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On the cover, a series of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase transition state inhibitors was synthesized with some of the tightest binding affinities reported (10^-12-10 M). The nucleosidase is complexed with (3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine (MT-DADMe-ImmA), and the analysis of the mode of binding provides extraordinary insight into the structural basis for its affinity. For details see the articles by Lee et al., pages 18274-18282 and Singhet al., pages 18265-18273.
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