407466200 [Abstract] [Full Text] [PDF]

Steven H. Schwartz, Xiaoqiong Qin, and Michele C. Loewen: The Biochemical Characterization of Two Carotenoid Cleavage Enzymes from Arabidopsis Indicates That a Carotenoid-derived Compound Inhibits Lateral Branching
J. Biol. Chem. 2004 279: 46940-46945. First Published on September 1, 2004; doi:10.1074/jbc.M409004200 [Abstract] [Full Text] [PDF] Supplemental Data

Khalid A. Hanafy, Emil Martin, and Ferid Murad: CCT ${eta}$ , a Novel Soluble Guanylyl Cyclase-interacting Protein
J. Biol. Chem. 2004 279: 46946-46953. First Published on August 30, 2004; doi:10.1074/jbc.M404134200 [Abstract] [Full Text] [PDF]

John P. Hobson, Sarah Netzel-Arnett, Roman Szabo, Sophie M. Réhault, Frank C. Church, Dudley K. Strickland, Daniel A. Lawrence, Toni M. Antalis, and Thomas H. Bugge: Mouse DESC1 Is Located within a Cluster of Seven DESC1-like Genes and Encodes a Type II Transmembrane Serine Protease That Forms Serpin Inhibitory Complexes
J. Biol. Chem. 2004 279: 46981-46994. First Published on August 24, 2004; doi:10.1074/jbc.M403299200 [Abstract] [Full Text] [PDF]

Stephanie N. Hicks, R. Derike Smiley, Lori G. Stinnett, Kenneth H. Minor, and Elizabeth E. Howell: Role of Lys-32 Residues in R67 Dihydrofolate Reductase Probed by Asymmetric Mutations
J. Biol. Chem. 2004 279: 46995-47002. First Published on August 27, 2004; doi:10.1074/jbc.M404484200 [Abstract] [Full Text] [PDF] Supplemental Data

Lori G. Stinnett, R. Derike Smiley, Stephanie N. Hicks, and Elizabeth E. Howell: "Catch 222," the Effects of Symmetry on Ligand Binding and Catalysis in R67 Dihydrofolate Reductase as Determined by Mutations at Tyr-69
J. Biol. Chem. 2004 279: 47003-47009. First Published on August 27, 2004; doi:10.1074/jbc.M404485200 [Abstract] [Full Text] [PDF]

Vinod Vathipadiekal and Mala Rao: Inhibition of 1,4- ${beta}$ -D-Xylan Xylanohydrolase by the Specific Aspartic Protease Inhibitor Pepstatin: PROBING THE TWO-STEP INHIBITION MECHANISM
J. Biol. Chem. 2004 279: 47024-47033. First Published on August 17, 2004; doi:10.1074/jbc.M407866200 [Abstract] [Full Text] [PDF]

Yoh-hei Takahashi, Kenji Inaba, and Koreaki Ito: Characterization of the Menaquinone-dependent Disulfide Bond Formation Pathway of Escherichia coli
J. Biol. Chem. 2004 279: 47057-47065. First Published on August 30, 2004; doi:10.1074/jbc.M407153200 [Abstract] [Full Text] [PDF]

Jonathan Langdown, Daniel J. D. Johnson, Trevor P. Baglin, and James A. Huntington: Allosteric Activation of Antithrombin Critically Depends upon Hinge Region Extension
J. Biol. Chem. 2004 279: 47288-47297. First Published on August 23, 2004; doi:10.1074/jbc.M408961200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Andrew R. Green, Susan Aiston, Cynthia C. Greenberg, Susan Freeman, Simon M. Poucher, Matthew J. Brady, and Loranne Agius: The Glycogenic Action of Protein Targeting to Glycogen in Hepatocytes Involves Multiple Mechanisms Including Phosphorylase Inactivation and Glycogen Synthase Translocation
J. Biol. Chem. 2004 279: 46474-46482. First Published on August 18, 2004; doi:10.1074/jbc.M405660200 [Abstract] [Full Text] [PDF]

Jian Li Campian, Mingwei Qian, Xueshan Gao, and John W. Eaton: Oxygen Tolerance and Coupling of Mitochondrial Electron Transport
J. Biol. Chem. 2004 279: 46580-46587. First Published on August 24, 2004; doi:10.1074/jbc.M406685200 [Abstract] [Full Text] [PDF]

