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The cover shows superposed confocal images or 4,6-diamidino-2-phenylindole (DAPI) fluorescence (cyan) and Nomarski differential interference contrast (gray) of Toll-like receptor 2-/- macrophages infected with Coxiella burnetii phase II for 2 (inset) or 4 days. N labels cell nuclei. Intracellular bacteria (cyan) localizes in spacious vacuoles that are highly permissive to bacterial multiplication due to the absence of Toll-like receptor 2 gene. For details see the article by Zamboni et al., pages pages 54405-54415.