On The Cover: Structure of the Ca²⁺ regulatory site of the Na⁺-Ca²⁺ exchanger determined by x-ray crystallography. A cluster of four Ca²⁺ ions (silver spheres) are bound by several anionic residues in close proximity. The Na⁺-Ca² exchanger is abundant in cardiac sarcolemma where it has an important physiological role. In the background is an isolated cardiac myocyte stained (green) with a monoclonal antibody to the Na⁺-Ca²⁺ exchanger. For details see the article by Nicoll et al., pages 21577–21581.

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