Roman A. Eliseev, Beth VanWinkle, Randy N. Rosier, and Thomas E. Gunter: Diazoxide-mediated Preconditioning against Apoptosis Involves Activation of cAMP-response Element-binding Protein (CREB) and NF ${kappa}$ B
J. Biol. Chem. 2004 279: 46748-46754. First Published on August 23, 2004; doi:10.1074/jbc.M406217200 [Abstract] [Full Text] [PDF]

Xiaoying Liu, Chang-An Yu, and Linda Yu: The Role of Extra Fragment at the C-terminal of Cytochrome b (Residues 421–445) in the Cytochrome bc₁ Complex from Rhodobacter sphaeroides
J. Biol. Chem. 2004 279: 47363-47371. First Published on August 30, 2004; doi:10.1074/jbc.M406497200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Sachiko Aono, Yoshihito Tokita, Takuya Shuo, Shinobu Yamauchi, Fumiko Matsui, Keiko Nakanishi, Kanako Hirano, Mamoru Sano, and Atsuhiko Oohira: Glycosylation Site for Chondroitin Sulfate on the Neural Part-time Proteoglycan, Neuroglycan C
J. Biol. Chem. 2004 279: 46536-46541. First Published on August 24, 2004; doi:10.1074/jbc.M403263200 [Abstract] [Full Text] [PDF]

Marion L. Gehrmann, Justin T. Douglas, László Bányai, Hedvig Tordai, László Patthy, and Miguel Llinás: Modular Autonomy, Ligand Specificity, and Functional Cooperativity of the Three In-tandem Fibronectin Type II Repeats from Human Matrix Metalloproteinase 2
J. Biol. Chem. 2004 279: 46921-46929. First Published on August 17, 2004; doi:10.1074/jbc.M408859200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Ximing Du, Yen H. Pham, and Andrew J. Brown: Effects of 25-Hydroxycholesterol on Cholesterol Esterification and Sterol Regulatory Element-binding Protein Processing Are Dissociable: IMPLICATIONS FOR CHOLESTEROL MOVEMENT TO THE REGULATORY POOL IN THE ENDOPLASMIC RETICULUM
J. Biol. Chem. 2004 279: 47010-47016. First Published on August 17, 2004; doi:10.1074/jbc.M408690200 [Abstract] [Full Text] [PDF]

Josep A. Villena, Suheeta Roy, Eszter Sarkadi-Nagy, Kee-Hong Kim, and Hei Sook Sul: Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids: ECTOPIC EXPRESSION OF DESNUTRIN INCREASES TRIGLYCERIDE HYDROLYSIS
J. Biol. Chem. 2004 279: 47066-47075. First Published on August 27, 2004; doi:10.1074/jbc.M403855200 [Abstract] [Full Text] [PDF]

René L. Jacobs, Cecilia Devlin, Ira Tabas, and Dennis E. Vance: Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase ${alpha}$ in Mice Decreases Plasma High Density and Very Low Density Lipoproteins
J. Biol. Chem. 2004 279: 47402-47410. First Published on August 25, 2004; doi:10.1074/jbc.M404027200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Jo Beth Harry, Evgeny Kobrinsky, Darrell R. Abernethy, and Nikolai M. Soldatov: New Short Splice Variants of the Human Cardiac Ca_v ${beta}$ ₂ Subunit: REDEFINING THE MAJOR FUNCTIONAL MOTIFS IMPLEMENTED IN MODULATION OF THE Ca_v1.2 CHANNEL
J. Biol. Chem. 2004 279: 46367-46372. First Published on August 31, 2004; doi:10.1074/jbc.M409523200 [Abstract] [Full Text] [PDF]

Yan Guo, Kathryn Smith, and Michael J. Petris: Cisplatin Stabilizes a Multimeric Complex of the Human Ctr1 Copper Transporter: REQUIREMENT FOR THE EXTRACELLULAR METHIONINE-RICH CLUSTERS
J. Biol. Chem. 2004 279: 46393-46399. First Published on August 23, 2004; doi:10.1074/jbc.M407777200 [Abstract] [Full Text] [PDF]

Frank J. P. Kühn and Andreas Lückhoff: Sites of the NUDT9-H Domain Critical for ADP-ribose Activation of the Cation Channel TRPM2
J. Biol. Chem. 2004 279: 46431-46437. First Published on September 3, 2004; doi:10.1074/jbc.M407263200 [Abstract] [Full Text] [PDF]

