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On The Cover: Steroid and xenobiotic receptor (SXR) ligands vitamin K₂ (magenta) and rifampicin (gray) activate transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. The structure of the ligand-binding domain of human SXR (center) was retrieved from the NCBI's structure database Molecular Modeling DataBase and viewed by the Cn3D application. Three-dimensional structures of vitamin K₂ (RN: 863-61-6) and rifampicin (RN: 13292-46-1) were retrieved from the ChemIDplus Advanced Record of the National Library of Medicine. For details see the article by Ichikawa et al., pages 16927–16934.

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