On The Cover: Congested cholesterol: immunofluorescence staining of cholesterol in control or Niemann-Pick type C1 (NPC1)-depleted HeLa cells. Loss of NPC1 protein leads to a large accumulation of cholesterol in the late endocytic pathway, leading to impaired late endosome function. Cholesterol is labeled with fluorescent θ-toxin. For details see the article by Ganley and Pfeffer, pages 17890–17899.

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