Katarina Kristan, Zdravko Podlesek, Vesna Hojnik, Ion Gutiérrez-Aguirre, Gregor Guncar, Dusan Turk, Juan M. González-Mañas, Jeremy H. Lakey, Peter Macek, and Gregor Anderluh: Pore Formation by Equinatoxin, a Eukaryotic Pore-forming Toxin, Requires a Flexible N-terminal Region and a Stable ${beta}$ -Sandwich
J. Biol. Chem. 2004 279: 46509-46517. First Published on August 20, 2004; doi:10.1074/jbc.M406193200 [Abstract] [Full Text] [PDF]

Gregory Tombline, Lori A. Bartholomew, Grace A. Tyndall, Khursheed Gimi, Ina L. Urbatsch, and Alan E. Senior: Properties of P-glycoprotein with Mutations in the "Catalytic Carboxylate" Glutamate Residues
J. Biol. Chem. 2004 279: 46518-46526. First Published on August 23, 2004; doi:10.1074/jbc.M408052200 [Abstract] [Full Text] [PDF]

Jin V. Wu, Mauri E. Krouse, Arjun Rustagi, Nam Soo Joo, and Jeffrey J. Wine: An Inwardly Rectifying Potassium Channel in Apical Membrane of Calu-3 Cells
J. Biol. Chem. 2004 279: 46558-46565. First Published on August 24, 2004; doi:10.1074/jbc.M406058200 [Abstract] [Full Text] [PDF]

João Costa-Rodrigues, Andreia F. Carvalho, Alexandra M. Gouveia, Marc Fransen, Clara Sá-Miranda, and Jorge E. Azevedo: The N Terminus of the Peroxisomal Cycling Receptor, Pex5p, Is Required for Redirecting the Peroxisome-associated Peroxin Back to the Cytosol
J. Biol. Chem. 2004 279: 46573-46579. First Published on August 24, 2004; doi:10.1074/jbc.M406399200 [Abstract] [Full Text] [PDF]

Teah L. Witt, Sarah E. Stapels, and Larry H. Matherly: Restoration of Transport Activity by Co-expression of Human Reduced Folate Carrier Half-molecules in Transport-impaired K562 Cells: LOCALIZATION OF A SUBSTRATE BINDING DOMAIN TO TRANSMEMBRANE DOMAINS 7–12
J. Biol. Chem. 2004 279: 46755-46763. First Published on August 26, 2004; doi:10.1074/jbc.M408696200 [Abstract] [Full Text] [PDF]

Mike Mueckler, William Roach, and Carol Makepeace: Transmembrane Segment 3 of the Glut1 Glucose Transporter Is an Outer Helix
J. Biol. Chem. 2004 279: 46876-46881. First Published on August 10, 2004; doi:10.1074/jbc.M408632200 [Abstract] [Full Text] [PDF]

Alesia M. Hruska-Hageman, Christopher J. Benson, A. Soren Leonard, Margaret P. Price, and Michael J. Welsh: PSD-95 and Lin-7b Interact with Acid-sensing Ion Channel-3 and Have Opposite Effects on H⁺-gated Current
J. Biol. Chem. 2004 279: 46962-46968. First Published on August 17, 2004; doi:10.1074/jbc.M405874200 [Abstract] [Full Text] [PDF]

Decha Enkvetchakul, Jaya Bhattacharyya, Iana Jeliazkova, Darcy K. Groesbeck, Catherine A. Cukras, and Colin G. Nichols: Functional Characterization of a Prokaryotic Kir Channel
J. Biol. Chem. 2004 279: 47076-47080. First Published on September 23, 2004; doi:10.1074/jbc.C400417200 [Abstract] [Full Text] [PDF]

Mikhail Khvotchev and Thomas C. Südhof: Proteolytic Processing of Amyloid- ${beta}$ Precursor Protein by Secretases Does Not Require Cell Surface Transport
J. Biol. Chem. 2004 279: 47101-47108. First Published on August 16, 2004; doi:10.1074/jbc.M408474200 [Abstract] [Full Text] [PDF]

Takashi Tsuboi, Harvey T. McMahon, and Guy A. Rutter: Mechanisms of Dense Core Vesicle Recapture following "Kiss and Run" ("Cavicapture") Exocytosis in Insulin-secreting Cells
J. Biol. Chem. 2004 279: 47115-47124. First Published on August 25, 2004; doi:10.1074/jbc.M408179200 [Abstract] [Full Text] [PDF] Supplemental Data

