About the Cover
On The Cover: This figure shows osteoclasts, with grainy red stain for tartrate-resistant acid phosphatase, in tibia of toothless osteopetrotic rat, toluidine blue counterstain. A prominent osteoclast with 3 nuclei is visible near the center. In this mutant, osteoclasts only appear in response to injections of CSF-1. This dynamic in vivo model was used to discover novel osteoclast genes. One of these, OGR1, is a G-protein-coupled receptor that responds to extracellular pH. In addition, Yang et al. show by inhibition studies that OGR1 also regulates the differentiation of osteoclasts. For details see the article by Yang et al., pages 23598–23605.
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Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.
