On The Cover: Cathepsin K is shown bound to the peptide sequence, His-Gly-Pro-Arg, on a background of peptides. The positional scanning synthetic combinatorial libraries (PS-SCL) described by Choe et al. provide an unbiased method for identifying the preferred substrate for a particular proteolytic enzyme. The protease selects the preferred substrate from a total of 160,000 tetrapeptide sequences that have been completely randomized at each subsite position. For details see the article by Choe et al., pages 12824–12832.

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