Youhou Kang, Yuk-Man Leung, Jocelyn E. Manning-Fox, Fuzhen Xia, Huanli Xie, Laura Sheu, Robert G. Tsushima, Peter E. Light, and Herbert Y. Gaisano: Syntaxin-1A Inhibits Cardiac K_ATP Channels by Its Actions on Nucleotide Binding Folds 1 and 2 of Sulfonylurea Receptor 2A
J. Biol. Chem. 2004 279: 47125-47131. First Published on August 31, 2004; doi:10.1074/jbc.M404954200 [Abstract] [Full Text] [PDF]

Lionel Breuza, Regula Halbeisen, Paul Jenö, Stefan Otte, Charles Barlowe, Wanjin Hong, and Hans-Peter Hauri: Proteomics of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membranes from Brefeldin A-treated HepG2 Cells Identifies ERGIC-32, a New Cycling Protein That Interacts with Human Erv46
J. Biol. Chem. 2004 279: 47242-47253. First Published on August 11, 2004; doi:10.1074/jbc.M406644200 [Abstract] [Full Text] [PDF] Supplemental Data

Mechanisms Of Signal Transduction:

Jui-Hsiang Hung, Ih-Jen Su, Huan-Yao Lei, Hui-Ching Wang, Wan-Chi Lin, Wen-Tsan Chang, Wenya Huang, Wen-Chang Chang, Yung-Sheng Chang, Ching-Chow Chen, and Ming-Derg Lai: Endoplasmic Reticulum Stress Stimulates the Expression of Cyclooxygenase-2 through Activation of NF- ${kappa}$ B and pp38 Mitogen-activated Protein Kinase
J. Biol. Chem. 2004 279: 46384-46392. First Published on August 19, 2004; doi:10.1074/jbc.M403568200 [Abstract] [Full Text] [PDF]

Ryu Imamura, Kenji Konaka, Norihiko Matsumoto, Mizuho Hasegawa, Masayuki Fukui, Naofumi Mukaida, Takeshi Kinoshita, and Takashi Suda: Fas Ligand Induces Cell-autonomous NF- ${kappa}$ B Activation and Interleukin-8 Production by a Mechanism Distinct from That of Tumor Necrosis Factor- ${alpha}$
J. Biol. Chem. 2004 279: 46415-46423. First Published on August 26, 2004; doi:10.1074/jbc.M403226200 [Abstract] [Full Text] [PDF] Supplemental Data

Melanie Keiper, Matthias B. Stope, Daniel Szatkowski, Anja Böhm, Karina Tysack, Frank vom Dorp, Oliver Saur, Paschal A. Oude Weernink, Sandrine Evellin, Karl H. Jakobs, and Martina Schmidt: Epac- and Ca²+-controlled Activation of Ras and Extracellular Signal-regulated Kinases by G_s-coupled Receptors
J. Biol. Chem. 2004 279: 46497-46508. First Published on August 19, 2004; doi:10.1074/jbc.M403604200 [Abstract] [Full Text] [PDF]

Ivanka Dilova, Sofia Aronova, Jenny C.-Y. Chen, and Ted Powers: Tor Signaling and Nutrient-based Signals Converge on Mks1p Phosphorylation to Regulate Expression of Rtg1p·Rtg3p-dependent Target Genes
J. Biol. Chem. 2004 279: 46527-46535. First Published on August 23, 2004; doi:10.1074/jbc.M409012200 [Abstract] [Full Text] [PDF]

Gilles Guihard, Gregory Bellot, Carole Moreau, Gilbert Pradal, Nicolas Ferry, Raphael Thomy, Paulette Fichet, Khaled Meflah, and François Marie Vallette: The Mitochondrial Apoptosis-induced Channel (MAC) Corresponds to a Late Apoptotic Event
J. Biol. Chem. 2004 279: 46542-46550. First Published on August 24, 2004; doi:10.1074/jbc.M405153200 [Abstract] [Full Text] [PDF]

