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On the cover, metabolic dynamics in the brain are imaged using the fluorescence of endogenous reduced -nicotinamide adenine dinucleotide (NADH). Fluorescence measurements, however, are complicated by the dependence of the quantum efficiency of NADH on its free/bound state. Time-resolved fluorescence anisotropy discriminates free/bound NADH and shows a preferential increase in free NADH during the normoxic (blue curve) to hypoxic (red curve) metabolic transition. For details see the article by Vishwasrao et al., pages 25119-25126.
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