Alessandra Trencia, Francesca Fiory, Maria Alessandra Maitan, Pasquale Vito, Alessia Paola Maria Barbagallo, Anna Perfetti, Claudia Miele, Paola Ungaro, Francesco Oriente, Lucia Cilenti, Antonis S. Zervos, Pietro Formisano, and Francesco Beguinot: Omi/HtrA2 Promotes Cell Death by Binding and Degrading the Anti-apoptotic Protein ped/pea-15
J. Biol. Chem. 2004 279: 46566-46572. First Published on August 24, 2004; doi:10.1074/jbc.M406317200 [Abstract] [Full Text] [PDF]

Kathie A. Mihindukulasuriya, Guisheng Zhou, Jun Qin, and Tse-Hua Tan: Protein Phosphatase 4 Interacts with and Down-regulates Insulin Receptor Substrate 4 following Tumor Necrosis Factor- ${alpha}$ Stimulation
J. Biol. Chem. 2004 279: 46588-46594. First Published on August 24, 2004; doi:10.1074/jbc.M408067200 [Abstract] [Full Text] [PDF]

Guofei Zhou, Teresa Golden, Ileana V. Aragon, and Richard E. Honkanen: Ser/Thr Protein Phosphatase 5 Inactivates Hypoxia-induced Activation of an Apoptosis Signal-regulating Kinase 1/MKK-4/JNK Signaling Cascade
J. Biol. Chem. 2004 279: 46595-46605. First Published on August 24, 2004; doi:10.1074/jbc.M408320200 [Abstract] [Full Text] [PDF]

Rebecca A. Stockton, Erik Schaefer, and Martin Alexander Schwartz: p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility
J. Biol. Chem. 2004 279: 46621-46630. First Published on August 27, 2004; doi:10.1074/jbc.M408877200 [Abstract] [Full Text] [PDF]

Natasha C. Browner, Nupur B. Dey, Kenneth D. Bloch, and Thomas M. Lincoln: Regulation of cGMP-dependent Protein Kinase Expression by Soluble Guanylyl Cyclase in Vascular Smooth Muscle Cells
J. Biol. Chem. 2004 279: 46631-46636. First Published on August 26, 2004; doi:10.1074/jbc.M408518200 [Abstract] [Full Text] [PDF]

Elad Anter, Shane R. Thomas, Eberhard Schulz, Oz M. Shapira, Joseph A. Vita, and John F. Keaney, Jr.: Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols
J. Biol. Chem. 2004 279: 46637-46643. First Published on August 27, 2004; doi:10.1074/jbc.M405547200 [Abstract] [Full Text] [PDF]

Francesca Spinella, Laura Rosanò, Valeriana Di Castro, Pier Giorgio Natali, and Anna Bagnato: Endothelin-1-induced Prostaglandin E2-EP2, EP4 Signaling Regulates Vascular Endothelial Growth Factor Production and Ovarian Carcinoma Cell Invasion
J. Biol. Chem. 2004 279: 46700-46705. First Published on September 3, 2004; doi:10.1074/jbc.M408584200 [Abstract] [Full Text] [PDF]

Alfonso Catalano, Sabrina Rodilossi, Maria Rita Rippo, Paola Caprari, and Antonio Procopio: Induction of Stem Cell Factor/c-Kit/Slug Signal Transduction in Multidrug-resistant Malignant Mesothelioma Cells
J. Biol. Chem. 2004 279: 46706-46714. First Published on August 26, 2004; doi:10.1074/jbc.M406696200 [Abstract] [Full Text] [PDF]

Sonia Colombo, Daniela Ronchetti, Johan M. Thevelein, Joris Winderickx, and Enzo Martegani: Activation State of the Ras2 Protein and Glucose-induced Signaling in Saccharomyces cerevisiae
J. Biol. Chem. 2004 279: 46715-46722. First Published on August 31, 2004; doi:10.1074/jbc.M405136200 [Abstract] [Full Text] [PDF]

Patrick Legembre, Robert Schickel, Bryan C. Barnhart, and Marcus E. Peter: Identification of SNF1/AMP Kinase-related Kinase as an NF- ${kappa}$ B-regulated Anti-apoptotic Kinase Involved in CD95-induced Motility and Invasiveness
J. Biol. Chem. 2004 279: 46742-46747. First Published on September 3, 2004; doi:10.1074/jbc.M404334200 [Abstract] [Full Text] [PDF]

Vivek Mittal and Maurine E. Linder: The RGS14 GoLoco Domain Discriminates among G ${alpha}$ _i Isoforms
J. Biol. Chem. 2004 279: 46772-46778. First Published on August 26, 2004; doi:10.1074/jbc.M407409200 [Abstract] [Full Text] [PDF]

Masumi Tsuda, Yoshinori Makino, Toshinori Iwahara, Hiroshi Nishihara, Hirofumi Sawa, Kazuo Nagashima, Hidesaburo Hanafusa, and Shinya Tanaka: Crk Associates with ERM Proteins and Promotes Cell Motility toward Hyaluronic Acid
J. Biol. Chem. 2004 279: 46843-46850. First Published on August 23, 2004; doi:10.1074/jbc.M401476200 [Abstract] [Full Text] [PDF]

Fernando Ribeiro-Neto, Angelica Leon, Julie Urbani-Brocard, Liguang Lou, Abraham Nyska, and Daniel L. Altschuler: cAMP-dependent Oncogenic Action of Rap1b in the Thyroid Gland
J. Biol. Chem. 2004 279: 46868-46875. First Published on August 25, 2004; doi:10.1074/jbc.M406858200 [Abstract] [Full Text] [PDF]

Hilary Highfield Nickols, Vikas N. Shah, Walter J. Chazin, and Lee E. Limbird: Calmodulin Interacts with the V2 Vasopressin Receptor: ELIMINATION OF BINDING TO THE C TERMINUS ALSO ELIMINATES ARGININE VASOPRESSIN-STIMULATED ELEVATION OF INTRACELLULAR CALCIUM
J. Biol. Chem. 2004 279: 46969-46980. First Published on August 19, 2004; doi:10.1074/jbc.M407351200 [Abstract] [Full Text] [PDF]

José M. Sarmiento, Carolina C. Añazco, Danae M. Campos, Gregory N. Prado, Javier Navarro, and Carlos B. González: Novel Down-regulatory Mechanism of the Surface Expression of the Vasopressin V₂ Receptor by an Alternative Splice Receptor Variant
J. Biol. Chem. 2004 279: 47017-47023. First Published on September 8, 2004; doi:10.1074/jbc.M410011200 [Abstract] [Full Text] [PDF]

Feyza Sancar and Cynthia Czajkowski: A GABA_A Receptor Mutation Linked to Human Epilepsy ( ${gamma}$ ₂R43Q) Impairs Cell Surface Expression of ${alpha}$ ${beta}$ ${gamma}$ Receptors
J. Biol. Chem. 2004 279: 47034-47039. First Published on September 1, 2004; doi:10.1074/jbc.M403388200 [Abstract] [Full Text] [PDF]

Ron Diskin, Nadav Askari, Ricardo Capone, David Engelberg, and Oded Livnah: Active Mutants of the Human p38 ${alpha}$ Mitogen-activated Protein Kinase
J. Biol. Chem. 2004 279: 47040-47049. First Published on July 28, 2004; doi:10.1074/jbc.M404595200 [Abstract] [Full Text] [PDF]

Melanie B. Laederich, Melanie Funes-Duran, Lily Yen, Ellen Ingalla, Xiuli Wu, Kermit L. Carraway, III, and Colleen Sweeney: The Leucine-rich Repeat Protein LRIG1 Is a Negative Regulator of ErbB Family Receptor Tyrosine Kinases
J. Biol. Chem. 2004 279: 47050-47056. First Published on September 1, 2004; doi:10.1074/jbc.M409703200 [Abstract] [Full Text] [PDF]

Olivier Basset, François-Xavier Boittin, Olivier M. Dorchies, Jean-Yves Chatton, Cornelis van Breemen, and Urs T. Ruegg: Involvement of Inositol 1,4,5-Trisphosphate in Nicotinic Calcium Responses in Dystrophic Myotubes Assessed by Near-plasma Membrane Calcium Measurement
J. Biol. Chem. 2004 279: 47092-47100. First Published on August 18, 2004; doi:10.1074/jbc.M405054200 [Abstract] [Full Text] [PDF]

Shishir Shishodia and Bharat B. Aggarwal: Guggulsterone Inhibits NF- ${kappa}$ B and I ${kappa}$ B ${alpha}$ Kinase Activation, Suppresses Expression of Anti-apoptotic Gene Products, and Enhances Apoptosis
J. Biol. Chem. 2004 279: 47148-47158. First Published on August 17, 2004; doi:10.1074/jbc.M408093200 [Abstract] [Full Text] [PDF]

Clive P. Morgan, Alison Skippen, Bruno Segui, Andrew Ball, Victoria Allen-Baume, Banafshe Larijani, Judith Murray-Rust, Neil McDonald, Gopal Sapkota, Nick Morrice, and Shamshad Cockcroft: Phosphorylation of a Distinct Structural Form of Phosphatidylinositol Transfer Protein ${alpha}$ at Ser¹⁶⁶ by Protein Kinase C Disrupts Receptor-mediated Phospholipase C Signaling by Inhibiting Delivery of Phosphatidylinositol to Membranes
J. Biol. Chem. 2004 279: 47159-47171. First Published on August 18, 2004; doi:10.1074/jbc.M405827200 [Abstract] [Full Text] [PDF]

Stefania Saoncella, Enzo Calautti, Wendy Neveu, and Paul F. Goetinck: Syndecan-4 Regulates ATF-2 Transcriptional Activity in a Rac1-dependent Manner
J. Biol. Chem. 2004 279: 47172-47176. First Published on September 13, 2004; doi:10.1074/jbc.C400299200 [Abstract] [Full Text] [PDF]

Andrew M. Seeds, Joshua C. Sandquist, Eric P. Spana, and John D. York: A Molecular Basis for Inositol Polyphosphate Synthesis in Drosophila melanogaster
J. Biol. Chem. 2004 279: 47222-47232. First Published on August 20, 2004; doi:10.1074/jbc.M408295200 [Abstract] [Full Text] [PDF]

Stefan Wüller, Burkhard Wiesner, Anja Löffler, Jens Furkert, Gerd Krause, Ricardo Hermosilla, Michael Schaefer, Ralf Schülein, Walter Rosenthal, and Alexander Oksche: Pharmacochaperones Post-translationally Enhance Cell Surface Expression by Increasing Conformational Stability of Wild-type and Mutant Vasopressin V₂ Receptors
J. Biol. Chem. 2004 279: 47254-47263. First Published on August 19, 2004; doi:10.1074/jbc.M408154200 [Abstract] [Full Text] [PDF] Supplemental Data

Ramesh Narayanan, Veronica A. Tovar Sepulveda, Miriam Falzon, and Nancy L. Weigel: The Functional Consequences of Cross-talk between the Vitamin D Receptor and ERK Signaling Pathways Are Cell-specific
J. Biol. Chem. 2004 279: 47298-47310. First Published on August 25, 2004; doi:10.1074/jbc.M404101200 [Abstract] [Full Text] [PDF]

Gregory C. Amberg, Charles F. Rossow, Manuel F. Navedo, and Luis F. Santana: NFATc3 Regulates Kv2.1 Expression in Arterial Smooth Muscle
J. Biol. Chem. 2004 279: 47326-47334. First Published on August 22, 2004; doi:10.1074/jbc.M408789200 [Abstract] [Full Text] [PDF]

Romana Kristelly, Guang Gao, and John J. G. Tesmer: Structural Determinants of RhoA Binding and Nucleotide Exchange in Leukemia-associated Rho Guanine-Nucleotide Exchange Factor
J. Biol. Chem. 2004 279: 47352-47362. First Published on August 25, 2004; doi:10.1074/jbc.M406056200 [Abstract] [Full Text] [PDF]

Rajinder S. Sawhney, Michelle M. Cookson, Bhavya Sharma, Jennie Hauser, and Michael G. Brattain: Autocrine Transforming Growth Factor ${alpha}$ Regulates Cell Adhesion by Multiple Signaling via Specific Phosphorylation Sites of p70S6 Kinase in Colon Cancer Cells
J. Biol. Chem. 2004 279: 47379-47390. First Published on August 10, 2004; doi:10.1074/jbc.M402031200 [Abstract] [Full Text] [PDF]

Annette Flotho, David M. Simpson, Maosong Qi, and Elaine A. Elion: Localized Feedback Phosphorylation of Ste5p Scaffold by Associated MAPK Cascade
J. Biol. Chem. 2004 279: 47391-47401. First Published on August 20, 2004; doi:10.1074/jbc.M405681200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Robert J. Klose and Adrian P. Bird: MeCP2 Behaves as an Elongated Monomer That Does Not Stably Associate with the Sin3a Chromatin Remodeling Complex
J. Biol. Chem. 2004 279: 46490-46496. First Published on August 18, 2004; doi:10.1074/jbc.M408284200 [Abstract] [Full Text] [PDF]

Dmitri V. Rozanov, Alexei Y. Savinov, Vladislav S. Golubkov, Tatiana I. Postnova, Albert Remacle, Stephen Tomlinson, and Alex Y. Strongin: Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Cleaves C3b, an Essential Component of the Complement System
J. Biol. Chem. 2004 279: 46551-46557. First Published on September 14, 2004; doi:10.1074/jbc.M405284200 [Abstract] [Full Text] [PDF]

Soundara Raghavan Pavithra, Gowrishankar Banumathy, Omana Joy, Varsha Singh, and Utpal Tatu: Recurrent Fever Promotes Plasmodium falciparum Development in Human Erythrocytes
J. Biol. Chem. 2004 279: 46692-46699. First Published on August 31, 2004; doi:10.1074/jbc.M409165200 [Abstract] [Full Text] [PDF]

Marie-France Gaumont-Leclerc, Uptal Kumar Mukhopadhyay, Stéphane Goumard, and Gerardo Ferbeyre: PEA-15 Is Inhibited by Adenovirus E1A and Plays a Role in ERK Nuclear Export and Ras-induced Senescence
J. Biol. Chem. 2004 279: 46802-46809. First Published on August 25, 2004; doi:10.1074/jbc.M403893200 [Abstract] [Full Text] [PDF]

Matthew J. Morgan, Joost M. Woltering, Paul M. J. In der Rieden, Antony J. Durston, and Jean Paul Thiery: YY1 Regulates the Neural Crest-associated slug Gene in Xenopus laevis
J. Biol. Chem. 2004 279: 46826-46834. First Published on August 23, 2004; doi:10.1074/jbc.M406140200 [Abstract] [Full Text] [PDF]

Cédric Delevoye, Michael Nilges, Alice Dautry-Varsat, and Agathe Subtil: Conservation of the Biochemical Properties of IncA from Chlamydia trachomatis and Chlamydia caviae: OLIGOMERIZATION OF IncA MEDIATES INTERACTION BETWEEN FACING MEMBRANES
J. Biol. Chem. 2004 279: 46896-46906. First Published on August 16, 2004; doi:10.1074/jbc.M407227200 [Abstract] [Full Text] [PDF] Supplemental Data

Vassilios Beglopoulos, Xiaoyan Sun, Carlos A Saura, Cynthia A. Lemere, Richard D. Kim, and Jie Shen: Reduced ${beta}$ -Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knock-out Mice
J. Biol. Chem. 2004 279: 46907-46914. First Published on September 1, 2004; doi:10.1074/jbc.M409544200 [Abstract] [Full Text] [PDF]

Xiangyu Li, Gyosuke Sakashita, Hideki Matsuzaki, Kenji Sugimoto, Keiji Kimura, Fumio Hanaoka, Hisaaki Taniguchi, Koichi Furukawa, and Takeshi Urano: Direct Association with Inner Centromere Protein (INCENP) Activates the Novel Chromosomal Passenger Protein, Aurora-C
J. Biol. Chem. 2004 279: 47201-47211. First Published on August 16, 2004; doi:10.1074/jbc.M403029200 [Abstract] [Full Text] [PDF] Supplemental Data

Laurence Leconte, Laure Lecoin, Patrick Martin, and Simon Saule: Pax6 Interacts with cVax and Tbx5 to Establish the Dorsoventral Boundary of the Developing Eye
J. Biol. Chem. 2004 279: 47272-47277. First Published on August 18, 2004; doi:10.1074/jbc.M406624200 [Abstract] [Full Text] [PDF]

Tomoko Nishiyama, Isao Kii, and Akira Kudo: Inactivation of Rho/ROCK Signaling Is Crucial for the Nuclear Accumulation of FKHR and Myoblast Fusion
J. Biol. Chem. 2004 279: 47311-47319. First Published on August 22, 2004; doi:10.1074/jbc.M403546200 [Abstract] [Full Text] [PDF]

Risa Takazaki, Yuji Shishido, Ryo Iwamoto, and Eisuke Mekada: Suppression of the Biological Activities of the Epidermal Growth Factor (EGF)-like Domain by the Heparin-binding Domain of Heparin-binding EGF-like Growth Factor
J. Biol. Chem. 2004 279: 47335-47343. First Published on August 24, 2004; doi:10.1074/jbc.M408556200 [Abstract] [Full Text] [PDF]